Effects of bacterial infection on airway antimicrobial peptides and proteins in COPD.


BACKGROUND:Pathogenic bacteria colonize the airways of 30% to 40% of patients with COPD and cause approximately 50% of exacerbations. New strains of nontypeable Haemophilus influenzae (NTHI) and Moraxella catarrhalis are associated with exacerbations. Antimicrobial protein/peptides (AMPs) play important roles in innate lung defense against pathogens. To our knowledge, the changes in AMP baseline levels in respiratory secretions during bacterial colonization and exacerbation have not been described. The objective of this study was to elucidate the effects of the acquisition of a new strain of pathogenic bacteria on the airway levels of AMPs in patients with COPD. METHODS:One hundred fifty-three samples from 11 patients were selected from COPD sputum samples collected prospectively over 6 years. Samples were grouped as culture-negative (no pathogenic bacteria), colonization, and exacerbation due to new strains of NTHI and M catarrhalis. Levels of lysozyme, lactoferrin, LL-37, and secretory leukocyte protease inhibitor (SLPI) were measured by enzyme-linked immunosorbent assay and compared among groups by paired analysis. RESULTS:Compared with baseline, sputum lysozyme levels were significantly lower during colonization and exacerbation by NTHI (P = .001 and P = .013, respectively) and M catarrhalis (P = .007 and P = .018, respectively); SLPI levels were lower with exacerbation due to NTHI and M catarrhalis (P = .002 and P = .004, respectively), and during colonization by M catarrhalis (P = 032). Lactoferrin levels did not change significantly; LL-37 levels were higher during exacerbation by NTHI and M catarrhalis (P = .001 and P = .018, respectively). CONCLUSIONS:Acquisition of NTHI and M catarrhalis is associated with significant changes in airway levels of AMPs, with larger changes in exacerbation. Airway AMP levels are likely to be important in pathogen clearance and clinical outcomes of infection in COPD.






Parameswaran GI,Sethi S,Murphy TF




Has Abstract


2011-09-01 00:00:00
















  • Airway pressure release ventilation in severe acute respiratory failure.

    abstract::Airway pressure release ventilation (APRV), a new ventilatory support technique, was compared with conventional intermittent positive-pressure ventilation plus PEEP (CPPV) in 18 patients with severe acute respiratory failure. Patients were initially stabilized on CPPV and then switched to APRV. The APRV provided effec...


    pub_type: 杂志文章


    authors: Cane RD,Peruzzi WT,Shapiro BA

    更新日期:1991-08-01 00:00:00

  • Assessment and diagnosis of renal dysfunction in the ICU.

    abstract::Identifying patients with impaired renal function is crucial in the setting of critical illness. Serum creatinine serves as the gold standard for assessing steady-state renal function, helping to define those with chronic kidney disease (CKD). Although these baseline creatinine values are often not available in the se...


    pub_type: 杂志文章,评审


    authors: Koyner JL

    更新日期:2012-06-01 00:00:00

  • Detection of intrapulmonary shunts in schistosomal cor pulmonale.

    abstract::Two patients with schistosomal cor pulmonale and central cyanosis were studied by contrast-enhanced echocardiography, using indocyanine green injection. Intrapulmonary shunts were detected by this method. To our knowledge, this is the first report that proves the presence of intrapulmonary shunts in schistosomal cor p...


    pub_type: 杂志文章


    authors: Rafla SM,Sourour S

    更新日期:1993-10-01 00:00:00

  • A comparison of two challenge tests for identifying exercise-induced bronchospasm in figure skaters.

    abstract:OBJECTIVES:Studies documenting the increased incidence of exercise-induced bronchospasm (EIB) in figure skaters have employed a method that incorporates on-ice exercise with rink-side spirometry. The literature suggests that bronchial provocation challenge testing is better than exercise testing for identifying EIB. To...


    pub_type: 杂志文章


    authors: Mannix ET,Manfredi F,Farber MO

    更新日期:1999-03-01 00:00:00

  • Respiratory muscle performance, pulmonary mechanics, and gas exchange between the BiPAP S/T-D system and the Servo Ventilator 900C with bilevel positive airway pressure ventilation following gradual pressure support weaning.

    abstract:STUDY OBJECTIVE:Our objective was to compare respiratory muscle performance, pulmonary mechanics, and gas exchange between the BiPAP S/T-D ventilation system (Respironics Inc; Murrysville, PA) and the Servo Ventilator 900C (Siemens-Elma AB; Sweden) with similar inspiratory and expiratory airway pressure in patients who...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Patel RG,Petrini MF

