Abstract:
STUDY OBJECTIVES:To evaluate the chest radiographic filling pattern associated with partial liquid ventilation (PLV) with the perfluorochemical perflubron (LiquiVent; Alliance Pharmaceutical Corp; San Diego CA) as a function of dose and timing. DESIGN:Post hoc review of chest radiographs by three independent observers with correlation to clinical variables. SETTING:Phase II randomized, uncontrolled, prospective, multicenter clinical trial. PATIENTS:Sixteen adult patients with diffuse bilateral infiltrates consistent with acute lung injury and a PaO(2)/fraction of inspired oxygen (FIO(2)) ratio < 300 with positive end-expiratory pressure of 13 cm H(2)O and FIO(2) > or = 0.5. INTERVENTIONS:All patients were treated with either a 10-mL/kg or 20-mL/kg loading dose of perflubron followed by maintenance dosing at 3-h intervals to protocol-determined levels. RESULTS:There was a significant relationship between inhomogeneous radiographic filling during the first 48 h of treatment and the use of the lower loading dose of perflubron. Inhomogeneous radiographic filling (in 5 patients) was associated with a lower high-dose/FIO(2) ratio at 24 h compared with the remaining patients. These differences resolved by 48 h. There were no other statistically significant correlations identified. CONCLUSIONS:The radiographic appearance of PLV with perflubron appears to depend on the dose administered. Lower doses can be associated with both inhomogeneous radiographic filling and a transient deterioration in oxygenation during the first 24 to 48 h of treatment.
journal_name
Chestjournal_title
Chestauthors
Schuster DP,Lange NR,Tutuncu A,Wedel M,LiquiVent Study Group.doi
10.1378/chest.119.5.1503subject
Has Abstractpub_date
2001-05-01 00:00:00pages
1503-9issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)39613-6journal_volume
119pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
CHEST文献大全abstract:OBJECTIVES:The objectives of this study were to determine the prevalence of Aspergillus fumigatus and Candida albicans in the sputa of patients with cystic fibrosis (CF), to assess serologic IgE responses of these patients to the presence of fungi in the sputum, to evaluate what effect this may have on clinical status,...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.3.782
更新日期:2002-03-01 00:00:00
abstract::The aim of this study was to investigate whether the demonstration of plasma cells (PC), which are normally absent in bronchoalveolar lavage (BAL) fluid, facilitates differentiation among pulmonary disorders. Initial BAL fluid samples of 1,260 patients were analyzed. In 83 of these, PC were found. Of these 83, 47 were...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.6.1720
更新日期:1993-06-01 00:00:00
abstract::We report three cases of pulmonary edema associated with hyperbaric oxygen therapy, including one fatality. All three patients had cardiac disease and reduced left ventricular (LV) ejection fractions (EFs). Two patients had diabetes, and one patient had severe aortic stenosis. Hyperbaric oxygen therapy may contribute ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.4.1407
更新日期:2001-10-01 00:00:00
abstract::The effects were assessed of ingestion of 1 ml/kg of 100 proof vodka on sleep-disordered breathing, nocturnal oxygen desaturation, and ventricular ectopy in patients with chronic obstructive pulmonary disease (COPD). Ethanol ingestion (mean blood alcohol concentration of 40 mg/dl) was associated with a significant inc...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.3.469
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Tobacco smoke is a major risk factor in the development of COPD. Secondhand smoke (SHS) exposure is a known risk factor in asthma, bronchitis, and coronary artery disease. Elastin is a recognized target for injury in COPD, and the amino acids desmosine and isodesmosine (D/I), which are specific for elastin d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-2298
更新日期:2011-10-01 00:00:00
abstract::Immediate responses of hypersensitivity to skin testing with purified derivative of tuberculin (PPD) were observed in 2.3 percent of 3,248 patients seen in an allergy clinic, and the relationship to delayed responses was questioned. Immediate cutaneous reactions to testing with PPD appeared in all age groups and occur...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.1.33
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Carotid arteriosclerosis and sleep apnea are considered as independent risk factors for stroke. Whether sleep apnea mediates severity of carotid stenosis remains unclear. Sleep apnea comprises two pathophysiologic conditions: OSA and central sleep apnea (CSA). Although OSA results from upper airway occlusion...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-1655
