Surgical treatment of malignant pleural mesothelioma: a review.

Abstract:

:Despite many years of clinical research, there is still no effective therapy for malignant pleural mesothelioma (MPM). Untreated, the prognosis is poor, with a median survival of < 1 year. Single-agent or combination chemotherapy as well as radiotherapy have not shown persistent improvements in response or survival. In general, MPM is a disease confined to the pleural cavity for a long time before metastasizing. Therefore, focus on local treatment seems rational. Surgical resection has been considered the mainstay of treatment by some. However, surgery alone results in high recurrence rates, and the survival benefit remains questionable. In recent years, the emphasis has been on surgery combined with adjuvant therapies. In this article, the present state of surgical management of MPM will be reviewed.

journal_name

Chest

journal_title

Chest

authors

van Ruth S,Baas P,Zoetmulder FA

doi

10.1378/chest.123.2.551

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

551-61

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)32470-3

journal_volume

123

pub_type

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