Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma.

Abstract:

STUDY OBJECTIVES:To clarify the pathophysiologic features of the relation between asthma and obesity, we measured the effects of weight reduction on peak expiratory flow (PEF) variability and airways obstruction, compared to simultaneous changes in lung volumes and ventilatory mechanics in obese patients with stable asthma. METHODS:Fourteen obese asthma patients (11 women and 3 men; aged 25 to 62 years) were studied before and after a very-low-calorie-diet period of 8 weeks. PEF variability was determined as diurnal and day-to-day variations. FEV(1) and maximal expiratory flow values were measured with a flow-volume spirometer. Lung volumes, airways resistance (Raw), and specific airways conductance were measured using a constant-volume body plethysmograph. Minute ventilation was monitored in patients in supine and standing positions. RESULTS:As patients decreased their body mass index (SD) from 37.2 (3.7) to 32.1(4.2) kg/m(2) (p < 0. 001), diurnal PEF variation declined from 5.5% (2.4) to 4.5% (1.5) (p = 0.01), and day-to-day variation declined from 5.3% (2.6) to 3. 1% (1.3) (p < 0.005). The mean morning PEF, FEV(1), and FVC increased after weight loss (p = 0.001, p < 0.005, and p < 0.05, respectively). Flow rate at the middle part of FVC (FEF(25-75)) increased even when related to lung volumes (FEF(25-75)/FVC; p < 0. 05). Functional residual capacity and expiratory reserve volume were significantly higher after weight loss (p < 0.05 and p < 0.005, respectively). A significant reduction in Raw was found (p < 0.01). Resting minute ventilation decreased after weight loss (p = 0.01). CONCLUSION:Weight loss reduces airways obstruction as well as PEF variability in obese patients with asthma. The results suggest that obese patients benefit from weight loss by improved pulmonary mechanics and a better control of airways obstruction.

journal_name

Chest

journal_title

Chest

authors

Hakala K,Stenius-Aarniala B,Sovijärvi A

doi

10.1378/chest.118.5.1315

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

1315-21

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)51203-8

journal_volume

118

pub_type

杂志文章

相关文献

CHEST文献大全
  • The controversy of combination vs monotherapy in the treatment of hospitalized community-acquired pneumonia.

    abstract:BACKGROUND:The majority of community-acquired pneumonia (CAP) patients (about 80%) will be treated as outpatients, because therapy with a single agent will work. For the remaining 20% of patients requiring hospitalization, there is some growing debate regarding the efficacy of different management approaches. For hospi...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.128.2.940

    authors: Weiss K,Tillotson GS

    更新日期:2005-08-01 00:00:00

  • Primary pulmonary hypertension in HIV infection.

    abstract::A prospective evaluation of 74 human immunodeficiency virus (HIV)-infected patients with cardiopulmonary complaints revealed six patients (8.1 percent) with pulmonary hypertension with elevated right ventricular systolic over right atrial pressure of 58 +/- 8 mm Hg (range, 49 to 66 mm Hg), as documented by Doppler ech...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.5.1268

    authors: Speich R,Jenni R,Opravil M,Pfab M,Russi EW

    更新日期:1991-11-01 00:00:00

  • Radionuclide localization of massive pulmonary hemorrhage.

    abstract::Lung scans with technetium sulfur colloid were performed in ten patients with life-threatening hemoptysis and nondiagnostic chest roentgenograms. Localized deposition of radionuclide was demonstrated in five of the six patients who were studied during active bleeding. These abnormalities were confirmed bronchoscopical...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.86.2.208

    authors: Haponik EF,Rothfeld B,Britt EJ,Bleecker ER

    更新日期:1984-08-01 00:00:00

  • Focus on Idiopathic Pulmonary Fibrosis: Advancing Approaches to Diagnosis, Prognosis, and Treatment.

    abstract::As seen in this CME online activity (available at http://courses.elseviercme.com/694), idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive, fibrotic lung disease of unknown cause that is associated with substantial health-care utilization and high rates of mortality. The clinical symptoms of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2018.08.1021

    authors: Martinez FJ,Lederer DJ

    更新日期:2018-10-01 00:00:00

  • Long-term follow-up of partial atrioventricular septal defect repair in adults.

    abstract::Patients presenting with partial atrioventricular septal (PAVC) defects in adulthood are rare. Eight adult patients with this congenital heart defect who had surgical repair are described, along with their long-term postoperative follow-up data. Average age at operation was 48 years, and average follow-up was 13.4 yea...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.2.321

    authors: Barnett MG,Chopra PS,Young WP

    更新日期:1988-08-01 00:00:00

  • Dieulafoy's disease of the bronchus in association with a paravertebral neurilemoma.

