Abstract:
:A 55-year-old woman had bilateral hilar lymphadenopathy and retinouveitis. Microscopic examination of a biopsy specimen from a mediastinal lymph node revealed noncaseating epithelioid cell granulomas. Since granulomatous diseases of infectious origin and sarcoid reaction were reasonably excluded, she was diagnosed as having pulmonary sarcoidosis. Bronchoalveolar lavage findings were atypical in that the ratio of helper T cells to suppressor T cells (CD4/8 ratio) was 0.5 in two separate examinations, despite a moderately increased proportion of lymphocytes. Immunohistochemical examination of the lymph node also showed a predominancy of suppressor T cells. The inversion of the CD4/8 ratio suggests the presence of heterogeneity in the immunoregulatory mechanism in pulmonary sarcoidosis and may have a prognostic significance.
journal_name
Chestjournal_title
Chestauthors
Yamaguchi E,Haneda H,Okazaki N,Abe S,Kawakami Y,Nojima Tdoi
10.1378/chest.95.1.228subject
Has Abstractpub_date
1989-01-01 00:00:00pages
228-31issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(16)33621-2journal_volume
95pub_type
杂志文章相关文献
CHEST文献大全abstract::Disappointing results of surgery and postoperative adjuvant chemotherapy or chemoradiotherapy in stage IIIA (N2) lung cancer have led to a number of phase II trials of induction (neoadjuvant) chemotherapy given prior to surgery. Preliminary results of 2 such studies indicate that mitomycin, vinca alkaloid, and platinu...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.103.4_supplement.356s
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Dynamic hyperinflation (DH) develops in patients with COPD during incremental exercise with a cycle ergometer. The aims of this study were to determine whether DH can be evidenced after walking with a handheld spirometer and to determine its functional consequences. METHODS:Fifty patients with COPD (39 men;...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-0410
更新日期:2009-12-01 00:00:00
abstract:STUDY OBJECTIVES:There have been many studies on the physical characteristics at the time of contraction of a primary spontaneous pneumothorax (PSP), but it has not been shown when and how such physical characteristics develop. These issues were investigated. PATIENTS AND DESIGN:Physical development of 27 male patient...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.4.899
更新日期:1999-10-01 00:00:00
abstract::The value of home spirometry in detecting acute lung rejection and opportunistic infections was studied in 15 heart-lung transplant recipients over a six-month period. The patients measured their FEV1 and FVC twice daily at home using a portable turbine spirometer. The records were then reviewed in relation to the res...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.2.353
更新日期:1990-02-01 00:00:00
abstract::Eighty-two patients with mitral stenosis underwent cardiac catheterization with coronary angiography. Twenty-one patients (26 percent) had coronary artery disease. Characteristics of the mitral valve area, cardiac output, pulmonary artery pressure, pulmonary vascular resistance, left ventricular end-diastolic pressure...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.81.1.36
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:To examine the effect of preoperative smoking behavior on postoperative pulmonary complications. DESIGN:Prospective cohort study. SETTING:The Veterans Administration Medical Center, Syracuse, NY. PARTICIPANTS:Patients scheduled for noncardiac elective surgery (n=410). MEASUREMENTS AND RESULTS:Smoking stat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.4.883
更新日期:1998-04-01 00:00:00
abstract::Eighteen postmenopausal women were examined by Doppler echocardiography before initiation of HRT (T1), then after ten weeks (T2) and one year (T3). This study group was compared with another in which HRT was not used. Flow velocity integral, which correlates with SV, and MA, an indicator of cardiac contractility, were...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.5.1496
更新日期:1992-11-01 00:00:00
abstract::We describe the first case, to our knowledge, of usual interstitial pneumonia (UIP) as the pulmonary manifestation in primary Sjögren's syndrome (SjS). A 45-year-old woman was admitted to our hospital because of a dry cough and an interstitial shadow on a chest roentgenogram. Labial biopsy and sialogram confirmed a di...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.6.1756
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Augmentation therapy with pooled human plasma-derived alpha(1)-antitrypsin (AAT) has been shown to have biochemical efficacy in restoring serum AAT levels above the protective threshold. Also, clinical efficacy has been suggested. OBJECTIVE:To evaluate the bioequivalence of a new solvent detergent-treated p...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.122.1.66
更新日期:2002-07-01 00:00:00
abstract::Because of an emphasis on patient safety and recognition of the effectiveness of simulation as an educational modality across multiple medical specialties, use of health-care simulation (HCS) for medical education has become more prevalent. In this article, the effectiveness of simulation for areas important to the pr...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2019.07.011
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Septic pulmonary embolism (SPE) is an uncommon disorder with an insidious onset and is difficult to diagnose. STUDY OBJECTIVES:To characterize the presenting features and clinical course of patients with SPE. DESIGN:Retrospective study. SETTING:Tertiary care, referral medical center. PATIENTS:Fourteen su...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.1.162
更新日期:2005-07-01 00:00:00
abstract::Sepsis is among the most common reasons for admission to ICUs throughout the world, and it is believed to be the third most common cause of death in the United States. The pathogenetic mechanism and physiologic changes associated with sepsis are exceedingly complex, but our understanding is evolving rapidly. The major...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.13-2104
更新日期:2014-06-01 00:00:00
abstract::Clonidine was given to patients with essential hypertension, renovascular hypertension, and hypertension with parenchymal renal disease. The drug was effective in all groups but was more effective in patients with high plasma renin concentration. Renal function did not deteriorate when the drug was used, and there was...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.2_supplement.383
更新日期:1983-02-01 00:00:00
