Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension.


STUDY OBJECTIVES:To determine the selective vasodilatory effects of two inhaled "NONOate" aerosols in a closed chest pig model of acute pulmonary hypertension (APH). METHODS:APH was induced by IV infusion of the prostaglandin H(2)/thromboxane A(2) receptor agonist (U46619). Aerosolized diethylenetriamine nitric oxide (NO) adduct (DETA/NO, n = 4), dipropylenetriamine NO adduct (DPTA/NO, n = 4) [60 micro mol each], or placebo (n = 4) was delivered via the trachea. Hemodynamic parameters and blood samples were measured before and after inhalation therapy. RESULTS:Compared to control animals, pulmonary vascular resistance and pulmonary arterial pressure were significantly reduced from 10 to 105 min after DETA/NO administration and from 10 to 45 min after DPTA/NO aerosol administration (p < 0.05). Both aerosols had no significant effect on systemic vascular resistance or systemic BP. Serum nitrite significantly increased after the inhalation of both NONOates (p < 0.01). There was a tendency for reduced intrapulmonary shunting, particularly after treatment with DETA/NO. CONCLUSION:Both DETA/NO and DPTA/NO administered as aerosols selectively reduced pulmonary hypertension induced by U46619.






Lam CF,van Heerden PV,Ilett KF,Caterina P,Filion P




Has Abstract


2003-03-01 00:00:00
















  • Systemic artery-to-pulmonary artery fistula. A new therapeutic approach.

    abstract::A patient with systemic artery-to-pulmonary artery fistulae is described. Historically, all therapy of this type of lesion has been surgical. We describe a new mode of treatment, therapeutic embolization, which obviates surgical intervention and its attendant risks. Embolization is an alternative to surgery that shoul...


    pub_type: 杂志文章


    authors: Wolf DC,Wurtzbacher JJ,Horton J

    更新日期:1982-12-01 00:00:00

  • A 26-Year-Old Woman With a Small Right Lung and a Right-Sided Heart.

    abstract::A 26-year-old woman presented with abnormal findings on a chest radiograph. She had no significant history other than a fever 4 months prior to presentation that had resolved without a definite cause identified. She denied cough, shortness of breath, chest pain, history of smoking, environmental exposures, or prior pr...


    pub_type: 杂志文章


    authors: Albores J,Smith MI

    更新日期:2016-03-01 00:00:00

  • The impact of associated diabetic retinopathy on stroke and severe bleeding risk in diabetic patients with atrial fibrillation: the loire valley atrial fibrillation project.

    abstract:BACKGROUND:Diabetes mellitus is recognized as a stroke risk factor in atrial fibrillation (AF). Patients with diabetes with retinopathy have an increased risk for systemic cardiovascular complications, and severe diabetic retinopathy predisposes to ocular bleeding. We hypothesized that patients with diabetes, retinopat...


    pub_type: 杂志文章


    authors: Lip GYH,Clementy N,Pierre B,Boyer M,Fauchier L

    更新日期:2015-04-01 00:00:00

  • Acute respiratory and cardiovascular effects of inhaled ketanserin in chronic obstructive pulmonary disease. A comparative study with intravenously administered ketanserin.

    abstract::In a double-blind, crossover study, nebulized ketanserin, a 5-HT2 receptor antagonist, and a placebo were given to eight patients with moderate to severe nonasthmatic COPD. Intravenous ketanserin had rapid onset of action and induced a longer lasting bronchial response than inhaled ketanserin. These results confirm th...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cazzola M,Guidetti E,Sepe J,Assogna G,Lucchetti G,Santangelo G,D'Amato G

    更新日期:1990-04-01 00:00:00

  • Left lung asthma.

    abstract::The chest radiograph of a woman with acute asthma showed signs of obstructive emphysema of the left lung. Fiberoptic bronchoscopy excluded obstruction of a large bronchus. The signs disappeared after antiasthmatic treatment, suggesting that they were caused by airway closure. In usual asthma, airway closure affects bo...


    pub_type: 杂志文章


    authors: DiFrancia M,Barbier D,Orehek J

    更新日期:1993-12-01 00:00:00

  • Landmarks of tobacco use in the United States.

