Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosis.

abstract：:Cystic fibrosis is the most common fatal inherited disease of Caucasians. At present, cystic fibrosis accounts for most cases of chronic progressive pulmonary disease and for many other clinical features in the first three decades of life. Thus, it is a challenge to both pediatricians and internists, particularly ches...

journal_title：Chest

authors： Davis PB,di Sant'Agnese PA

更新日期：1984-06-01 00:00:00

abstract：:Eighteen postmenopausal women were examined by Doppler echocardiography before initiation of HRT (T1), then after ten weeks (T2) and one year (T3). This study group was compared with another in which HRT was not used. Flow velocity integral, which correlates with SV, and MA, an indicator of cardiac contractility, were...

journal_title：Chest

authors： Pines A,Fisman EZ,Ayalon D,Drory Y,Averbuch M,Levo Y

更新日期：1992-11-01 00:00:00

abstract：:We report the occurrence of an unusual variant of congenital adenomatoid malformation (CAM) of the lung in a 16-year-old male. Abundant cartilage in the walls of malformed bronchioles, an extremely rare finding in CAM, distinguishes this lesion from the usual forms. We present the roentgenographic, computed tomographi...

journal_title：Chest

authors： Benning TL,Godwin JD,Roggli VL,Askin FB

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:Both pulmonary hypertension and pulmonary overflow are associated with functional and structural changes of the pulmonary arterial wall. Current techniques to evaluate the pulmonary vasculature neglect the pulsatile nature of pulmonary flow. STUDY OBJECTIVES:To determine whether the dynamic properties of th...

journal_title：Chest

authors： Berger RM,Cromme-Dijkhuis AH,Hop WC,Kruit MN,Hess J

更新日期：2002-08-01 00:00:00

abstract：:Left hemorrhagic pleural effusion was the presenting sign of painless aortic dissecting aneurysm in two elderly hypertensive patients. Computed tomography (CT) of the chest revealed the aneurysmal dilatation of the thoracic aorta and an intimal flap connecting its descending part with the left pleural space. The patie...

journal_title：Chest

authors： Gandelman G,Barzilay N,Krupsky M,Resnitzky P

更新日期：1994-08-01 00:00:00

abstract：:The respiratory pattern during wakefulness and sleep was characterized in a 70-year-old woman with respiratory dyskinesia. During wakefulness, both respiratory frequency and tidal volume exhibited an irregularly irregular pattern. In addition, wide fluctuations occurred in the position of the rib cage and abdomen at e...

journal_title：Chest

authors： Kuna ST,Awan R

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Inaccurate symptom perception contributes to asthma morbidity and mortality in children and adults. Various methods have been used to quantify perceptual accuracy, including psychophysical (resistive loading) approaches, ratings of dyspnea during induced bronchoconstriction, and in vivo monitoring, but it is...

journal_title：Chest

authors： Fritz GK,Adams SK,McQuaid EL,Klein R,Kopel S,Nassau J,Mansell A

更新日期：2007-09-01 00:00:00

abstract：:Beginning in July 1977, cold potassium-induced cardioplegia has been used in 60 consecutive patients undergoing correction of congenital heart defects in whom the aorta was cross clamped. Ages ranged from 4 weeks to 18 years (mean 5.8 years); 40 percent were less than 24 months of age. Surgery included correction of v...

journal_title：Chest

authors： Crawford FA Jr,Barnes TY,Heath BJ

更新日期：1980-08-01 00:00:00

abstract：:Two rules of good graphs are presented and explicated. ...

journal_title：Chest

authors： Green J

更新日期：2006-08-01 00:00:00

abstract：:Inadequate tissue oxygenation may occur in critically ill patients with sepsis despite an apparently adequate O2 transport (QO2), and this may contribute to the development of an O2 debt and also to multiple organ failure. It has been shown that increasing QO2 by infusing a vasodilator may reveal this O2 debt in septi...

journal_title：Chest

authors： Pittet JF,Lacroix JS,Gunning K,Laverriere MC,Morel DR,Suter PM

更新日期：1990-12-01 00:00:00

abstract：:Byssinosis first became compensatable in Great Britain in May 1941. The claimants were examined by a specially constituted board consisting of chest physicians and medical specialists from the Manchester area. Following the Industrial Injuries Act of 1946, which became operative in July 1948, the examinations were tak...

