Transition from exercise to rest. Ventilatory and arterial blood gas responses.


:The mechanisms leading to rapid changes in arterial blood gas values soon after exercise ends have not been well established. To further study these phenomena, we exercised seven normal male volunteers to exhaustion on a cycle ergometer with a 25-W/min ramped protocol measuring arterial blood gas values, and breath-by-breath gas exchange from rest to exercise and through 15 minutes of recovery. Arterial PO2 (PaO2) increased from 108 mm Hg at peak exercise to 125 mm Hg at 2 minutes of recovery. There was a smaller rise in calculated alveolar PO2 (PAO2) from 121 to 128 mm Hg over the same period. Arterial PCO2 (PaCO2) fell from 35.0 mm Hg to 31.9 mm Hg. The gas exchange ratio R rose from 1.21 to 1.52, after having peaked at 1.68 at 1 minute. The alveolar-arterial O2 gradient (P[A-a]O2) fell from 12.3 mm Hg at peak exercise to 3.2 mm Hg at 2 minutes. Following exercise, the rise in R is related to a more rapid fall in O2 uptake than in CO2 output, and the fall in P(A-a)O2 is probably related to improved V/Q relationships and to a rise in mixed venous PO2. We conclude that the rise in PaO2 in the recovery period after progressive nonsteady state exercise is due to several factors, including a fall in P(A-a)O2 and a rise in PAO2 due primarily to an elevation of R and also to a fall in PaCO2.






O'Neill AV,Johnson DC




Has Abstract


1991-05-01 00:00:00
















  • Postnasal drip causes cough and is associated with reversible upper airway obstruction.

    abstract::We prospectively evaluated nine patients with cough from postnasal drip for evidence of extrathoracic upper airway obstruction. Patients compared before treatment to normal control subjects had physiologic evidence of extrathoracic upper airway obstruction; their mean FIF50%/FEF50% and FIF25-75%/FEF25-75% ratios of 0....


    pub_type: 杂志文章


    authors: Irwin RS,Pratter MR,Holland PS,Corwin RW,Hughes JP

    更新日期:1984-03-01 00:00:00

  • Tuberculosis in Korea. The relationship between prior therapy and drug resistance.

    abstract::A review of 121 culture-positive cases of pulmonary tuberculosis from 1979 to 1984, including both Korean and American patients, at the major US military hospital in Korea indicated that most antituberculosis drug resistance occurred in patients with a history of previous antituberculosis therapy. The 98 patients with...


    pub_type: 杂志文章


    authors: Etzkorn ET,Lillis PK,McAllister CK

    更新日期:1986-08-01 00:00:00

  • Epigenetics and prenatal influences on asthma and allergic airways disease.

    abstract::Uterine life is arguably the most critical time in developmental programming, when environmental exposures may have the greatest potential to influence evolving fetal structure and function. There has been substantial progress in understanding the epigenetic mechanisms through which environmental exposures can permane...


    pub_type: 杂志文章,评审


    authors: Martino D,Prescott S

    更新日期:2011-03-01 00:00:00

  • Immediate hypersensitivity to tuberculin. In vivo and in vitro studies.

    abstract::Immediate responses of hypersensitivity to skin testing with purified derivative of tuberculin (PPD) were observed in 2.3 percent of 3,248 patients seen in an allergy clinic, and the relationship to delayed responses was questioned. Immediate cutaneous reactions to testing with PPD appeared in all age groups and occur...


    pub_type: 杂志文章


    authors: Tarlo SM,Day JH,Mann P,Day MP

    更新日期:1977-01-01 00:00:00

  • Assessment of lymph node tuberculosis in northern Germany: a clinical review.

    abstract:AIM OF STUDY:To evaluate patient profiles, diagnostic approaches, and treatment strategies in patients with lymph node tuberculosis. METHODS:Demographic data, diagnostic findings, and therapies were retrospectively analyzed in 60 patients with lymph node tuberculosis who were hospitalized between 1992 and 1999. RESUL...


    pub_type: 杂志文章


    authors: Geldmacher H,Taube C,Kroeger C,Magnussen H,Kirsten DK

    更新日期:2002-04-01 00:00:00

  • Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids.

    abstract:STUDY OBJECTIVES:To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS). DESIGN:Double-blind, randomized, placebo-controlled trial. SETTING:Multicenter, tertiary referral centers. PATIENTS OR PARTICIPANTS:Forty-five subjects w...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Kraft M,Martin RJ,Lazarus SC,Fahy JV,Boushey HA,Lemanske RF Jr,Szefler SJ,Asthma Clinical Research Network.

