Effects of bacterial infection on airway antimicrobial peptides and proteins in COPD.


BACKGROUND:Pathogenic bacteria colonize the airways of 30% to 40% of patients with COPD and cause approximately 50% of exacerbations. New strains of nontypeable Haemophilus influenzae (NTHI) and Moraxella catarrhalis are associated with exacerbations. Antimicrobial protein/peptides (AMPs) play important roles in innate lung defense against pathogens. To our knowledge, the changes in AMP baseline levels in respiratory secretions during bacterial colonization and exacerbation have not been described. The objective of this study was to elucidate the effects of the acquisition of a new strain of pathogenic bacteria on the airway levels of AMPs in patients with COPD. METHODS:One hundred fifty-three samples from 11 patients were selected from COPD sputum samples collected prospectively over 6 years. Samples were grouped as culture-negative (no pathogenic bacteria), colonization, and exacerbation due to new strains of NTHI and M catarrhalis. Levels of lysozyme, lactoferrin, LL-37, and secretory leukocyte protease inhibitor (SLPI) were measured by enzyme-linked immunosorbent assay and compared among groups by paired analysis. RESULTS:Compared with baseline, sputum lysozyme levels were significantly lower during colonization and exacerbation by NTHI (P = .001 and P = .013, respectively) and M catarrhalis (P = .007 and P = .018, respectively); SLPI levels were lower with exacerbation due to NTHI and M catarrhalis (P = .002 and P = .004, respectively), and during colonization by M catarrhalis (P = 032). Lactoferrin levels did not change significantly; LL-37 levels were higher during exacerbation by NTHI and M catarrhalis (P = .001 and P = .018, respectively). CONCLUSIONS:Acquisition of NTHI and M catarrhalis is associated with significant changes in airway levels of AMPs, with larger changes in exacerbation. Airway AMP levels are likely to be important in pathogen clearance and clinical outcomes of infection in COPD.






Parameswaran GI,Sethi S,Murphy TF




Has Abstract


2011-09-01 00:00:00
















  • Clinical features of Pseudomonas cepacia pneumonia in an epidemic among immunocompromised patients.

    abstract::Between January 1990 and August 1991, there were 37 patients admitted to our Department of Internal Medicine with hematologic malignancies or solid tumors who showed colonization of the respiratory tract with Pseudomonas cepacia. Extensive surveillance cultures of the environmental surfaces and respiratory equipment o...


    pub_type: 杂志文章


    authors: Yamagishi Y,Fujita J,Takigawa K,Negayama K,Nakazawa T,Takahara J

    更新日期:1993-06-01 00:00:00

  • High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis.

    abstract:BACKGROUND:Histopathologic evidence of fibrosis on surgical lung biopsy has been associated with reduced survival in patients with hypersensitivity pneumonitis (HP). Changes of pulmonary fibrosis detected on CT may also correlate with prognosis in patients with HP. METHODS:We identified 69 consecutive patients with HP...


    pub_type: 杂志文章


    authors: Hanak V,Golbin JM,Hartman TE,Ryu JH

    更新日期:2008-07-01 00:00:00

  • Sleep medicine practices, training, and attitudes: a wake-up call for pulmonologists.

    abstract:STUDY OBJECTIVES:To determine attitudes and knowledge about sleep medicine among chest physicians. DESIGN:: Interactive survey of self-selected respondents. SETTING:Interactive session at the 1998 American College of Chest Physicians (ACCP) annual meeting. PARTICIPANTS:Approximately 60 chest physicians. INTERVENTIO...


    pub_type: 杂志文章


    authors: Phillips B,Collop N,Goldberg R

    更新日期:2000-06-01 00:00:00

  • Unsuspected infrahepatic interruption of inferior vena cava associated with floppy mitral valve, mitral valve prolapse, and severe mitral regurgitation.

    abstract::We describe a case of unsuspected infrahepatic interruption of the inferior vena cava with hemiazygos continuation in a 67-year-old man presenting with chest pain and evidence of mitral regurgitation. He had no persistent superior vena cava, with the hemiazygos draining directly into the right superior vena cava. Poly...


    pub_type: 杂志文章,评审


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    更新日期:1994-11-01 00:00:00

  • Measuring a change in self-efficacy following pulmonary rehabilitation: an evaluation of the PRAISE tool.

    abstract:BACKGROUND:Self-efficacy explores the emotional functioning and coping skills of an individual and is thought to be a strong predictor of health behaviors, which is particularly important for pulmonary rehabilitation (PR). However, to our knowledge, there is no measure of self-efficacy developed to explore behavior cha...


    pub_type: 杂志文章


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    更新日期:2011-12-01 00:00:00

  • Beta 2-adrenoceptors in human lung and peripheral mononuclear leukocytes of untreated and terbutaline-treated patients.

    abstract::Beta 2-adrenoceptor agonists act against bronchoconstriction by stimulating beta 2-adrenoceptors in bronchial smooth muscle. However, tachyphylaxis has been argued to occur because of beta 2-adrenoceptor down-regulation following therapy with beta 2-adrenergic agents. To investigate receptor alterations, human periphe...


    pub_type: 杂志文章


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  • Postembolotherapy Pulmonary Arteriovenous Malformation Follow-Up: A Role for Graded Transthoracic Contrast Echocardiography Prior to High-Resolution Chest CT Scan.

