The role of bacteria in exacerbations of COPD. A constructive view.

Abstract:

:The role of infection in exacerbations of COPD remains controversial and incompletely understood. Although some investigators believe that bacteria are not important for patients with exacerbation, we disagree and believe that patients with at least two of the three cardinal symptoms of exacerbation should receive antibiotic therapy. With an open-minded view of the area, we review the data, showing that bacteriologic studies, pathologic investigations, and clinical trials all support roles for bacteria and antibiotic therapy in this disease. Still, many questions remain, and future studies will be needed to better define the mechanisms of bacterial invasion in the bronchitic patient and to develop effective vaccines to prevent exacerbations. In the meantime, we must rely on antibiotic therapy, and we will need prospective studies to corroborate preliminary findings showing that different patients may require different therapies; thus, patient subsetting may be vital in the selection of antibiotic therapy for exacerbations of COPD.

journal_name

Chest

journal_title

Chest

authors

Murphy TF,Sethi S,Niederman MS

doi

10.1378/chest.118.1.204

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

204-9

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)39023-1

journal_volume

118

pub_type

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