abstract:STUDY OBJECTIVE:To measure the ability of a set of clinical parameters, the Winthrop-University Hospital (WUH) criteria, to identify Legionella pneumonia while discriminating against bacteremic pneumococcal pneumonia at the time of hospitalization for community-acquired pneumonia (CAP). DESIGN:Retrospective case-contr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.4.1064
更新日期:2001-10-01 00:00:00
abstract::Angiofollicular lymph node hyperplasia, known more commonly as Castleman disease, is a rare lymphoproliferative disorder. Castleman disease has two distinct clinical manifestations described as unicentric and multicentric disease. These presentations have distinct treatment algorithms and portend very different progno...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-2084
更新日期:2010-11-01 00:00:00
abstract::Respiratory rate is a sensitive clinical parameter in a multitude of pulmonary diseases, especially in the critical care setting. In order to validate the routine recording of the respiratory rate in the intensive care unit, we compared the values obtained from the nursing records with the breathing frequency continuo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.5.632
更新日期:1986-11-01 00:00:00
abstract::Prior to 1978, the conventional treatment of pneumothorax generally consisted of conservative therapies such as rest, needle puncture, or thoracic cavity drainage; however, when conservative therapies were ineffective or relapse occurred therapeutic approach, 34 percent (11/32) of our patients required a thoracotomy. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.4.953
更新日期:1991-10-01 00:00:00
abstract:STUDY OBJECTIVES:The aim of this study was to develop an acute asthma index for utilization in the early differentiation between patients with poor and good therapeutic response in the emergency department (ED) setting. SETTING:The ED of a large tertiary-care hospital in Montevideo, Uruguay. PATIENTS AND DESIGN:The s...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.4.1016
更新日期:1998-10-01 00:00:00
abstract::Breathing against positive expiratory pressure has been used to improve gas exchange in many forms of pulmonary edema, and forced expiration against resistance during exercise has been advocated for climbing at high altitude as a method to optimize performance. To evaluate the effect of expiratory positive airway pres...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.87.3.330
更新日期:1985-03-01 00:00:00
abstract::beta 2-agonist bronchodilators delivered by metered-dose inhalers (MDI) are commonly used in the treatment of bronchospasm in both intubated and nonintubated patients. Substantial data support the effectiveness of MDI delivery systems in nonintubated patients. However, few studies have examined the effectiveness of MD...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.1.210
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:It has been postulated that differences in provocative concentration of methacholine causing a 20% fall in FEV1 (PC20) values between the dosimeter method and tidal breathing method might be due to differences in the dose of agonist delivered to the mouth. The aim of the present study was to determine the in...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.08-0093
更新日期:2008-10-01 00:00:00
abstract::We evaluated two patients with systemic cholesterol embolization (SCE) associated with the development of pleural effusions. These two patients had evidence of atherosclerosis and presented with livedo reticularis, renal insufficiency, and gangrenous cutaneous changes as manifestations of their SCE. In both cases, clo...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.103.3.792
更新日期:1993-03-01 00:00:00
abstract::Lung scans with technetium sulfur colloid were performed in ten patients with life-threatening hemoptysis and nondiagnostic chest roentgenograms. Localized deposition of radionuclide was demonstrated in five of the six patients who were studied during active bleeding. These abnormalities were confirmed bronchoscopical...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.2.208
更新日期:1984-08-01 00:00:00
abstract::Health systems confronting the coronavirus disease 2019 (COVID-19) pandemic must plan for surges in ICU demand and equitably distribute resources to maximize benefit for critically ill patients and the public during periods of resource scarcity. For example, morbidity and mortality could be mitigated by a proactive re...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2020.04.026
更新日期:2020-08-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the efficacy of small-bore (12 French vanSonnenberg) catheters compared with standard large-bore chest tubes in the drainage and sclerotherapy of malignant pleural effusions. DESIGN:Retrospective review. SETTING:An academic tertiary care hospital. PATIENTS:Adult patients with documented n...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.1.19
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:There are several reports on underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.01.015
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Data on patients with cancer who have a prolonged length of stay (LOS) in the ICU are scarce. The aim of the present study was to evaluate the characteristics and the outcomes of cancer patients with life-threatening complications with an ICU stay > or = 21 days. METHODS:A cohort study performed at a 10-bed...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-0359
更新日期:2008-09-01 00:00:00
abstract::Angiographic documentation after single lung transplant showed pulmonary venous obstruction due to compression by the omental pedicle. Retransplantation is described, and this complication is examined. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.2.645
更新日期:1992-08-01 00:00:00
abstract::Benign thymic hyperplasia (BTH) is a known feature of hyperthyroidism, but is infrequently appreciated by clinicians. In most cases thymic enlargement is minimal; however, it may occasionally present as an appreciable anterior mediastinal mass. While surgical resection is a common approach to such a mass, recognition ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.90.5.691
更新日期:1986-11-01 00:00:00
abstract::Serum angiotensin-converting enzyme activity (SACE) and lysozyme activity were measured in a group of 40 underground coal miners and two control groups, 20 subjects with sarcoidosis and 15 normal non-dust-exposed volunteers. The miners were grouped first according to whether they had recent exposure (still actively mi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.4.1042
更新日期:1991-10-01 00:00:00