Combined pulmonary fibrosis and emphysema syndrome: a review.

Abstract:

:There is increasing clinical, radiologic, and pathologic recognition of the coexistence of emphysema and pulmonary fibrosis in the same patient, resulting in a clinical syndrome known as combined pulmonary fibrosis and emphysema (CPFE) that is characterized by dyspnea, upper-lobe emphysema, lower-lobe fibrosis, and abnormalities of gas exchange. This syndrome frequently is complicated by pulmonary hypertension, acute lung injury, and lung cancer. The CPFE syndrome typically occurs in male smokers, and the mortality associated with this condition, especially if pulmonary hypertension is present, is significant. In this review, we explore the current state of the literature and discuss etiologic factors and clinical characteristics of the CPFE syndrome.

journal_name

Chest

journal_title

Chest

authors

Jankowich MD,Rounds SIS

doi

10.1378/chest.11-1062

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

222-231

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(12)60035-X

journal_volume

141

pub_type

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