Formoterol as dry powder inhalation. A dose finding study in comparison with formoterol metered dose inhaler and placebo.

Abstract:

:We compared the bronchodilator effects and systemic tolerability of 12, 24 and 48 micrograms formoterol DP capsules with 12 micrograms formoterol MDI and placebo in 30 patients with reversible obstructive airway disease. Pulmonary function tests were done and pulse rate and blood pressure were recorded. We observed significant differences between all active substances vs placebo regarding peak effect, duration of effect and AUC value. No significant difference was observed between either 12 or 24 micrograms formoterol DP and 12 micrograms from MDI in all mentioned parameters. With 48 micrograms DP, increased peak effect, AUC and duration of effect were noted. Heart rate Holter monitoring showed a slightly more pronounced effect with 48 micrograms. We conclude that 12 to 24 micrograms formoterol DP capsules are equivalent to 12 micrograms of formoterol MDI regarding efficacy and tolerability, while 48 micrograms formoterol DP capsules cause more profound effects in bronchodilation and on the heart rate.

journal_name

Chest

journal_title

Chest

authors

Maesen FP,Costongs R,Smeets SJ,Zweers PG,Goedhart DM

doi

10.1378/chest.101.5.1376

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

1376-81

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)34145-9

journal_volume

101

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CHEST文献大全
  • Lower prevalence of positive atopic skin tests in lung cancer patients.

    abstract::Allergy prick skin testing was performed on 137 newly diagnosed patients with primary lung cancer and 137 age-(+/- 3 years) and sex-matched randomly selected control subjects. We also compared 38 patients with lung cancer and 38 of their closest in age, same-sex siblings. Demographic data, personal, medical, smoking a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.2.241

    authors: McDuffie HH,Cockcroft DW,Talebi Z,Klaassen DJ,Dosman JA

    更新日期:1988-02-01 00:00:00

  • Gastric surgery for respiratory insufficiency of obesity.

    abstract::Morbid obesity is often associated with severe respiratory insufficiency, commonly known as the pickwickian syndrome. This can be divided into the following two primary breathing disorders which can affect patients alone or in combination: the obstructive sleep apnea syndrome (SAS); and the obesity-hypoventilation syn...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.1.81

    authors: Sugerman HJ,Fairman RP,Baron PL,Kwentus JA

    更新日期:1986-07-01 00:00:00

  • Accuracy of an infrared tympanic thermometer.

    abstract:BACKGROUND:The use of infrared thermometry to measure temperatures in hospitalized patients is increasing. Although infrared thermometers have been proven to be accurate when they are used by well-trained personnel, no previous studies have examined their accuracy during routine hospital use. OBJECTIVE:To determine th...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.4.1002

    authors: Amoateng-Adjepong Y,Del Mundo J,Manthous CA

    更新日期:1999-04-01 00:00:00

  • Catheter-induced tricuspid regurgitation. Incidence and clinical significance.

    abstract::The incidence and severity of catheter-induced tricuspid regurgitation has not been studied extensively. Given the frequency with which right heart catheters are employed to measure cardiac output, it is important to know whether the severity of catheter-induced tricuspid regurgitation is sufficient to invalidate the ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.3.651

    authors: Stewart D,Leman RB,Kaiser J,Mann DL

    更新日期:1991-03-01 00:00:00

  • Considerations in optimizing radiation therapy for non-small cell lung cancer.

    abstract::Irradiation therapy for lung cancer is mostly restricted to conventional methods. To improve therapeutic ratio, we have combined a treatment planning and a gene therapy approach. Three-dimensional conformal radiotherapy is described as carried out by methods of gene therapy for radiation protection using the manganese...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.113.1_supplement.46s

    authors: Greenberger JS,Bahri S,Jett J,Belani C,Kalend A,Epperly M

    更新日期:1998-01-01 00:00:00

  • A new treatment strategy for advanced idiopathic interstitial pneumonia: living-donor lobar lung transplantation.

    abstract:BACKGROUND:Among patients awaiting cadaveric lung transplantation, patients with idiopathic interstitial pneumonia (IIP) have been demonstrated to have the highest mortality rate. Contraindications to cadaveric lung transplantation include current high-dose systemic corticosteroid therapy because it may increase airway...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.3.1364

    authors: Date H,Tanimoto Y,Goto K,Yamadori I,Aoe M,Sano Y,Shimizu N

    更新日期:2005-09-01 00:00:00

  • Pulmonary artery catheter-induced hemorrhage.

