Abstract:
:Residual volume (RV) was obtained by subtracting vital capacity from total lung capacity determined by the single breath helium dilution (TLCsb) to measure CO diffusing capacity in 2,680 subjects (8 to 64 years old) of a general population sample. There were 712 normal subjects (243 male and 469 female subjects) selected to evaluate the pattern of RV by age and to derive reference values for internal comparisons. From 8 to 20 years old, RV showed an increase because of the cross-sectional body size effect; after 20 to 30 years, RV was still increasing, however, at a lower level. Age and height coefficients were significantly related to RV in younger and older ages, both in male and female subjects. The RV percent predicted and RV/TLC percent were higher in smokers when compared to nonsmokers and exsmokers (the difference was significant in male subjects). A dose-response effect was observed between RV percent predicted, RV/TLC percent, and pack-years. The RV percent predicted and RV/TLC percent were significantly higher in smokers and nonsmokers with FEV1 percent predicted below the normal limit (the difference was significant in male subjects). Moreover, higher values of RV percent predicted and RV/TLC percent were observed in subjects with wheezy symptoms in male smokers and nonsmokers. A negative significant correlation was observed between RV/TLC percent and the diffusing capacity adjusted for lung volume (DL/VA) in smokers, exsmokers and nonsmokers of both sexes, confirming the hypothesis that the decrease in DL/VA may be ascribed to the enlargement of terminal air spaces. In conclusion, determination of RV by the single breath helium dilution method is suitable in epidemiology, and it allows additional important information for understanding the physiopathologic mechanisms related to the pathogenesis of chronic obstructive lung disease.
journal_name
Chestjournal_title
Chestauthors
Paoletti P,Viegi G,Carrozzi L,Di Pede F,Modena P,Ballerin L,Baldacci S,Pedreschi M,Pistelli G,Giuntini Cdoi
10.1378/chest.102.4.1209subject
Has Abstractpub_date
1992-10-01 00:00:00pages
1209-15issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(16)34308-2journal_volume
102pub_type
杂志文章相关文献
CHEST文献大全abstract:BACKGROUND:Characterizing acute exacerbations of COPD (AECOPD) and individualizing therapy is challenging. Key exacerbation therapies include antibiotics and systemic corticosteroids. Blood eosinophils, when either low or high, may offer a simple, inexpensive distinction to predict beneficial responses to these therapi...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1016/j.chest.2019.02.406
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Although marital status has been shown to affect the outcomes of many conditions, there are limited data on the relationships between marital status and the presentation and outcomes of pneumonia. METHODS:We used Veterans Affairs administrative databases to identify a retrospective cohort of male veterans a...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.11-3183
更新日期:2012-10-01 00:00:00
abstract::Intraoperative two-dimensional echocardiography allows visualization of cardiac anatomy and function not possible by other techniques. Although preoperative evaluation by noninvasive methods is usually adequate for diagnosis of cardiac tumors, two-dimensional echocardiography can be beneficial intraoperatively. Intrao...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.1.142
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:Studies documenting the increased incidence of exercise-induced bronchospasm (EIB) in figure skaters have employed a method that incorporates on-ice exercise with rink-side spirometry. The literature suggests that bronchial provocation challenge testing is better than exercise testing for identifying EIB. To...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.3.649
更新日期:1999-03-01 00:00:00
abstract::The successful use of streptokinase therapy in a child with chronic thrombosis of a prosthetic valve (Carbomedics) in the tricuspid position is presented. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.5.1599
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Cough is a common symptom prompting patients to seek medical care. Like patients in the general population, patients with compromised immune systems also seek care for cough. However, it is unclear whether the causes of cough in immunocompromised patients who are deemed unlikely to have a life-threating cond...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2017.07.039
更新日期:2017-11-01 00:00:00
abstract::OSA is a common yet underdiagnosed disorder encountered in everyday practice. The disease is a unique physiologic stressor that contributes to the development or progression of many other disorders, particularly cardiovascular conditions. The pulmonary circulation is specifically affected by the intermittent hypoxic a...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.14-0614
更新日期:2015-03-01 00:00:00
abstract::An asymptomatic young man presented with a cardiac murmur and hypertension only in the right arm. Angiograms showed kinking of the aortic arch with a figure-eight appearance consistent with pseudocoarctation. Before the kinked segment, also demonstrated were a stenotic lesion in the aortic arch proximal to the left ca...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.5.1239
更新日期:1990-05-01 00:00:00
abstract::Native valve endocarditis normally presents with fever and only later in its course demonstrates dysfunction of the affected valve. We describe a case of endocarditis due to Neisseria subflava, a Gram-negative diplococcal saprophyte of the oral cavity, which was unsuspected clinically and found unexpectedly during a m...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.109.1.280
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:This multicenter, double-blind, placebo-controlled study evaluated the dose response to 6 weeks of triamcinolone acetonide inhalation aerosol (TAA, 100 microg per puff) in patients with moderately severe asthma. STUDY DESIGN:A total of 285 patients were randomly assigned to treatment with 1, 2, 4, or 8 puff...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.112.3.597
更新日期:1997-09-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the chest radiographic filling pattern associated with partial liquid ventilation (PLV) with the perfluorochemical perflubron (LiquiVent; Alliance Pharmaceutical Corp; San Diego CA) as a function of dose and timing. DESIGN:Post hoc review of chest radiographs by three independent observers...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.119.5.1503
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) has been reported to be associated with increased values of exhaled nitric oxide (ENO), which could not be entirely explained by the association between CRS and asthma. The aim of this study was to investigate the variables associated with increased ENO in patients with CRS. MET...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-0667
更新日期:2010-03-01 00:00:00
