Abstract:
:Despite many years of clinical research, there is still no effective therapy for malignant pleural mesothelioma (MPM). Untreated, the prognosis is poor, with a median survival of < 1 year. Single-agent or combination chemotherapy as well as radiotherapy have not shown persistent improvements in response or survival. In general, MPM is a disease confined to the pleural cavity for a long time before metastasizing. Therefore, focus on local treatment seems rational. Surgical resection has been considered the mainstay of treatment by some. However, surgery alone results in high recurrence rates, and the survival benefit remains questionable. In recent years, the emphasis has been on surgery combined with adjuvant therapies. In this article, the present state of surgical management of MPM will be reviewed.
journal_name
Chestjournal_title
Chestauthors
van Ruth S,Baas P,Zoetmulder FAdoi
10.1378/chest.123.2.551subject
Has Abstractpub_date
2003-02-01 00:00:00pages
551-61issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)32470-3journal_volume
123pub_type
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