A randomized trial of delayed thoracic radiotherapy in complete responder patients with small-cell lung cancer. Petites Cellules Group.

Abstract:

:In small-cell lung cancer, the optimal combination of chemotherapy and radiotherapy is not clearly established. To assess the value of delayed thoracic radiotherapy, we performed a randomized clinical trial in 53 complete responder patients after eight courses of chemotherapy. Twenty-seven patients received a mean of 46.5 Gy-equivalent of radiotherapy and 26 patients received no treatment until relapse. No patient dropped out of the study. Median survival time from radiotherapy randomization was 316 days in the radiotherapy group and 496 days in the no radiotherapy group. No difference was observed in survival between the two groups (p = 0.66, log-rank test) perhaps because of the small sample size. In fact, this delayed thoracic radiotherapy seemed to worsen the outcome of complete responders with small-cell lung cancer and should be avoided.

journal_name

Chest

journal_title

Chest

authors

Lebeau B,Chastang C,Brechot JM,Capron F

doi

10.1378/chest.104.3.726

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

726-33

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)38862-6

journal_volume

104

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CHEST文献大全
  • Oxidative stress after lung resection therapy: A pilot study.

    abstract:STUDY OBJECTIVES:To investigate whether oxidative stress occurs following lobectomy and pneumonectomy and to evaluate whether markers of oxidative stress might be of value in the assessment of the diagnosis, course, and prognosis of postoperative complications. DESIGN:A prospective study. SETTING:A specialized thorac...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.4.999

    authors: Lases EC,Duurkens VA,Gerritsen WB,Haas FJ

    更新日期:2000-04-01 00:00:00

  • Measurement of surface temperature in lung cancer.

    abstract::We measured the surface temperature of the tumors in 27 patients with primary lung cancer, using a flexible bronchofiberscope and a thermometer made from chromel-constantan. The thermometer was inserted into the aspiration channel of the bronchofiberscope, and temperature was studied under bronchofiberscopic located i...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.81.1.62

    authors: Ohgimi T,Akiyama S,Shimokata K

    更新日期:1982-01-01 00:00:00

  • Subepicardial infarction, myocardial impression, and ventricular penetration by sutureless electrode and leads.

    abstract::Postmortem examination two weeks following implantation of a demand pacemaker with sutureless electrodes demonstrated that (1) the loops of intrapericardial electrode leads indented the myocardium and produced a circumscribed area of subepicardial necrosis, and (2) one of the electrode coils protruded into the right v...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.1.80

    authors: Steinke WE,Thomas FT,ul Hassan Z,Mendoza RA,Gear AS

    更新日期:1976-07-01 00:00:00

  • Hemodynamic effects of epoprostenol in patients with systemic sclerosis and pulmonary hypertension.

    abstract:STUDY OBJECTIVES:To determine the cause of pulmonary hypertension (PH) in systemic sclerosis (SSc) patients since PH can occur because of pulmonary arteriopathy, pulmonary parenchymal destruction, and left ventricular cardiac dysfunction. DESIGN AND SETTING:Consecutive case series in a university hospital. PATIENTS:N...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.4.1077

    authors: Strange C,Bolster M,Mazur J,Taylor M,Gossage JR,Silver R

    更新日期:2000-10-01 00:00:00

  • Löffler's syndrome secondary to crack cocaine.

    abstract::Eosinophilic pulmonary infiltration is an uncommon presentation from cocaine abuse. We present a patient with migratory pulmonary infiltrates and eosinophilia consistent with Löffler's syndrome. Our review uncovered two other similar patients. The importance of early recognition is stressed in our report. Either absti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.5.1599

    authors: Nadeem S,Nasir N,Israel RH

    更新日期:1994-05-01 00:00:00

  • Influence of deviation from guidelines on the outcome of community-acquired pneumonia.

    abstract:STUDY OBJECTIVE:s: Consensus guidelines for the empirical treatment of community-acquired pneumonia (CAP) have been published. We investigated the following factors: (1) the degree of adherence to American Thoracic Society (ATS) and the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) guidelines; and (2) the...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.122.2.612

    authors: Menéndez R,Ferrando D,Vallés JM,Vallterra J

    更新日期:2002-08-01 00:00:00

  • Dynamic expiratory tracheal collapse in COPD: correlation with clinical and physiologic parameters.

