Whole-lung lavage in alveolar proteinosis by a modified lavage technique.


:Whole-lung lavage is the only efficient treatment in pulmonary alveolar proteinosis. A 36-year-old woman with severe pulmonary alveolar proteinosis confirmed by video-assisted thoracoscopic lung biopsies underwent repetitive whole-lung lavages without improvement. A modified technique consisting of manual ventilation between instillation and aspiration of half the amount of saline used for conventional lavage was applied. Impressive clinical and functional improvement occurred and persisted for 1 year. We believe that the amelioration can be attributed to the technique described above.






Bingisser R,Kaplan V,Zollinger A,Russi EW




Has Abstract


1998-06-01 00:00:00
















  • Is an abbreviated bronchial challenge with histamine valid?

    abstract::Investigators have validated an abbreviated protocol for testing nonspecific bronchial reactivity with methacholine. We performed a similar validation study with histamine, another bronchoprovocative agent known to induce airflow obstruction. Histamine is pharmacologically distinct from methacholine and, under some ci...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Schmidt LE,Thorne PS,Watt JL,Schwartz DA

    更新日期:1992-01-01 00:00:00

  • Dyspnea in a patient years after severe poliomyelitis. The role of cardiopulmonary exercise testing.

    abstract::Dyspnea after polio can occur for a variety of reasons, including neuromuscular disease and upper airway abnormalities resulting from prolonged intubation, including tracheal stenosis, tracheomalacia, and vocal cord paralysis. Routine studies such as spirometry and maximum voluntary ventilation (MVV) measurements can ...


    pub_type: 杂志文章


    authors: Knobil K,Becker FS,Harper P,Graf LB,Wolf GT,Martinez FJ

    更新日期:1994-03-01 00:00:00

  • Antibiotic levels in empyemic pleural fluid.

    abstract:OBJECTIVE:To determine the degree to which bioactive penicillin, metronidazole, ceftriaxone, clindamycin, vancomycin, and gentamicin penetrate into empyemic pleural fluid using our new rabbit model of empyema. METHODS:An empyema was created via the intrapleural injection of 10(8)()Pasteurella multocida bacteria into t...


    pub_type: 杂志文章


    authors: Teixeira LR,Sasse SA,Villarino MA,Nguyen T,Mulligan ME,Light RW

    更新日期:2000-06-01 00:00:00

  • Pericarditis with effusion casued by Actinomyces israelii.

    abstract::Actinomyces israelii is a rare cause of pericarditis. Infection spreads to pericardium from an intrathoracic focus. Branching gram-positive filaments are seen on microscopic examination of clinical specimens. Cultures should be performed under anaerobic conditions. Both surgical drainage and antibiotics (penicillin) a...


    pub_type: 杂志文章


    authors: Schlossberg D,Franco-Jove D,Woodward C,Shulman J

    更新日期:1976-05-01 00:00:00

  • Stability of blood gases in ice and at room temperature.

    abstract::Arterial blood samples from 75 patients were analyzed for PO2, PCO2, and pH at 0, 15, and 30 min. After the baseline analysis, 60 samples were kept in ice while 59 samples were left at room temperature. There was a statistically significant increase in the PO2 at 15 min and again at 30 min in both groups. There was a ...


    pub_type: 杂志文章


    authors: Liss HP,Payne CP Jr

    更新日期:1993-04-01 00:00:00

  • Improved surgical approach to cardiac tumors with intraoperative two-dimensional echocardiography.

    abstract::Intraoperative two-dimensional echocardiography allows visualization of cardiac anatomy and function not possible by other techniques. Although preoperative evaluation by noninvasive methods is usually adequate for diagnosis of cardiac tumors, two-dimensional echocardiography can be beneficial intraoperatively. Intrao...


    pub_type: 杂志文章


    authors: Mora F,Mindich BP,Guarino T,Goldman ME

    更新日期:1987-01-01 00:00:00

  • Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

    abstract::This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that i...


    pub_type: 指南,杂志文章,实务指引,评审


    authors: Singer DE,Albers GW,Dalen JE,Go AS,Halperin JL,Manning WJ

    更新日期:2004-09-01 00:00:00

  • Multimodality therapy for stage IIIA (N2) lung cancer. An overview.

