Characterization of chronic fatigue in patients with sarcoidosis in clinical remission.


BACKGROUND:Patients with sarcoidosis frequently complain of fatigue, even when sarcoidosis has come into clinical remission. The primary aim of this study was to assess the severity of fatigue in patients with sarcoidosis in clinical remission and to characterize it according to the international criteria for chronic fatigue syndrome (CFS). Furthermore, we evaluated whether fatigue is associated with depression and anxiety, health status, and patient-reported sleep quality, and we recorded physical activity levels and muscle strength as objective assessments of fatigue. METHODS:Data on 75 patients with sarcoidosis in clinical remission were obtained by questionnaires (Checklist Individual Strength [CIS], Symptom Checklist-90, Beck Depression Inventory for primary care, Medical Outcomes Study 36-Item Short-Form Health Survey), standardized interview (CFS criteria), sleep diary, accelerometer, and muscle strength tests. RESULTS:Fatigue severity mean score in patients with sarcoidosis in clinical remission was high (CIS fatigue severity 30.5 ± 15.5), and criteria for CFS were met in 47% of fatigued participants. Median time since diagnosis was 9 years. Fatigue was associated with depression (P = .01), anxiety (P = .013), and reduced health status (P < .001). Scores on sleep quality were normal. Physical activity levels were reduced in fatigued participants. Muscle strength, particularly handgrip (P = .006) and quadriceps strength (P < .001), was significantly associated with fatigue. CONCLUSIONS:Fatigue in patients with sarcoidosis in clinical remission is a frequent symptom and can be characterized as a severe and long-lasting problem, symptomatically similar to CFS. Psychologic distress and reduced health status are associated with fatigue. Interestingly, we observed significantly reduced physical activity and muscle weakness in fatigued patients.






Korenromp IHE,Heijnen CJ,Vogels OJM,van den Bosch JMM,Grutters JC




Has Abstract


2011-08-01 00:00:00
















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    abstract::Atherosclerosis occurred in a coronary artery saphenous vein bypass graft. Serial angiograms are presented documenting subtotal occlusion of this graft which occurred over a nine-month period. Pathologic examination of graft material obtained at surgery demonstrated ulcerating atherosclerotic plaque. The occurrence of...


    pub_type: 杂志文章


    authors: Hanlon JT,Massie B,Riches W,Wilson J,Ellis RJ,Gertz EW

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  • Clinical pharmacokinetics of theophylline and levels of alpha 1-acid glycoprotein in smokeless tobacco users.

    abstract::Elimination half-life and apparent volume of distribution of theophylline were determined in ten healthy volunteers who used smokeless tobacco (snuff or chewing tobacco) regularly but did not smoke cigarettes. Serum concentrations of the acute phase reactant alpha 1-acid glycoprotein (AAG) were also measured. The elim...


    pub_type: 杂志文章


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  • Standard therapy for tuberculosis 1985.

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    更新日期:1978-12-01 00:00:00

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    authors: Lam CF,van Heerden PV,Ilett KF,Caterina P,Filion P

    更新日期:2003-03-01 00:00:00

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    authors: Nosotti M,Rebulla P,Riccardi D,Baisi A,Bellaviti N,Rosso L,Santambrogio L

    更新日期:2003-07-01 00:00:00

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    authors: Kiaii B,McClure RS,Kostuk WJ,Rayman R,Swinamer S,Dobkowski WB,Novick RJ

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    authors: Hawker FH,Torzillo PJ,Southee AE

    更新日期:1991-04-01 00:00:00

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    pub_type: 杂志文章


    authors: Heffner JE,Standerfer RJ,Torstveit J,Unruh L

    更新日期:1994-06-01 00:00:00

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    authors: White SR,Hall JB,Little A

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  • Diagnosis of tracheal injury in mechanically ventilated premature infants by flexible bronchoscopy. A pilot study.

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    pub_type: 杂志文章


    authors: Schellhase DE,Graham LM,Fix EJ,Sparks LM,Fan LL

    更新日期:1990-11-01 00:00:00

  • Periodic breathing with no heart beat.

    abstract::A protocol was originally designed to study breathing control during and following cardiac arrest in humans, taking advantage of the period of pulseless ventricular fibrillation (PVF) produced while testing a newly implanted cardioverter-defibrillator device. A patient aged in his 60s with New York Heart Association c...


    pub_type: 杂志文章


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  • In vivo right heart thrombus. Precursor of life-threatening pulmonary embolism.

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    pub_type: 杂志文章,评审


    authors: Crowell RH,Adams GS,Koilpillai CJ,McNutt EJ,Montague TJ

    更新日期:1988-12-01 00:00:00

  • Ultrastructural and functional studies of cilia from patients with asthma, aspirin intolerance, and nasal polyps.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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  • Subaortic stenosis caused by two discrete membranes.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Fleisher LA,Bass EB,McKeown P,American College of Chest Physicians.

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    pub_type: 杂志文章


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    更新日期:2009-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Steffenino G,Ferrero G,Forni B,Giustetto C,Ottino G,Conte M

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  • Supplementing defect in club cell secretory protein attenuates airway inflammation in COPD.

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    pub_type: 杂志文章


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    更新日期:2015-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Schulz C,Krätzel K,Wolf K,Schroll S,Köhler M,Pfeifer M

    更新日期:2004-05-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kirsch JL,Muro JR,Stansbury DW,Fischer CE,Monfore R,Light RW

    更新日期:1989-10-01 00:00:00