    abstract:BACKGROUND:COPD has been described as a risk factor for excessive expiratory tracheal collapse, but its prevalence and clinical correlates have not been fully determined. The purpose of this study is to prospectively determine the prevalence of excessive expiratory tracheal collapse among patients with COPD and to test...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-0299

    authors: Boiselle PM,Michaud G,Roberts DH,Loring SH,Womble HM,Millett ME,O'Donnell CR

    更新日期:2012-12-01 00:00:00

  • Latent class analysis identifies distinct phenotypes of primary graft dysfunction after lung transplantation.

    abstract:BACKGROUND:There is significant heterogeneity within the primary graft dysfunction (PGD) syndrome. We aimed to identify distinct grade 3 PGD phenotypes based on severity of lung dysfunction and patterns of resolution. METHODS:Subjects from the Lung Transplant Outcomes Group (LTOG) cohort study with grade 3 PGD within ...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.12-1480

    authors: Shah RJ,Diamond JM,Cantu E,Lee JC,Lederer DJ,Lama VN,Orens J,Weinacker A,Wilkes DS,Bhorade S,Wille KM,Ware LB,Palmer SM,Crespo M,Localio AR,Demissie E,Kawut SM,Bellamy SL,Christie JD

    更新日期:2013-08-01 00:00:00

  • Pulmonary edema associated with hyperbaric oxygen therapy.

    abstract::We report three cases of pulmonary edema associated with hyperbaric oxygen therapy, including one fatality. All three patients had cardiac disease and reduced left ventricular (LV) ejection fractions (EFs). Two patients had diabetes, and one patient had severe aortic stenosis. Hyperbaric oxygen therapy may contribute ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.4.1407

    authors: Weaver LK,Churchill S

    更新日期:2001-10-01 00:00:00

  • Reversal of the central hypotensive effect of clonidine by intracisternal curare-like agents.

    abstract::Administration of tubocurarine, pancuronium, gallamine, or decamethonium into the cisterna magna of chloralosed dogs induced a rise in blood pressure. Clonidine (3 micrograms/kg) administered into the cisterna magna after tubocurarine, pancuronium, or gallamine significantly increased blood pressure; no significant ch...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.83.2_supplement.349

    authors: Tsoucaris-Kupfer D,Schmitt H

    更新日期:1983-02-01 00:00:00

  • Paclitaxel and docetaxel combinations in non-small cell lung cancer.

    abstract::Paclitaxel, the first of the taxanes, has exhibited unique and encouraging single-agent activity in the treatment of non-small cell lung cancer (NSCLC). Yet, with single-agent response rates approaching 25%, it was logical to examine the impact of paclitaxel in combination chemotherapy regimens. In trials evaluating t...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.117.4_suppl_1.144s

    authors: Belani CP

    更新日期:2000-04-01 00:00:00

  • Calcified plaque in the superior portion of the major fissure. An unusual manifestation of asbestos exposure.

    abstract::Parietal pleural plaque is a well-recognized sign of exposure to asbestos. Visceral pleural involvement is an uncommon manifestation, and calcified visceral pleural plaques are rare. Those reported have been in the minor fissure and inferior major fissure. We describe a unique calcified plaque in the superior major fi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.6.1436

    authors: Rupp SB,Jolles H

    更新日期:1989-12-01 00:00:00

  • Interpreting periodic lung function tests in individuals: the relationship between 1- to 5-year and long-term FEV1 changes.

    abstract:STUDY OBJECTIVE:Spirometry is performed to monitor lung health, but variability between tests can hinder recognition of excessive FEV(1) declines. We sought to describe the relationship between FEV(1) changes over 1 to 5 years and FEV(1) declines over longer terms, using 21,821 test results from 1,884 workers who parti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.2.493

    authors: Wang ML,Avashia BH,Petsonk EL

    更新日期:2006-08-01 00:00:00

  • Ventricular tachyarrhythmias following surgery for myocardial revascularization. A follow-up study.

    abstract::Of 1,599 patients who underwent surgery for direct myocardial revascularization in 1973 at Cleveland Clinic Hospital, 19 patients (1.2 percent) developed primary ventricular fibrillation or ventricular tachycardia during the immediate postoperative period. Occurrence of postoperative ventricular tachyarrhythmias could...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.72.4.426

    authors: Abedin Z,Soares J,Phillips DF,Sheldon WC

    更新日期:1977-10-01 00:00:00

  • Asbestos-related rounded atelectasis. Radiologic and mineralogic data in 23 cases.