    更新日期:2003-07-01 00:00:00

  • The clinician's perspective on parapneumonic effusions and empyema.

    abstract::Respondents at an interactive symposium on pleural space infections (n = 339) at the 1991 American College of Chest Physicians Annual Scientific Assembly recorded their personal management preferences for hypothetical patients with empyema. The group's preference was to treat pleural sepsis from an anaerobic multilocu...


    pub_type: 杂志文章


    authors: Strange C,Sahn SA

    更新日期:1993-01-01 00:00:00

  • Effects of prostaglandin E1 in postoperative surgical patients with circulatory deficiency.

    abstract::Hemodynamic and oxygen transport effects of PGE1 were observed in the early postoperative period before development of ARDS in two series of general surgical patients with circulatory deficiencies. The first was a series of 19 studies in 18 patients, the second was a placebo-controlled series of 20 patients (ten recei...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Appel PL,Shoemaker WC,Kram HB

    更新日期:1991-04-01 00:00:00

  • The effect of a peak flow-based action plan in the prevention of exacerbations of asthma.

    abstract:STUDY OBJECTIVE:To determine the effect of a symptom-based and a peak flow-based action plan in preventing acute exacerbations in subjects with poorly controlled asthma. DESIGN:A randomized controlled trial in which subjects who had required urgent treatment for their asthma were allocated to receive no action plan, a...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cowie RL,Revitt SG,Underwood MF,Field SK

    更新日期:1997-12-01 00:00:00

  • Antinuclear antibodies in pleural fluid.

    abstract::Systemic lupus erythematosus (SLE) frequently involves the pleura with resultant pleural effusion. Previous studies have reported that detection of antinuclear antibodies (ANA) in pleural fluid using animal tissue as substrate was a sensitive and specific method for distinguishing SLE pleural effusions from other etio...


    pub_type: 杂志文章


    authors: Khare V,Baethge B,Lang S,Wolf RE,Campbell GD Jr

    更新日期:1994-09-01 00:00:00

  • Standard therapy for tuberculosis 1985.

    abstract::Numerous clinical trials of chemotherapy for tuberculosis conducted throughout the world over the past 4 decades have established 2 basic principles of treatment: effective treatment requires the initial concomitant administration of at least 2 drugs to which the patient's organisms are susceptible; and cure of tuber...


    pub_type: 杂志文章,评审


    authors: Snider DE Jr,Cohn DL,Davidson PT,Hershfield ES,Smith MH,Sutton FD Jr

    更新日期:1985-02-01 00:00:00

  • High frequency of atopic asthma in a pulmonary clinic population.

    abstract::Seventy-two consecutive adult asthmatic patients seen in the Pulmonary Clinic at Rhode Island Hospital were tested for atopy by prick test with 14 standard aeroallergens and by in vitro total and specific IgE determinations (FAST). A total of 58.3 percent of patients were found to be atopic by these tests. There was a...


    pub_type: 杂志文章


    authors: Kalliel JN,Goldstein BM,Braman SS,Settipane GA

    更新日期:1989-12-01 00:00:00

  • Standard limb lead QRS concordance during wide QRS tachycardia. A new surface ECG sign of ventricular tachycardia.

    abstract::The differentiation of ventricular tachycardia from supraventricular conducted with aberration constitutes a perennial challenge. We report a new surface ECG clue, hitherto undescribed, the presence of which, during wide QRS tachycardia, indicates that the tachycardia in question is ventricular rather than supraventri...


    pub_type: 杂志文章


    authors: Reddy GV,Leghari RU

    更新日期:1987-10-01 00:00:00

  • Comparison of Dynamic Expiratory CT With Bronchoscopy for Diagnosing Airway Malacia: A Pilot Evaluation.

    abstract:OBJECTIVE:To assess the accuracy of dynamic expiratory CT for detecting airway malacia using bronchoscopy as the diagnostic "gold standard." MATERIALS AND METHODS:A computerized hospital information system was used to retrospectively identify all patients with bronchoscopically proven airway malacia referred for CT ai...


    pub_type: 杂志文章


    authors: Lee KS,Sun MRM,Ernst A,Feller-Kopman D,Majid A,Boiselle PM

    更新日期:2007-03-01 00:00:00

  • Increased soluble CD14 levels in BAL fluid in pulmonary tuberculosis.