journal_title：Chest

authors： Rooke GB

更新日期：1981-04-01 00:00:00

abstract：STUDY OBJECTIVES:To determine attitudes and knowledge about sleep medicine among chest physicians. DESIGN:: Interactive survey of self-selected respondents. SETTING:Interactive session at the 1998 American College of Chest Physicians (ACCP) annual meeting. PARTICIPANTS:Approximately 60 chest physicians. INTERVENTIO...

journal_title：Chest

authors： Phillips B,Collop N,Goldberg R

更新日期：2000-06-01 00:00:00

abstract：STUDY OBJECTIVES:Anastomotic leakage after esophagectomy is associated with high postoperative morbidity and mortality. The most important predisposing factors for anastomotic leaks are ischemia of the gastric conduit and low blood oxygen content. The aim of this study was to evaluate the influence of thoracic epidural...

journal_title：Chest

authors： Michelet P,D'Journo XB,Roch A,Papazian L,Ragni J,Thomas P,Auffray JP

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:IV hydration before and after cardiac catheterization is effective in preventing contrast-associated renal dysfunction for patients with mild-to-moderate renal insufficiency, but necessitates overnight hospital admission. We tested an outpatient oral precatheterization hydration strategy in comparison with o...

journal_title：Chest

authors： Taylor AJ,Hotchkiss D,Morse RW,McCabe J

更新日期：1998-12-01 00:00:00

abstract：STUDY OBJECTIVES:To measure the prevalence of exercise-induced bronchospasm (EIB) and to determine its effect on the physical performance response to training in otherwise healthy young adults. DESIGN:Observational, retrospective study. SETTING:Fort Jackson, SC, May to July 1998. PARTICIPANTS:One hundred thirty-seve...

journal_title：Chest

authors： Sonna LA,Angel KC,Sharp MA,Knapik JJ,Patton JF,Lilly CM

更新日期：2001-06-01 00:00:00

abstract：:Recent extensive development of thoracic surgery meets the need to treat elderly patients with a wide variety of pathophysiologic alterations, even if they require continuous medical assistance and high technologic support. Methods in providing such care are still limited by imprecision in evaluation of results; in th...

journal_title：Chest

authors： Giangiuliani G,Gui D,Bonatti P,Tozzi P,Caracciolo F

更新日期：1990-09-01 00:00:00

abstract：:Positron emission tomography (PET) imaging is an important tool to refine the diagnosis and staging approach in patients with a possible lung cancer. In addition, other applications of PET imaging are being explored. Data consistently show that the intensity of uptake on a PET scan correlates with the biological aggre...

journal_title：Chest

authors： Detterbeck FC,Vansteenkiste JF,Morris DE,Dooms CA,Khandani AH,Socinski MA

更新日期：2004-11-01 00:00:00

abstract：:The narcotic antagonists naloxone and naltrexone were used as respiratory stimulants in two patients failing traditional medical therapy for COPD. Both patients demonstrated improvement while receiving the drugs, but developed respiratory failure when they were discontinued abruptly. In selected patients with COPD, na...

journal_title：Chest

authors： Reents SB,Beck CA Jr

更新日期：1988-01-01 00:00:00

abstract：:We wanted to determine the long-term effects of a continuous infusion of PGE1 on DO2 and VO2 in patients with ARDS. Data were obtained from a randomized double-blind multicenter trial, which evaluated the effects of PGE1 on survival in patients with ARDS. Patients were stratified according to treatment and outcome: pl...

journal_title：Chest

authors： Silverman HJ,Slotman G,Bone RC,Maunder R,Hyers TM,Kerstein MD,Ursprung JJ

更新日期：1990-08-01 00:00:00

abstract：:A 42-year-old woman with an anomalous left coronary artery originating from the pulmonary artery and a fistula from the left coronary artery to the left ventricle was treated by aortocoronary bypass grafting of an autologous saphenous vein. The presence of an abundant collateral circulation and of fistulous communicat...

journal_title：Chest

authors： Krajcer Z,Leachman RD,Lufschanowski R,Cooley DA,Angelini P

更新日期：1978-07-01 00:00:00

abstract：:Tracheobronchial injury is a rare but a potentially high-impact event with significant morbidity and mortality. Common etiologies include blunt or penetrating trauma and iatrogenic injury that might occur during surgery, endotracheal intubation, or bronchoscopy. Early recognition of clinical signs and symptoms can hel...

