Abstract:
:The role of infection in exacerbations of COPD remains controversial and incompletely understood. Although some investigators believe that bacteria are not important for patients with exacerbation, we disagree and believe that patients with at least two of the three cardinal symptoms of exacerbation should receive antibiotic therapy. With an open-minded view of the area, we review the data, showing that bacteriologic studies, pathologic investigations, and clinical trials all support roles for bacteria and antibiotic therapy in this disease. Still, many questions remain, and future studies will be needed to better define the mechanisms of bacterial invasion in the bronchitic patient and to develop effective vaccines to prevent exacerbations. In the meantime, we must rely on antibiotic therapy, and we will need prospective studies to corroborate preliminary findings showing that different patients may require different therapies; thus, patient subsetting may be vital in the selection of antibiotic therapy for exacerbations of COPD.
journal_name
Chestjournal_title
Chestauthors
Murphy TF,Sethi S,Niederman MSdoi
10.1378/chest.118.1.204subject
Has Abstractpub_date
2000-07-01 00:00:00pages
204-9issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(15)39023-1journal_volume
118pub_type
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