    更新日期:1998-11-01 00:00:00

  • T and B lymphocytes in pleural effusions.

    abstract::To determine the diagnostic significance of the determination of T and B lymphocytes in pleural fluid, we studied these cells in peripheral blood and in pleural fluid by means of surface markers. Our study comprised 30 patients suffering from pulmonary tuberculosis, pulmonary malignancy, connective tissue disease, non...


    pub_type: 杂志文章


    authors: Pettersson T,Klockars M,Hellström PE,Riska H,Wangel A

    更新日期:1978-01-01 00:00:00

  • Transmission of Mycobacterium tuberculosis to a funeral director during routine embalming.

    abstract::Several studies have shown that funeral directors have an increased risk of tuberculosis (TB). Although there is indirect evidence of transmission of TB from cadavers to mortuary workers, there is only one recently documented case in the literature. We report here another case of occupationally acquired TB in a funera...


    pub_type: 杂志文章


    authors: Lauzardo M,Lee P,Duncan H,Hale Y

    更新日期:2001-02-01 00:00:00

  • A 76-Year-Old Woman With Incidental Right Middle Lobe Atelectasis.

    abstract:CASE PRESENTATION:A 76-year-old nonsmoking woman visiting from Honduras for the last 6 months with no known medical history originally presented to the ED complaining of abdominal pain. While in the ED, an incidental right middle lobe collapse was found on CT abdomen scan. Review of systems was positive for a chronic p...


    pub_type: 杂志文章,评审


    authors: Henson T,Matayeva E,Chua W,Iqbal J

    更新日期:2019-05-01 00:00:00

  • Breathomics in lung disease.

    abstract::Volatile organic compounds (VOCs) are produced by virtually all metabolic processes of the body. As such, they have potential to serve as noninvasive metabolic biomarkers. Since exhaled VOCs are either derived from the respiratory tract itself or have passed the lungs from the circulation, they are candidate biomarker...


    pub_type: 杂志文章,评审


    authors: van der Schee MP,Paff T,Brinkman P,van Aalderen WMC,Haarman EG,Sterk PJ

    更新日期:2015-01-01 00:00:00

  • Age and Sex Disparities in Adherence to CPAP.

    abstract:BACKGROUND:CPAP effectiveness is limited by suboptimal adherence. Prior studies of adherence have focused on middle-aged men. RESEARCH QUESTION:Does CPAP adherence vary by age and sex? STUDY DESIGN AND METHODS:Telemonitoring data from a CPAP manufacturer database were used to assess adherence in patients initiating C...


    pub_type: 杂志文章


    authors: Patel SR,Bakker JP,Stitt CJ,Aloia MS,Nouraie SM

    更新日期:2021-01-01 00:00:00

  • Phosphodiesterase 4 inhibitors for the treatment of COPD.

    abstract::Phosphodiesterase 4 (PDE4) is a major cyclic adenosine-3',5'-monophosphate-metabolizing enzyme in immune and inflammatory cells, airway smooth muscle, and pulmonary nerves. Selective inhibitors of this enzyme have been available for a number of years and show a broad spectrum of activity in animal models of COPD and a...


    pub_type: 杂志文章,评审


    authors: Sturton G,Fitzgerald M

    更新日期:2002-05-01 00:00:00

  • Gastric tonometry in patients with sepsis. Effects of dobutamine infusions and packed red blood cell transfusions.

    abstract::We wanted to determine the efficacy of dobutamine infusions and Prbc transfusions on splanchnic tissue oxygen utilization by measuring gastric pHi. Physiologic parameters and pHi measurements via the use of a gastric tonometer were obtained in 21 septic patients before and after the administration of a dobutamine infu...


    pub_type: 杂志文章


    authors: Silverman HJ,Tuma P

    更新日期:1992-07-01 00:00:00

  • Acute lung disease in the immunocompromised host. Diagnostic accuracy of the chest radiograph.

    abstract:PURPOSE:To assess the diagnostic accuracy of the chest radiograph in the evaluation of acute pulmonary complications in immunocompromised patients. METHODS:The study included the chest radiographs in 149 consecutive acute pulmonary complications seen in immunocompromised patients in whom a definitive diagnosis was mad...


    pub_type: 杂志文章


    authors: Logan PM,Primack SL,Staples C,Miller RR,Müller NL

    更新日期:1995-11-01 00:00:00

  • Lymphocytic alveolitis after primary HIV infection with CMV coinfection.

