Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?

Abstract:

:OSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction during sleep. Recurrent collapse of the upper airway develops with sleep onset and is associated with both intermittent hypoxemia and sleep fragmentation. The microbiome is a vast and complex polymicrobial ecosystem that coexists with the human organism, and it has been identified as playing significant roles in the development of host immunologic phenotypes. In humans and animal models, changes in gut microbial communities occur with lifestyle behaviors, such as smoking, long-distance travel, dietary preferences, physical exercise, and circadian rhythm disturbances. In parallel, diseases previously attributed in part to lifestyle such as obesity, coronary heart disease, depression, and asthma (also associated with OSA) are now claimed as microbiota related. We therefore posit that altered patterns of sleep and oxygenation, as seen in OSA, will promote specific alterations in gut microbiota that in turn will elicit the immunologic alterations that lead to OSA-induced end-organ morbidities. The present article assesses the potential mechanistic links between OSA-induced changes in gut microbiota and its morbid phenotypes.

journal_name

Chest

journal_title

Chest

authors

Farré N,Farré R,Gozal D

doi

10.1016/j.chest.2018.03.001

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

754-759

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(18)30405-7

journal_volume

154

pub_type

杂志文章

相关文献

CHEST文献大全
  • Gastric rupture complicating post-extubation laryngeal edema and the use of a manual resuscitation bag.

    abstract::This report describes a patient who developed gastric rupture as a result of post-extubation laryngeal edema and the use of a manual resuscitation bag. The association between oxygen administraton and gastric rupture is reviewed. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.3.324

    authors: Eichenhorn MS

    更新日期:1979-09-01 00:00:00

  • Elevated histamine and tryptase levels in smokers' bronchoalveolar lavage fluid. Do lung mast cells contribute to smokers' emphysema?

    abstract::Human lung mast cells have been reported recently to contain small amounts of the elastolytic protease present in the neutrophil and implicated in the pathogenesis of alveolar wall destruction in emphysema. Since mast cells are numerous within alveolar walls, release of inflammatory mediators (and possibly elastase) b...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.1.119

    authors: Kalenderian R,Raju L,Roth W,Schwartz LB,Gruber B,Janoff A

    更新日期:1988-07-01 00:00:00

  • Analysis of neural mechanisms accompanying different intensities of dynamic exercise.

    abstract::The neural mechanisms accompanying dynamic exercise of different intensities were analyzed in dogs and human subjects by means of autoregressive spectral analysis of heart period and arterial pressure variabilities. In the animal experiments, 8 conscious dogs were examined after implanting a solid state pressure gauge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.5_supplement.226s

    authors: Rimoldi O,Furlan R,Pagani MR,Piazza S,Guazzi M,Pagani M,Malliani A

    更新日期:1992-05-01 00:00:00

  • The echocardiographic diagnosis of rupture of a papillary muscle.

    abstract::The echocardiographic diagnosis of acute rupture of a papillary muscle is described. The pertinent findings included (1) decreased systolic motion of the posterior wall, (2) exaggerated septal motion, (3) left ventricular enlargement and pattern suggesting left ventricular diastolic overload, and (4) bizarre flutterin...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.73.2.232

    authors: Ahmad S,Kleiger RE,Connors J,Krone R

    更新日期:1978-02-01 00:00:00

  • Prolonged mechanical ventilation: review of care settings and an update on professional reimbursement.

    abstract::The goal of this article is to provide an update on recent changes to current procedural terminology codes used for billing physician services for mechanical ventilation in chronic care facilities. In addition to billing information, background data relevant to prolonged mechanical ventilation are reviewed. Topics cov...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.07-0656

    authors: White AC,O'Connor HH,Kirby K

    更新日期:2008-02-01 00:00:00

  • The effect of marital status on the presentation and outcomes of elderly male veterans hospitalized for pneumonia.

    abstract:BACKGROUND:Although marital status has been shown to affect the outcomes of many conditions, there are limited data on the relationships between marital status and the presentation and outcomes of pneumonia. METHODS:We used Veterans Affairs administrative databases to identify a retrospective cohort of male veterans a...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.11-3183

    authors: Metersky ML,Fine MJ,Mortensen EM

    更新日期:2012-10-01 00:00:00

  • Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis.