    abstract::Pulmonary artery rupture by a flow-directed balloon-tipped catheter is a rare complication if guidelines for insertion of catheters are strictly applied. It should be stressed that the need for a "confirmed" wedge pressure should be weighed against the very real risk of this potentially fatal complication. Users of th...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.85.1.128

    authors: Hannan AT,Brown M,Bigman O

    更新日期:1984-01-01 00:00:00

  • Ventilatory constraints during exercise in patients with chronic heart failure.

    abstract::We examined the degree of ventilatory constraint in patients with a history of chronic heart failure (CHF; n = 11; mean +/- SE age, 62 +/- 4 years; cardiac index [CI], 2.0 +/- 0.1; and ejection fraction [EF], 24 +/- 2%) and in control subjects (CTLS; n = 8; age, 61 +/- 5 years; CI, 2.6 +/- 0.3) by plotting the tidal f...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.2.321

    authors: Johnson BD,Beck KC,Olson LJ,O'Malley KA,Allison TG,Squires RW,Gau GT

    更新日期:2000-02-01 00:00:00

  • Decrease in mortality in severe community-acquired pneumococcal pneumonia: impact of improving antibiotic strategies (2000-2013).

    abstract:OBJECTIVE:The objective of the present study was to compare antibiotic prescribing practices and survival in the ICU for patients with pneumococcal severe community-acquired pneumonia (SCAP) between 2000 and 2013. METHODS:This was a matched case-control study of two prospectively recorded cohorts in Europe. Eighty pat...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.13-1531

    authors: Gattarello S,Borgatta B,Solé-Violán J,Vallés J,Vidaur L,Zaragoza R,Torres A,Rello J,Community-Acquired Pneumonia en la Unidad de Cuidados Intensivos II Study Investigators*.

    更新日期:2014-07-01 00:00:00

  • A prospective evaluation of lung volume reduction surgery in 200 consecutive patients.

    abstract:OBJECTIVES:Though numerous studies have demonstrated the short-term efficacy of lung volume reduction surgery (LVRS) in select patients with emphysema, the longer-term follow-up studies are just being reported. The primary objectives of this study were to assess long-term health-related quality of life, satisfaction, p...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.123.4.1026

    authors: Yusen RD,Lefrak SS,Gierada DS,Davis GE,Meyers BF,Patterson GA,Cooper JD

    更新日期:2003-04-01 00:00:00

  • Decortication after 35 years.

    abstract::A 66-year-old white woman had a paraffin plombage performed in 1940 for tuberculosis. In 1975, she had decortication for terminal respiratory insufficiency, with return to an active life. Thirty-five years of pulmonary compression does not produce irreversible changes in the pulmonary parenchyma. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.5.668

    authors: Knudsen DF

    更新日期:1977-05-01 00:00:00

  • Severe gastroesophageal reflux is associated with reduced carbon monoxide diffusing capacity.

    abstract:OBJECTIVE:To assess whether severe gastroesophageal reflux (GER) is associated with abnormalities in lung function including measures of lung volume and gas diffusion. METHODS:Data from 147 patients with obesity (body mass index [BMI] range, 31.7 to 70 kg/m(2)) who presented for obesity surgery was analyzed retrospect...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.123.6.1932

    authors: Schachter LM,Dixon J,Pierce RJ,O'Brien P

    更新日期:2003-06-01 00:00:00

  • Intrapleural therapy for malignant pleural effusions. A randomized comparison of bleomycin and tetracycline.

    abstract::Between December 1985 and August 1988, there were 115 patients at 13 centers who were entered on a randomized comparison of tetracycline and bleomycin for treatment of malignant pleural effusions. Fifteen patients were not treated, primarily due to rapid progression of systemic cancer. Fifteen patients entered on a hi...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.100.6.1528

    authors: Ruckdeschel JC,Moores D,Lee JY,Einhorn LH,Mandelbaum I,Koeller J,Weiss GR,Losada M,Keller JH

    更新日期:1991-12-01 00:00:00

  • Aortopulmonary window or aortopulmonary communication?