    abstract::The idea of inhaling smoke from cigarettes is historically new, actually less than a century old. Consumption of tobacco has changed from chewing tobacco and pipe smoking to smoking cigarettes; smokeless tobaccos are growing tremendously in popularity. The modern smoker is confronted with a highly engineered, complex ...


    pub_type: 历史文章,杂志文章


    authors: McCusker K

    更新日期:1988-02-01 00:00:00

  • Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients.

    abstract:BACKGROUND:Critically ill patients who develop ARDS have substantial associated morbidity and mortality. Circulating mitochondrial DNA (mtDNA) released during critical illness causes endothelial dysfunction and lung injury in experimental models. This study hypothesized that elevated plasma mtDNA is associated with ARD...


    pub_type: 杂志文章


    authors: Faust HE,Reilly JP,Anderson BJ,Ittner CAG,Forker CM,Zhang P,Weaver BA,Holena DN,Lanken PN,Christie JD,Meyer NJ,Mangalmurti NS,Shashaty MGS

    更新日期:2020-01-01 00:00:00

  • Interferon-related bronchiolitis obliterans organizing pneumonia.

    abstract::We present an unusual case of a patient with chronic hepatitis C who experienced dyspnea, fever, and cough after 2 1/2 months' treatment with interferon. His radiograph demonstrated diffuse pulmonary infiltrates and bronchoalveolar lavage fluid showed an increase in lymphocytes, especially CD8-positive cells. The lung...


    pub_type: 杂志文章


    authors: Ogata K,Koga T,Yagawa K

    更新日期:1994-08-01 00:00:00

  • Inspiratory work and airway pressure with continuous positive airway pressure delivery systems.

    abstract::To determine work-of breathing with continuous positive airway pressure (CPAP) delivery systems, we used a lung model to simulate spontaneous breathing. "Additional work" during tidal breathing was derived by comparing change in airway pressure with change in tidal volume. Seven demand-flow CPAP delivery systems were ...


    pub_type: 杂志文章


    authors: Katz JA,Kraemer RW,Gjerde GE

    更新日期:1985-10-01 00:00:00

  • Lack of influence of gender on outcomes of mechanically ventilated medical ICU patients.

    abstract:STUDY OBJECTIVES:Recent studies combining medical and surgical patients have suggested that mortality is higher for mechanically ventilated women than for men. This study was designed to determine whether there are gender-based differences in outcomes in mechanically ventilated medical ICU (MICU) patients. DESIGN AND ...


    pub_type: 杂志文章


    authors: Epstein SK,Vuong V

    更新日期:1999-09-01 00:00:00

  • Direct mechanical ventricular actuation for cardiac arrest in humans. A clinical feasibility trial.

    abstract::Direct mechanical ventricular actuation (DMVA) is a non-blood-contacting method of biventricular cardiac massage which may be applied expediently for total circulatory support. The purpose of this study was to assess the feasibility of DMVA application for patients suffering refractory cardiac arrest. Following inform...


    pub_type: 杂志文章


    authors: Anstadt MP,Bartlett RL,Malone JP,Brown GR,Martin S,Nolan DJ,Oberheu KH,Anstadt GL

    更新日期:1991-07-01 00:00:00

  • Detection of intrapulmonary shunts in schistosomal cor pulmonale.

    abstract::Two patients with schistosomal cor pulmonale and central cyanosis were studied by contrast-enhanced echocardiography, using indocyanine green injection. Intrapulmonary shunts were detected by this method. To our knowledge, this is the first report that proves the presence of intrapulmonary shunts in schistosomal cor p...


    pub_type: 杂志文章


    authors: Rafla SM,Sourour S

    更新日期:1993-10-01 00:00:00

  • Relationship between pulmonary function and sleep-induced respiratory abnormalities.

    abstract::The relationships between pulmonary function and sleep-induced respiratory events were studied in 34 consecutive male patients with suspected sleep apnea syndrome. In view of the effects of obstructive airway disease on pulmonary volume and airway resistance (Raw), patients were divided into two groups, those with and...


    pub_type: 杂志文章


    authors: Onal E,Leech JA,Lopata M

    更新日期:1985-04-01 00:00:00

  • Left subclavian steal, interrupted aortic arch, complete transposition of the great vessels and single left ventricle.