abstract::Cardiac imaging with dipyridamole infusion has been proposed as an exercise-independent tool for the diagnosis of coronary artery disease. Dipyridamole acts through the accumulation of adenosine, which reduces sympathetic tone in vasomotor nuclei of the brainstem and inhibits norepinephrine release in noradrenergic ne...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.2.444
更新日期:1992-08-01 00:00:00
abstract::The pathogenesis and clinical manifestations of COPD are not restricted to pulmonary inflammation and structural remodeling. Rather, this disorder is associated with clinically significant systemic alterations in biochemistry and organ function. The systemic aspects of COPD include oxidative stress and altered circula...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.121.5_suppl.127s
更新日期:2002-05-01 00:00:00
abstract:STUDY OBJECTIVES:To determine if soluble leukocyte selectin (sL-selectin) levels in serum and pleural fluid (PF) are an inflammatory marker that differentiates pleural effusion transudates from exudates. DESIGN:sL-selectin PF and serum levels were measured in consecutive patients and compared to established criteria. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.2.362
更新日期:2001-08-01 00:00:00
abstract:STUDY OBJECTIVES:There have been many studies on the physical characteristics at the time of contraction of a primary spontaneous pneumothorax (PSP), but it has not been shown when and how such physical characteristics develop. These issues were investigated. PATIENTS AND DESIGN:Physical development of 27 male patient...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.4.899
更新日期:1999-10-01 00:00:00
abstract::Echocardiographic studies were performed in 86 patients with right ventricular volume overload. In 45 of these 86 patients, 58 echocardiograms were performed at different intervals in the postoperative period. For control purposes, 60 normal subjects and 18 patients with right ventricular pressure overload were also e...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.3.388
更新日期:1976-03-01 00:00:00
abstract::We describe the management of bronchopleurobiliary fistula in a 56-year-old woman who underwent a (L) mastectomy with postoperative radio- and chemotherapy for advanced breast carcinoma and required insertion of inhabiliary Silastic stents for the relief of severe obstructive jaundice. During restaging of her carcinom...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.4.874
更新日期:1988-10-01 00:00:00
abstract::To evaluate comparative bronchodilator efficacy with chronic airflow obstruction (CAO), we randomly administered to ten patients week-long treatments consisting of: inhaled metaproterenol from a metered dose canister (1.30 mg six times a day) and doses of a sustained-release theophylline formulation sufficient to achi...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.89.2.171
更新日期:1986-02-01 00:00:00
abstract:STUDY OBJECTIVE:Depressive symptoms and reduced health-related quality of life are common in patients with severe COPD. Therefore, understanding the association between preferences for life-sustaining treatment and depression or quality of life is important in providing care. No prior studies have examined the effects ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.1.328
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) is a highly prevalent disorder that has been associated with an increased risk for cardiovascular morbidity, even in children. However, not all children with OSA manifest alterations in endothelial postocclusive hyperemia, an endothelial nitric oxide synthase (eNOS)-dependent re...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-2026
更新日期:2013-04-01 00:00:00
abstract:STUDY OBJECTIVES:To examine the association of occult atherosclerosis of carotid, femoral, and popliteal arteries with the presence and severity of obstructive coronary artery disease (CAD) in patients without a history or presence of cerebrovascular or peripheral arterial disease using ultrasound examination of periph...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.4.2538
更新日期:2005-10-01 00:00:00
abstract::To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hem...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.2.344
更新日期:1997-02-01 00:00:00
abstract::The characteristic arteriopathy of primary pulmonary hypertension (PPH) with attendant endothelial dysfunction provides an opportunity for enhanced cellular activation in the lung. Data from many laboratories support the concept of altered eicosanoid metabolism in PPH. Rigorously quantitative measurements of the excre...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.114.3_supplement.205s
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:It has been reported, but not proven, that perioperative blood transfusions have a detrimental effect on the survival of patients undergoing surgery for lung cancer. STUDY DESIGN:and methods: A prospective study was carried out on the patients undergoing lobectomy for stage I lung cancer at our department f...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.1.102
更新日期:2003-07-01 00:00:00
abstract::We describe two patients with AIDS who developed new diffuse pulmonary infiltrates during the course of their hospitalization. In both cases, the infiltrates were attributed to pulmonary hemorrhage complicating an existing condition rather than representing a new pulmonary process. Identification of pulmonary hemorrha...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.6.1891
更新日期:1994-12-01 00:00:00
abstract:STUDY OBJECTIVES:Poor dental hygiene has been linked to respiratory pathogen colonization in residents of long-term care facilities. We sought to investigate the association between dental plaque (DP) colonization and lower respiratory tract infection in hospitalized institutionalized elders using molecular genotyping....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.5.1575
更新日期:2004-11-01 00:00:00
abstract::Significant concentrations of asbestos fibers have been found in samples of laryngeal tissue from two patients with past exposure to asbestos and associated asbestosis. In one case, there was a polyp on a vocal cord and in the other one a laryngeal carcinoma. These findings could provide an indication of a local carci...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.76.6.697
更新日期:1979-12-01 00:00:00
abstract:STUDY OBJECTIVES:Among adults presenting to the emergency department (ED) with acute asthma, we sought to determine the prevalence of obesity, and the relation of body mass index (BMI) to asthma severity in this high-risk population. DESIGN:Multicenter, prospective cohort study. SETTING:Twenty-six North American EDs....
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.124.3.795
更新日期:2003-09-01 00:00:00
abstract::Chemical sclerosis of the pleural space is used to prevent recurrence of spontaneous pneumothorax. To test whether sclerosis restricts diaphragmatic excursion, we measured diaphragmatic excursion by ultrasonography in subjects with unilateral pleural sclerosis and compared it with diaphragmatic excursions in normal su...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.2.374
更新日期:1989-02-01 00:00:00