Pathogenesis and pathology of liver disease associated with alpha 1-antitrypsin deficiency.

abstract：:OSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction du...

journal_title：Chest

authors： Farré N,Farré R,Gozal D

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Obesity hypoventilation syndrome (OHS) conventionally includes awake hypercapnia, but an isolated raised bicarbonate, even in the absence of awake hypercapnia, may represent evidence of "early" OHS. We investigated whether such individuals exhibit certain features characteristic of established OHS. METHODS:...

journal_title：Chest

authors： Manuel ARG,Hart N,Stradling JR

更新日期：2015-02-01 00:00:00

abstract：:The relative usefulness of a combination of some tumor markers, such as CEA, AFP, ferritin and NSE for the diagnosis of lung cancer was assessed by multiple logistic analysis. Serum concentration of these markers was determined in 68 patients with lung cancer (50 with NSCLC and 18 with SCLC, in 68 patients with benign...

journal_title：Chest

authors： Lombardi C,Tassi GF,Pizzocolo G,Donato F

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Airway inflammation is important in the development and progression of asthma. Activation of inflammatory cells induces a respiratory burst resulting in the production of reactive oxygen species, such as H(2)O(2). The aim of this study was to measure the concentration of H(2)O(2) in exhaled breath condensate...

journal_title：Chest

authors： Emelyanov A,Fedoseev G,Abulimity A,Rudinski K,Fedoulov A,Karabanov A,Barnes PJ

更新日期：2001-10-01 00:00:00

abstract：:Clotting abnormalities are well-recognized complications that occur with high frequency in patients suffering from underlying malignant diseases. New and highly sensitive molecular markers of hemostasis, thrombin-antithrombin III complex (TAT III), D-dimer fragments (DD), and plasmin-alpha 2-antiplasmin complex (PIC) ...

journal_title：Chest

authors： Gabazza EC,Taguchi O,Yamakami T,Machishi M,Ibata H,Suzuki S

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Lung cancer screening (LCS) is an important secondary prevention measure to reduce lung cancer mortality. The goal of this study was to assess state-level variations in LCS among the US elderly during the first 3 years since Medicare began its LCS reimbursement policy in 2015. METHODS:This ecological study ...

journal_title：Chest

authors： Liu B,Dharmarajan K,Henschke CI,Taioli E

更新日期：2020-04-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate in patients submitted to minute ventilation > 10 L/min the ability to preserve patients' heat and humidity of two heat and moisture exchangers (HMEs) and one vaporizing humidifier (VH). DESIGN:Prospective, randomized, comparative, non-blinded study. SETTING:Intensive care unit of a univers...

journal_title：Chest

authors： Martin C,Thomachot L,Quinio B,Viviand X,Albanese J

更新日期：1995-05-01 00:00:00

abstract：:Reliable long-term assessment of cough is necessary in many clinical and scientific settings. A new method for long-term recording and automatic analysis of cough is presented. The method is based on simultaneous recording of two independent signals: high-pass filtered cough sounds and cough-induced fast movements of ...

journal_title：Chest

authors： Salmi T,Sovijärvi AR,Brander P,Piirilä P

更新日期：1988-11-01 00:00:00

abstract：:Bitolterol mesylate (WIN 37284) is alpha-[tert-butylaminomethyl]-3,4-dihydroxybenzyl alcohol 3,4-di(p-toluate) methanesulfonate, a diester sympathomimetic amine bronchodilator. Bitolterol mesylate represents a new concept in sympathomimetic amine therapy. It is "prodrug" which is inactive until altered in the body. Th...

journal_title：Chest

authors： Kass I,Mingo TS

更新日期：1980-08-01 00:00:00

abstract：:Pulmonary embolism (PE) is a common disorder that is accompanied by significant morbidity and mortality. Although anticoagulation is the standard treatment for PE, thrombolytic therapy, with its ability to produce rapid clot lysis, has long been considered an attractive alternative. Although many studies have been per...

journal_title：Chest

authors： Arcasoy SM,Kreit JW

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Little is known about the prevalence, predictors, and outcomes of late vasopressor administration which evolves after admission to the ICU. RESEARCH QUESTION:What is the epidemiology of late vasopressor administration in the ICU? STUDY DESIGN AND METHODS:We retrospectively studied a cohort of veterans admi...

