Clinical correlation with changing radiographic appearance during partial liquid ventilation.

Abstract:

STUDY OBJECTIVES:To evaluate the chest radiographic filling pattern associated with partial liquid ventilation (PLV) with the perfluorochemical perflubron (LiquiVent; Alliance Pharmaceutical Corp; San Diego CA) as a function of dose and timing. DESIGN:Post hoc review of chest radiographs by three independent observers with correlation to clinical variables. SETTING:Phase II randomized, uncontrolled, prospective, multicenter clinical trial. PATIENTS:Sixteen adult patients with diffuse bilateral infiltrates consistent with acute lung injury and a PaO(2)/fraction of inspired oxygen (FIO(2)) ratio < 300 with positive end-expiratory pressure of 13 cm H(2)O and FIO(2) > or = 0.5. INTERVENTIONS:All patients were treated with either a 10-mL/kg or 20-mL/kg loading dose of perflubron followed by maintenance dosing at 3-h intervals to protocol-determined levels. RESULTS:There was a significant relationship between inhomogeneous radiographic filling during the first 48 h of treatment and the use of the lower loading dose of perflubron. Inhomogeneous radiographic filling (in 5 patients) was associated with a lower high-dose/FIO(2) ratio at 24 h compared with the remaining patients. These differences resolved by 48 h. There were no other statistically significant correlations identified. CONCLUSIONS:The radiographic appearance of PLV with perflubron appears to depend on the dose administered. Lower doses can be associated with both inhomogeneous radiographic filling and a transient deterioration in oxygenation during the first 24 to 48 h of treatment.

journal_name

Chest

journal_title

Chest

authors

Schuster DP,Lange NR,Tutuncu A,Wedel M,LiquiVent Study Group.

doi

10.1378/chest.119.5.1503

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

1503-9

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)39613-6

journal_volume

119

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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