Abstract:
:Bitolterol mesylate (WIN 37284) is alpha-[tert-butylaminomethyl]-3,4-dihydroxybenzyl alcohol 3,4-di(p-toluate) methanesulfonate, a diester sympathomimetic amine bronchodilator. Bitolterol mesylate represents a new concept in sympathomimetic amine therapy. It is "prodrug" which is inactive until altered in the body. The intact 3,4-diester molecule is metabolized by esterase hydrolysis to release the active catecholamine, N-t-butylarterenol. Because the level of esterase is greater in the pulmonary tissue than in the heart, bitolterol mesylate aerosol was shown to be an effective bronchodilator drug, without any significant cardic side effects. The onset of action was rapid and lasted more than six hours. The improvement over baseline values in the forced expiratory volume in the first second and the mean forced expiratory flow during the middle half of the forced vital capacity was greater than 15 percent and 30 percent, respectively.
journal_name
Chestjournal_title
Chestauthors
Kass I,Mingo TSdoi
10.1378/chest.78.2.283subject
Has Abstractpub_date
1980-08-01 00:00:00pages
283-7issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(16)55982-0journal_volume
78pub_type
临床试验,杂志文章相关文献
CHEST文献大全abstract:BACKGROUND:COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.11.033
更新日期:2017-05-01 00:00:00
abstract::A 60-year-old black woman presented with nonproductive cough of 1-month duration. She had also experienced rapidly progressive dyspnea for 1 week and one bout of vomiting a day before presentation. Her symptoms had failed to improve with a course of amoxicillin-clavulanate. Her medical history was significant for diab...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.15-0388
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a devastating disease, yet validated, reliable criteria for evaluating patient response to therapies in clinical trials are lacking. METHODS:To optimize selection of end point criteria for the study of interferon (IFN)-gamma1b in patients with IPF, we retrospectively a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.1.171
更新日期:2005-01-01 00:00:00
abstract::Nd-YAG laser resection of a completely obstructing right mainstem tumor in a 36-year-old man was complicated by right lung hyperinflation and left lung collapse and accompanying ventilatory failure. This was attributed to obstruction of the right mainstem bronchus during exhalation, but not inhalation, in a patent but...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.6.1302
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:In daily clinical work, we often face delayed or recurrent pneumothorax after radiofrequency (RF) ablation for lung tumors, but a large study on this theme has not been done. Thus, we examined the rate of delayed or recurrent pneumothorax after RF ablation for lung tumors and the risk factors associated with...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-1499
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The US Centers for Disease Control and Prevention has implemented a new, multitiered definition for ventilator-associated events (VAEs) to replace their former definition of ventilator-associated pneumonia (VAP). We hypothesized that the new definition could be implemented in an automated, efficient, and rel...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-2255
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the usefulness of a specific inspiratory muscle training in Duchenne muscular dystrophy (DMD). PATIENTS AND METHODS:Fifteen patients with DMD started 6 months of training the inspiratory muscles and 15 patients served as a control group. Pulmonary and inspiratory muscle func...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.105.2.475
更新日期:1994-02-01 00:00:00
abstract::A pulmonary arteriovenous malformation was embolized in a patient with hereditary hemorrhagic telangiectasia. Several unusual complications, including early deflation of a detachable balloon, migration of a coil, and development of severe pulmonary hypertension, occurred. Pulmonary hypertension was attributed to a coe...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.109.5.1401
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVES:Studies documenting the increased incidence of exercise-induced bronchospasm (EIB) in figure skaters have employed a method that incorporates on-ice exercise with rink-side spirometry. The literature suggests that bronchial provocation challenge testing is better than exercise testing for identifying EIB. To...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.3.649
更新日期:1999-03-01 00:00:00
abstract::beta 2-agonist bronchodilators delivered by metered-dose inhalers (MDI) are commonly used in the treatment of bronchospasm in both intubated and nonintubated patients. Substantial data support the effectiveness of MDI delivery systems in nonintubated patients. However, few studies have examined the effectiveness of MD...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.1.210
更新日期:1995-01-01 00:00:00
abstract::A 53-year-old man with tracheobronchomalacia had two stents placed in his airways to maintain patency. He ingested one of the tracheal stents that was inadvertently dislodged during a brief coughing episode. The swallowed stent was recovered without complications. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.3.875
更新日期:1995-09-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the efficacy of albuterol by metered-dose inhaler (MDI) and spacer compared to a nebulizer. DESIGN:A prospective, open-label study. SETTING:Large urban emergency department (ED). PATIENTS:All consecutive adult asthma patients over a 2.5-year period. INTERVENTIONS:ED personnel used a st...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.4.1036
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Central sleep apnea (CSA) is common among patients with heart failure (HF) and is promoted by elevated CO2 chemosensitivity. Left atrial size is a marker of the hemodynamic severity of HF. The aim of this study was to determine if left atrial size predicts chemosensitivity to CO2 and CSA in patients with HF....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-0309
更新日期:2014-07-01 00:00:00
abstract::A patient had left ventricular pseudoaneurysm after mitral valve replacement surgery. The diagnosis was made by color flow Doppler demonstration of systolic flow between the left ventricular chamber and an echo-free space posterior to the heart which was initially interpreted as localized pleural effusion. Color Doppl...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.1.231
