Abstract:
:Diurnal variability of peak expiratory flow rates (PEFRs) was assessed in 1,237 children. The PEFR was measured twice daily over a 1-week period. As an index of variability, the log of a week's mean of daily amplitude was calculated. Linear regression analyses revealed a significant positive association between maternal smoking and the variability of PEFR for nonasthmatic children. For these children, exposure to maternal smoking was associated with a 13.7 percent increase (confidence interval [CI], 3.8 to 24.7 percent) in PEFR variability. For asthmatic children an effect was found for nonatopic (54.7 percent increase; CI, 5.5 to 226.8 percent) but not for atopic children (-8.5 percent change; CI, -41.2 to 42.3 percent). In the latter group, there was evidence that mothers changed their smoking habits subsequent to the development of disease in their children. We conclude that exposure to maternal smoking can increase the variability of PEFR and thus might contribute to the development of asthma.
journal_name
Chestjournal_title
Chestauthors
Frischer T,Kühr J,Meinert R,Karmaus W,Urbanek Rdoi
10.1378/chest.104.4.1133subject
Has Abstractpub_date
1993-10-01 00:00:00pages
1133-7issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(16)37301-9journal_volume
104pub_type
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