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  • Acute relief of exercise-induced bronchoconstriction by inhaled formoterol in children with persistent asthma.

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    pub_type: 杂志文章,随机对照试验


    authors: Hermansen MN,Nielsen KG,Buchvald F,Jespersen JJ,Bengtsson T,Bisgaard H

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  • Acute cavitary histoplasmosis.

    abstract::A case of acute cavitary histoplasmosis in the upper lobes is documented. The relationship of this entity to chronic cavitary histoplasmosis is discussed. ...


    pub_type: 杂志文章


    authors: Davies SF,Sarosi GA

    更新日期:1978-01-01 00:00:00

  • Using the chest radiograph to determine intravascular volume status: the role of vascular pedicle width.

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    pub_type: 杂志文章


    authors: Ely EW,Haponik EF

    更新日期:2002-03-01 00:00:00

  • Hypoxic activation of adventitial fibroblasts: role in vascular remodeling.

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    pub_type: 杂志文章,评审


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    更新日期:2002-12-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1991-01-01 00:00:00

  • Roxithromycin reduces the degree of bronchial hyperresponsiveness in children with asthma.

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    pub_type: 临床试验,杂志文章


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    更新日期:1994-08-01 00:00:00

  • Esophageal cyst as a cause of chronic cough.

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    pub_type: 杂志文章


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  • Epidemiology and outcomes of clostridium difficile-associated disease among patients on prolonged acute mechanical ventilation.

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    pub_type: 杂志文章


    authors: Zilberberg MD,Nathanson BH,Sadigov S,Higgins TL,Kollef MH,Shorr AF

    更新日期:2009-09-01 00:00:00

  • Thoracic splenosis presenting with hemoptysis.

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    pub_type: 杂志文章


    authors: Cordier JF,Gamondes JP,Marx P,Heinen I,Loire R

    更新日期:1992-08-01 00:00:00

  • Characteristics and outcomes of patients hospitalized following pulmonary aspiration.

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    pub_type: 杂志文章


    authors: Lee A,Festic E,Park PK,Raghavendran K,Dabbagh O,Adesanya A,Gajic O,Bartz RR,United States Critical Illness and Injury Trials Group.

    更新日期:2014-10-01 00:00:00

  • Results of long-term follow-up of photodynamic therapy for roentgenographically occult bronchogenic squamous cell carcinoma.

    abstract:BACKGROUND:Photodynamic therapy (PDT) is considered a useful and minimally invasive modality for treating centrally located early lung cancer. To date, there has been limited information on the long-term outcome of patients treated with PDT, especially those who are medically operable. METHODS:Beginning in 1994, patie...


    pub_type: 杂志文章


    authors: Endo C,Miyamoto A,Sakurada A,Aikawa H,Sagawa M,Sato M,Saito Y,Kondo T

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  • A 78-Year-Old Man With Repeated Dyspnea and Neutrophilia in Peripheral Blood and BAL.

    abstract:CASE PRESENTATION:A 78-year-old man with asthma and COPD presented with shortness of breath, cough, and severe malaise for 4 days. Upon arrival, the patient was conscious and body temperature was 37.5°C. Arterial oxygen saturation (Spo2) was 80% on room air. Laboratory data demonstrated a WBC count of 17,400/μL (89.5% ...


    pub_type: 杂志文章


    authors: Nakamatsu E,Morita T,Morishima A,Tagawa H,Furukawa M,Matsushita M,Yamane H

    更新日期:2020-01-01 00:00:00

  • Monitoring the effect of CPAP on left ventricular function using continuous mixed-blood saturation.

    abstract::The hypothetic benefit of CPAP on cardiac performance and on a reduction in VO2 was tested in a patient before heart transplantation after acute myocardial infarction using continuous SvO2 monitoring. The CPAP added to inotropic support (enoximone plus dobutamine) and intraaortic balloon pumping dramatically increased...


    pub_type: 杂志文章


    authors: Pery N,Payen D,Pinsky MR

    更新日期:1991-02-01 00:00:00

  • Effect of lung volume reduction surgery on bony thorax configuration in severe COPD.