更新日期:1989-01-01 00:00:00
abstract::False-negative results from transthoracic needle aspiration biopsy of malignant lung masses may occur if a central necrotic area is present and is the source of the biopsy material. The purpose of this study is to determine if the use of ultrasonic guidance can improve the sensitivity of lung needle biopsies in this c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.5.1452
更新日期:1993-05-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the incidence and mortality as well as to analyze the clinical and pathologic changes of aortic dissection. DESIGN AND SETTING:A population-based longitudinal study over 27 years on a study population of 106,500, including 66 hospitalized and 18 nonhospitalized consecutively observed pati...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.5.1271
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVES:To compare the systemic bioavailability (assessed by cortisol suppression) of high-dose budesonide when given by four inhaler devices and orally. Also studied are the relative systemic potencies of three inhaled steroids (budesonide, fluticasone propionate, and beclomethasone dipropionate) when given by mete...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.115.5.1278
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Pulmonary artery remodeling triggered by alveolar hypoxia is considered the main mechanism of pulmonary hypertension (PH) in COPD patients. We hypothesized that the risk for PH in COPD is increased by an elevation in the proinflammatory cytokines interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1)...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-2420
更新日期:2009-09-01 00:00:00
abstract::Fifteen patients (range of ages, 18 to 35 years) who survived an acute episole of the adult respiratory distress syndrome caused by mechanical or thermal injuries, sepsis, and shock were studied during 1 to 30 months after recovery. The patients had had no previous pulmonary diseases, and only two had been smokers. Al...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.74.3.247
更新日期:1978-09-01 00:00:00
abstract::We present two cases of sarcoidosis complicated by HIV infection. Each case had a different level of sarcoidosis activity and coexisted with either an AIDS-related infection or a HIV-positive state. Manifestations of sarcoidosis were not apparent in the patient with the AIDS-defining opportunistic infection, but were ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.5.1454
更新日期:1992-05-01 00:00:00
abstract::This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that i...
journal_title:Chest
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1378/chest.126.3_suppl.429S
更新日期:2004-09-01 00:00:00
abstract:STUDY OBJECTIVE:In these days, it was reported that bone marrow (BM) cells might take part in the remodeling of some systemic vascular diseases; however, it remains unknown whether the BM cells were involved in the vascular remodeling of pulmonary arteries and the progression of pulmonary hypertension (PH). The purpose...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.5.1793
更新日期:2005-05-01 00:00:00
abstract::We studied the incidence and mechanisms of cardiovascular complications and postoperative respiratory insufficiency associated with GA and Nd:YAG laser endobronchial tumor resection. The records of 73 patients undergoing 87 procedures were reviewed. Preoperative status, anesthetic methods and perioperative complicatio...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.1.72
更新日期:1991-01-01 00:00:00
abstract::We describe the Ca2+ movements in smooth muscle cells at rest and during activation and relaxation as deduced from transplasmalemmal Ca2+ fluxes and contractile respnses. The general picture which emerges is: the resting cell has a [Ca2+]cyt below 10(-7) M and large gradients are poised across both the cell membrane a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.1_supplement.157
更新日期:1980-07-01 00:00:00
abstract:STUDY OBJECTIVE:To examine the hemodynamic and metabolic short-term effects of hypophosphatemia correction in patients with septic shock receiving catecholamine therapy. DESIGN:Prospective, single cohort study. SETTING:ICU, university hospital. PATIENTS:Ten patients with septic shock and hypophosphatemia below 2 mg/...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.6.1698
更新日期:1995-06-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the extent to which a mixture of human gastric juice and enteral formula stained with two concentrations of FD&C Blue No. 1 food dye (0.8 and 1.5 mL/L) is visible in suctioned tracheobronchial secretions following three forced small-volume pulmonary aspirations over a 6-h period in an anima...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.1.276
更新日期:2002-07-01 00:00:00
abstract::Body position can lead to respiratory symptoms and affect gas exchange in disease states. We describe a patient with carcinoma of the left lung in whom dyspnea and oxygen desaturation developed in the right lateral position only. Fiberoptic bronchoscopic study demonstrated a tumor mass protruding into the left main-st...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.5.826
更新日期:1983-05-01 00:00:00
abstract::Pancreaticopleural fistula secondary to chronic pancreatitis is a rare cause of recurrent pleural effusion. The demonstration of the fistula with endoscopic retrograde pancreatography and CT is invasive or limited. We report in two patients the use of magnetic resonance pancreatography as a noninvasive alternative to ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.3.912
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Physicians are often asked about complementary therapies by patients with cancer, and data show that the interest in and use of these therapies among patients with cancer is common. Therefore, it is important to assess the current evidence base on the benefits and risks of complementary therapies (modalities...
journal_title:Chest
pub_type: 杂志文章,实务指引
doi:10.1378/chest.12-2364
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Cilia line the surface of the respiratory tract and beat in a coordinated wave to protect the lungs against infection. Bardet Biedl Syndrome (BBS) is a rare condition attributed to cilia dysfunction. Murine models of BBS suggest a respiratory phenotype; however, no reports have studied the translation of the...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-2913
更新日期:2015-03-01 00:00:00