Abstract:
BACKGROUND:Induced sputum cytology and protein biomarkers can be used to assess airways inflammation. Increases in sputum iron have been described in inflammatory lung disease. We hypothesized that other sputum metals may be affected by airways inflammation and investigated their potential value as biomarkers. METHODS:Sputum was obtained from 20 healthy control subjects and from patients with inflammatory pulmonary diseases (23 with cystic fibrosis [CF], 16 with bronchiectasis, 17 with asthma, and 23 with COPD), and iron, zinc, manganese, and copper were measured. Fourteen patients with CF were also studied through an exacerbation cycle. RESULTS:Sputum zinc and iron were elevated in CF and non-CF bronchiectasis vs controls (P < .001, zinc; P < .01 iron). Manganese was elevated in asthma (P < .01) and bronchiectasis (P < .05) vs controls. Copper was elevated in CF vs controls (P < .05). Zinc decreased (P < .01) following treatment of CF exacerbation. In subjects with CF zinc levels correlated with other biomarkers. CONCLUSIONS:These results suggest a relationship of high concentrations of total zinc and iron with airways inflammation in CF and non-CF bronchiectasis, with longitudinal changes being observed in CF. Further work is required to elucidate potential inflammatory mechanisms related to these observations.
journal_name
Chestjournal_title
Chestauthors
Gray RD,Duncan A,Noble D,Imrie M,O'Reilly DS,Innes JA,Porteous DJ,Greening AP,Boyd ACdoi
10.1378/chest.09-1047subject
Has Abstractpub_date
2010-03-01 00:00:00pages
635-41issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(10)60142-0journal_volume
137pub_type
杂志文章相关文献
CHEST文献大全abstract::We retrospectively evaluated the clinical effectiveness of a treatment schedule with intermittent positive pressure ventilation via nasal mask in 49 patients with acute exacerbations of COLD. According to the ability to successfully tolerate a preliminary trial with NIPPV, patients were submitted either to standard tr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.6.1533
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:The objective of this study was to systematically review and quantitatively synthesize all randomized controlled trials (RCTs), comparing important outcomes in ventilated critically ill patients who received an early or late tracheotomy. METHODS:A systematic literature search of PubMed, Cumulative Index to ...
journal_title:Chest
pub_type: 杂志文章,meta分析,评审
doi:10.1378/chest.11-2024
更新日期:2011-12-01 00:00:00
abstract::To elucidate the criterion for amplitude of circadian FEV1 variation suitable for phase analysis, six FEV1 measurements within a day were made on 346 days in 125 stable asthmatic children aged 8 to 12 years. Since coefficient of variation (CV) of FEV1 within a day in nonasthmatic children in our laboratory is less tha...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.3.771
更新日期:1992-09-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the safety and efficacy of sitaxsentan, an endothelin-A receptor antagonist, in a 12-week, open-label trial of patients with pulmonary arterial hypertension (PAH). PATIENTS:Six children and 14 adults with New York Heart Association (NYHA) functional class II, III, or IV primary pulmonary h...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1378/chest.121.6.1860
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Emphysema is the only smoking-related disease in which white patients have higher prevalence and higher attributable mortality rates than African-American patients. Epidemiologic studies have not addressed, nor explained, the observed racial differences in emphysema. STUDY OBJECTIVES:To determine whether wh...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.1.108
更新日期:2006-07-01 00:00:00
abstract:STUDY OBJECTIVES:Cellular growth in the vascular wall, including endothelial and smooth-muscle cell proliferation, is recognized as a component of the obstructive vasculopathy observed in the small vessels of the lungs in pulmonary arterial hypertension (PAH). We hypothesized that angiogenic growth factors may have a r...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.126.4.1255
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Among patients hospitalized for community-acquired pneumonia (CAP), the risk factors for short-term hospital readmission after discharge are unknown. METHODS:We conducted a prospective observational study of 1,117 patients who had been discharged alive after hospitalization for CAP. We collected variables a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-2950