    abstract:BACKGROUND:Prostasin, a trypsin-like serine protease, is a channel-activating protease and major regulator of epithelial sodium channel-mediated sodium absorption. Its direct inhibition by camostat represents a potential approach to inhibiting sodium transport in cystic fibrosis (CF). METHODS:To determine whether a to...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.12-2431

    authors: Rowe SM,Reeves G,Hathorne H,Solomon GM,Abbi S,Renard D,Lock R,Zhou P,Danahay H,Clancy JP,Waltz DA

    更新日期:2013-07-01 00:00:00

  • A 3-month-old infant with recurrent apparent life-threatening events in a car seat.

    abstract::A 3-month-old infant was brought to clinic for evaluation of recurrent apparent life-threatening events (ALTEs). Two ALTE episodes occurred while the infant was sleeping in a safety car seat. The first one occurred when he was 4 weeks old. His mother noticed that he was not breathing; he appeared limp with full body c...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-1595

    authors: DelRosso LM

    更新日期:2015-04-01 00:00:00

  • Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta 2-adrenergic stimulation with terbutaline in healthy subjects.

    abstract:OBJECTIVE:To study the effect of intravenous (i.v.) terbutaline on potassium (K) and magnesium (Mg) distribution, ECG changes, and prevalence of ventricular ectopic beats in healthy subjects. DESIGN:Randomized double-blind, placebo-controlled crossover. Subjects received either placebo or terbutaline (bolus, 0.25 mg; ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.106.6.1654

    authors: Tveskov C,Djurhuus MS,Klitgaard NA,Egstrup K

    更新日期:1994-12-01 00:00:00

  • Thomas A. Neff lecture. Application of expression profiling to the developing lung: identification of putative regulatory networks controlling matrix production.

    abstract::If we hope to repair damaged lung tissue associated with a variety of acquired and developmental diseases, we must first gain a full appreciation of normal lung development. As an approach, we have utilized Affymetrix (Santa Clara, CA) high-density, oligonucleotide-based microarrays to generate an expression profile o...

    journal_title:Chest

    pub_type:

    doi:10.1378/chest.121.3_suppl.42s

    authors: Mariani TJ,Shapiro SD

    更新日期:2002-03-01 00:00:00

  • Poor prognosis in patients with rheumatoid arthritis hospitalized for interstitial lung fibrosis.

    abstract::Fifty-seven patients with rheumatoid arthritis (RA) were treated in hospital for diffuse interstitial lung fibrosis. Although interstitial fibrosis (either on the basis of lung function tests or chest roentgenograms or both) is fairly common among patients with RA, according to this study interstitial fibrosis of suff...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.1.114

    authors: Hakala M

    更新日期:1988-01-01 00:00:00

  • Propofol-induced pancreatitis: recurrence of pancreatitis after rechallenge.

    abstract::We report a case of pancreatitis, which occurred while the patient was on a propofol drip and then recurred after resolution following an inadvertent rechallenge with propofol. The initial episode was associated with hypertriglyceridemia, whereas the latter was not. The association between propofol and pancreatitis is...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.4.1198

    authors: Kumar AN,Schwartz DE,Lim KG

    更新日期:1999-04-01 00:00:00

  • Emergency room intubations--complications and survival.

    abstract::Forty-three consecutive patients requiring endotracheal intubation in an emergency room were studied prospectively to define the complications associated with intubation and the survival of these patients, and to evaluate emergency room policies. The indications for intubation were acute respiratory failure (ARF) in 2...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.5.541

    authors: Taryle DA,Chandler JE,Good JT Jr,Potts DE,Sahn SA

    更新日期:1979-05-01 00:00:00

  • Mine is bigger than yours: measures of effect size in research.

    abstract::Results of studies that use laboratory tests are often easy to interpret, because we are familiar with the units and how to interpret them. However, this is not the case when the results are presented as ORs, relative risks, correlation, or scores on an unfamiliar scale. This article explains these various indices of ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-2473

    authors: Streiner DL,Norman GR

    更新日期:2012-03-01 00:00:00

  • Myocardial infarction with normal coronary arteries after acute exposure to carbon monoxide.

