Systolic time intervals in chronic hypertension: Alterations and response to treatment.

Abstract:

:Systolic time interval studies were performed to evaluate left ventricular performance in 28 patients with untreated systemic hypertension but without clinical heart failure. The pre-ejection period (PEP) was significantly prolonged (p smaller than 0.001) and left ventricular ejectime time (LVET) was shortened (p smaller than 0.02) when compared to rate-corrected predicted values. The PEP/LVET ratio was abnormally high in 18 of the patients and the average ratio was 0.45 ( smaller than 0.001). Eleven patients with abnormal time intervals were restudied during treatment with antilypertensive drugs. The PEP/LVET raio decreased in ten and became normal in nine. The average ratio decreased from 0.49 to 0.41 (p smaller than 0.001), due to both shortening of PEP (p smaller than 0.02) and lengthening of LVET (p smaller than 0.001). These findings indicate that alterations in left ventricular function may occur commonly in chronic hypertension in the absence of clinical heart failure, and can be reversed with appropriate therapy. This technique may be useful in evaluating hypertensive patients and in determining the efficacy of treatment.

journal_name

Chest

journal_title

Chest

authors

Dodek A,Burg JR,Kloster FR

doi

10.1378/chest.68.1.51

subject

Has Abstract

pub_date

1975-07-01 00:00:00

pages

51-5

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)36560-0

journal_volume

68

pub_type

杂志文章

相关文献

CHEST文献大全
  • Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies.

    abstract:BACKGROUND:Recent study of the inflammatory reactions occurring during and after cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the inflammatory cascade in perioperative injury. However, the exact mechanisms of this complex response remain to be fully determined. METHODS:Literature o...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.112.3.676

    authors: Wan S,LeClerc JL,Vincent JL

    更新日期:1997-09-01 00:00:00

  • Unruptured congenital aneurysm of the left sinus of Valsalva presenting as acute right ventricular failure.

    abstract::A patient with unruptured congenital aneurysm of the left coronary sinus of Valsalva presented with acute right-sided heart failure due to right ventricular outflow tract obstruction. The mechanism for such an acute presentation may have been a sudden increase in the size of the aneurysm. The surgical importance of th...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.2.578

    authors: D'Silva SA,Dalvi BV,Lokhandwala YY,Kale PA,Tendolkar AG

    更新日期:1992-02-01 00:00:00

  • Diagnostic value of pleural fluid adenosine deaminase in tuberculous pleuritis with reference to HIV coinfection and a Bayesian analysis.

    abstract:OBJECTIVES:To evaluate the diagnostic use of pleural fluid adenosine deaminase (ADAPF) levels in tuberculous pleuritis (TBpl), with a special reference to HIV coinfection and a Bayesian analysis. METHODS:We investigated a total of 216 patients with pleural effusion, including 100 with TBpl, 68 with malignant effusion,...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.1.97

    authors: Riantawan P,Chaowalit P,Wongsangiem M,Rojanaraweewong P

    更新日期:1999-07-01 00:00:00

  • Selective digestive decontamination should not be routinely employed.

    abstract::There is a general consensus that antimicrobial resistance in the hospital setting has emerged as an important variable influencing patient outcome and resource utilization. Hospitals worldwide are faced with increasingly rapid emergence and spread of antibiotic-resistant bacteria. Both antibiotic-resistant Gram-negat...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.123.5_suppl.464s

    authors: Kollef MH

    更新日期:2003-05-01 00:00:00

  • Dangerous curves. A perspective on exercise, lactate, and the anaerobic threshold.

    abstract::A number of general observations can be made from these recent studies. Lactate is a ubiquitous substance that is produced and removed from the body at all times, even at rest, both with and without the availability of oxygen. It is now recognized that lactate accumulates in the blood for several reasons, not just the...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.111.3.787

    authors: Myers J,Ashley E

    更新日期:1997-03-01 00:00:00

  • Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?

    abstract::OSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction du...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2018.03.001

    authors: Farré N,Farré R,Gozal D

    更新日期:2018-10-01 00:00:00

  • Maximal sniff mouth pressure compared with maximal inspiratory pressure in acute respiratory failure.

    abstract::Inspiratory muscle strength most often is better reflected by sniff Pes than PImax against occlusion. Furthermore, sniff Pes can be estimated noninvasively by the measurement of sniff Pmo in normal subjects and in patients with respiratory muscle weakness. The aim of this study was to compare sniff Pmo and P.PImax to ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.1.175

    authors: Héritier F,Perret C,Fitting JW

    更新日期:1991-07-01 00:00:00

  • A significant increase in breathing amplitude precedes sleep bruxism.

    abstract:BACKGROUND:Sleep bruxism (SB) is a stereotyped movement disorder that is characterized by rhythmic masticatory muscle activity (RMMA) and tooth grinding. Evidence has suggested that SB is associated with sleep arousals and that most RMMA episodes are preceded by physiologic changes occurring in sequence, namely, a rise...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-0115

    authors: Khoury S,Rouleau GA,Rompré PH,Mayer P,Montplaisir JY,Lavigne GJ

    更新日期:2008-08-01 00:00:00

  • Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions.

