Abstract:
BACKGROUND:In COPD, a decreased inspiratory capacity to total lung capacity ratio (IC/TLC) is associated with dynamic hyperinflation and poor exercise capacity. The association with upper-extremity force measured by handgrip strength (HGS) and 6-min walk distance (6MWD) has not been previously described. We hypothesized that IC/TLC affects muscle strength in the upper and lower extremities, affecting HGS and 6MWD. METHODS:We prospectively measured lung function, HGS, and 6MWD in 27 patients with COPD and 12 healthy nonsmokers twice, 1 year apart. The patients were classified according to level of hyperinflation: IC/TLC > 25% or IC/TLC ≤ 25%. RESULTS:Patients with COPD had reduced lung function, static hyperinflation, and reduced HGS and 6MWD compared with the control subjects on both evaluations (P < .01). There was a statistically significant deterioration in HGS, IC/TLC, and 6MWD after 1-year follow-up in the COPD compared with the control group (P < .001). More hyperinflation (IC/TLC < 0.25) was associated with lower HGS and 6MWD (P < .001). Changes in IC/TLC correlated with changes in HGS (r = 0.429, P < .05). Multivariate analysis determined that IC/TLC is an independent factor associated with HSG and 6MWD. CONCLUSIONS:HGS and 6MWD are reduced in patients with COPD, particularly in those with hyperinflation and evidence of longitudinal deterioration not seen in control subjects. This finding suggests that resting hyperinflation may exert a detrimental effect on cardiac function and plays a role in reduced exercise performance in patients with COPD.
journal_name
Chestjournal_title
Chestauthors
Felipe C,Bartolome C,Miguel D,Victor PPdoi
10.1378/chest.14-2878subject
Has Abstractpub_date
2015-10-01 00:00:00pages
986-994issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(15)50287-0journal_volume
148pub_type
杂志文章相关文献
CHEST文献大全abstract::The effects of six weeks of threshold pressure inspiratory muscle training (IMT) on inspiratory muscle performance, breathing pattern and exercise performance were studied in eight patients with severe airflow obstruction. The results indicated that IMT improved inspiratory muscle performance but did not affect exerci...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.3.535
更新日期:1989-03-01 00:00:00
abstract::A 62-year-old woman had had kyphoscoliosis since age 12 years. Respiratory failure developed at age 35 years following a respiratory infection. A tracheostomy was done and she required assisted ventilation using a respiratory (Bird). Many attempts at weaning her from the ventilator were unsuccessful. She has remained ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.5.1297
更新日期:1990-11-01 00:00:00
abstract::Health systems confronting the coronavirus disease 2019 (COVID-19) pandemic must plan for surges in ICU demand and equitably distribute resources to maximize benefit for critically ill patients and the public during periods of resource scarcity. For example, morbidity and mortality could be mitigated by a proactive re...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2020.04.026
更新日期:2020-08-01 00:00:00
abstract::The American Association of Critical-Care Nurses (AACN) Standards for Establishing and Sustaining Healthy Work Environments and the American College of Chest Physicians (ACCP) Patient-Focused Care Project are complementary initiatives that provide a road map for creating practice environments where interdisciplinary, ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.5.1571
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To compare the bronchodilator effectiveness of albuterol reformulated in the chlorofluorocarbon-free propellant hydrofluoroalkane (HFA)134a (Proventil HFA) to that of Ventolin and HFA placebo over 12 weeks of regular dosing. DESIGN:Randomized, double-blind, double-dummy, parallel group, placebo-controlled, m...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.113.2.283
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To determine the incidence, diagnostic features, and perioperative predictors of acute cholecystitis after cardiovascular surgery. DESIGN:Inception cohort study. SETTING:A tertiary care 54-bed cardiothoracic ICU. PATIENTS:All patients admitted to an ICU after cardiovascular surgery during a 42-month period...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.1.76
更新日期:1998-07-01 00:00:00
abstract::Thirteen patients with stable airway disease were fed a diet high in carbohydrates, and 35 minutes later metabolic and ventilatory effects were observed. The six patients who did not retain carbon dioxide increased their mean respiratory quotient from 0.86 +/- 0.07 to 1.03 +/- 0.04, their mean minute ventilation from ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.1.55