    abstract::This report describes a 46-year-old white man who suffered an acute myocardial infarction after carbon monoxide exposure. The electrocardiogram and serum enzymes showed myocardial infarction. The coronary angiogram performed one week after admission failed to reveal evidence of coronary obstructive lesions. The case p...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.2.491

    authors: Marius-Nunez AL

    更新日期:1990-02-01 00:00:00

  • Relationship between the electrical (electrocardiographic) and mechanical (echocardiographic) events in Wolff-Parkinson-White syndrome.

    abstract::Studies using epicardial mapping on patients with Wolff-Parkinson-White syndrome have demonstrated that the delta vector of the electrocardiogram is a detector of the location of at least one bypass tract. In order to relate the electrical activities (preexcitation) with the mechanical activity (septal and ventricular...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.4.463

    authors: Lebovitz JA,Mandel WJ,Laks MM,Kraus R,Weinstein S

    更新日期:1977-04-01 00:00:00

  • Predictors of short-term rehospitalization following discharge of patients hospitalized with community-acquired pneumonia.

    abstract:BACKGROUND:Among patients hospitalized for community-acquired pneumonia (CAP), the risk factors for short-term hospital readmission after discharge are unknown. METHODS:We conducted a prospective observational study of 1,117 patients who had been discharged alive after hospitalization for CAP. We collected variables a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-2950

    authors: Capelastegui A,España Yandiola PP,Quintana JM,Bilbao A,Diez R,Pascual S,Pulido E,Egurrola M

    更新日期:2009-10-01 00:00:00

  • Left ventricular laceration due to stented prosthesis.

    abstract::Complications following open chest massage in patients with porcine xenografts in the mitral location have not been previously described. The authors report a case of cardiac resuscitation following mitral valve replacement with a stented porcine valve. The patient died following brief closed chest, and then, prolonge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.77.2.216

    authors: Wild LM,Lajos TZ,Lee AB Jr,Wright J

    更新日期:1980-02-01 00:00:00

  • Successful withdrawal of long-term epoprostenol therapy for pulmonary arterial hypertension.

    abstract:BACKGROUND:IV epoprostenol treatment of pulmonary arterial hypertension (PAH) has been believed to require an indefinite duration of therapy OBJECTIVE:To describe the successful discontinuation of long-term epoprostenol therapy in four patients DESIGN:Case reports SETTING:Outpatient clinic, tertiary-care hospital P...

    journal_title:Chest

    pub_type: 杂志文章

    doi:

    authors: Kim NH,Channick RN,Rubin LJ

    更新日期:2003-10-01 00:00:00

  • Research bronchoscopies do not adversely affect HIV-infected individuals' future health-care decisions.

    abstract:STUDY OBJECTIVES:Asymptomatic HIV-infected individuals are increasingly recruited for studies involving invasive procedures such as bronchoscopy. We sought to determine the response to and outcome of a request for a research bronchoscopy in HIV-positive individuals with no respiratory disease, and whether this would ad...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.1.284

    authors: Lipman MC,Stobbs D,Madge S,Miller R,Johnson MA

    更新日期:1998-07-01 00:00:00

  • The role of bacteria in exacerbations of COPD. A constructive view.

    abstract::The role of infection in exacerbations of COPD remains controversial and incompletely understood. Although some investigators believe that bacteria are not important for patients with exacerbation, we disagree and believe that patients with at least two of the three cardinal symptoms of exacerbation should receive ant...

    journal_title:Chest

    pub_type: 评论,杂志文章,评审

    doi:10.1378/chest.118.1.204

    authors: Murphy TF,Sethi S,Niederman MS

    更新日期:2000-07-01 00:00:00

  • Endobronchial tamponade therapy for intractable hemoptysis.

    abstract::The management of intractable hemoptysis, short of surgery, is poorly defined. A technique is described utilizing a bronchofiberscope and a Fogarty catheter that not only provides visualization of the source of bleeding, but also furnishes a means of controlling the bleeding. This technique can also be used through a ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.67.4.482

    authors: Gottlieb LS,Hillberg R

    更新日期:1975-04-01 00:00:00

  • New pentasaccharides for the prophylaxis of venous thromboembolism: clinical studies.