journal_title：Chest

authors： Grewal HS,Dangayach NS,Ahmad U,Ghosh S,Gildea T,Mehta AC

更新日期：2019-03-01 00:00:00

abstract：:It has been demonstrated that total parenteral nutrition (TPN) results in increased O2 consumption (VO2), CO2 production (VCO2) and minute ventilation (VE). TPN consists of a mixture of glucose and amino acids. The individual role of each of these nutrients in mediating these changes has not been well established. To ...

journal_title：Chest

authors： Rodriguez JL,Askanazi J,Weissman C,Hensle TW,Rosenbaum SH,Kinney JM

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Little is known about the association between left ventricular (LV) diastolic dysfunction and outcomes in patients with idiopathic or heritable pulmonary arterial hypertension (PAH). Our rationale was to investigate the prevalence of LV diastolic dysfunction, and its association with disease severity and out...

journal_title：Chest

authors： Tonelli AR,Plana JC,Heresi GA,Dweik RA

更新日期：2012-06-01 00:00:00

abstract：:The Bayesian analysis was used in this study to investigate the diagnostic value of the bronchial provocation test with methacholine in patients with asthma. The best cutoff value of accumulated concentration of methacholine administered that caused a 20 percent fall in FEV1 post-saline (PC20) in our sample, determine...

journal_title：Chest

authors： Perpiñá M,Pellicer C,de Diego A,Compte L,Macián V

更新日期：1993-07-01 00:00:00

abstract：:The mechanisms leading to rapid changes in arterial blood gas values soon after exercise ends have not been well established. To further study these phenomena, we exercised seven normal male volunteers to exhaustion on a cycle ergometer with a 25-W/min ramped protocol measuring arterial blood gas values, and breath-by...

journal_title：Chest

authors： O'Neill AV,Johnson DC

更新日期：1991-05-01 00:00:00

abstract：:alpha 1-Antitrypsin (alpha 1-AT) accumulates in the rough endoplasmic reticulum through a mechanism of polymerization. Polymerization is favored by the incorrect tertiary structure of the alpha 1-AT caused by a point mutation at position 342 of the protein. Accumulation of alpha 1-AT in the liver cells (and in hepatoc...

journal_title：Chest

authors： Massi G

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Histopathologic evidence of fibrosis on surgical lung biopsy has been associated with reduced survival in patients with hypersensitivity pneumonitis (HP). Changes of pulmonary fibrosis detected on CT may also correlate with prognosis in patients with HP. METHODS:We identified 69 consecutive patients with HP...

journal_title：Chest

authors： Hanak V,Golbin JM,Hartman TE,Ryu JH

更新日期：2008-07-01 00:00:00

abstract：STUDY OBJECTIVES:COPD patients run a risk of developing nocturnal oxygen desaturation. When evaluating patients with nocturnal hypoxemia, an unfamiliar hospital environment and the monitoring equipment may cause sleep disturbances. It was hypothesized that increased sleep disruption will lead to fewer instances of desa...

journal_title：Chest

authors： Brijker F,van den Elshout FJ,Heijdra YF,Folgering HT

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The practice of treating a solitary pulmonary nodule (SPN) suspicious for stage I non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR) in the absence of pathology is growing. In the absence of randomized evidence, the appropriate prior probability threshold of lung cancer of when...

journal_title：Chest

authors： Louie AV,Senan S,Patel P,Ferket BS,Lagerwaard FJ,Rodrigues GB,Salama JK,Kelsey C,Palma DA,Hunink MG

更新日期：2014-10-01 00:00:00

abstract：STUDY OBJECTIVES:Evaluation of the effectiveness of negative-pressure ventilation (NPV) with the use of the iron lung vs noninvasive positive-pressure ventilation (NIPPV) in the treatment of COPD patients with acute on chronic respiratory failure. DESIGN:A retrospective case-control study. SETTING:Four Italian respir...

journal_title：Chest

authors： Corrado A,Confalonieri M,Marchese S,Mollica C,Villella G,Gorini M,Della Porta R

更新日期：2002-01-01 00:00:00