    abstract::Two patients had a vessel-like aortopulmonary "window" which could be ligated without the institution of cardiopulmonary bypass. While embryologically and functionally these communications are identical to the classic aortopulmonary "window," it is suggested that the term "aortopulmonary communication" is more appropr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.3.397

    authors: Belcourt CL,Aterman K,Gillis DA,Roy DL

    更新日期:1979-03-01 00:00:00

  • Evaluation of the Winthrop-University Hospital criteria to identify Legionella pneumonia.

    abstract:STUDY OBJECTIVE:To measure the ability of a set of clinical parameters, the Winthrop-University Hospital (WUH) criteria, to identify Legionella pneumonia while discriminating against bacteremic pneumococcal pneumonia at the time of hospitalization for community-acquired pneumonia (CAP). DESIGN:Retrospective case-contr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.4.1064

    authors: Gupta SK,Imperiale TF,Sarosi GA

    更新日期:2001-10-01 00:00:00

  • Symptomatic high grade heart block in Lyme disease.

    abstract::We describe an unusual and remediable form of heart block which developed in the course of Lyme disease. The diagnosis of Lyme disease requires a careful clinical history pertaining to epidemiologic geography or a history of erythema chronicum migrans. In this case, a highly selective cardiac abnormality responded pro...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.79.2.236

    authors: Bedell SE,Pastor BM,Cohen SI

    更新日期:1981-02-01 00:00:00

  • Video-assisted contralateral treatment for bronchial stump diastasis after left pneumonectomy.

    abstract::Postoperative bronchial stump failure is a life-threatening complication, and several surgical approaches and procedures have been developed to close the stump. In this report, we describe a case of left mainstem bronchial stump diastasis after pneumonectomy for lung cancer, in which the bronchial stump was re-closed ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.3.884

    authors: Tsunezuka Y,Sato H,Kodama T

    更新日期:2000-03-01 00:00:00

  • Childhood obstructive sleep-disordered breathing: a clinical update and discussion of technological innovations and challenges.

    abstract::Childhood sleep-disordered breathing (SDB) has been known to be associated with health and cognitive impacts for more than a century, and yet our understanding of this disorder is in its infancy. Neuropsychological consequences in children with snoring or subtle breathing disturbances not meeting the traditional defin...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.06-2827

    authors: Halbower AC,Ishman SL,McGinley BM

    更新日期:2007-12-01 00:00:00

  • Comparison of the bronchodilator effects of oral therapy with fenoterol hydrobromide and ephedrine.

    abstract::Fenoterol hydrobromide (Berotec; formerly Th 1165a) is a sympathomimetic bronchodilator drug. Twenty subjects with mild to moderate reversible bronchospasm completed a double-blind multiple crossover study of single doses of 5 mg, 7.5 mg, and 10 mg of fenoterol hydrobromide, 24 mg of ephedrine, and placebo. Spirometri...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.72.3.291

    authors: Steen SN,Smith R,Kuo J,Ziment I,Beall G

    更新日期:1977-09-01 00:00:00

  • Therapeutic impact of pulmonary artery catheterization in a medical/surgical ICU.

    abstract::The objective of this study was to determine the following: (1) if standard clinical evaluation is sufficient to provide an accurate estimate of hemodynamic status of unstable ICU patients; (2) the impact of pulmonary artery catheterization (PAC) on diagnosis and treatment plan; and (3) whether therapy provided after ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.6.1451

    authors: Steingrub JS,Celoria G,Vickers-Lahti M,Teres D,Bria W

    更新日期:1991-06-01 00:00:00

  • A case of orthodeoxia caused by an atrial septal aneurysm.

    abstract::Platypnea-orthodeoxia is an uncommon syndrome that may occur due to the postpneumonectomy state, cirrhosis of the liver, recurrent pulmonary embolism, and intracardiac shunting. We describe a patient who was found to have a positional change in desaturation after being admitted for dehydration. Workup revealed an atri...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.3.871

    authors: Acharya SS,Kartan R

    更新日期:2000-09-01 00:00:00

  • Relevance of latent TB infection in areas of high TB prevalence.

    abstract::About one-third of the world population has latent TB infection (LTBI), the majority of which is distributed in 22 high-burden countries. Early diagnosis and treatment of active TB remains the top priority in resource-poor countries with high TB prevalence. Notwithstanding, because LTBI contributes significantly to th...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.12-0142

    authors: Sharma SK,Mohanan S,Sharma A

    更新日期:2012-09-01 00:00:00

  • Prolonged myocardial ischemia after intravenous dipyridamole thallium imaging.

