Abstract:
:To clarify the interrelation between interleukin-2 (IL-2) and soluble IL-2R receptor (sIL-2R), as products of T-cell activation in the bronchial tree of patients with bronchial asthma, we measured the concentration of IL-2, sIL-2R, and the cellular composition in bronchoalveolar lavage (BAL) fluid. We also measured physiologic parameters, including provocation concentration of histamine required to reduce the forced expiratory volume in 1 s by 20 percent of the prechallenge baseline (PC20). The concentrations of IL-2 and sIL-2R were higher in BAL fluid of symptomatic patients with bronchial asthma than those of normal subjects and asymptomatic patients. There was a significant correlation between IL-2 and sIL-2 concentrations in BAL fluid of the patients with bronchial asthma. Patients with other lung diseases had significantly higher concentration of IL-2 than normal control; however, sIL-2R was not detected in their BAL fluids. The concentration of IL-2 inversely correlated with FEV1 in symptomatic bronchial asthma. Among the inflammatory cells in BAL fluid, percentages of eosinophils showed significant correlation with the concentrations of IL-2 and sIL-2R in BAL fluid of the patients with bronchial asthma. In conclusion, IL-2 within the bronchial tree appears to be associated with eosinophil infiltration. This leads to physiologic changes in symptomatic patients with bronchial asthma, which may be influenced by the presence of sIL-2R in BAL fluid.
journal_name
Chestjournal_title
Chestauthors
Park CS,Lee SM,Chung SW,Uh S,Kim HT,Kim YHdoi
10.1378/chest.106.2.400subject
Has Abstractpub_date
1994-08-01 00:00:00pages
400-6issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)44214-Xjournal_volume
106pub_type
杂志文章相关文献
CHEST文献大全abstract::Massive pulmonary emboli is a rare disease in children, with only 39 reported cases in the last 50 years. Almost 50% of the patients died suddenly without receiving medical treatment. Most of the patients who were managed medically (70% of the treated patients) underwent surgical pulmonary embolectomy with 80% surviva...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.11-2759
更新日期:2013-02-01 00:00:00
abstract:STUDY OBJECTIVES:Vascular endothelial growth factor (VEGF) signaling may be required for maintenance of the alveolar structures, and alveolar septal cell apoptosis could contribute to the pathogenesis of COPD presenting emphysematous changes; however, the common mutation at position 936 in the 3' untranslated region of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.1.323
更新日期:2003-07-01 00:00:00
abstract::We studied retrospectively 69 cases of chagasic megaesophagus (group 1) and 207 cases of chronic chagasic myocardiopathy (CCM) without megaesophagus (group 2) by autopsy in the Pathology Department of the Federal University of Bahia, Brazil, from 1953 to 1975. It was shown that pulmonary tuberculosis was significantly...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.1.87
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To assess the effect of baseline variables, including treatment, on outcome in patients with nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). DESIGN:Retrospective analysis of data from two prospective, randomized, double-blind studies. SETTING:Multinational study with 134 site...
journal_title:Chest
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of deep lung insufflations on maximum insufflation capacities (MICs) and peak cough flows (PCFs) for patients with neuromuscular disease. METHOD:Forty-three patients with neuromuscular disease were trained in stacking delivered volumes of air to deep lung insufflation and were presc...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.1.61
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:There is no consensus at the present time about the effect of welding on lung function decline. This study compared lung function decline between blue-collar workers exposed and not exposed to welding fumes in a French longitudinal cohort of 21,238 subjects aged 37 to 52 years at inclusion. METHODS:Medical ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-0647
更新日期:2012-07-01 00:00:00
abstract::A nationwide study of acute myocardial infarction in Israel was carried out during a one-year period. There were 2,504 new and 968 repeated attacks. Annual incidence rate of first attacks was 0.9 per 1,000 (1.3 in men and 0.5 in women). Incidence was highest among the European born in both sexes. But, while the patter...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.68.2.214
更新日期:1975-08-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the role of quantitative cultures of BAL for diagnosing nosocomial pneumonia in mechanically ventilated patients. DESIGN:Cohort study. SETTING:Medical ICU, Hôpital Bichat, Paris, France, an academic tertiary care center. PATIENTS:A total of 141 episodes of suspected lung infection in 84 c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.2.411
更新日期:1997-02-01 00:00:00
abstract:STUDY OBJECTIVES:Evaluation of the effectiveness of negative-pressure ventilation (NPV) with the use of the iron lung vs noninvasive positive-pressure ventilation (NIPPV) in the treatment of COPD patients with acute on chronic respiratory failure. DESIGN:A retrospective case-control study. SETTING:Four Italian respir...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.121.1.189
更新日期:2002-01-01 00:00:00
abstract::The incidence of congenital heart disease is approximately 8/1,000 live births and appears to be constant around the world. The currently accepted paradigm for the development of pulmonary vascular disease associated with congenital heart disease maintains that increased pulmonary blood flow and pressure trigger unfav...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-2861
更新日期:2010-06-01 00:00:00
abstract::The objective of the present study was to investigate nasal function by active anterior rhinomanometry with respect to spirometric data and bronchial hyperresponsiveness to methacholine in 9-year-old children. The study population consisted of 300 children (ages 8 to 11 years; mean, 9.3 years; 161 male, 139 female), w...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.6.1582
更新日期:1995-06-01 00:00:00
abstract::This commentary heralds the recognition in China of a new subspecialty, Pulmonary and Critical Care Medicine, and the first national fellowship training pathway in any medical specialty. Because of striking environmental health-care similarities that existed in the United States, the Chinese medical community decided ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-2082
更新日期:2014-01-01 00:00:00
abstract::A comparison was made between the noncounterweighted Jones and Stead-Wells spirometers, and "conversion factors" were determined for the forced expiratory volume in one second (FEV1) and the forced vital capacity (FVC). A cross-sectional study produced a high correlation between the instruments for these two measureme...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.73.5.596