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVES:To measure tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in pleural effusions caused by tuberculosis (TB) and malignancy and their relationship with plasminogen activator inhibitor type I (PAI-1) and tissue type plasminogen activator (tPA), and to compare the differences between tu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.5.1292
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:The study documented the emergence of new forms of resistant bacilli (totally drug-resistant [TDR] or super extensively drug-resistant [XDR] tuberculosis [TB] strains) among patients with multidrug-resistant TB (MDR-TB). METHODS:Susceptibility testing against first- and second-line drugs was performed on is...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-2427
更新日期:2009-08-01 00:00:00
abstract::Whole-lung lavage is the only efficient treatment in pulmonary alveolar proteinosis. A 36-year-old woman with severe pulmonary alveolar proteinosis confirmed by video-assisted thoracoscopic lung biopsies underwent repetitive whole-lung lavages without improvement. A modified technique consisting of manual ventilation ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.6.1718
更新日期:1998-06-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the interaction between craniofacial structure and obesity in male patients with obstructive sleep apnea (OSA). DESIGN:Retrospective analysis of a cohort of OSA patients. The relationships between neck circumference (NC), body mass index, apnea severity, and craniofacial and upper airway so...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.2.375
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Although marital status has been shown to affect the outcomes of many conditions, there are limited data on the relationships between marital status and the presentation and outcomes of pneumonia. METHODS:We used Veterans Affairs administrative databases to identify a retrospective cohort of male veterans a...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.11-3183
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Early high-dose IV vitamin C is being investigated as adjuvant therapy in patients who are critically ill, but the optimal dose and infusion method are unclear. The primary aim of this study was to describe the dose-plasma concentration relationship and safety of four different dosing regimens. METHODS:This...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.chest.2018.02.025
更新日期:2018-06-01 00:00:00
abstract:STUDY OBJECTIVE:Our objective was to determine if the hemosiderin content of BAL macrophages allows us to draw any differential diagnostic conclusions in a variety of lung diseases. PATIENTS AND STUDY DESIGN:One hundred one patients who underwent BAL for different diagnostic reasons were studied prospectively. MAIN R...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1794
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Long-term outcomes of awakened survivors of out-of-hospital cardiac arrest (OHCA) are poorly known. RESEARCH QUESTION:What are the month (M) 18 outcomes of survivors of out-of-hospital cardiac arrest (OHCA) who awakened during the first 2 weeks' post-OHCA and their poor-outcome risk factors? STUDY DESIGN A...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.07.022
更新日期:2020-07-20 00:00:00
abstract::The solitary pulmonary nodule (SPN) is frequently encountered on chest imaging and poses an important diagnostic challenge to clinicians. The differential diagnosis is broad, ranging from benign granulomata and infectious processes to malignancy. Important concepts in the evaluation of SPNs include the definition, mor...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.12-0960
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:To address the burden of tobacco use in underserved populations, our safety net hospital developed a tobacco treatment intervention consisting of an "opt-out" electronic health record-based best practice alert + order set, which triggers consultation to an inpatient tobacco treatment consult (TTC) service fo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.04.062
更新日期:2020-10-01 00:00:00
abstract::Radiation therapy has been the usual initial treatment for mediastinal seminoma in the past. However, 25 to 40 percent of patients are not cured by this therapy, and other therapy is needed. Review of case reports show that vinblastine, bleomycin, and cis-platinum are effective therapy for metastatic disease, advanced...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.2.263
更新日期:1983-02-01 00:00:00
