Role of neurohumoral control of the circulation in determining exercise capacity in patients with heart failure.

Abstract:

:The weak relationship between left ventricular function and exercise capacity in heart failure has stimulated interest in neurohumoral mechanisms as possibly contributing to exercise intolerance. Although chronic activation of neuroendocrine systems is characteristic of heart failure and is accompanied by impaired reflex responsiveness to physiologic stimuli, data from clinical trials do not support the hypothesis that the abnormal neurohumoral state is directly related to exercise intolerance. Thus, these systems may play an important role in the natural history of the disease and its high mortality, but they may not be critical to the impaired exercise capacity.

journal_name

Chest

journal_title

Chest

authors

Cohn JN

doi

10.1378/chest.101.5_supplement.347s

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

347S-349S

issue

5 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)32929-4

journal_volume

101

pub_type

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