更新日期:2015-04-01 00:00:00
abstract::Recurrent pericardial effusion or tamponade can complicate malignant disease. The medical approach with pharmacologic agents has a high recurrence rate. Balloon pericardiotomy (BP) may provide a less invasive alternative to surgery. We performed BP in ten high-risk patients with malignant pericardial tamponade (MPT). ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.6.1499
更新日期:1995-12-01 00:00:00
abstract::Several studies have shown that funeral directors have an increased risk of tuberculosis (TB). Although there is indirect evidence of transmission of TB from cadavers to mortuary workers, there is only one recently documented case in the literature. We report here another case of occupationally acquired TB in a funera...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.2.640
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:COPD, the fifth-leading cause of death worldwide, is characterized by chronic inflammation. However, no available agent can effectively cure this inflammation. A dietary supplement containing omega-3 polyunsaturated fatty acids (PUFAs) has anti-inflammatory effects. In this study, we hypothesized that nutrit...
journal_title:Chest
pub_type: 杂志文章,随机对照试验,收录出版
doi:10.1378/chest.128.6.3817
更新日期:2005-12-01 00:00:00
abstract::A 53-year-old woman with a large pericardial effusion and tamponade presented with signs of IHSS including a grade 4/6 apical systolic murmur, severe SAM, early systolic aortic valve closure and a small hypercontractile left ventricle but at most borderline left ventricular hypertrophy. Following pericardiocentesis, t...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.4.631
更新日期:1987-04-01 00:00:00
abstract:UNLABELLED:STUDY OBJECTIVES AND DESIGN: Health-related quality of life (QoL) instruments are generally used for studies of asthma in specialized settings. For primary care use, there is a need for brief and simple questionnaires for structured patient-reported outcomes. We validated the Mini-Asthma Quality of Life Ques...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.129.4.925
更新日期:2006-04-01 00:00:00
abstract::Prior to 1978, the conventional treatment of pneumothorax generally consisted of conservative therapies such as rest, needle puncture, or thoracic cavity drainage; however, when conservative therapies were ineffective or relapse occurred therapeutic approach, 34 percent (11/32) of our patients required a thoracotomy. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.4.953
更新日期:1991-10-01 00:00:00
abstract::A 39-year-old woman presented with recurrent acute illness, characterized by high-grade fever, pleuritic chest pain, and unilateral nodular infiltrate on chest radiograph. During the follow-up period, there were six similar episodes, each starting 2 to 3 days prior to her menstrual period and resolving within 5 to 10 ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.1.253
更新日期:2000-07-01 00:00:00
abstract::Two recent epidemiologic case-control studies suggested that fenoterol, a selective beta-adrenergic agonist, was associated with an increase in the risk of asthma death. The results of these studies were criticized because of methodologic problems in the choice and selection of control subjects; the different methods ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.6.1586
更新日期:1991-12-01 00:00:00
abstract::Advanced or second-degree atrioventricular (AV) heart block pre-existing or developing during atrial pacing (AP) at low heart rates of smaller than 130 per minute, limits the value of AP to stress the left ventricle. When Wenkebach type AV block is present, the heart rate can be increased by administration of atropine...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.5.540
更新日期:1975-05-01 00:00:00
abstract::Acute pulmonary illness compatible with previously described nitrofurantoin toxicity and requiring hospitalization occurred three times among 16,101 first courses of therapy with nitrofurantoin. One case of fatal pulmonary fibrosis was ascribed to long-term use of nitrofurantoin among 742 observed recipients of ten or...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.3.512
更新日期:1989-09-01 00:00:00
abstract::Improved airway resistance following bronchodilator inhalation is not always accompanied by improvement in forced expiratory flow. We studied 241 patients with airways obstruction to learn whether changes in static lung volumes (vital capacity and function residual capacity measured by body plethysmography [FRCB]) wou...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.76.6.622
更新日期:1979-12-01 00:00:00
