Comparison of the bronchodilator effects of oral therapy with fenoterol hydrobromide and ephedrine.

Abstract:

:Fenoterol hydrobromide (Berotec; formerly Th 1165a) is a sympathomimetic bronchodilator drug. Twenty subjects with mild to moderate reversible bronchospasm completed a double-blind multiple crossover study of single doses of 5 mg, 7.5 mg, and 10 mg of fenoterol hydrobromide, 24 mg of ephedrine, and placebo. Spirometric and body-plethysmographic measurements were performed sequentially prior to administration of drug or placebo and each hour up to eight hours afterwards. No significant drug-response relationship was noted for pulse rate or blood pressures, and side effects (eg, shakiness, nervousness) were minimal. Administration of fenoterol resulted in bronchodilation; a peak effect was noted at two to three hours after administration, and the duration of action was up to eight hours. A statistically significant dose-response relationship was observed; therapy with 5 mg of fenoterol hydrobromide was superior to placebo and equal to ephedrine, and doses of 7.5 mg and 10 mg of fenoterol hydrobromide were significantly better than placebo or ephedrine.

journal_name

Chest

journal_title

Chest

authors

Steen SN,Smith R,Kuo J,Ziment I,Beall G

doi

10.1378/chest.72.3.291

subject

Has Abstract

pub_date

1977-09-01 00:00:00

pages

291-5

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)37587-0

journal_volume

72

pub_type

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