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    pub_type: 杂志文章


    authors: Lando Y,Boiselle P,Shade D,Travaline JM,Furukawa S,Criner GJ

    更新日期:1999-07-01 00:00:00

  • Improvement in arterial oxygenation by saralasin infusion in man.

    abstract::Simultaneous hemodynamic and blood gas measurements were performed in 26 hypertensive adults, who were cigarette smokers, before and after a 30-minute infusion of saralasin (5 microgram/kg/min) which is a highly specific competitive antagonist of angiotensin II (AII). The arterial pressure fell in nine, rose in seven ...


    pub_type: 杂志文章


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    更新日期:1979-04-01 00:00:00

  • Distribution of bronchial nonspecific reactivity in the general population.

    abstract::We investigated 654 subjects of a small Lombardy (Italy) town between 15 and 64 years of age who were representative of the general population. By clinical examination, the sample included 535 normal subjects (164 normal smokers, 341 normal nonsmokers, 30 normal subjects with acute upper respiratory illness within 30 ...


    pub_type: 杂志文章


    authors: Cerveri I,Bruschi C,Zoia MC,Zanon P,Maccarini L,Grassi M,Rampulla C

    更新日期:1988-01-01 00:00:00

  • Performance and Interpretation of Invasive Hemodynamic Exercise Testing.

    abstract::Exertional dyspnea is a common complaint for patients seen in pulmonary, cardiac, and general medicine clinics, and elucidating the cause is often challenging, particularly when physical examination, echocardiography, radiography, and pulmonary function test results are inconclusive. Invasive cardiopulmonary exercise ...


    pub_type: 杂志文章,评审


    authors: Jain CC,Borlaug BA

    更新日期:2020-11-01 00:00:00

  • Diagnostic value of the bronchial provocation test with methacholine in asthma. A Bayesian analysis approach.

    abstract::The Bayesian analysis was used in this study to investigate the diagnostic value of the bronchial provocation test with methacholine in patients with asthma. The best cutoff value of accumulated concentration of methacholine administered that caused a 20 percent fall in FEV1 post-saline (PC20) in our sample, determine...


    pub_type: 杂志文章


    authors: Perpiñá M,Pellicer C,de Diego A,Compte L,Macián V

    更新日期:1993-07-01 00:00:00

  • Endobronchial tuberculosis simulating lung cancer.

    abstract::Endobronchial tuberculosis, while relatively common before the advent of effective antituberculosis chemotherapy, is seldom recognized now. Four patients with what appeared to be primary tuberculosis complicated by endobronchial spread were recently seen by us. Three of the four patients presented with anterior segmen...


    pub_type: 杂志文章


    authors: Matthews JI,Matarese SL,Carpenter JL

    更新日期:1984-10-01 00:00:00

  • Supplemental oxygen and exercise performance in patients with cystic fibrosis with severe pulmonary disease.

    abstract::Patients with cystic fibrosis (CF) and advanced pulmonary disease have pulmonary limitation of exercise, often associated with arterial oxygen desaturation. Improving oxygenation during exercise by providing supplemental oxygen may improve exercise performance in these patients. To test this, we performed graded exerc...


    pub_type: 杂志文章


    authors: Marcus CL,Bader D,Stabile MW,Wang CI,Osher AB,Keens TG

    更新日期:1992-01-01 00:00:00

  • Early detection of COPD in a high-risk population using spirometric screening.

    abstract:STUDY OBJECTIVES:To evaluate the efficacy of mass spirometry use for the detection of airflow obstruction in a high-risk population. DESIGN:Free spirometry was offered to smokers who were > 39 years of age with a smoking history of > 10 pack-years. Action was preceded by the dissemination of information on the causes ...


    pub_type: 杂志文章


    authors: Zieliñski J,Bednarek M,Know the Age of Your Lung Study Group.

    更新日期:2001-03-01 00:00:00

  • Long-term survival and risk factors for recurrence in stage I non-small cell lung cancer patients with tumors up to 3 cm in maximum dimension.

    abstract:BACKGROUND:The purpose of this study was to evaluate patients with stage I non-small cell lung cancer (NSCLC) and tumors up to 3 cm in maximum dimension who underwent surgical resection on the revised TNM classification and to investigate the risk factors for recurrence. METHODS:Between 1994 and 2003, 713 consecutive ...


    pub_type: 杂志文章


    authors: Maeda R,Yoshida J,Ishii G,Hishida T,Aokage K,Nishimura M,Nishiwaki Y,Nagai K

    更新日期:2010-08-01 00:00:00