Influence of maternal smoking on variability of peak expiratory flow rate in school children.

Abstract:

:Diurnal variability of peak expiratory flow rates (PEFRs) was assessed in 1,237 children. The PEFR was measured twice daily over a 1-week period. As an index of variability, the log of a week's mean of daily amplitude was calculated. Linear regression analyses revealed a significant positive association between maternal smoking and the variability of PEFR for nonasthmatic children. For these children, exposure to maternal smoking was associated with a 13.7 percent increase (confidence interval [CI], 3.8 to 24.7 percent) in PEFR variability. For asthmatic children an effect was found for nonatopic (54.7 percent increase; CI, 5.5 to 226.8 percent) but not for atopic children (-8.5 percent change; CI, -41.2 to 42.3 percent). In the latter group, there was evidence that mothers changed their smoking habits subsequent to the development of disease in their children. We conclude that exposure to maternal smoking can increase the variability of PEFR and thus might contribute to the development of asthma.

journal_name

Chest

journal_title

Chest

authors

Frischer T,Kühr J,Meinert R,Karmaus W,Urbanek R

doi

10.1378/chest.104.4.1133

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

1133-7

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)37301-9

journal_volume

104

pub_type

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