journal_title：Chest

authors： Viglianti EM,Bagshaw SM,Bellomo R,McPeake J,Molling DJ,Wang XQ,Seelye S,Iwashyna TJ

更新日期：2020-08-01 00:00:00

abstract：STUDY OBJECTIVE:Depressive symptoms and reduced health-related quality of life are common in patients with severe COPD. Therefore, understanding the association between preferences for life-sustaining treatment and depression or quality of life is important in providing care. No prior studies have examined the effects ...

journal_title：Chest

authors： Stapleton RD,Nielsen EL,Engelberg RA,Patrick DL,Curtis JR

更新日期：2005-01-01 00:00:00

abstract：RATIONALE:Malnutrition in patients with COPD is associated with an impaired pulmonary status, reduced diaphragmatic mass, lower exercise capacity, and higher mortality rate when compared to adequately nourished individuals with COPD. Nutritional support may therefore be a useful part of their comprehensive care. PURPO...

journal_title：Chest

authors： Ferreira IM,Brooks D,Lacasse Y,Goldstein RS

更新日期：2000-03-01 00:00:00

abstract：STUDY OBJECTIVES:The purpose of this 12-week study was to evaluate the efficacy and safety of adjunct modafinil to treat excessive sleepiness in patients with obstructive sleep apnea (OSA) who experience residual sleepiness despite regular nasal continuous positive airway pressure (nCPAP) use. DESIGN:Twelve-week, open...

journal_title：Chest

authors： Schwartz JR,Hirshkowitz M,Erman MK,Schmidt-Nowara W

更新日期：2003-12-01 00:00:00

abstract：:Between January 1990 and August 1991, there were 37 patients admitted to our Department of Internal Medicine with hematologic malignancies or solid tumors who showed colonization of the respiratory tract with Pseudomonas cepacia. Extensive surveillance cultures of the environmental surfaces and respiratory equipment o...

journal_title：Chest

authors： Yamagishi Y,Fujita J,Takigawa K,Negayama K,Nakazawa T,Takahara J

更新日期：1993-06-01 00:00:00

abstract：:Six patients with hemoptysis were treated by endobronchial sealing, with n-butyl cyanoacrylate, of the bleeding segment or subsegment. There was an immediate arrest of bleeding without any recurrence for a mean follow-up period of 127 (+/- 67.17) days. Endobronchial sealing appears to be an effective method of managin...

journal_title：Chest

authors： Bhattacharyya P,Dutta A,Samanta AN,Chowdhury SR

更新日期：2002-06-01 00:00:00

abstract：:Familial Mediterranean fever (FMF) is an autosomal recessive disease affecting predominantly populations surrounding the Mediterranean basin. It is the most prevalent hereditary periodic fever syndrome characterized mainly by recurrent and short attacks of fever and serositis (pleuritis, arthritis, peritonitis). Unila...

journal_title：Chest

authors： Katsenos S,Mermigkis C,Psathakis K,Tsintiris K,Polychronopoulos V,Panagou P,Ritis K,Light RW

更新日期：2008-04-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate early and late lung function abnormalities and their predictors in a large sample of children who underwent bone marrow transplantation (BMT) for leukemias in the 1990s, highlighting changes with respect to the 1980s. DESIGNS:Prospective cohort. SETTING:A university department of pediatri...

journal_title：Chest

authors： Cerveri I,Fulgoni P,Giorgiani G,Zoia MC,Beccaria M,Tinelli C,Locatelli F

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:The clinical course of idiopathic pulmonary fibrosis (IPF) is characterized by progressive decline in lung function and eventual mortality. We sought to determine if future declines in pulmonary function, mortality, or both can be predicted from prior trends in pulmonary function tests (PFTs). METHODS:Data ...

journal_title：Chest

authors： Schmidt SL,Tayob N,Han MK,Zappala C,Kervitsky D,Murray S,Wells AU,Brown KK,Martinez FJ,Flaherty KR

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Early-life stress is becoming an important determinant of immune system programming. Maternal prenatal distress is found to be associated with atopic disease in offspring but the separate effects of postnatal distress are not well-studied. RESEARCH QUESTION:Does the likelihood of asthma and atopic dermatiti...

journal_title：Chest

authors： van der Leek AP,Bahreinian S,Chartier M,Dahl ME,Azad MB,Brownell MD,Kozyrskyj AL