    abstract::Congenital subclavian steal consists of atresia of the proximal end of the subclavian artery, while the blood supply to the distal portion of the subclavian artery originates from the circle of Willis. It should be suspected in complicated malformations of the heart associated with marked hypoplasia or interruption of...


    pub_type: 杂志文章


    authors: Garcia O,Wilkins R,Cunha D,Jesse MJ

    更新日期:1975-03-01 00:00:00

  • Dilated right ventricular cardiomyopathy: Uhl's disease.

    abstract::Uhl's disease is a rare disorder originally described in 1952 in an infant with severe diffuse right ventricular dysfunction with total absence of the myocardium. Uhl considered the disease to be congenital in origin. We report a patient with severe dilated congestive cardiomyopathy limited to the right ventricle but ...


    pub_type: 杂志文章


    authors: Bewick DJ,Chandler BM,Montague TJ

    更新日期:1986-08-01 00:00:00

  • Pulse pressure and cardiovascular events in postmenopausal women with coronary heart disease.

    abstract:BACKGROUND:Pulse pressure (PP) has been shown to predict risk for cardiovascular events in men; however, this association has not been well established in women. Hormone replacement therapy may improve arterial compliance, but findings from cross-sectional and prospective studies report inconsistent results. We sought ...


    pub_type: 杂志文章


    authors: Nair GV,Chaput LA,Vittinghoff E,Herrington DM,Heart and Estrogen\/Progestin Replacement Study Investigators.

    更新日期:2005-05-01 00:00:00

  • Effect of pneumothorax on pleurodesis induced with talc in rabbits.

    abstract:OBJECTIVE:The purpose of this study was to determine if a small pneumothorax would influence the pleurodesis resulting from talc instillation. METHODS:Sixty rabbits received an intrapleural injection of 400 mg/kg talc slurry. One half also received 10 mL of air intrapleurally after the talc. Ten rabbits in each group ...


    pub_type: 杂志文章


    authors: Xie C,Teixeira LR,McGovern JP,Light RW

    更新日期:1998-10-01 00:00:00

  • Antinuclear antibodies in pleural fluid.

    abstract::Systemic lupus erythematosus (SLE) frequently involves the pleura with resultant pleural effusion. Previous studies have reported that detection of antinuclear antibodies (ANA) in pleural fluid using animal tissue as substrate was a sensitive and specific method for distinguishing SLE pleural effusions from other etio...


    pub_type: 杂志文章


    authors: Khare V,Baethge B,Lang S,Wolf RE,Campbell GD Jr

    更新日期:1994-09-01 00:00:00

  • Bronchial thermoplasty: reappraising the evidence (or lack thereof).

    abstract::Bronchial thermoplasty (BT) involves the application of radiofrequency energy to visible proximal airways to selectively ablate airway smooth muscle. BT is the first nonpharmacologic interventional therapy approved by the US Food and Drug Administration (FDA) for severe asthma. This approval was based on the results o...


    pub_type: 杂志文章,评审


    authors: Iyer VN,Lim KG

    更新日期:2014-07-01 00:00:00

  • Sleep-disordered breathing in Down syndrome.

    abstract::OSA is associated with significant adverse outcomes with far-reaching health-care implications. OSA is much more common and severe in patients with Down syndrome (DS) than in the general population, yet there is a striking lack of literature in this area. In this review article, we have summarized the current state of...


    pub_type: 杂志文章,评审


    authors: Lal C,White DR,Joseph JE,van Bakergem K,LaRosa A

    更新日期:2015-02-01 00:00:00

  • Reducing COPD Readmissions: Strategies for the Pulmonologist to Improve Outcomes.

    abstract::Hospitalizations for patients with acute exacerbations of COPD are associated with several adverse patient outcomes as well as with significant health-care costs. Despite many interventions targeted at reducing readmissions following an initial hospitalization, there are few strategies that have been consistently asso...


    pub_type: 杂志文章,评审


    authors: Freedman N

    更新日期:2019-10-01 00:00:00

  • Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection.

    abstract:STUDY OBJECTIVES:To investigate the roles of human alpha-defensin (HAD), human beta-defensin (HBD)-1, and HBD-2, novel antimicrobial peptides, in patients with Mycobacterium avium-intracellulare infection (MAI). PATIENTS:The study included 25 patients (10 men) with MAI who visited our hospital between June 1998 and Au...