更新日期:1978-05-01 00:00:00
abstract::We report three cases of organophosphate (OP) poisoning. One patient was a 19-year-old woman who drank OP compounds in an attempt at suicide. The other two patients became intoxicated on the way to the hospital during mouth-to-mouth breathing. The first patient died in the emergency department, and the other two were ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.2.740
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to determine the accuracy of the cuff-leak test in a cardiovascular ICU. METHODS:Five hundred twenty-four patients were tested immediately before being extubated 531 times. The cuff-leak test was performed with the ventilator set in assist-control mode at a tidal volume (VT) of 1...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.4.1029
更新日期:1999-10-01 00:00:00
abstract:STUDY OBJECTIVES:Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO(2)) on autonomic modulation in a group of COPD patients. DESIGN:We measured autonomic modulation before and during the adm...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.118.3.691
更新日期:2000-09-01 00:00:00
abstract::Klippel-Trenaunay syndrome (KTS) is a congenital disorder characterized by a triad of cutaneous vascular nevi, soft tissue or bony hypertrophy, and varicose veins or venous malformations involving one or more extremities. An incidence of venous thromboembolism of up to 22% has been reported in this disorder. Also repo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.5.1520
更新日期:2000-05-01 00:00:00
abstract::An unusual case of essential thrombocythemia in a young man presenting with progressive angina pectoris is presented. Angiography revealed proximal left anterior descending artery stenosis. Successful percutaneous transluminal angioplasty along with antiplatelet therapy and a calcium channel blocking drug have rendere...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.6.933
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Balance deficits and an increased fall risk are well documented in individuals with COPD. Despite evidence that balance training programs can improve performance on clinical balance tests, their minimal clinically important difference (MCID) is unknown. The aim of this study was to determine the MCID of the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.15-0717
更新日期:2016-03-01 00:00:00
abstract:STUDY OBJECTIVE:To analyze the cough response to three airway challenges in order to clarify whether the recording of the provoked coughs would be beneficial in the management of asthma. DESIGN:A prospective study. SETTING:University hospital. PARTICIPANTS:Fifteen healthy subjects, 16 steroid-naïve subjects with ast...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.128.5.3329
更新日期:2005-11-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the accuracy of the respiratory inductive plethysmography in the measurement of PEEP-induced changes in end-expiratory lung volume during mechanical ventilation and its accuracy and stability in the measurement of ventilation during controlled mechanical ventilation and spontaneous breathing. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.1.234
更新日期:1992-07-01 00:00:00
abstract::A 35-year-old man had a history of recurrent syncope for more than a decade. During a witnessed episode, an ambulatory electrocardiographic recording showed ventricular flutter/fibrillation that lasted for 2 1/2 minutes and terminated spontaneously without adverse neurologic sequelae. No structural heart disease and n...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.106.5.1601
更新日期:1994-11-01 00:00:00
abstract:STUDY OBJECTIVE:The diagnostic value of tumor markers in pleural fluid is subject to debate. The aim of this study was to evaluate the diagnostic performance of several tumor markers in common use for detecting malignant pleural disease. DESIGN:Blinded comparison of four tumor markers in pleural fluid with a confirmat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.6.1757
更新日期:2004-12-01 00:00:00
abstract:STUDY OBJECTIVE:Doppler-derived myocardial performance index (MPI), a measure of combined systolic and diastolic myocardial performance, was assessed at rest and after low-dose dobutamine administration in patients with idiopathic or ischemic dilated cardiomyopathy. MPI also was correlated with other conventional echoc...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.6.1935
更新日期:2002-06-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effect of a symptom-based and a peak flow-based action plan in preventing acute exacerbations in subjects with poorly controlled asthma. DESIGN:A randomized controlled trial in which subjects who had required urgent treatment for their asthma were allocated to receive no action plan, a...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.112.6.1534
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Limited data are available on the impact of time to ICU admission and outcomes for patients with severe community acquired pneumonia (CAP). Our objective was to examine the association of time to ICU admission and 30-day mortality in patients with severe CAP. METHODS:A retrospective cohort study of 161 ICU ...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.09-1547
更新日期:2010-03-01 00:00:00
abstract::Extrapulmonary tuberculosis refers to Mycobacterium tuberculosis involving organs other than the lungs (eg, pleura, lymph nodes, genitourinary tract, abdomen, skin, joints and bones, or meninges). In non-HIV-endemic areas, where reactivation is the predominant mechanism of tuberculosis, pleural involvement occurs in 4...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.02.655
更新日期:2016-10-01 00:00:00
abstract::We report the findings in a patient known to have olivopontocerebellar atrophy who developed respiratory distress, inspiratory stridor, and maximum inspiratory and expiratory flow volume loops. Treatment with carbidopa-levodopa gave symptomatic relief. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.4.1291
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:A pulmonary right-to-left shunt (RLS) carries the risk of cerebral paradoxical embolization and severe neurologic complications. Recognizing patients at risk is important to facilitate appropriate management strategies, but a direct relation between pulmonary shunt size and risk of complications remains cont...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.12-1599
更新日期:2013-08-01 00:00:00
abstract::We carried out a study to assess the prevalence of respiratory disease in lead miners and to investigate the roles of silica and lead. We used a questionnaire for symptoms and examinations for signs of respiratory disease, chest roentgenograms, and spirometric study in 45 lead miners. Six underwent bronchoscopy and tr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.1.18
更新日期:1989-07-01 00:00:00