abstract::The purpose of this study was to determine the number of procedures necessary to become proficient in flexible fiberoptic bronchoscopic examination. I performed 99 bronchoscopic procedures during a formal training program under the direct supervision of instructors with varying experience. There were no statistical di...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.1.65
更新日期:1980-01-01 00:00:00
abstract::Actinomyces israelii is a rare cause of pericarditis. Infection spreads to pericardium from an intrathoracic focus. Branching gram-positive filaments are seen on microscopic examination of clinical specimens. Cultures should be performed under anaerobic conditions. Both surgical drainage and antibiotics (penicillin) a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.5.680
更新日期:1976-05-01 00:00:00
abstract::As seen in this CME online activity (available at http://courses.elseviercme.com/694), idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive, fibrotic lung disease of unknown cause that is associated with substantial health-care utilization and high rates of mortality. The clinical symptoms of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.08.1021
更新日期:2018-10-01 00:00:00
abstract::Bronchodilator responses to both nebulized albuterol (salbutamol) and ipratropium bromide and aerosol delivery to the tracheobronchial tree have been assessed in eight patients with chronic stable asthma (mean baseline FEV1, 50 percent; reversibility greater than 20 percent). Two commercially available nebulizer syste...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.96.1.6
更新日期:1989-07-01 00:00:00
abstract::In summary, this is a patient who presented with respiratory acidosis and cor pulmonale. The major diagnostic challenge was in differentiating primary cardiopulmonary disease from a central abnormality of ventilatory drive. The arterial blood gases showed a normal A-a gradient suggesting hypoventilation as the etiolog...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.3.823
更新日期:1991-09-01 00:00:00
abstract::We prospectively evaluated nine patients with cough from postnasal drip for evidence of extrathoracic upper airway obstruction. Patients compared before treatment to normal control subjects had physiologic evidence of extrathoracic upper airway obstruction; their mean FIF50%/FEF50% and FIF25-75%/FEF25-75% ratios of 0....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.85.3.346
更新日期:1984-03-01 00:00:00
abstract::A 60-year-old black woman presented with nonproductive cough of 1-month duration. She had also experienced rapidly progressive dyspnea for 1 week and one bout of vomiting a day before presentation. Her symptoms had failed to improve with a course of amoxicillin-clavulanate. Her medical history was significant for diab...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.15-0388
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Altitude exposure is associated with mild pulmonary hypertension and decreased exercise capacity. We tested the hypothesis that pulmonary vascular resistance (PVR) contributes to decreased exercise capacity in hypoxic healthy subjects. METHODS:An incremental cycle ergometer cardiopulmonary exercise test and...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.08-2222
更新日期:2009-05-01 00:00:00
abstract::We report a case of pleural dissemination of invasive thymoma, which was successfully treated with intrathoracic chemothermotherapy following panpleuropneumonectomy. Intrathoracic chemothermotherapy in combination with surgery may be a hopeful adjuvant treatment to control pleural disseminated lesions of invasive thym...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.6.1884
更新日期:1994-06-01 00:00:00
abstract:STUDY OBJECTIVE:To ascertain the incidence, types, morbidity, and mortality of infectious episodes in isolated lung transplant recipients. DESIGN:Retrospective chart review of patients who have undergone transplants over a six-year period in one institution. PATIENTS:Twenty-three single and 17 double lung transplants...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.4.1056
更新日期:1992-04-01 00:00:00
abstract::We report the findings in two patients with sulfasalazine-induced pulmonary disease. The first patient developed pulmonary interstitial fibrosis after more than 4 yr of treatment for Crohn's disease. Pulmonary symptoms and chest roentgenographic and pulmonary function abnormalities gradually reversed after stopping th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.4.1033
更新日期:1992-04-01 00:00:00
abstract::We report the occurrence of an unusual variant of congenital adenomatoid malformation (CAM) of the lung in a 16-year-old male. Abundant cartilage in the walls of malformed bronchioles, an extremely rare finding in CAM, distinguishes this lesion from the usual forms. We present the roentgenographic, computed tomographi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.3.514
更新日期:1987-09-01 00:00:00