Esophageal pressure measurements in cardiopulmonary exercise testing.


STUDY OBJECTIVES:We sought to determine the adaptability and effectiveness of a new esophageal balloon technique to measure changes in esophageal pressure (Pes) as a reflection of pleural pressure with progressive incremental exercise testing in normal subjects. DESIGN:An 8F (0.9 cm) esophageal balloon catheter (Smart Cath; Allied Health Products; Riverside, Calif), a CP-100 pulmonary monitor (BiCore Monitoring Systems PC-100; Irvine, Calif), and a flow transducer (Var flex; Allied Health Products; Riverside, Calif) were connected to a breathing valve (model 2700; Hans-Rudolph Inc; Kansas City, Mo). This apparatus was then used to measure Pes during a graded cardiopulmonary exercise test (CPX) to symptom limitation. SETTING:University-affiliated Veterans Affairs Hospital. PARTICIPANTS:Eight nonsmoking volunteers with normal results of pulmonary function tests. INTERVENTIONS:Plots of deltaPes against pressure time product (PTP), minute ventilation (VE), and oxygen consumption (VO2) were obtained. Pes at baseline, anaerobic threshold (AT), and maximum oxygen consumption (VO2max) were obtained by comparing the Pes measurements from the computer printout to the corresponding breath-by-breath measurements on the CPX. MEASUREMENTS AND RESULTS:The flow transducer (Varflex) connection added only 20 mL of dead space to the standard mouthpiece apparatus. The mean maximum work performance was 203+/-32 W. The mean VO2max was 29+/-9 mL/kg/min. The Pes at AT was 16+/-3 cm H2O. The Pes at maximal exercise was 42+/-16 cm H2O. CONCLUSION:The small esophageal balloon was well tolerated by all subjects. Plots of deltaPes vs PTP, VE, and VO2 demonstrated a linear correlation. This apparatus could be added to the standard CPX to assess the contribution of the diaphragm and respiratory muscles in patients with dyspnea.






Thomas AM,Turner RE,Tenholder MF




Has Abstract


1997-09-01 00:00:00
















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    abstract::Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; sh...


    pub_type: 杂志文章,评审


    authors: Durairaj L,Schmidt GA

    更新日期:2008-01-01 00:00:00

  • Characterization of chronic fatigue in patients with sarcoidosis in clinical remission.

    abstract:BACKGROUND:Patients with sarcoidosis frequently complain of fatigue, even when sarcoidosis has come into clinical remission. The primary aim of this study was to assess the severity of fatigue in patients with sarcoidosis in clinical remission and to characterize it according to the international criteria for chronic f...


    pub_type: 杂志文章


    authors: Korenromp IHE,Heijnen CJ,Vogels OJM,van den Bosch JMM,Grutters JC

    更新日期:2011-08-01 00:00:00

  • The changing status of ejection fraction as a predictor of early mortality following surgery for acquired heart disease.

    abstract::Several reports in the literature and our experience prior to 1974 support the thesis that operative risk in patients with acquired heart disease and poor ventricular function (as assessed by a biplane ejection fraction [EF] less than or equal to 0.40) was very significantly increased over the risk in patients with no...


    pub_type: 杂志文章


    authors: Tyers GF,Williams DR,Babb JD,Levenson L,Zelis RF,Waldhausen JA

    更新日期:1977-03-01 00:00:00

  • The Accuracy of Repeated Sleep Studies in OSA: A Longitudinal Observational Study With 14 Nights of Oxygen Saturation Monitoring.

    abstract:BACKGROUND:Strong evidence exists for clinically relevant night-to-night variability of respiratory events in patients with suspected OSA. RESEARCH QUESTION:How many sleep study nights are required to diagnose OSA accurately? STUDY DESIGN AND METHODS:Patients with suspected OSA underwent up to 14 nights of pulse oxim...


    pub_type: 杂志文章


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    更新日期:2020-09-25 00:00:00

  • Iron lung vs mask ventilation in the treatment of acute on chronic respiratory failure in COPD patients: a multicenter study.