    abstract::Fondaparinux, a selective inhibitor of factor Xa, is the first of a new class of antithrombotic compounds, the synthetic pentasaccharides. Its benefit-to-risk ratio in preventing venous thromboembolism after major orthopedic surgery was investigated in four randomized, double-blind international phase III trials in pa...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:

    authors: Turpie AG,Eriksson BI,Bauer KA,Lassen MR

    更新日期:2003-12-01 00:00:00

  • Specific expiratory muscle training in COPD.

    abstract:BACKGROUND:There are several reports showing that expiratory muscle strength and endurance can be impaired in patients with COPD. This muscle weakness may have clinically relevant implications. Expiratory muscle training tended to improve cough and to reduce the sensation of respiratory effort during exercise in patien...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.124.2.468

    authors: Weiner P,Magadle R,Beckerman M,Weiner M,Berar-Yanay N

    更新日期:2003-08-01 00:00:00

  • The hypotensive effect of L-arginine is associated with increased expired nitric oxide in humans.

    abstract::Endothelial metabolism of L-arginine to L-citrulline and the potent vasodilator, nitric oxide (NO), is important in the regulation of vascular tone and resting BP. L-arginine improves abnormal endothelium-dependent vasodilation in the setting of hypercholesterolemia and has a vasodilatory effect in normal vessels, eff...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.109.6.1550

    authors: Mehta S,Stewart DJ,Levy RD

    更新日期:1996-06-01 00:00:00

  • Encroachment upon the lungs of large chronic pericardial effusion. Pulmonary tamponade?

    abstract::Pulmonary encroachment by a large chronic pericardial effusion is reported in a woman with pericardiocentesis whom we recently treated. A restrictive pulmonary impairment is documented with pulmonary function data obtained before and after drainage of the effusion and the patient's dyspnea improved. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.2.434

    authors: Kane GC,Figueroa WG

    更新日期:1988-02-01 00:00:00

  • Effects of long-term treatment with corticosteroids in COPD.

    abstract:STUDY OBJECTIVE:To determine the effectiveness of treatment with corticosteroids in patients with COPD. METHODS:In this study, we investigated the effect of a 2-year treatment with corticosteroids on clinical symptoms and the decline of lung function in 58 nonallergic patients with COPD. Subjects were treated in a dou...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.109.5.1156

    authors: Renkema TE,Schouten JP,Koëter GH,Postma DS

    更新日期:1996-05-01 00:00:00

  • The prognostic value of undetectable highly sensitive cardiac troponin I in patients with acute pulmonary embolism.

    abstract:BACKGROUND:Elevated cardiac troponin levels have been shown to be associated with adverse outcomes in patients with acute pulmonary embolism (PE). However, few data address the management implications of undetectable cardiac troponin I (cTnI) using a highly sensitive assay. We hypothesized that undetectable cTnI predic...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-0700

    authors: Hakemi EU,Alyousef T,Dang G,Hakmei J,Doukky R

    更新日期:2015-03-01 00:00:00

  • Asbestos-related rounded atelectasis. Radiologic and mineralogic data in 23 cases.

    abstract::A retrospective study was conducted in 23 subjects with previous occupational exposure to asbestos and exhibiting rounded atelectasis (RA) on high-resolution computed tomography scan (HRCT scan) to evaluate the retention of asbestos bodies (ABs) using light microscopy in the bronchoalveolar lavage (BAL) fluid or lung ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.2.477

    authors: Voisin C,Fisekci F,Voisin-Saltiel S,Ameille J,Brochard P,Pairon JC

    更新日期:1995-02-01 00:00:00

  • Pre- and postoperative pulmonary function abnormalities in coronary artery revascularization surgery.

    abstract::Pulmonary function studies were conducted one to two days prior to, two weeks after, and an average of 116 days after coronary artery revascularization surgery. Preoperation it was found that 11 of 19 patients had mild to moderate obstruction, 8 of 17 had diffusing capacity less than 80 percent of predicted, and 9 of ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.73.3.316

    authors: Braun SR,Birnbaum ML,Chopra PS

    更新日期:1978-03-01 00:00:00