Abstract:
:There is increasing clinical, radiologic, and pathologic recognition of the coexistence of emphysema and pulmonary fibrosis in the same patient, resulting in a clinical syndrome known as combined pulmonary fibrosis and emphysema (CPFE) that is characterized by dyspnea, upper-lobe emphysema, lower-lobe fibrosis, and abnormalities of gas exchange. This syndrome frequently is complicated by pulmonary hypertension, acute lung injury, and lung cancer. The CPFE syndrome typically occurs in male smokers, and the mortality associated with this condition, especially if pulmonary hypertension is present, is significant. In this review, we explore the current state of the literature and discuss etiologic factors and clinical characteristics of the CPFE syndrome.
journal_name
Chestjournal_title
Chestauthors
Jankowich MD,Rounds SISdoi
10.1378/chest.11-1062subject
Has Abstractpub_date
2012-01-01 00:00:00pages
222-231issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(12)60035-Xjournal_volume
141pub_type
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