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of noninvasive positive pressure ventilation (NPPV) by helmet and face mask in immunocompromised patients with hypoxemic acute respiratory failure (ARF). DESIGN:Case-control study. SETTING:The general ICU of a university hospital. PATIENTS:Nineteen immunocompromised patients (hemato...

journal_title：Chest

authors： Rocco M,Dell'Utri D,Morelli A,Spadetta G,Conti G,Antonelli M,Pietropaoli P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Recent studies have implicated the 5-lipoxygenase/leukotriene (LT) pathway in cardiovascular disease (CVD), which may have important implications for asthmatics because several drugs that target this pathway are currently used to treat asthma. We sought to determine whether montelukast, a cysteinyl LT antago...

journal_title：Chest

authors： Allayee H,Hartiala J,Lee W,Mehrabian M,Irvin CG,Conti DV,Lima JJ

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Habitual smoking of alkaloidal cocaine (crack) has been reported to be associated with a number of cardiopulmonary complications that may not be clinically obvious but could potentially interfere with normal physiologic responses to exercise and thus impair maximum exercise performance. STUDY OBJECTIVE:To e...

journal_title：Chest

authors： Marques-Magallanes JA,Koyal SN,Cooper CB,Kleerup EC,Tashkin DP

更新日期：1997-10-01 00:00:00

abstract：PURPOSES:To determine the diagnostic accuracy of ultrasound in the diagnosis of pneumothorax in patients with COPD with particular regard to false-positive diagnoses. MATERIALS AND METHODS:This was a single-center, prospective, blinded study. Nine patients with pneumothorax, 9 patients with cystic fibrosis, 17 patient...

journal_title：Chest

authors： Slater A,Goodwin M,Anderson KE,Gleeson FV

更新日期：2006-03-01 00:00:00

abstract：STUDY OBJECTIVE:Childhood exposure to environmental tobacco smoke (ETS) adversely affects dynamic spirometric indexes as a result of combined early life (including in utero) and current exposure to parental smoking. The aim of our study was to investigate the effect of ETS on lung function and to identify the most sens...

journal_title：Chest

authors： Rizzi M,Sergi M,Andreoli A,Pecis M,Bruschi C,Fanfulla F

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:A fixed combination of long-acting beta(2)-agonists (LABA) plus inhaled corticosteroids (ICS) has never been proven to reduce asthma exacerbations vs ICS alone in children. This 12-month, double-blind, randomized study in 341 children (age range, 4 to 11 years) with asthma uncontrolled on ICS investigated wh...

journal_title：Chest

authors： Bisgaard H,Le Roux P,Bjåmer D,Dymek A,Vermeulen JH,Hultquist C

更新日期：2006-12-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the performance of continuous fiberoptic blood gas monitoring with standard, intermittent blood gas sampling in the measurement of arterial and central venous blood gases during marked hemodynamic changes. DESIGN:Prospective, consecutive, enrollment, experimental study. SETTING:Research lab...

journal_title：Chest

authors： Oropello JM,Manasia A,Hannon E,Leibowitz A,Benjamin E

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical feasibility of using real-time measurements of work of breathing obtained at the bedside with a portable, commercially available respiratory monitor as an objective and quantifiable guideline for appropriately setting pressure support ventilation (PSV) to partially and totally unload ...

journal_title：Chest

authors： Banner MJ,Kirby RR,Gabrielli A,Blanch PB,Layon AJ

更新日期：1994-12-01 00:00:00

abstract：:We describe an unusual case of orthodeoxia platypnea syndrome exacerbated by right ventricular inflow obstruction due to iatrogenic steroid-induced adipose deposition in cardiac tissues. A 68-year-old man on long-term prednisone therapy for eosinophilic pneumonia presented with progressive dyspnea worsened by bending ...

journal_title：Chest

authors： Bokhari SSI,Willens HJ,Lowery MH,Wanner A,deMarchena E

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has been documented to cause community-acquired pneumonias (CAP), notable for necrotizing features. The frequency of occurrence, risk factors, and optimal treatment of CA-MRSA CAP are unclear. METHODS:This was a retrospective analysis ...

journal_title：Chest

authors： Lobo LJ,Reed KD,Wunderink RG

更新日期：2010-07-01 00:00:00