Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension.

Abstract:

STUDY OBJECTIVES:To determine the selective vasodilatory effects of two inhaled "NONOate" aerosols in a closed chest pig model of acute pulmonary hypertension (APH). METHODS:APH was induced by IV infusion of the prostaglandin H(2)/thromboxane A(2) receptor agonist (U46619). Aerosolized diethylenetriamine nitric oxide (NO) adduct (DETA/NO, n = 4), dipropylenetriamine NO adduct (DPTA/NO, n = 4) [60 micro mol each], or placebo (n = 4) was delivered via the trachea. Hemodynamic parameters and blood samples were measured before and after inhalation therapy. RESULTS:Compared to control animals, pulmonary vascular resistance and pulmonary arterial pressure were significantly reduced from 10 to 105 min after DETA/NO administration and from 10 to 45 min after DPTA/NO aerosol administration (p < 0.05). Both aerosols had no significant effect on systemic vascular resistance or systemic BP. Serum nitrite significantly increased after the inhalation of both NONOates (p < 0.01). There was a tendency for reduced intrapulmonary shunting, particularly after treatment with DETA/NO. CONCLUSION:Both DETA/NO and DPTA/NO administered as aerosols selectively reduced pulmonary hypertension induced by U46619.

journal_name

Chest

journal_title

Chest

authors

Lam CF,van Heerden PV,Ilett KF,Caterina P,Filion P

doi

10.1378/chest.123.3.869

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

869-74

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)34757-2

journal_volume

123

pub_type

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