    abstract:INTRODUCTION:CD14 is a cell surface glycoprotein expressed mainly on mature monocytes and macrophages. Soluble CD14 (sCD14) is present in normal plasma and is found increased in serum of patients with septicemia, polytrauma, and sarcoidosis. In active sarcoidosis, increased levels of sCD14 in BAL supernatant have been ...


    pub_type: 杂志文章


    authors: Hoheisel G,Zheng L,Teschler H,Striz I,Costabel U

    更新日期:1995-12-01 00:00:00

  • Occult pulmonary abnormalities in asymptomatic asthmatic children.

    abstract::The pulmonary status of 178 asymptomatic asthmatic children with normal time-volume spirograms was further evaluated using flow-volume loops, body plethysmographic studies, and blood gas tensions in arterialized capillary blood. Residual volume (RV) was abnormal in 26%, total lung capacity (TLC) in 33%, RV/TLC% in 41%...


    pub_type: 杂志文章


    authors: Cooper DM,Cutz E,Levison H

    更新日期:1977-03-01 00:00:00

  • The components of a respiratory rehabilitation program: a systematic overview.

    abstract:OBJECTIVE:To determine the contribution of the various components of a rehabilitation program to the improvement of exercise capacity and health-related quality of life (HRQL) in patients with COPD. DATA SOURCES:MEDLINE (1966 to April 1996) was searched. Abstracts presented at international conferences were also hand ...


    pub_type: 杂志文章,meta分析


    authors: Lacasse Y,Guyatt GH,Goldstein RS

    更新日期:1997-04-01 00:00:00

  • T and B lymphocytes in pleural effusions.

    abstract::To determine the diagnostic significance of the determination of T and B lymphocytes in pleural fluid, we studied these cells in peripheral blood and in pleural fluid by means of surface markers. Our study comprised 30 patients suffering from pulmonary tuberculosis, pulmonary malignancy, connective tissue disease, non...


    pub_type: 杂志文章


    authors: Pettersson T,Klockars M,Hellström PE,Riska H,Wangel A

    更新日期:1978-01-01 00:00:00

  • Pulmonary vascular disease in secundum atrial septal defect with pulmonary hypertension.

    abstract::Histopathologic and morphometric studies of small pulmonary arteries were performed in 16 cases of secundum atrial septal defect (ASD) and severe pulmonary hypertension. Besides typical plexogenic arteriopathies found in six cases, organized microthrombi and what we call "musculoelastosis," that is, proliferation of l...


    pub_type: 杂志文章


    authors: Yamaki S,Horiuchi T,Miura M,Suzuki Y,Ishizawa E,Takahashi T

    更新日期:1986-05-01 00:00:00

  • Mediastinal abscess due to passage of a broncholith.

    abstract::We report a case of a 32-year-old woman who, after passage of broncholiths, developed a mediastinal abscess that required surgical drainage for treatment. Previously reported infectious complications resulting from broncholiths include obstructive pneumonitis and recurrent aspiration pneumonitis secondary to bronchoes...


    pub_type: 杂志文章


    authors: Studer SM,Heitmiller RF,Terry PB

    更新日期:2002-01-01 00:00:00

  • Application of electrical impedance analysis for diagnosis of a pulmonary mass.

    abstract::The electrical impedance of a pulmonary mass was measured in 53 patients of whom 44 had primary lung cancer, 5 had metastatic lung tumor, and 4 had organizing pneumonia. Because biologic tissue can be regarded, electrically, to consist of extracellular resistance (Re), intracellular resistance (Ri), and the electrical...


    pub_type: 杂志文章


    authors: Kimura S,Morimoto T,Uyama T,Monden Y,Kinouchi Y,Iritani T

    更新日期:1994-06-01 00:00:00

  • Intensive Monitoring of Urine Output Is Associated With Increased Detection of Acute Kidney Injury and Improved Outcomes.

    abstract:BACKGROUND:Urine output (UO) is a vital sign for critically ill patients, but standards for monitoring and reporting vary widely between ICUs. Careful monitoring of UO could lead to earlier recognition of acute kidney injury (AKI) and better fluid management. We sought to determine if the intensity of UO monitoring is ...


    pub_type: 杂志文章


    authors: Jin K,Murugan R,Sileanu FE,Foldes E,Priyanka P,Clermont G,Kellum JA

    更新日期:2017-11-01 00:00:00

  • Enoximone vs nicardipine during the early postoperative course of patients undergoing cardiac surgery. A prospective study of two therapeutic strategies.