    abstract::A retrospective study was conducted in 23 subjects with previous occupational exposure to asbestos and exhibiting rounded atelectasis (RA) on high-resolution computed tomography scan (HRCT scan) to evaluate the retention of asbestos bodies (ABs) using light microscopy in the bronchoalveolar lavage (BAL) fluid or lung ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.2.477

    authors: Voisin C,Fisekci F,Voisin-Saltiel S,Ameille J,Brochard P,Pairon JC

    更新日期:1995-02-01 00:00:00

  • The echocardiographic diagnosis of rupture of a papillary muscle.

    abstract::The echocardiographic diagnosis of acute rupture of a papillary muscle is described. The pertinent findings included (1) decreased systolic motion of the posterior wall, (2) exaggerated septal motion, (3) left ventricular enlargement and pattern suggesting left ventricular diastolic overload, and (4) bizarre flutterin...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.73.2.232

    authors: Ahmad S,Kleiger RE,Connors J,Krone R

    更新日期:1978-02-01 00:00:00

  • Pulmonary abnormalities on high-resolution CT demonstrate more rapid decline than FEV1 in adults with cystic fibrosis.

    abstract:BACKGROUND:FEV1 may remain stable while high-resolution CT (HRCT) appearances deteriorate in children with cystic fibrosis (CF). However, spirometry results commonly decline in older age groups. OBJECTIVES:To compare the rate of decline in HRCT abnormalities and spirometry results over time in an adult cohort with CF....

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.5.1424

    authors: Judge EP,Dodd JD,Masterson JB,Gallagher CG

    更新日期:2006-11-01 00:00:00

  • Tamponade: Hemodynamic and Echocardiographic Diagnosis.

    abstract::Cardiac tamponade is a medical emergency that can be readily reversed with timely recognition and appropriate intervention. The clinical diagnosis of cardiac tamponade requires synthesis of a constellation of otherwise nonspecific features based on an understanding of the underlying pathophysiological characteristics....

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2017.11.003

    authors: Kearns MJ,Walley KR

    更新日期:2018-05-01 00:00:00

  • Special problems in the elderly.

    abstract::With aging, the heart, kidneys, liver, lungs, and brain lose mass. While not inherently impaired, the reserve capacity of the older individual to compensate for stress, metabolic derangement, and drug metabolism is increasingly limited. Functional disability occurs faster and takes longer to remediate, necessitating e...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.115.suppl_2.158s

    authors: Oskvig RM

    更新日期:1999-05-01 00:00:00

  • Severe COPD and acute respiratory failure. Correlates for survival at the time of tracheal intubation.

    abstract::The recognition of a reversible cause for acute respiratory failure (ARF) is frequently difficult in patients with severe chronic obstructive pulmonary disease (COPD). We sought to identify clinical findings present at the time of tracheal intubation that were associated with successful weaning and short-term survival...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.3.854

    authors: Rieves RD,Bass D,Carter RR,Griffith JE,Norman JR

    更新日期:1993-09-01 00:00:00

  • Continuous noninvasive monitoring of respiratory rate in critically ill patients.

    abstract::Respiratory rate is a sensitive clinical parameter in a multitude of pulmonary diseases, especially in the critical care setting. In order to validate the routine recording of the respiratory rate in the intensive care unit, we compared the values obtained from the nursing records with the breathing frequency continuo...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.5.632

    authors: Krieger B,Feinerman D,Zaron A,Bizousky F

    更新日期:1986-11-01 00:00:00

  • Systolic time intervals in chronic hypertension: Alterations and response to treatment.

    abstract::Systolic time interval studies were performed to evaluate left ventricular performance in 28 patients with untreated systemic hypertension but without clinical heart failure. The pre-ejection period (PEP) was significantly prolonged (p smaller than 0.001) and left ventricular ejectime time (LVET) was shortened (p smal...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.68.1.51

    authors: Dodek A,Burg JR,Kloster FR

    更新日期:1975-07-01 00:00:00

  • Closure of a tracheoesophageal fistula by bronchoscopic application of fibrin glue and decontamination of the oral cavity.

