Abstract:
:If we hope to repair damaged lung tissue associated with a variety of acquired and developmental diseases, we must first gain a full appreciation of normal lung development. As an approach, we have utilized Affymetrix (Santa Clara, CA) high-density, oligonucleotide-based microarrays to generate an expression profile of the entire process of rodent lung development, which will be made publicly available. Our initial results were internally consistent and correlated closely with those generated with standard expression techniques such as Northern hybridization. We have verified known expression of genes, found other genes with previously unsuspected expression during lung development, as well as uncovered many expressed sequence tags whose role in lung development awaits further study. Data mining reveals close relationships of expression profiles between specific genes, suggesting novel regulatory relationships. In the future, application of these methods to the study of gene-targeted mice with abnormal lung development should uncover pathways of airway and alveolar development. Ultimately, expression profiling of diseased lungs might allow us to understand why the lung fails to repair, and strategies to influence repair might become apparent.
journal_name
Chestjournal_title
Chestauthors
Mariani TJ,Shapiro SDdoi
10.1378/chest.121.3_suppl.42ssubject
Has Abstractpub_date
2002-03-01 00:00:00pages
42S-44Sissue
3 Suppleissn
0012-3692issn
1931-3543pii
S0012-3692(15)35459-3journal_volume
121pub_type
相关文献
CHEST文献大全abstract:BACKGROUND:In patients who have experienced acute myocardial infarction (MI), primary percutaneous coronary intervention (PCI) has been shown to be of benefit in terms of clinical outcomes. However, the value of performing routine PCI in patients with early MI (ie, an MI occurring > 12 h to < or = 7 days before patient...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.1.38
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:COPD is a major cause of morbidity and mortality in the United States as well as throughout the rest of the world. An exacerbation of COPD (periodic escalations of symptoms of cough, dyspnea, and sputum production) is a major contributor to worsening lung function, impairment in quality of life, need for urg...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.14-1676
更新日期:2015-04-01 00:00:00
abstract:STUDY OBJECTIVE:To examine the relation between left atrial (LA) function and exercise performance. DESIGN AND SETTING:Retrospective study at a referral cardiopulmonary exercise laboratory in a university hospital. PATIENTS:Forty-one patients with recent myocardial infarction. INTERVENTIONS:M-mode echocardiography a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.4.922
更新日期:1997-04-01 00:00:00
abstract::Two cases are presented in which a Dormia ureteral stone dislodger with straight filiform tip was used to retrieve broken central venous pressure catheters from the right side of the heart and vena cavae. It should be emphasized that this particular model is more easily passed into the vascular system and more easily ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.3.435
更新日期:1976-03-01 00:00:00
abstract::False-negative supine M-mode echocardiograms occur in some patients with proved mitral valve prolapse. To investigate further, we performed M-mode echocardiography (MME) during standing and after the inhalation of amyl nitrite in 17 patients (group 1) selected for auscultatory evidence of mitral valve prolapse (MVP) b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.82.2.158
更新日期:1982-08-01 00:00:00
abstract::A new, simpler method to re-expand collapsed lungs was introduced in 14 procedures in 12 critically ill patients. To close the bronchus, we wedge the fiberoptic bronchoscope into each segment or subsegment of the collapsed lung instead of using a balloon cuff. Room air was then insufflated into the atelectatic alveoli...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.2.435
更新日期:1990-02-01 00:00:00
abstract::This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that i...
journal_title:Chest
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1378/chest.126.3_suppl.429S
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:The leading cause of pericardial effusion in urban hospitals is now AIDS-related pathologies. Clinically, these effusions are a diagnostic and management dilemma. In our institution, pericardial biopsy and operative drainage have become part of the diagnostic and management plan. Surgical intervention, howev...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.6.1522
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are recommended as initial maintenance treatments for COPD, with their combination (LABA-LAMA) advocated as the disease progresses. Randomized trials comparing the effectiveness of this combination with the alternative combination...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.03.005
更新日期:2019-06-01 00:00:00
abstract::Improved airway resistance following bronchodilator inhalation is not always accompanied by improvement in forced expiratory flow. We studied 241 patients with airways obstruction to learn whether changes in static lung volumes (vital capacity and function residual capacity measured by body plethysmography [FRCB]) wou...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.76.6.622
更新日期:1979-12-01 00:00:00
abstract::Fenoterol hydrobromide (Berotec; formerly Th 1165a) is a sympathomimetic bronchodilator drug. Twenty subjects with mild to moderate reversible bronchospasm completed a double-blind multiple crossover study of single doses of 5 mg, 7.5 mg, and 10 mg of fenoterol hydrobromide, 24 mg of ephedrine, and placebo. Spirometri...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.72.3.291
更新日期:1977-09-01 00:00:00
abstract::Autopsy findings and a morphometric study of the lungs were compared in 18 subjects receiving nocturnal oxygen and 15 receiving continuous oxygen in the National Heart, Lung, and Blood Institute Nocturnal Oxygen Therapy Trial (about half of those who died). The emphysema score, average interalveolar wall distance, cen...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.86.2.230
更新日期:1984-08-01 00:00:00
abstract::Idiopathic bronchiolitis obliterans with organizing pneumonia (BOOP) is a clinicopathologic syndrome characterized by an indolent course and favorable prognosis. This report describes five patients with a fulminating and life-threatening variant of this syndrome. Four patients presented with respiratory failure requir...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.1.271
更新日期:1995-07-01 00:00:00
abstract::Despite many years of clinical research, there is still no effective therapy for malignant pleural mesothelioma (MPM). Untreated, the prognosis is poor, with a median survival of < 1 year. Single-agent or combination chemotherapy as well as radiotherapy have not shown persistent improvements in response or survival. I...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.123.2.551