    abstract::Intravenous dipyridamole thallium imaging is reported to be a safe test with minimal side effects. It has been proposed by some that the test simply dilates the coronary vessels without actually producing myocardial ischemia. In this report, we describe a patient who, following intravenous dipyridamole thallium imagin...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.6.1102

    authors: Lewen MK,Labovitz AJ,Kern MJ,Chaitman BR

    更新日期:1987-12-01 00:00:00

  • The irregularly irregular pattern of respiratory dyskinesia.

    abstract::The respiratory pattern during wakefulness and sleep was characterized in a 70-year-old woman with respiratory dyskinesia. During wakefulness, both respiratory frequency and tidal volume exhibited an irregularly irregular pattern. In addition, wide fluctuations occurred in the position of the rib cage and abdomen at e...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.5.779

    authors: Kuna ST,Awan R

    更新日期:1986-11-01 00:00:00

  • Airway inflammation and etiology of acute exacerbations of chronic bronchitis.

    abstract:STUDY OBJECTIVES:The etiologic role of bacterial pathogens isolated from sputum culture in 40 to 50% of acute exacerbations of chronic bronchitis (AECB) is controversial. If bacterial pathogens cause these AECB, they should be associated with greater neutrophilic airway inflammation than pathogen-negative exacerbations...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.6.1557

    authors: Sethi S,Muscarella K,Evans N,Klingman KL,Grant BJ,Murphy TF

    更新日期:2000-12-01 00:00:00

  • Current status of new drugs and multidisciplinary approaches in patients with carcinoma of the esophagus.

    abstract::The incidence of distal esophageal adenocarcinoma and primary proximal gastric carcinoma has increased substantially in the past 15 years, particularly in North America and in some European countries. Patients with curatively resected cancer consistently have a 10 to 20% 5-year survival rate. Radiation therapy alone s...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.113.1_supplement.112s

    authors: Ajani JA

    更新日期:1998-01-01 00:00:00

  • Variation in Patient Smoking Cessation Rates Among Health-Care Providers: An Observational Study.

    abstract:BACKGROUND:Physicians play a crucial role in providing smoking cessation counseling and medications. However, it is unknown whether individual physicians' approaches affect whether patients quit. RESEARCH QUESTION:This study assessed patient quit rates within a national quality-improvement learning collaborative to do...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.05.599

    authors: Almaaitah S,Ciemins EL,Joshi V,Arora A,Meskow C,Rothberg MB

    更新日期:2020-11-01 00:00:00

  • Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience.

    abstract:BACKGROUND:Pulmonary hypertension (PH) is a common complication of sarcoidosis that is associated with increased mortality. The pathogenesis of PH in sarcoidosis is uncertain, and the role of pulmonary arterial hypertension (PAH)-specific therapies remains to be determined. METHODS:We conducted a retrospective study o...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.08-1881

    authors: Barnett CF,Bonura EJ,Nathan SD,Ahmad S,Shlobin OA,Osei K,Zaiman AL,Hassoun PM,Moller DR,Barnett SD,Girgis RE

    更新日期:2009-06-01 00:00:00

  • Safety and Efficacy of Remimazolam Compared With Placebo and Midazolam for Moderate Sedation During Bronchoscopy.

    abstract:BACKGROUND:While the complexity of flexible bronchoscopy has increased, standard options for moderate sedation medications have not changed in three decades. There is a need to improve moderate sedation while maintaining safety. Remimazolam was developed to address shortcomings of current sedation strategies. METHODS:...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.chest.2018.09.015

    authors: Pastis NJ,Yarmus LB,Schippers F,Ostroff R,Chen A,Akulian J,Wahidi M,Shojaee S,Tanner NT,Callahan SP,Feldman G,Lorch DG Jr,Ndukwu I,Pritchett MA,Silvestri GA,PAION Investigators.

    更新日期:2019-01-01 00:00:00

  • Acetaminophen-induced eosinophilic pneumonia.

    abstract::We present the first case (to our knowledge) of acetaminophen-induced eosinophilic pneumonia. Although the patient had taken an acetaminophen-containing combination drug, Kinuya-chinnetsu, for only three days, the abnormal shadow on his chest radiograph continued for about a month. Lymphocyte stimulation tests showed ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.1.291

    authors: Kondo K,Inoue Y,Hamada H,Yokoyama A,Kohno N,Hiwada K

    更新日期:1993-07-01 00:00:00