Abstract:
:In small-cell lung cancer, the optimal combination of chemotherapy and radiotherapy is not clearly established. To assess the value of delayed thoracic radiotherapy, we performed a randomized clinical trial in 53 complete responder patients after eight courses of chemotherapy. Twenty-seven patients received a mean of 46.5 Gy-equivalent of radiotherapy and 26 patients received no treatment until relapse. No patient dropped out of the study. Median survival time from radiotherapy randomization was 316 days in the radiotherapy group and 496 days in the no radiotherapy group. No difference was observed in survival between the two groups (p = 0.66, log-rank test) perhaps because of the small sample size. In fact, this delayed thoracic radiotherapy seemed to worsen the outcome of complete responders with small-cell lung cancer and should be avoided.
journal_name
Chestjournal_title
Chestauthors
Lebeau B,Chastang C,Brechot JM,Capron Fdoi
10.1378/chest.104.3.726subject
Has Abstractpub_date
1993-09-01 00:00:00pages
726-33issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(16)38862-6journal_volume
104pub_type
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