abstract::Benign thymic hyperplasia (BTH) is a known feature of hyperthyroidism, but is infrequently appreciated by clinicians. In most cases thymic enlargement is minimal; however, it may occasionally present as an appreciable anterior mediastinal mass. While surgical resection is a common approach to such a mass, recognition ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.90.5.691
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Communication between families and providers in the ICU affects patient and family outcomes and use of health-care resources. Recent research studies have tested interventions designed to improve communication quality and outcomes between providers and families of patients in the ICU. We conducted a systemat...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.10-0595
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Low-density gas mixtures and oxygen (O₂) supplementation are known to improve physical performance and ventilatory adaptation during incremental maximal exercise in COPD. We investigated whether their combined use during intense physical training is also effective in ameliorating exercise tolerance in patien...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.10-0120
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Disease-specific patient-reported outcome (PRO) instruments are important in assessing the impact of disease and treatment. The Pulmonary Arterial Hypertension-Symptoms and Impact Questionnaire is the first instrument for quantifying pulmonary arterial hypertension (PAH) symptoms and impacts developed accord...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.chest.2018.04.027
更新日期:2018-10-01 00:00:00
abstract::Hemodynamic and metabolic effects of methylprednisolone were investigated in a double-blind study of 28 patients with acute myocardial infarction (AMI), confirmed by unequivocal electrocardiographic and enzyme changes. Measurements were performed prior to and at 1.5, 3, 4, 4.5, 12 and 24 hours following infusion of me...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.79.2.186
更新日期:1981-02-01 00:00:00
abstract::Forty-seven cases of quadricuspid semilunar valves which were autopsied were reviewed. The ratio of quadricuspid pulmonic valve to quadricuspid aortic valve was 5:1. Among the 35 patients with quadricuspid pulmonic valves, there were ten patients with clinical and pathologic evidence of coexisting congenital cardiac d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.2.186
更新日期:1977-08-01 00:00:00
abstract:BACKGROUND:There is a growing use of procalcitonin (PCT) to facilitate the diagnosis and management of severe sepsis. We investigated the impact of one to two PCT determinations on ICU day 1 on health-care utilization and cost in a large research database. METHODS:A retrospective, propensity score-matched multivariabl...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.06.046
更新日期:2017-01-01 00:00:00
abstract::OSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction du...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.03.001
更新日期:2018-10-01 00:00:00
abstract::Histopathologic and morphometric studies of small pulmonary arteries were performed in 16 cases of secundum atrial septal defect (ASD) and severe pulmonary hypertension. Besides typical plexogenic arteriopathies found in six cases, organized microthrombi and what we call "musculoelastosis," that is, proliferation of l...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.89.5.694
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:In addition to affecting the oxygen supply to the brain, pulmonary function is a marker of multiple insults throughout life (including smoking, illness, and socioeconomic deprivation). In this meta-analysis of existing longitudinal studies, the hypothesis that lower pulmonary function and respiratory illness...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.12.012
更新日期:2020-06-01 00:00:00
abstract::We analyzed seven patients with beta-thalassemia intermedia presenting with congestive heart failure secondary to pulmonary hypertension. This condition has been recognized only recently as part of the clinical spectrum of beta-thalassemia. Our group of patients included two men and five women with the clinical pictur...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.1.50
更新日期:1995-01-01 00:00:00
abstract::Bronchoscopy specimens from 183 known/suspected acquired immunodeficiency syndrome patients were evaluated for pathogens. In each case, transbronchial biopsies were evaluated and bronchoalveolar lavage material was cultured for viruses, fungi and mycobacteria and examined cytologically. A specimen was considered posit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.1.24
更新日期:1990-07-01 00:00:00