    abstract::Disappointing results of surgery and postoperative adjuvant chemotherapy or chemoradiotherapy in stage IIIA (N2) lung cancer have led to a number of phase II trials of induction (neoadjuvant) chemotherapy given prior to surgery. Preliminary results of 2 such studies indicate that mitomycin, vinca alkaloid, and platinu...


    pub_type: 杂志文章,评审


    authors: Ginsberg RJ

    更新日期:1993-04-01 00:00:00

  • Effect of the cold pressor test on diffusing capacity. Comparison of normal subjects and those with Raynaud's disease and progressive systemic sclerosis.

    abstract::Single-breath carbon monoxide diffusing capacity (Dsb) was measured before and during immersion of one hand in ice water (cold pressor test) in the following three groups of subjects: (1) normal subjects; (2) patients with isolated Raynaud's disease; and (3) patients with Raynaud's phenomenon and progressive systemic ...


    pub_type: 杂志文章


    authors: Miller MJ

    更新日期:1983-09-01 00:00:00

  • Surveillance tracheal aspirate cultures do not reliably predict bacteria cultured at the time of an acute respiratory infection in children with tracheostomy tubes.

    abstract:BACKGROUND:The aim of this study was to characterize the practice of routinely obtaining tracheal aspirate cultures in children with tracheostomy tubes and to analyze the appropriateness of using this information to guide antibiotic selection for treatment of subsequent lower respiratory infections. METHODS:Pediatric ...


    pub_type: 杂志文章


    authors: Cline JM,Woods CR,Ervin SE,Rubin BK,Kirse DJ

    更新日期:2012-03-01 00:00:00

  • Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy.

    abstract::Systemically bioavailable leukotriene receptor antagonists (LTRAs) can reduce the essential components of allergic inflammation in allergic rhinitis (AR) and asthma by blocking cysteinyl leukotriene (CysLT) activity, resulting in a wide range of clinical effects. CysLTs, mediators, and modulators in the pathophysiolog...


    pub_type: 杂志文章,评审


    authors: Busse W,Kraft M

    更新日期:2005-04-01 00:00:00

  • Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis.

    abstract:BACKGROUND:It is unknown if the radiographic fibrosis score predicts mortality in persistent hypersensitivity pneumonitis (HP) and if survival is similar to that observed in idiopathic pulmonary fibrosis (IPF) when adjusting for the extent of radiographic fibrosis. METHODS:We reviewed records from 177 patients with HP...


    pub_type: 杂志文章


    authors: Mooney JJ,Elicker BM,Urbania TH,Agarwal MR,Ryerson CJ,Nguyen MLT,Woodruff PG,Jones KD,Collard HR,King TE Jr,Koth LL

    更新日期:2013-08-01 00:00:00

  • Meta-analysis of Gastroesophageal Reflux Disease and Idiopathic Pulmonary Fibrosis.

    abstract:BACKGROUND:The relationship between gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) is controversial. Current guidelines recommend that clinicians use regular antacid treatment, while two recent meta-analyses of antacid therapy in IPF were inconclusive. The objective of this study was to ...


    pub_type: 杂志文章,meta分析,评审


    authors: Bédard Méthot D,Leblanc É,Lacasse Y

    更新日期:2019-01-01 00:00:00

  • A prospective long-term study of 220 patients with a retrievable vena cava filter for secondary prevention of venous thromboembolism.

    abstract:BACKGROUND:The immediate and long-term clinical events associated with the placement and removal of a retrievable filter (ALN filter; ALN Implants Chirurgicaux; Ghisonaccia, France) remain largely unknown. METHODS:This was a prospective cohort study with an 18-month follow-up. All consecutive patients scheduled for pl...


    pub_type: 杂志文章


    authors: Mismetti P,Rivron-Guillot K,Quenet S,Décousus H,Laporte S,Epinat M,Barral FG

    更新日期:2007-01-01 00:00:00

  • Predictors of short-term rehospitalization following discharge of patients hospitalized with community-acquired pneumonia.

    abstract:BACKGROUND:Among patients hospitalized for community-acquired pneumonia (CAP), the risk factors for short-term hospital readmission after discharge are unknown. METHODS:We conducted a prospective observational study of 1,117 patients who had been discharged alive after hospitalization for CAP. We collected variables a...