更新日期:2003-02-01 00:00:00
abstract::We report a case of pleural dissemination of invasive thymoma, which was successfully treated with intrathoracic chemothermotherapy following panpleuropneumonectomy. Intrathoracic chemothermotherapy in combination with surgery may be a hopeful adjuvant treatment to control pleural disseminated lesions of invasive thym...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.6.1884
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND AND STUDY OBJECTIVES:Noninvasive positive airway pressure may play a significant role in treating patients with congestive heart failure (CHF). We tested our hypothesis that noninvasive bilevel positive airway pressure improves left ventricular performance in patients with chronic CHF secondary to severe sys...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.118.4.1004
更新日期:2000-10-01 00:00:00
abstract::We prospectively looked at the prognostic value of bronchoalveolar lavage (BAL) lymphocyte count in 98 patients with recently diagnosed (less than 4 months) untreated sarcoidosis. These 50 men and 48 women (mean age, 37.4) were followed up for a period of 6 to 60 months (mean, 25.6), and were clinically evaluated ever...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.2.380
更新日期:1991-08-01 00:00:00
abstract::POC testing provides an opportunity for clinicians and laboratorians to work together to consider how best to serve the patients within an individual institution. Each health system has unique characteristics relative to patient population, as well as a unique laboratory structure. If physicians, nurses, laboratorians...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.4.1140
更新日期:1999-04-01 00:00:00
abstract::Mycobacterium tuberculosis (MTB) isolation from clinical specimens is the standard for TB diagnosis. Positive MTB cultures are rarely questioned, but false-positive culture rates range from 2% to 4%. In December 2011, two smear-negative, culture-positive TB cases were reported to the Oklahoma State Department of Healt...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-2294
更新日期:2013-07-01 00:00:00
abstract::Irradiation therapy for lung cancer is mostly restricted to conventional methods. To improve therapeutic ratio, we have combined a treatment planning and a gene therapy approach. Three-dimensional conformal radiotherapy is described as carried out by methods of gene therapy for radiation protection using the manganese...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.113.1_supplement.46s
更新日期:1998-01-01 00:00:00
abstract::Although NCPAP is the most efficient nonsurgical treatment for patients with OSA, many patients do not accept sleeping with a nose mask. To determine the factors influencing acceptance, treatment with NCPAP was offered to 95 patients with an AHI greater than 15. After the first night on NCPAP, 47 of 65 patients decide...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.4.1019
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVES:Clinical practice guidelines have been devised to change practitioner performance and to improve the process and outcomes of care. The objective of this study was to determine whether adherence to a practice guideline on noninvasive positive-pressure ventilation (NPPV) for the treatment of patients with acut...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.6.2062
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Walking is a familiar daily activity that is generally limited by breathlessness, whereas cycling is an uncommon physical effort typically limited by leg discomfort. The hypothesis was that patients with COPD would exhibit greater improvements in exercise endurance and relief of breathlessness with bronchodi...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.09-2470
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) is a rare form of interstitial pneumonia and sometimes coexists with a histologic usual interstitial pneumonia (UIP) pattern. This study aimed to describe the distinct clinical features of PPFE with UIP pattern compared with idiopathic pulmonary fibrosis (IPF). METHOD...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-2866
更新日期:2014-11-01 00:00:00
abstract::A 72-year-old physician with myeloid metaplasia developed marked thrombocytosis, pulmonary hypertension, and right heart failure following splenectomy. No cause for the pulmonary hypertension could be found. The pulmonary hypertension and right heart failure returned to normal when hydroxyurea therapy corrected the th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.2.642
更新日期:1993-02-01 00:00:00
abstract::In 283 patients referred for testing in an outpatient pulmonary function laboratory, we studied the single-breath diffusing capacity of the lungs for carbon monoxide (Dco) using the Ogilvie (Og), Jones-Meade (JM), Epidemiological Standardization Project (ESP), and three-phase iterative methods (3PIT, similar to the th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.2.594
更新日期:1994-02-01 00:00:00
abstract::A 60-year-old black woman presented with nonproductive cough of 1-month duration. She had also experienced rapidly progressive dyspnea for 1 week and one bout of vomiting a day before presentation. Her symptoms had failed to improve with a course of amoxicillin-clavulanate. Her medical history was significant for diab...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.15-0388
更新日期:2015-10-01 00:00:00
abstract::We reviewed results of 78 diagnostic thoracoscopic examinations of patients with lung cancer and homolateral pleural effusion. The study stresses the main locations of pleural metastasis in cases of lung cancer and correlates these data with the pleural spread from extrathoracic primary neoplasms. Also pointed out is ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.87.5.649
更新日期:1985-05-01 00:00:00
abstract:STUDY OBJECTIVES:Nasal polyps frequently appear in patients with cystic fibrosis (CF). The aims of this study were to focus on what problems (symptoms, endoscopic findings, and laboratory correlates) nasal polyps cause the CF patient, and how these correlate to the total health situation of this patient group. PATIENT...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.1.40
更新日期:2002-01-01 00:00:00
abstract::This study describes the extent of agreement in classification of chest radiographs using the International Labor Organization (ILO) classification among six readers from the United States and Canada. A set of 119 radiographs was created and read by three Canadian and three US readers. The two ratings of interest were...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.6.1740
更新日期:1998-12-01 00:00:00