    abstract::The levels of soluble IL-2R were measured in pleural fluid from patients with tuberculosis pleurisy. There were significantly elevated soluble IL-2R values in tuberculous pleural fluid as compared with pleural fluid of nontuberculous etiology including malignant, bacterial and transudative pleural effusions. In patien...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.5.1141

    authors: Ito M,Kojiro N,Shirasaka T,Moriwaki Y,Tachibana I,Kokubu T

    更新日期:1990-05-01 00:00:00

  • Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome.

    abstract::The adult respiratory distress syndrome (ARDS) is a devastating clinical illness characterized by refractory hypoxemia and high-permeability pulmonary edema. Reactive oxygen species such as hydrogen peroxide and hypochlorous acid may play a key role in the pathogenesis of the acute lung injury. Glutathione (GSH) is a ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.5.1397

    authors: Pacht ER,Timerman AP,Lykens MG,Merola AJ

    更新日期:1991-11-01 00:00:00

  • Assessment of usefulness of endobronchial ultrasonography in determination of depth of tracheobronchial tumor invasion.

    abstract:STUDY OBJECTIVE:We assessed the usefulness of endobronchial ultrasonography in the determination of the depth of tumor invasion of the tracheobronchial wall. METHODS:We performed a needle-puncture experiment on normal tissue of 45 specimens to determine the laminar structure of the tracheobronchial wall. In addition, ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.6.1500

    authors: Kurimoto N,Murayama M,Yoshioka S,Nishisaka T,Inai K,Dohi K

    更新日期:1999-06-01 00:00:00

  • The measurement of thoraco-abdominal asynchrony in infants with severe laryngotracheobronchitis.

    abstract::Retractions of the lower ribcage (chest wall distortion [CWD]) during inspiration are frequently observed with moderate to severe respiratory disease in the infant. Laryngotracheobronchitis (LTB) results in a reversible partial airway obstruction with severe CWD. We wished to measure the motion of the chest wall durin...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.6.1842

    authors: Davis GM,Cooper DM,Mitchell I

    更新日期:1993-06-01 00:00:00

  • PEEP increases non-pulmonary microvascular fluid flux in healthy and septic sheep.

    abstract::The potential for significant interaction between PEEP and the peripheral microcirculations is not as well appreciated as are its central circulatory effects. Therefore, we studied the effects of PEEP, 15 mm Hg, on microvascular fluid flux in the hindlimb of ten mature sheep. Changes in prefemoral lymph flow (QL) and ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.5.1142

    authors: Hersch M,Bersten A,Robertson S,Rutledge F,Sibbald WJ

    更新日期:1989-11-01 00:00:00

  • Dead space loading and exercise limitation in patients with interstitial lung disease.

    abstract:STUDY DESIGN:We tested the hypothesis that maximal exercise performance in subjects with interstitial lung disease (ILD) is limited by respiratory factors. Assuming this is so, ventilatory stimulation by added dead space (VD) should impair exercise capacity. METHODS:Six subjects with ILD each underwent three maximal i...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.1.183

    authors: Marciniuk DD,Watts RE,Gallagher CG

    更新日期:1994-01-01 00:00:00

  • Thomas A. Neff lecture. Application of expression profiling to the developing lung: identification of putative regulatory networks controlling matrix production.

    abstract::If we hope to repair damaged lung tissue associated with a variety of acquired and developmental diseases, we must first gain a full appreciation of normal lung development. As an approach, we have utilized Affymetrix (Santa Clara, CA) high-density, oligonucleotide-based microarrays to generate an expression profile o...

    journal_title:Chest

    pub_type:

    doi:10.1378/chest.121.3_suppl.42s

    authors: Mariani TJ,Shapiro SD

    更新日期:2002-03-01 00:00:00

  • Mucoepidermoid tumor of trachea.

    abstract::Mucoepidermoid carcinoma of the trachea is rare. Its occurence in a 14-year-old boy is reported here. This case illustrates the typical course of tracheal tumors with clinical manifestations of cough, wheezing, and hemoptysis, the intially reported normal chest roentgenogram, and the common failure to diagnose trachea...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.6.782

    authors: Bharani SN,Arbeit JM,Hyde JS,Dainauskas JR,Wilson RR

    更新日期:1976-12-01 00:00:00

  • Questionnaires and pocket spirometers provide an alternative approach for COPD screening in the general population.

    abstract:BACKGROUND:In response to the Agency for Healthcare Research and Quality statement questioning the usefulness of “screening spirometry,” the National Heart, Lung, and Blood Institute and the COPD Foundation held a consensus conference in June 2008 to establish a procedure to detect cases of COPD in the general populati...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.11-1474

    authors: Nelson SB,LaVange LM,Nie Y,Walsh JW,Enright PL,Martinez FJ,Mannino DM,Thomashow BM