    pub_type: 杂志文章


    authors: Capelastegui A,España Yandiola PP,Quintana JM,Bilbao A,Diez R,Pascual S,Pulido E,Egurrola M

    更新日期:2009-10-01 00:00:00

  • Nutritional status and lung function in patients with emphysema and chronic bronchitis.

    abstract::This study compared the nutritional status of patients with emphysema and chronic bronchitis and examined the relationship between lung dysfunction and nutritional depletion in patients with emphysema. There was no evidence of nutritional depletion in patients with chronic bronchitis (n = 4). In contrast, patients wit...


    pub_type: 杂志文章


    authors: Openbrier DR,Irwin MM,Rogers RM,Gottlieb GP,Dauber JH,Van Thiel DH,Pennock BE

    更新日期:1983-01-01 00:00:00

  • Pathogenesis and pathology of liver disease associated with alpha 1-antitrypsin deficiency.

    abstract::alpha 1-Antitrypsin (alpha 1-AT) accumulates in the rough endoplasmic reticulum through a mechanism of polymerization. Polymerization is favored by the incorrect tertiary structure of the alpha 1-AT caused by a point mutation at position 342 of the protein. Accumulation of alpha 1-AT in the liver cells (and in hepatoc...


    pub_type: 杂志文章,评审


    authors: Massi G

    更新日期:1996-12-01 00:00:00

  • Serologic IgE immune responses against Aspergillus fumigatus and Candida albicans in patients with cystic fibrosis.

    abstract:OBJECTIVES:The objectives of this study were to determine the prevalence of Aspergillus fumigatus and Candida albicans in the sputa of patients with cystic fibrosis (CF), to assess serologic IgE responses of these patients to the presence of fungi in the sputum, to evaluate what effect this may have on clinical status,...


    pub_type: 杂志文章


    authors: Máiz L,Cuevas M,Quirce S,Cañón JF,Pacheco A,Sousa A,Escobar H

    更新日期:2002-03-01 00:00:00

  • Supraventricular tachyarrhythmias in hospitalized adults after surgery. Clinical correlates in patients over 40 years of age after major noncardiac surgery.

    abstract::To assess the clinical correlates and therapeutic outcome of new postoperative supraventricular tachyarrhythmias, 916 patients who were in sinus rhythm throughout the course of surgery were prospectively followed after major noncardiac surgery. The 35 patients (4 percent) who developed new postoperative supraventricul...


    pub_type: 杂志文章


    authors: Goldman L

    更新日期:1978-04-01 00:00:00

  • Cough and wheezing from beclomethasone aerosol.

    abstract::Cough and wheezing are frequent side effects of inhaling beclomethasone dipropionate aerosol (BA) in patients with asthma. Twenty percent of our outpatient asthmatic subjects are unable to take BA due to these side effects. Twelve patients with history of severe cough and wheezing after inhaling BA were tested. Three ...


    pub_type: 临床试验,杂志文章


    authors: Shim C,Williams MH Jr

    更新日期:1987-02-01 00:00:00

  • Reducing maintenance and repair costs in an interventional pulmonology program.

    abstract:BACKGROUND:In the current economic climate, hospitals and academic institutions demand that medical departments function in an efficient and cost-effective manner. Detailed business plans are necessary to build new clinical programs, and institutions have learned that new programs are associated with significant costs ...


    pub_type: 杂志文章


    authors: Lunn W,Garland R,Gryniuk L,Smith L,Feller-Kopman D,Ernst A

    更新日期:2005-04-01 00:00:00

  • Preflight medical screenings of patients. Analysis of health and flight characteristics.

    abstract::We evaluated the demographic, medical, and flight characteristics of 1,115 passengers who were routinely referred for preflight medical screening by a major domestic air carrier. The largest category consisted of 892 patients who requested in-flight oxygen therapy for cardiopulmonary conditions, of which COPD and card...


    pub_type: 杂志文章


    authors: Gong H Jr,Mark JA,Cowan MN

    更新日期:1993-09-01 00:00:00

  • Contrast-enhanced sonography for differential diagnosis of pleurisy and focal pleural lesions of unknown cause.

    abstract:BACKGROUND:Ultrasound enables the visualization of pleural-based lesions with a poor correlation to specific pathology. At this time, there are no data about the diagnostic value of contrast-enhanced sonography (CES) in pleural lesions. METHODS:From August 2004 to January 2005, 25 consecutive patients with clinical sy...