    abstract::Herein is a report of an adult case of primary HIV infection with cytomegalovirus coinfection causing cough, fever, and lymphocytic alveolitis. Primary HIV infection has not been previously reported as a cause of lymphocytic alveolitis. ...


    pub_type: 杂志文章


    authors: Jouveshomme S,Couderc LJ,Ferchal F,Vignon D,Autran B,Balloul E,Caubarrere I

    更新日期:1997-10-01 00:00:00

  • Infectious mononucleosis complicated by necrotizing epiglottitis, dysphagia, and pneumonia.

    abstract::Although infectious mononucleosis is usually a benign illness, life-threatening complications may occur. We describe a 17-year-old pregnant girl who developed necrotizing epiglottitis and dysphagia progressing to aspiration pneumonia and respiratory failure. The factors predisposing to this life-threatening complicati...


    pub_type: 杂志文章


    authors: Biem J,Roy L,Halik J,Hoffstein V

    更新日期:1989-07-01 00:00:00

  • Role of chest physicians in detection and treatment of occupational and environmental respiratory disease. A practice survey.

    abstract::A survey of American College of Chest Physicians (ACCP) members was conducted to determine their degree of involvement in the diagnosis and prevention of occupational and environmental respiratory disease (OERD). Although the response rate was relatively low, the results are likely to be representative. Calculations b...


    pub_type: 杂志文章


    authors: Harber P,Scanlon PD,do Pico G,Garshick E

    更新日期:1995-04-01 00:00:00

  • Giant cell arteritis presenting with annuloaortic ectasia.

    abstract::Four cases of giant cell arteritis causing severe aortic regurgitation secondary to an aneurysm of the ascending aorta are described. In two cases, the nature of the aortic pathology could be suspected considering the past clinical evidence of temporal arteritis and/or polymyalgia rheumatica. In the two other cases, t...


    pub_type: 杂志文章


    authors: Nesi G,Anichini C,Pedemonte E,Tozzini S,Calamai G,Montesi GF,Gori F

    更新日期:2002-04-01 00:00:00

  • Comparative Effectiveness of Proton Pump Inhibitors vs Histamine Type 2 Receptor Blockers for Preventing Clinically Important Gastrointestinal Bleeding During Intensive Care: A Population-Based Study.

    abstract:BACKGROUND:Proton pump inhibitors (PPIs) and histamine type 2 receptor blockers (H2Bs) are used for stress ulcer prophylaxis. Although the PPIs have greater potency for acid suppression, their relative effectiveness for preventing clinically important GI bleeding (CIGIB) has not been established. The goal of this study...


    pub_type: 杂志文章


    authors: Lilly CM,Aljawadi M,Badawi O,Onukwugha E,Tom SE,Magder LS,Harris I

    更新日期:2018-09-01 00:00:00

  • Reliability, repeatability, and sensitivity of the modified shuttle test in adult cystic fibrosis.

    abstract:STUDY OBJECTIVES:The purpose of this study was to investigate the test-retest reliability, repeatability, and sensitivity of the modified shuttle test (MST) in adult patients with cystic fibrosis (CF). DESIGN:: Prospective study. SETTING:Adult CF Unit, Belfast City Hospital. PATIENTS:: Adult patients with CF. INTER...


    pub_type: 杂志文章


    authors: Bradley J,Howard J,Wallace E,Elborn S

    更新日期:2000-06-01 00:00:00

  • Bronchial adenoma. Clinicopathologic study and results of treatment.

    abstract::Among 1,700 primary tumors of the lung, there were 53 cases of bronchial adenoma (3.1 percent); 38 (72 percent) of the 53 were typical carcinoids, and the remaining 15 were of a higher grade of malignant neoplasm. There was a slight predominance of female patients, and the age of greatest incidence was between 30 and ...


    pub_type: 杂志文章


    authors: de Lima R

    更新日期:1980-01-01 00:00:00

  • Integration of clinical and hemodynamic parameters in the prediction of long-term survival in patients with pulmonary arterial hypertension.

    abstract:BACKGROUND:Current management guidelines for pulmonary arterial hypertension (PAH) recommend a treatment choice based primarily on World Health Organization (WHO) functional class. This study was designed to assess how the incorporation of readily obtained clinical and test-based information may significantly improve t...


    pub_type: 杂志文章


    authors: Kane GC,Maradit-Kremers H,Slusser JP,Scott CG,Frantz RP,McGoon MD

    更新日期:2011-06-01 00:00:00

  • Prophylactic irradiation of the lung in Ewing's sarcoma.