    abstract::Dieulafoy's disease is a vascular anomaly characterized by the presence of a dysplastic artery that is related to an epithelial ulcer. While it is most frequently a GI condition, occurrence in the bronchus has been reported previously in six cases. We present the case of a 51-year-old man with severe hemoptysis and ep...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.119.1.292

    authors: Stoopen E,Baquera-Heredia J,Cortes D,Green L

    更新日期:2001-01-01 00:00:00

  • Needle aspiration biopsy of malignant lung masses with necrotic centers. Improved sensitivity with ultrasonic guidance.

    abstract::False-negative results from transthoracic needle aspiration biopsy of malignant lung masses may occur if a central necrotic area is present and is the source of the biopsy material. The purpose of this study is to determine if the use of ultrasonic guidance can improve the sensitivity of lung needle biopsies in this c...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.5.1452

    authors: Pan JF,Yang PC,Chang DB,Lee YC,Kuo SH,Luh KT

    更新日期:1993-05-01 00:00:00

  • Detection of right-to-left shunt with radionuclide angiocardiography in refractory hypoxemia.

    abstract::A significant right-to-left shunt at the atrial level was diagnosed by radionuclide angiocardiographic examination in a patient with hypoxemia whose perfusion scan showed no pulmonary uptake. The shunt occurred through a patent foramen ovale due to increased right ventricular afterload, subsequently confirmed at autop...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.88.5.784

    authors: Salimi Z,Thomasson J,Vas W,Salimi A

    更新日期:1985-11-01 00:00:00

  • Epidemiology and ethnic distribution of multidrug-resistant tuberculosis in southern Israel, 1992-1997: the impact of immigration.

    abstract:STUDY OBJECTIVES:To assess the incidence of tuberculosis in the native and immigrant populations of southern Israel in the period between 1992 and 1997, and to study the prevalence of drug resistance overall and among these subpopulations in the region in order to create guidelines for empirical antituberculous treatme...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.3.738

    authors: Gilad J,Borer A,Riesenberg K,Peled N,Schlaeffer F

    更新日期:2000-03-01 00:00:00

  • A 2-Year-Old Boy With Hypoxemia, Pulmonary Hypertension, and Digital Clubbing.

    abstract:CASE PRESENTATION:A 2-year-old boy was referred to the Ankara University School of Medicine Children's Hospital with a history of recurrent respiratory distress and cyanosis since birth. His medical history was significant for premature birth at 31 weeks via cesarean section, as an infant of a diabetic mother. There wa...

    journal_title:Chest

    pub_type:

    doi:10.1016/j.chest.2020.08.2103

    authors: Zirek F,Akova BŞ,Özcan G,Fitoz S,Çobanoğlu N

    更新日期:2021-01-01 00:00:00

  • Significance of the magnitude of a QS wave deflection in evaluating the uninvolved muscle in anterior wall myocardial infarction.

    abstract::The significance of dynamic changes of the QS wave magnitude, as demonstrated in the precordial leads, within the natural evolution of acute anterior wall myocardial infarction (AAMI) was assessed in 25 patients within two weeks of their admission to the intensive cardiac care unit. Two sets of tests, including 12-lea...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.5.1002

    authors: Klainman E,Sclarovsky S,Zafrir N,Lewin RF,Farbstein H,Agmon J

    更新日期:1988-11-01 00:00:00

  • Natural history of tako-tsubo cardiomyopathy.

    abstract:BACKGROUND:Stress-induced or tako-tsubo cardiomyopathy (TTC) is a rare acute cardiac syndrome characterized by transient left ventricular (LV) dysfunction of uncertain cause and outcome. This study sought to assess the long-term outcome of patients with TTC. METHODS:One-hundred sixteen consecutive patients were prospe...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.10-1041

    authors: Parodi G,Bellandi B,Del Pace S,Barchielli A,Zampini L,Velluzzi S,Carrabba N,Gensini GF,Antoniucci D,Tuscany Registry of Tako-Tsubo Cardiomyopathy.