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To compare the rapid shallow breathing index (RSBI) under different ventilatory support settings prior to extubation trials. DESIGN:Prospective study. SETTING:Cardiac surgery unit at a university hospital. PATIENTS:A total of 33 coronary artery bypass grafting patients ready for extubation. INTERVENTIONS...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.121.2.475
更新日期:2002-02-01 00:00:00
abstract::Three young men died of rapidly progressive pulmonary edema of delayed onset after inhalation of fumes from an accidental nitric acid explosion. Electron microscopy revealed altered neutrophils and necrotic endothelial cells in alveolar capillaries. Immunohistochemistry showed small and large serum proteins, including...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.2.487
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:The accuracy of combined clinical examination (CE) and chest radiography (CXR) (CE + CXR) vs thoracic ultrasonography in the acute assessment of pneumothorax, hemothorax, and lung contusion in chest trauma patients is unknown. METHODS:We conducted a prospective, observational cohort study involving 119 adul...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-0208
更新日期:2012-05-01 00:00:00
abstract::Tobacco smoking during pregnancy is the most important modifiable risk factor for adverse pregnancy outcomes and long-term health complications for mother and baby. Tobacco use during pregnancy has decreased in high-income countries but not in Indigenous women in Australia, New Zealand, the United States, and Canada. ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2017.06.033
更新日期:2017-10-01 00:00:00
abstract::In November 2007, the Josiah Macy, Jr. Foundation convened a conference to address a number of complex issues concerning continuing education (CE) in the health professions. Participants concluded that CE, as currently practiced, does not focus adequately on improving clinician performance and patient care, is too dep...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.08-1022
更新日期:2008-12-01 00:00:00
abstract:STUDY OBJECTIVE:To assess factors associated with initiating therapy and compliance with treatment for latent tuberculosis infection among health-care workers with positive tuberculin skin test results. DESIGN:Prospective cohort study. SETTING:An urban midwestern teaching hospital in St. Louis, MO. STUDY POPULATION:...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.5.1609
更新日期:2002-11-01 00:00:00
abstract::This study analyzes the use of PAC in a registry comprising 5,841 hospitalized patients with AMI. A total of 371 patients received PAC. In-hospital mortality was higher in patients with CHF who received PAC, while there was no difference in patients with cardiogenic shock or persistent hypotension. Mortality in patien...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.6.1331
更新日期:1990-12-01 00:00:00
abstract::Two patients had a vessel-like aortopulmonary "window" which could be ligated without the institution of cardiopulmonary bypass. While embryologically and functionally these communications are identical to the classic aortopulmonary "window," it is suggested that the term "aortopulmonary communication" is more appropr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.3.397
更新日期:1979-03-01 00:00:00
abstract::Although NCPAP is the most efficient nonsurgical treatment for patients with OSA, many patients do not accept sleeping with a nose mask. To determine the factors influencing acceptance, treatment with NCPAP was offered to 95 patients with an AHI greater than 15. After the first night on NCPAP, 47 of 65 patients decide...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.4.1019
更新日期:1991-10-01 00:00:00
abstract::The weak relationship between left ventricular function and exercise capacity in heart failure has stimulated interest in neurohumoral mechanisms as possibly contributing to exercise intolerance. Although chronic activation of neuroendocrine systems is characteristic of heart failure and is accompanied by impaired ref...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.101.5_supplement.347s
更新日期:1992-05-01 00:00:00
abstract::The findings in a 22-year-old man with Ebstein's anomaly of the tricuspid valve, Wolff-Parkinson-White syndrome, and a persistent left superior vena cava are reported. This is the first reported case of this combination of anomalies in which the atrial septum was intact and the left superior vena cava communicated wit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.79.6.700
更新日期:1981-06-01 00:00:00
abstract:BACKGROUND:Postnasal drip (PND) is a common symptom associated with upper respiratory tract disorders. It occurs without other symptoms or combined with chronic rhinosinusitis. However, the pathophysiology of PND is debated to this day, and an objective definition of PND has not been established. Therefore, we aimed to...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.04.133
