Characterization of chronic fatigue in patients with sarcoidosis in clinical remission.


BACKGROUND:Patients with sarcoidosis frequently complain of fatigue, even when sarcoidosis has come into clinical remission. The primary aim of this study was to assess the severity of fatigue in patients with sarcoidosis in clinical remission and to characterize it according to the international criteria for chronic fatigue syndrome (CFS). Furthermore, we evaluated whether fatigue is associated with depression and anxiety, health status, and patient-reported sleep quality, and we recorded physical activity levels and muscle strength as objective assessments of fatigue. METHODS:Data on 75 patients with sarcoidosis in clinical remission were obtained by questionnaires (Checklist Individual Strength [CIS], Symptom Checklist-90, Beck Depression Inventory for primary care, Medical Outcomes Study 36-Item Short-Form Health Survey), standardized interview (CFS criteria), sleep diary, accelerometer, and muscle strength tests. RESULTS:Fatigue severity mean score in patients with sarcoidosis in clinical remission was high (CIS fatigue severity 30.5 ± 15.5), and criteria for CFS were met in 47% of fatigued participants. Median time since diagnosis was 9 years. Fatigue was associated with depression (P = .01), anxiety (P = .013), and reduced health status (P < .001). Scores on sleep quality were normal. Physical activity levels were reduced in fatigued participants. Muscle strength, particularly handgrip (P = .006) and quadriceps strength (P < .001), was significantly associated with fatigue. CONCLUSIONS:Fatigue in patients with sarcoidosis in clinical remission is a frequent symptom and can be characterized as a severe and long-lasting problem, symptomatically similar to CFS. Psychologic distress and reduced health status are associated with fatigue. Interestingly, we observed significantly reduced physical activity and muscle weakness in fatigued patients.






Korenromp IHE,Heijnen CJ,Vogels OJM,van den Bosch JMM,Grutters JC




Has Abstract


2011-08-01 00:00:00
















  • Effects of augmented continuous positive airway pressure education and support on compliance and outcome in a Chinese population.

    abstract:OBJECTIVES:To study the effects of augmentation of continuous positive airway pressure (CPAP) education and support on compliance and outcome in patients with obstructive sleep apnea (OSA). DESIGN:A randomized, controlled, parallel study of basic vs augmented CPAP education and support. SETTING:A university teaching ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hui DS,Chan JK,Choy DK,Ko FW,Li TS,Leung RC,Lai CK

    更新日期:2000-05-01 00:00:00

  • Periodic limb movements during sleep in patients with congestive heart failure.

    abstract::The prevalence of periodic limb movements (PLM) during sleep and their effect on sleep and daytime alertness were determined in 23 men with severe, stable congestive heart failure (CHF) and 9 healthy control subjects. Each subject had overnight polysomnography and the following day completed a subjective assessment of...


    pub_type: 杂志文章


    authors: Hanly PJ,Zuberi-Khokhar N

    更新日期:1996-06-01 00:00:00

  • A cross-cultural comparison of critical care delivery: Japan and the United States.

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    pub_type: 杂志文章


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    更新日期:2002-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Marchant JM,Newcombe PA,Juniper EF,Sheffield JK,Stathis SL,Chang AB

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    pub_type: 杂志文章


    authors: Pernat A,Weil MH,Sun S,Tang W,Yamaguchi H,Bisera J

    更新日期:2000-04-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:1987-03-01 00:00:00

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    authors: Amoateng-Adjepong Y,Del Mundo J,Manthous CA

    更新日期:1999-04-01 00:00:00

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    更新日期:1990-02-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Thomson CC,Clark S,Camargo CA Jr,MARC Investigators.

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    更新日期:1988-08-01 00:00:00

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    authors: Mekontso Dessap A,Katsahian S,Roche-Campo F,Varet H,Kouatchet A,Tomicic V,Beduneau G,Sonneville R,Jaber S,Darmon M,Castanares-Zapatero D,Brochard L,Brun-Buisson C

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    更新日期:1986-05-01 00:00:00

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  • Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

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  • State-Level Variations in the Utilization of Lung Cancer Screening Among Medicare Fee-for-Service Beneficiaries: An Analysis of the 2015 to 2017 Physician and Other Supplier Data.

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    authors: Hoffstein V,Herridge M,Mateika S,Redline S,Strohl KP

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    更新日期:1995-11-01 00:00:00

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    pub_type: 临床试验,杂志文章


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    pub_type: 杂志文章


    authors: Collard P,Njinou B,Nejadnik B,Keyeux A,Frans A

    更新日期:1994-05-01 00:00:00

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    pub_type: 杂志文章,评审


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    更新日期:2009-10-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1998-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Shlaes DM,Lederman M,Chmielewski R,Tweardy D,Wolinsky E

    更新日期:1983-06-01 00:00:00