Abstract:
:The weak relationship between left ventricular function and exercise capacity in heart failure has stimulated interest in neurohumoral mechanisms as possibly contributing to exercise intolerance. Although chronic activation of neuroendocrine systems is characteristic of heart failure and is accompanied by impaired reflex responsiveness to physiologic stimuli, data from clinical trials do not support the hypothesis that the abnormal neurohumoral state is directly related to exercise intolerance. Thus, these systems may play an important role in the natural history of the disease and its high mortality, but they may not be critical to the impaired exercise capacity.
journal_name
Chestjournal_title
Chestauthors
Cohn JNdoi
10.1378/chest.101.5_supplement.347ssubject
Has Abstractpub_date
1992-05-01 00:00:00pages
347S-349Sissue
5 Suppleissn
0012-3692issn
1931-3543pii
S0012-3692(16)32929-4journal_volume
101pub_type
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