    abstract::A tracheoesophageal fistula was successfully closed with a fibrin adhesive applied by means of a fiberoptic bronchoscope, instead of by esophagoscopy. To facilitate closure of the fistula, the technique was combined with decontamination of the oral cavity, to avoid bacterial contamination. The procedure is proposed as...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.2.578

    authors: Antonelli M,Cicconetti F,Vivino G,Gasparetto A

    更新日期:1991-08-01 00:00:00

  • Usefulness of fine-needle aspiration biopsy of spleen in diagnosis of sarcoidosis.

    abstract::Fine-needle aspiration biopsy of the spleen was carried out in 557 patients. In 381 cases, the aspiration was performed because of suspected sarcoidosis. The sensitivity of the technique was 59 percent and the specificity 97 percent. The cytologic picture of the spleen was abnormal in 184 patients with sarcoidosis and...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.83.2.193

    authors: Selroos O,Koivunen E

    更新日期:1983-02-01 00:00:00

  • Ultrasonic visualization of the posterior thoracic aorta in long axis: diagnosis of a saccular mycotic aneurysm.

    abstract::A saccular aneurysm arising from the descending thoracic aorta was identified ultrasonically in a 60-year-old man with a subsequent pathologic diagnosis of a Listeria monocytogenes mycotic aneurysm. A cross-sectional scanning technique, which permitted visualization of the descending thoracic aorta in long axis, demon...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.79.4.470

    authors: Come PC,Sacks B,Vine H,McArdle C,Koretsky S,Weintraub R

    更新日期:1981-04-01 00:00:00

  • Persistent pulmonary granulomas after recovery from varicella pneumonia.

    abstract::A 41-year-old man was found to have a miliary infiltrate on chest roentgenogram two months after recovery from varicella pneumonia. The patient remained in good health and there was no objective sign of pulmonary disease. The infiltrate showed no change in subsequent serial chest films, and after one year, open lung b...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.89.3.457

    authors: Meyer B,Stalder H,Wegmann W

    更新日期:1986-03-01 00:00:00

  • Pulmonary Langerhans cell histiocytosis-associated pulmonary hypertension: clinical characteristics and impact of pulmonary arterial hypertension therapies.

    abstract:BACKGROUND:Precapillary pulmonary hypertension (PH) is a complication of pulmonary Langerhans cell histiocytosis (PLCH) associated with increased mortality. However, outcomes and efficacy of pulmonary arterial hypertension (PAH) therapies in patients with PH complicating PLCH(PLCH-PH) remain unknown. METHODS:Consecuti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-2490

    authors: Le Pavec J,Lorillon G,Jaïs X,Tcherakian C,Feuillet S,Dorfmüller P,Simonneau G,Humbert M,Tazi A

    更新日期:2012-11-01 00:00:00

  • Obstructing tracheal pulmonary Langerhans cell histiocytosis.

    abstract::Pulmonary Langerhans cell histiocytosis, also known as eosinophilic granuloma, is an uncommon interstitial lung disease. A solitary nodule, usually parenchymal, may rarely be the only manifestation of the disease. We describe a case of Langerhans cell histiocytosis presenting as an obstructing tracheal lesion in a 55-...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.2.1057

    authors: Fridlender ZG,Glazer M,Amir G,Berkman N

    更新日期:2005-08-01 00:00:00

  • Pulmonary hypertension in chronic obstructive pulmonary disease. Multivariate analysis.

    abstract::The severity of pulmonary hypertension was evaluated by right cardiac catheterization in 89 patients with stable chronic obstructive pulmonary disease, both at rest and during maximum treadmill exercise. Thirty-one patients were found to have pulmonary hypertension at rest, defined as a mean pulmonary arterial pressur...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.2.185

    authors: Keller CA,Shepard JW Jr,Chun DS,Vasquez P,Dolan GF

    更新日期:1986-08-01 00:00:00

  • CPAP reduces inspiratory work more than dyspnea during hyperinflation with intrinsic PEEP.

    abstract::Hyperinflation with intrinsic positive end-expiratory pressure (PEEPi) loads the respiratory muscles and causes dyspnea in obstructive lung disease. Continuous positive airway pressure (CPAP) has shown some efficacy in reducing inspiratory work and dyspnea. However, in obstructive lung disease, inspiratory work and dy...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.108.2.432

    authors: Fessler HE,Brower RG,Permutt S

    更新日期:1995-08-01 00:00:00