    pub_type: 杂志文章


    authors: Görg C,Bert T,Görg K

    更新日期:2005-12-01 00:00:00

  • Cyclophosphamide in the treatment of pulmonary diseases: survey of use, training, and practitioner knowledge base.

    abstract:OBJECTIVE:To assess pulmonologists' use, training in the use, and knowledge base of the drug cyclophosphamide. DESIGN:Survey through questionnaire. Testing of knowledge base before and after instructional conference. PARTICIPANTS AND METHODS:Pulmonologists (94 attendings, 31 fellows), selected randomly at the 1996 an...


    pub_type: 杂志文章


    authors: Cozzi PJ,Hall JB

    更新日期:1999-11-01 00:00:00

  • Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective.

    abstract:BACKGROUND:Many critically ill patients who die will do so after a decision has been made to withhold/withdraw life-sustaining therapy. The objective of this study was to document the characteristics of ICU patients with a decision to withhold/withdraw life-sustaining treatment, including the types of supportive treatm...


    pub_type: 杂志文章,多中心研究


    authors: Lobo SM,De Simoni FHB,Jakob SM,Estella A,Vadi S,Bluethgen A,Martin-Loeches I,Sakr Y,Vincent JL,ICON investigators.

    更新日期:2017-08-01 00:00:00

  • Emphysema presence, severity, and distribution has little impact on the clinical presentation of a cohort of patients with mild to moderate COPD.

    abstract:BACKGROUND:Phenotypic characterization of patients with COPD may have potential prognostic and therapeutic implications. Available information on the relationship between emphysema and the clinical presentation in patients with COPD is limited to advanced stages of the disease. The objective of this study was to descri...


    pub_type: 杂志文章


    authors: de Torres JP,Bastarrika G,Zagaceta J,Sáiz-Mendiguren R,Alcaide AB,Seijo LM,Montes U,Campo A,Zulueta JJ

    更新日期:2011-01-01 00:00:00

  • Comparison of the effectiveness of tetracycline and minocycline as pleural sclerosing agents in rabbits.

    abstract::Parenteral tetracycline, one of the most commonly used agents for producing pleurodesis, is no longer available because of stricter regulations governing the manufacturing process. The objective of this project was to determine whether minocycline, a tetracycline derivative, is an effective sclerosant in an experiment...


    pub_type: 杂志文章


    authors: Light RW,Wang NS,Sassoon CS,Gruer SE,Vargas FS

    更新日期:1994-08-01 00:00:00

  • Noninvasive positive pressure ventilation: successful outcome in patients with acute lung injury/ARDS.

    abstract:BACKGROUND:There is increasing support for the use of noninvasive positive pressure ventilation (NPPV) in the treatment of patients with acute respiratory failure. Highest success rates are recorded in patients with exacerbation of COPD, particularly in patients presenting primarily with hypercarbic respiratory failure...


    pub_type: 杂志文章


    authors: Rocker GM,Mackenzie MG,Williams B,Logan PM

    更新日期:1999-01-01 00:00:00

  • Genetics of COPD and emphysema.

    abstract::COPD is a highly prevalent disorder that results from the interplay of genetic susceptibility and environmental exposures. Over the past 2 decades, significant technological advances have been made in genetic investigations of complex diseases, yet limited progress has been made in the identification of additional COP...


    pub_type: 杂志文章,评审


    authors: Wan ES,Silverman EK

    更新日期:2009-09-01 00:00:00

  • Safety and Tolerability of Alveolar Type II Cell Transplantation in Idiopathic Pulmonary Fibrosis.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited response to currently available therapies. Alveolar type II (ATII) cells act as progenitor cells in the adult lung, contributing to alveolar repair during pulmonary injury. However, in IPF, ATII cells die and are replace...


    pub_type: 杂志文章


    authors: Serrano-Mollar A,Gay-Jordi G,Guillamat-Prats R,Closa D,Hernandez-Gonzalez F,Marin P,Burgos F,Martorell J,Sánchez M,Arguis P,Soy D,Bayas JM,Ramirez J,Tetley TD,Molins L,de la Bellacasa JP,Rodríguez-Villar C,Rovira I,Fi

    更新日期:2016-09-01 00:00:00