    更新日期:2011-04-01 00:00:00

  • Congenital aneurysms adjacent to the anuli of the aortic and/or mitral valves.

    abstract::The unusual occurrence of non-infected submitral and aortic aneurysms developing sequentially in an adult prompted us to review the pathogenesis of congenital aneurysms adjacent to the aortic and mitral valves. The findings support the suggestion that subvalvular aneurysms, like aortic sinus aneurysms, are a result of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.82.3.334

    authors: Chesler E,Mitha AS,Edwards JE

    更新日期:1982-09-01 00:00:00

  • Serum angiotensin-converting enzyme levels in patients with pigeon-breeder's disease.

    abstract::The serum concentration of angiotensin-converting enzyme is frequently elevated in individuals with active sarcoidosis. The enzyme is presumably actively synthesized by the epithelioid and giant cells of the granuloma. Hypersensitivity pneumonitis, resulting from the inhalation of antigens from pigeons by susceptible ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.80.4.431

    authors: McCormick JR,Thrall RS,Ward PA,Moore VL,Fink JN

    更新日期:1981-10-01 00:00:00

  • Massive hemoptysis during catheterization of the internal jugular vein.

    abstract::Percutaneous cannulation of the internal jugular vein is commonly performed to obtain central venous access. We report the first case of massive hemoptysis occurring during cannulation of the internal jugular vein. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.5.1143

    authors: Friedman Y,Tilly E,Rackow EC,Weil MH

    更新日期:1989-05-01 00:00:00

  • Heimlich valve treatment of Pneumocystis carinii-associated pneumothorax.

    abstract::Two patients were treated for AIDS-associated bilateral pneumothoraces which persisted despite prolonged chest tube drainage. Heimlich flutter valves were used to facilitate the outpatient management of these patients. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.1.281

    authors: Driver AG,Peden JG,Adams HG,Rumley RL

    更新日期:1991-07-01 00:00:00

  • Acute and chronic effects of fire fighting on pulmonary function.

    abstract::The acute and chronic effects of fire fighting on pulmonary function were studied in 54 fire fighters from Connecticut, 32 smokers and 22 nonsmokers. Baseline studies of maximum expiratory flow-volume curves while breathing air and a mixture of 80 percent helium and 20 percent oxygen revealed obstruction of the small ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.77.3.369

    authors: Loke J,Farmer W,Matthay RA,Putman CE,Smith GJ

    更新日期:1980-03-01 00:00:00

  • Distinct characteristics of pleuroparenchymal fibroelastosis with usual interstitial pneumonia compared with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) is a rare form of interstitial pneumonia and sometimes coexists with a histologic usual interstitial pneumonia (UIP) pattern. This study aimed to describe the distinct clinical features of PPFE with UIP pattern compared with idiopathic pulmonary fibrosis (IPF). METHOD...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.13-2866

    authors: Oda T,Ogura T,Kitamura H,Hagiwara E,Baba T,Enomoto Y,Iwasawa T,Okudela K,Takemura T,Sakai F,Hasegawa Y

    更新日期:2014-11-01 00:00:00

  • STOP-Bang Questionnaire: A Practical Approach to Screen for Obstructive Sleep Apnea.

    abstract::There exists a high prevalence of OSA in the general population, a great proportion of which remains undiagnosed. The snoring, tiredness, observed apnea, high BP, BMI, age, neck circumference, and male gender (STOP-Bang) questionnaire was specifically developed to meet the need for a reliable, concise, and easy-to-use...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.15-0903

    authors: Chung F,Abdullah HR,Liao P

    更新日期:2016-03-01 00:00:00

  • The preflight evaluation. A comparison of the hypoxia inhalation test with hypobaric exposure.

    abstract:STUDY OBJECTIVES:We sought to compare arterial oxygen partial pressure (PaO2) relationships between a 15.1% hypoxia inhalation test (HIT) at sea level and a hypobaric chamber exposure equivalent to 2,438 m (8,000 feet) of altitude above sea level in patients with chronic obstructive pulmonary disease (COPD) and healthy...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.2.352

    authors: Dillard TA,Moores LK,Bilello KL,Phillips YY

    更新日期:1995-02-01 00:00:00

  • Plasmacytoma as a cause of obstructive sleep apnea.

    abstract::Solitary extramedullary plasmacytomas are uncommon neoplasms. They occur most frequently in the upper aerodigestive tract and account for 4% of the nonepithelial tumors in this site. The evolution of a plasmacytoma is unsteady and symptoms at presentation have included dystonia, dysphagia, oral pain, cough, and dyspne...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.109.6.1657

    authors: Byrd RP Jr,Roy TM,Bentz W,Mehta JB

    更新日期:1996-06-01 00:00:00

  • Beliefs among pulmonologists and thoracic surgeons in the therapeutic approach to non-small cell lung cancer.

    abstract:STUDY OBJECTIVES:The physicians who initially evaluate patients with non-small cell lung cancer (NSCLC) strongly impact the course of therapy. Their beliefs in treatment and prognosis may contribute to practices of variable quality and appropriateness. We sought to better describe beliefs among pulmonologists and thora...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.1.129

    authors: Schroen AT,Detterbeck FC,Crawford R,Rivera MP,Socinski MA

    更新日期:2000-07-01 00:00:00

  • Analysis of indications for early discharge from the intensive care unit. Clinical efficacy assessment project: American College of Physicians.