    pub_type: 杂志文章


    authors: Ashitani J,Mukae H,Hiratsuka T,Nakazato M,Kumamoto K,Matsukura S

    更新日期:2001-04-01 00:00:00

  • The role of physician-assistants in critical care units.

    abstract::We evaluated the feasibility of utilizing physician assistants as providers of primary care in a medical ICU. After a three-month period of rigorous training, two PAs were assigned to the ICU. Their performance as well as the operation of the ICU over a two-year period was evaluated and compared to two preceding years...


    pub_type: 杂志文章


    authors: Dubaybo BA,Samson MK,Carlson RW

    更新日期:1991-01-01 00:00:00

  • Oxidative DNA damage and somatic mutations: a link to the molecular pathogenesis of chronic inflammatory airway diseases.

    abstract:BACKGROUND:Acquired somatic mutations induced by oxidative stress may contribute to the molecular pathogenesis of chronic inflammatory airway diseases. The objective of this study was to assess the intensity of oxidative DNA damage and the presence of microsatellite DNA instability (MSI), a marker of acquired somatic m...


    pub_type: 杂志文章


    authors: Tzortzaki EG,Dimakou K,Neofytou E,Tsikritsaki K,Samara K,Avgousti M,Amargianitakis V,Gousiou A,Menikou S,Siafakas NM

    更新日期:2012-05-01 00:00:00

  • Pericarditis with effusion casued by Actinomyces israelii.

    abstract::Actinomyces israelii is a rare cause of pericarditis. Infection spreads to pericardium from an intrathoracic focus. Branching gram-positive filaments are seen on microscopic examination of clinical specimens. Cultures should be performed under anaerobic conditions. Both surgical drainage and antibiotics (penicillin) a...


    pub_type: 杂志文章


    authors: Schlossberg D,Franco-Jove D,Woodward C,Shulman J

    更新日期:1976-05-01 00:00:00

  • Ostial left main stenosis following repair of a ruptured sinus of Valsalva aneurysm.

    abstract::A patient complained of angina pectoris nine months after surgical repair of an aortic right atrial fistula and mitral valve replacement. Subsequently, he was shown to have a new obstruction of the ostium of the left main coronary artery. This case illustrates the need to consider this syndrome in the differential dia...


    pub_type: 杂志文章


    authors: Coplan NL,Estioko MR,Ambrose JA

    更新日期:1985-09-01 00:00:00

  • A rare endobronchial neurilemmoma (Schwannoma).

    abstract::Primary neurogenic tumors of the lung are rare. Often, their histologic behavior presents a treatment dilemma. We present a case of benign endobronchial neurilemmoma managed by means of YAG laser resection together with a brief discussion of the management options available for these tumors. ...


    pub_type: 杂志文章


    authors: Feldhaus RJ,Anene C,Bogard P

    更新日期:1989-02-01 00:00:00

  • Hypoplastic left heart syndrome associated with congenital right-sided diaphragmatic hernia and omphalocele.

    abstract::Congenital diaphragmatic hernia (CDH) is associated with a variety of cardiac anomalies. However, its association with hypoplastic left heart syndrome (HLHS) is rare. We treated a female newborn with CDH, HLHS, and omphalocele. The operation for omphalocele and the diaphragmatic defect was successful, although the pat...


    pub_type: 杂志文章


    authors: Nishimura M,Taniguchi A,Imanaka H,Taenaka N

    更新日期:1992-01-01 00:00:00

  • A prospective evaluation of lung volume reduction surgery in 200 consecutive patients.

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    pub_type: 杂志文章


    authors: Yusen RD,Lefrak SS,Gierada DS,Davis GE,Meyers BF,Patterson GA,Cooper JD

    更新日期:2003-04-01 00:00:00

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    abstract::Histochemical quantification of goblet cells and measurements of the epithelial thickness were made in the trachea of male and female rats exposed to fresh whole tobacco smoke for 30 consecutive days. Exposure to tobacco smoke resulted in an increase in the total goblet cell count in both sexes, with the female rats d...


    pub_type: 杂志文章


    authors: Hayashi M,Sornberger GC,Huber GL

    更新日期:1978-04-01 00:00:00