Abstract:
STUDY OBJECTIVE:To evaluate the efficacy of small-bore (12 French vanSonnenberg) catheters compared with standard large-bore chest tubes in the drainage and sclerotherapy of malignant pleural effusions. DESIGN:Retrospective review. SETTING:An academic tertiary care hospital. PATIENTS:Adult patients with documented neoplasms and malignant pleural effusions, treated between 1986 and 1995. INTERVENTION:All patients included in the study underwent drainage of malignant pleural effusions either by large-bore chest tube or by ultrasound-guided small-bore catheter. After drainage, pleurodesis was performed. RESULTS:Outcome as defined by recurrence of effusion was determined by blinded examination of all postpleurodesis chest radiographs. We identified 58 cases of malignant pleural effusion in which small-bore catheters were used and 44 in which large-bore chest tubes were used. The majority of patients had breast (n = 56, 55%) or lung cancer (n = 29, 28%). The median age was 65 years. Fifty-nine patients were actively being treated with chemotherapy at the time of pleurodesis. The following sclerosing agents were used: talc, 27 (26%); tetracycline, 72 (70%); bleomycin, 2 (2%); and interferon, 1 (1%). Actuarial probabilities of recurrence at 6 weeks and 4 months were 45% and 53% for the small tubes vs 45% and 51% for the large tubes. Univariate and multivariate analyses failed to demonstrate that tube size had any influence on the rate of recurrence. CONCLUSIONS:We were unable to detect any major differences in outcomes with the use of either size of chest tube. Our study suggests that small-bore catheters may be effective in the treatment of malignant pleural effusions and deserve further evaluation in prospectively designed trials.
journal_name
Chestjournal_title
Chestauthors
Parulekar W,Di Primio G,Matzinger F,Dennie C,Bociek Gdoi
10.1378/chest.120.1.19subject
Has Abstractpub_date
2001-07-01 00:00:00pages
19-25issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(15)35786-Xjournal_volume
120pub_type
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