    abstract:OBJECTIVE:To formulate recommendations for the development of early intensive care unit (ICU) discharge criteria for low-risk monitor patients. DESIGN:Literature review of published reports over the period 1966 to 1991 pertaining to ICU discharge criteria. PATIENTS:Studies identifying patients admitted to ICUs who co...

    journal_title:Chest

    pub_type: 指南,杂志文章

    doi:10.1378/chest.104.6.1812

    authors: Bone RC,McElwee NE,Eubanks DH,Gluck EH

    更新日期:1993-12-01 00:00:00

  • Single-breath nitrogen washout; effects of alterations of lung volumes and elastic recoil.

    abstract::Strapping of the chest causes decreased lung volumes and increased elastic recoil pressure. Such strapping was used in conjunction with single-breath nitrogen washout to study the effects of changes in these factors on the dynamics of the small airways. Studies consisted of simultaneous measurements of the quasistatic...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.1.83

    authors: Al-Bazzaz FJ

    更新日期:1979-07-01 00:00:00

  • Tuberculous pneumonia with the syndrome of inappropriate secretion of antidiuretic hormone: cause of the adult respiratory distress syndrome.

    abstract::Bilateral tuberculous pneumonia with the syndrome of inappropriate secretion of antidiuretic hormone was the cause of the adult respiratory distress syndrome in an elderly patient. Early recognition and prompt therapy enabled the patient to make a complete recovery without the necessity for mechanical ventilation. Wit...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.72.5.678

    authors: Sahn SA,Skeff KM

    更新日期:1977-11-01 00:00:00

  • Femoral venoarterial extracorporeal membrane oxygenation for severe reimplantation response after lung transplantation.

    abstract::Severe pulmonary reimplantation response after lung transplantation is not very common, although the mortality can be high. We present a patient who developed an extremely severe reperfusion injury after bilateral lung transplantation. Because of severe hypoxia and hemodynamic instability, despite aggressive ventilato...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.2.559

    authors: Vlasselaers D,Verleden GM,Meyns B,Van Raemdonck D,Demedts M,Lerut A,Lauwers P

    更新日期:2000-08-01 00:00:00

  • The epidemiology of lung cancer.

    abstract::Lung cancer rates and mortality have risen in epidemic proportions in the United States and other industrialized nations during the 20th century. Case-control and cohort studies performed in the 1950s and 1960s firmly established cigarette smoking as the single greatest risk factor for lung cancer. In the United State...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.103.1_supplement.20s

    authors: Samet JM

    更新日期:1993-01-01 00:00:00

  • When is a biopsy-proven diagnosis necessary before stereotactic ablative radiotherapy for lung cancer?: A decision analysis.

    abstract:BACKGROUND:The practice of treating a solitary pulmonary nodule (SPN) suspicious for stage I non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR) in the absence of pathology is growing. In the absence of randomized evidence, the appropriate prior probability threshold of lung cancer of when...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.13-2924

    authors: Louie AV,Senan S,Patel P,Ferket BS,Lagerwaard FJ,Rodrigues GB,Salama JK,Kelsey C,Palma DA,Hunink MG

    更新日期:2014-10-01 00:00:00

  • Efficacy of Acupuncture Is Noninferior to Nicotine Replacement Therapy for Tobacco Cessation: Results of a Prospective, Randomized, Active-Controlled Open-Label Trial.

    abstract:BACKGROUND:We designed and conducted this multicenter randomized active-controlled open-label trial to evaluate the efficacy of acupuncture, auricular point pressing, and nicotine replacement therapy (NRT) on tobacco cessation in the Chinese population. METHODS:This randomized controlled trial was conducted in seven h...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.chest.2017.11.015

    authors: Wang YY,Liu Z,Wu Y,Yang L,Guo LT,Zhang HB,Yang JS,Chinese Acupuncture for Tobacco Cessation Research Team.

    更新日期:2018-03-01 00:00:00

  • Relationship of resting lung mechanics and exercise pattern of breathing in patients with chronic obstructive lung disease.

    abstract::To investigate the influence of resting pulmonary mechanics on the pattern of breathing during exercise in chronic obstructive pulmonary disease (COPD), we studied 29 patients with moderate to severe COPD (FEV1 50 +/- 20 percent predicted), and 10 normal subjects. Lung mechanics were studied using esophageal balloon t...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.3.705

    authors: Marin JM,Hussain SN,Gibbons WJ,Polverino M,Levy RD,Cosio MG

    更新日期:1993-09-01 00:00:00