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    pub_type: 杂志文章,多中心研究


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    更新日期:2002-01-01 00:00:00

  • Clinical characteristics of unexpected death among young enlisted military personnel: results of a three-decade retrospective surveillance.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2001-08-01 00:00:00

  • Does oximetry contribute to the detection of apneic events? Mathematical processing of the SaO2 signal.

    abstract::The purpose of this study was to assess the ability of continuous nocturnal oximetry to detect sleep apnea syndrome (SAS) and to recognize nonapneic oxyhemoglobin desaturations. Oxygen saturation oscillations, related to successive apneas in SAS or to apneic episodes in COPD or restrictive patients, were quantified us...


    pub_type: 杂志文章


    authors: Pépin JL,Lévy P,Lepaulle B,Brambilla C,Guilleminault C

    更新日期:1991-05-01 00:00:00

  • Multiple aseptic pulmonary nodules with central necrosis in association with pyoderma gangrenosum.

    abstract::Pulmonary manifestations of pyoderma gangrenosum are relatively rare. We report the case of a 45-year-old patient with multiple pulmonary nodules with central necrosis as assessed by CT scan. The patient had a 4-year history of pyoderma gangrenosum with only minor skin manifestations. A CT-guided, fine-needle biopsy o...


    pub_type: 杂志文章


    authors: Krüger S,Piroth W,Amo Takyi B,Breuer C,Schwarz ER

    更新日期:2001-03-01 00:00:00

  • Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group B.

    abstract:PURPOSE:To examine the individual and joint effect of various pretreatment clinical characteristics on the survival of patients with mesothelioma treated by the Cancer and Leukemia Group B (CALGB). PATIENTS AND METHODS:Between June 1984 and September 1994, 337 patients with malignant mesothelioma and no prior chemothe...


    pub_type: 临床试验,杂志文章


    authors: Herndon JE,Green MR,Chahinian AP,Corson JM,Suzuki Y,Vogelzang NJ

    更新日期:1998-03-01 00:00:00

  • Ethnicity in Pulmonary Arterial Hypertension: Possibilities for Novel Phenotypes in the Age of Personalized Medicine.

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    pub_type: 杂志文章,评审


    authors: Medrek SK,Sahay S

    更新日期:2018-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Falsetti HL,Carrol RJ

    更新日期:1976-05-01 00:00:00

  • Better With Ultrasound: Transesophageal Echocardiography.

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    pub_type: 杂志文章,评审


    authors: Jaidka A,Hobbs H,Koenig S,Millington SJ,Arntfield RT

    更新日期:2019-01-01 00:00:00

  • Formoterol suspension aerosol. Comparison with formoterol solution aerosol for 12 weeks in asthmatic patients.

    abstract:UNLABELLED:Formoterol solution aerosol has proved to be a fast and long-acting beta 2-sympathicomimetic drug in many clinical trials. The physical stability, however, was such that storage needed to be at 4 degrees C to 8 degrees C before first use; afterwards, the aerosol could be used for another three months at room...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Maesen FP,Nakratzas G,Bantje TA,Prins J,Zweers PG

    更新日期:1992-11-01 00:00:00

  • VATS (video-assisted thoracic surgery) of undefined pulmonary nodules. Preoperative evaluation of videoendoscopic resectability.

    abstract::Peripheral undefined pulmonary nodules have become a favorable indication for the videoendoscopic approach in thoracic surgery. In our latest experience, we also successfully applied this technique in centrally located lesions of the lung. In reviewing our first 29 cases, we looked for preoperative features of videoen...


    pub_type: 杂志文章


    authors: Schwarz CD,Lenglinger F,Eckmayr J,Schauer N,Hartl P,Mayer KH

    更新日期:1994-11-01 00:00:00

  • Clinical challenges in pulmonary hypertension: Roger S. Mitchell lecture.

    abstract::Despite major advances in our understanding of the pathophysiologic processes leading to pulmonary arterial hypertension and recent developments in therapeutic approaches, the long-term prognosis for patients with pulmonary arterial hypertension remains unsatisfactory. Early detection and adequate clinical classificat...


    pub_type: 杂志文章,评审


    authors: Provencher S,Jais X,Yaici A,Sitbon O,Humbert M,Simonneau G

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    pub_type: 杂志文章


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    更新日期:2000-12-01 00:00:00

  • Doxycycline pleurodesis for pneumothorax in patients with AIDS.

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    authors: Read CA,Reddy VD,O'Mara TE,Richardson MS

    更新日期:1994-03-01 00:00:00

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  • High-Flow Nasal Cannula in the Immediate Postoperative Period: A Systematic Review and Meta-analysis.

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  • Reason-Giving and Medical Futility: Contrasting Legal and Social Discourse in the United States With the United Kingdom and Ontario, Canada.

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    pub_type: 杂志文章


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    authors: Davis WJ,Pang LM,Chernack WJ,Mellins RB

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    pub_type: 杂志文章,评审


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