    abstract::The hemodynamic effects of enoximone and nicardipine were compared during the early postcardiac surgery period in 40 patients with systemic hypertension and moderate cardiac dysfunction. Patients were prospectively randomized into two groups. Mean right atrial pressure was maintained above 7 mm Hg. The drug infusion r...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Squara P,Denjean D,Godard P,Brunet F,Brusset A,Dubois C

    更新日期:1994-07-01 00:00:00

  • Physiologic effects and side effects of prostaglandin E1 in the adult respiratory distress syndrome.

    abstract::Because PGE1 previously has been reported to increase survival of patients with ARDS, we evaluated physiologic effects and side effects of PGE1 in a prospective open-label study of patients with ARDS. Seventeen patients with ARDS who did not have significant renal or hepatic dysfunction received PGE1 by continuous cen...


    pub_type: 杂志文章


    authors: Russell JA,Ronco JJ,Dodek PM

    更新日期:1990-03-01 00:00:00

  • Breathing pattern and arterial blood gases during Nd-YAG laser photoresection of endobronchial lesions under general anesthesia: use of negative pressure ventilation: a preliminary study.

    abstract:STUDY OBJECTIVE:To evaluate the efficacy of negative pressure ventilation (NPV) in avoiding or reducing apneas and related hypoxemia and respiratory acidosis during laser therapy (LT) of endobronchial lesions. DESIGN:A prospective, controlled, randomized study. SETTING:An operating theater of a respiratory endoscopy ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vitacca M,Natalini G,Cavaliere S,Clini E,Foccoli P,Candiani A,Ambrosino N

    更新日期:1997-12-01 00:00:00

  • Interferon-related bronchiolitis obliterans organizing pneumonia.

    abstract::We present an unusual case of a patient with chronic hepatitis C who experienced dyspnea, fever, and cough after 2 1/2 months' treatment with interferon. His radiograph demonstrated diffuse pulmonary infiltrates and bronchoalveolar lavage fluid showed an increase in lymphocytes, especially CD8-positive cells. The lung...


    pub_type: 杂志文章


    authors: Ogata K,Koga T,Yagawa K

    更新日期:1994-08-01 00:00:00

  • Increased expression of leukocyte function associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) by alveolar macrophages of patients with pulmonary sarcoidosis.

    abstract::Leukocyte function associated antigen-1 (LFA-1) and its ligand intercellular adhesion molecule-1 (ICAM-1) are cell adhesion molecules that play an important role in the capacity of monoculear phagocytes (MPs) to present antigens to T lymphocytes. Since in pulmonary sarcoidosis (PS) this capacity is increased at sites ...


    pub_type: 杂志文章


    authors: Melis M,Gjomarkaj M,Pace E,Malizia G,Spatafora M

    更新日期:1991-10-01 00:00:00

  • Effect of filtration and concentration on the composition of bronchoalveolar lavage fluid.

    abstract::The effects of filtration and concentration on the cellular and protein composition of bronchoalveolar lavage fluids were examined in ten normal subjects and 11 patients with asthma. Filtration of lavage fluid preferentially removed bronchial epithelial cells, resulting in a relative increase in the proportion of alve...


    pub_type: 杂志文章


    authors: Lam S,LeRiche JC,Kijek K

    更新日期:1985-06-01 00:00:00

  • Cerebral vascular responsiveness in chronic hypercapnia.

    abstract::To assess the responsiveness of the cerebral vessels to chronic hypercapnia, we measured middle cerebral artery flow velocity by transcranial Doppler ultrasound in 20 normal subjects and in 14 COLD patients before and after stimulation by progressive hypercapnia (rebreathing test) or by intravenous administration of a...


    pub_type: 杂志文章


    authors: Clivati A,Ciofetti M,Cavestri R,Longhini E

    更新日期:1992-07-01 00:00:00

  • Lung cancer chemoprevention: ACCP evidence-based clinical practice guidelines (2nd Edition).

    abstract:BACKGROUND:Lung cancer is the most common cause of cancer death in the United States. Cigarette smoking is the main risk factor. Former smokers are at a substantially increased risk for lung cancer compared with lifetime never-smokers. Chemoprevention is the use of specific agents to reverse, suppress, or prevent the p...


    pub_type: 杂志文章,实务指引


    authors: Gray J,Mao JT,Szabo E,Kelley M,Kurie J,Bepler G,American College of Chest Physicians.

    更新日期:2007-09-01 00:00:00