    abstract::A patient with Ewing's sarcoma of the left scapula received prophylactic radiotherapy to the left lung following wide excision of the tumor. While the left lung remained free of tumor, there was metastatic invasion of the right lung within ten months of the initial diagnosis of the disease. Since Ewing's sarcoma frequ...


    pub_type: 杂志文章


    authors: Mintz U,Keinan Z,Wainrach B

    更新日期:1976-09-01 00:00:00

  • Effects of hypercapnia on hemodynamic, inotropic, lusitropic, and electrophysiologic indices in humans.

    abstract:STUDY OBJECTIVE:The inotropic, lusitropic, and electrophysiologic effects of acute hypercapnia in humans are not known. Although the effects of hypercapnia on the systemic circulation have been well documented, there is still some debate as to whether hypercapnia causes true pulmonary vasoconstriction in vivo. We have ...


    pub_type: 杂志文章


    authors: Kiely DG,Cargill RI,Lipworth BJ

    更新日期:1996-05-01 00:00:00

  • Alternans of the ST segment in variant angina. Incidence, time course and relation to ventricular arrhythmias during ambulatory electrocardiographic recording.

    abstract::The ST alternans was recorded during at least one ischemic attack with ST elevation in nine of 65 patients with variant angina. The magnitude and duration of ST elevation during ischemic attacks were significantly greater in patients with than in those without ST alternans. It always appeared during the occlusion phas...


    pub_type: 杂志文章


    authors: Turitto G,El-Sherif N

    更新日期:1988-03-01 00:00:00

  • Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies.

    abstract:BACKGROUND:Recent study of the inflammatory reactions occurring during and after cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the inflammatory cascade in perioperative injury. However, the exact mechanisms of this complex response remain to be fully determined. METHODS:Literature o...


    pub_type: 杂志文章,评审


    authors: Wan S,LeClerc JL,Vincent JL

    更新日期:1997-09-01 00:00:00

  • Felodipine improves pulmonary hemodynamics in chronic obstructive pulmonary disease.

    abstract::Pulmonary hypertension in chronic obstructive pulmonary disease (COPD) is associated with a poor prognosis. Reduction of pulmonary artery pressure in COPD by prolonged oxygen treatment has been shown to be associated with increased survival. In an attempt to find a suitable pharmacologic method of reducing pulmonary a...


    pub_type: 杂志文章


    authors: Sajkov D,McEvoy RD,Cowie RJ,Bradley JA,Antic R,Morris RG,Frith PA

    更新日期:1993-05-01 00:00:00

  • Regulation of breathing and perception of dyspnea in healthy pregnant women.

    abstract:STUDY OBJECTIVE:To examine if the perception of dyspnea during normal pregnancy may be related to an inappropriate ventilatory response to the increased metabolic rate, due to a higher chemosensitivity. PATIENTS AND INTERVENTIONS:At weeks 12, 24, and 36 of gestation and 4 months after delivery, 11 healthy pregnant wom...


    pub_type: 杂志文章


    authors: García-Rio F,Pino JM,Gómez L,Alvarez-Sala R,Villasante C,Villamor J

    更新日期:1996-08-01 00:00:00

  • Silica-induced pleural disease: an unusual case mimicking malignant mesothelioma.

    abstract::A 57-year-old man with a history of exposure to silica for 32 years presented with pleural thickening of the lower lobe of the left lung and a chronic right-sided pleural effusion without any radiographic evidence of parenchymal nodules in either lung. Light microscopic examination of a left visceral pleural biopsy sp...


    pub_type: 杂志文章,评审


    authors: Zeren EH,Colby TV,Roggli VL

    更新日期:1997-11-05 00:00:00

  • Measurements of cardiac output in seriously ill patients using a CO2 rebreathing method.

    abstract::A CO2 rebreathing method for the measurement of cardiac output was evaluated by comparison with the direct Fick O2 method in 26 studies performed in 18 patients who were critically ill. The method requires measurement of CO2 output by collection of expired gas, of arterial PCO2, and of mixed venous PCO2 by rebreathing...


    pub_type: 临床试验,杂志文章


    authors: Davis CC,Jones NL,Sealey BJ

    更新日期:1978-02-01 00:00:00

  • Persistent pulmonary granulomas after recovery from varicella pneumonia.

    abstract::A 41-year-old man was found to have a miliary infiltrate on chest roentgenogram two months after recovery from varicella pneumonia. The patient remained in good health and there was no objective sign of pulmonary disease. The infiltrate showed no change in subsequent serial chest films, and after one year, open lung b...


    pub_type: 杂志文章


    authors: Meyer B,Stalder H,Wegmann W

    更新日期:1986-03-01 00:00:00