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Exhaled nitric oxide (eNO) is a convenient noninvasive marker for airway inflammation in several pulmonary diseases. However, external factors such as nitrate-rich nutrition can affect the levels of eNO and thus compromise its diagnostic value. STUDY OBJECTIVES:The objective of this investigation was to hav...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.4.2465
更新日期:2005-10-01 00:00:00
abstract::A young man presented to us with an asymptomatic ovoid mass which appeared to be in the right major fissure. The roentgenographic appearance of the lesion was that of a pseudotumor. The computerized tomography scan suggested tissue density leading to exploration. At surgery, we found the mass to be a portion of liver ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.2.346
更新日期:1980-08-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of deep lung insufflations on maximum insufflation capacities (MICs) and peak cough flows (PCFs) for patients with neuromuscular disease. METHOD:Forty-three patients with neuromuscular disease were trained in stacking delivered volumes of air to deep lung insufflation and were presc...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.1.61
更新日期:2000-07-01 00:00:00
abstract::Respiratory manifestations of systemic lupus erythematosus (SLE) are frequent. They include respiratory muscle abnormalities, which have been implicated in the pathogenesis of the "shrinking lung syndrome" (SLS). We report the case of a patient with this syndrome, in whom diaphragmatic paralysis due to demyelinating p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.4.1274
更新日期:2001-04-01 00:00:00
abstract::Administration of glucagon has been shown to decrease pulmonary vascular resistance, but its primary site of action is undetermined. Whether this is on the arterial or venous side of the capillary would be reflected in the microvascular hydrostatic pressure. We used the pulmonary flow of lymph, a sensitive index of th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.74.2.196
更新日期:1978-08-01 00:00:00
abstract:INTRODUCTION:Women who smoke have a higher rate of fatal breast cancer than nonsmoking women. An association between smoking and pulmonary metastases from breast cancer has been suggested by epidemiologic studies. STUDY OBJECTIVES:To examine the relationship between exposure to cigarette smoke and pulmonary metastasis...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.125.4.1467
更新日期:2004-04-01 00:00:00
abstract::Adults with CF followed in a university center were assessed for the presence of the most common CF gene mutation, delta-F508. Excluding one member of a sibling pair, 29 of 55 subjects had two copies of delta-F508 (homozygotes), 23 had one copy of delta-F508 with the other CF mutation not identified (complex heterozyg...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.2.506
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:D6 is an atypical chemokine receptor involved in chemokine degradation and resolution of acute inflammatory responses in mice. Emerging evidence suggests that D6 might behave differently in human chronic inflammatory conditions. We, therefore, investigated the involvement of D6 in the immune responses in COP...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-3220
更新日期:2013-01-01 00:00:00
abstract::The prevalence of periodic limb movements (PLM) during sleep and their effect on sleep and daytime alertness were determined in 23 men with severe, stable congestive heart failure (CHF) and 9 healthy control subjects. Each subject had overnight polysomnography and the following day completed a subjective assessment of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.109.6.1497
更新日期:1996-06-01 00:00:00
abstract::To assess the effects of intravenous aminophylline on the sinus node, 12 patients with clinical and Holter monitor-documented sick sinus syndrome were studied (1) during the control state, (2) after pharmacologic autonomic blockade and (3) 5 min after intravenous administration of aminophylline. The effects of aminoph...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.4.887
更新日期:1991-04-01 00:00:00
abstract::Coronary arteriovenous fistula is an uncommon, although not rare, congenital cardiac malformation, especially in the adult. Most such reported such cases have involved but a single coronary vessel. This report documents the second case of coronary arteriovenous fistulae involving the right and circumflex coronary vess...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.5.656
更新日期:1977-11-01 00:00:00