    更新日期:2012-08-01 00:00:00

  • Administration of anti-TNF antibody improves left ventricular function in septic shock patients. Results of a pilot study.

    abstract::In this pilot study, murine monoclonal anti-TNF antibody (2 mg/kg) was administered to ten patients within 24 h of septic shock which persisted after initial resuscitation with intravenous fluids and adrenergic agents. This treatment resulted in a reduction in heart rate (from 122 +/- 10 to 113 +/- 10 beats per minute...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.101.3.810

    authors: Vincent JL,Bakker J,Marécaux G,Schandene L,Kahn RJ,Dupont E

    更新日期:1992-03-01 00:00:00

  • Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report.

    abstract::Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves inn...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.14-1481

    authors: Canning BJ,Chang AB,Bolser DC,Smith JA,Mazzone SB,McGarvey L,CHEST Expert Cough Panel.

    更新日期:2014-12-01 00:00:00

  • Pulse transit time improves detection of sleep respiratory events and microarousals in children.

    abstract:OBJECTIVES:To evaluate the additional information provided by pulse transit time (PTT), a noninvasive tool, when using during polysomnography for the diagnosis of sleep breathing disorders in a pediatric population. MAIN FINDINGS:Respiratory and microarousals events were scored twice. The first scoring was performed u...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.3.722

    authors: Pépin JL,Delavie N,Pin I,Deschaux C,Argod J,Bost M,Levy P

    更新日期:2005-03-01 00:00:00

  • Echocardiographic evaluation of pulmonary embolism and its response to therapeutic interventions.

    abstract::Imaging and Doppler echocardiography permits assessment of right ventricular size and systolic function and of pulmonary arterial pressures, and it may facilitate detection of thromboemboli within the heart or pulmonary artery. In patients with acute pulmonary embolism of sufficient severity to appreciably increase ri...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.101.4_supplement.151s

    authors: Come PC

    更新日期:1992-04-01 00:00:00

  • How Health-Care Organizations Implement Shared Decision-making When It Is Required for Reimbursement: The Case of Lung Cancer Screening.

    abstract:BACKGROUND:The Centers for Medicare and Medicaid Services stipulate shared decision-making (SDM) counseling as a prerequisite to lung cancer screening (LCS) reimbursement, despite well-known challenges implementing SDM in practice. RESEARCH QUESTION:How have health-care organizations implemented SDM for LCS? STUDY DE...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.07.078

    authors: Alishahi Tabriz A,Neslund-Dudas C,Turner K,Rivera MP,Reuland DS,Elston Lafata J

    更新日期:2021-01-01 00:00:00

  • Predictors of time to death after terminal withdrawal of mechanical ventilation in the ICU.

    abstract:BACKGROUND:Little information exists about the expected time to death after terminal withdrawal of mechanical ventilation. We sought to determine the independent predictors of time to death after withdrawal of mechanical ventilation. METHODS:We conducted a secondary analysis from a cluster randomized trial of an end-o...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.10-0289

    authors: Cooke CR,Hotchkin DL,Engelberg RA,Rubinson L,Curtis JR

    更新日期:2010-08-01 00:00:00

  • Crackles in patients with fibrosing alveolitis, bronchiectasis, COPD, and heart failure.

    abstract::We have studied the crackling lung sounds of ten patients with cryptogenic fibrosing alveolitis, ten with bronchiectasis, ten with chronic obstructive pulmonary disease, and ten with heart failure by analyzing frequency, waveform, and timing of crackles. The upper frequency limit of inspiratory sounds was higher in CF...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.5.1076

    authors: Piirilä P,Sovijärvi AR,Kaisla T,Rajala HM,Katila T

    更新日期:1991-05-01 00:00:00

  • Oxygen supplementation and cardiac-autonomic modulation in COPD.

    abstract:STUDY OBJECTIVES:Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO(2)) on autonomic modulation in a group of COPD patients. DESIGN:We measured autonomic modulation before and during the adm...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.118.3.691

    authors: Bartels MN,Gonzalez JM,Kim W,De Meersman RE

    更新日期:2000-09-01 00:00:00

  • Coronary artery bypass performed without the use of cardiopulmonary bypass is associated with reduced cerebral microemboli and improved clinical results.

    abstract:STUDY OBJECTIVES:Strokes and neurocognitive dysfunction have been correlated with cerebral microemboli produced during cardiopulmonary bypass (CPB). The purpose of this study was to determine whether, and to what extent, off-pump coronary artery bypass (OPCAB) reduces the occurrence of cerebral microemboli compared wit...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.119.1.25

    authors: Bowles BJ,Lee JD,Dang CR,Taoka SN,Johnson EW,Lau EM,Nekomoto K

    更新日期:2001-01-01 00:00:00

  • A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria.

    abstract:BACKGROUND:In chronic obstructive pulmonary disease, both smaller and larger airways are affected. FEV1 mainly reflects large airways obstruction, while the later fraction of forced exhalation reflects reduction in terminal expiratory flow. In this study, the objective was to evaluate the relationship between spirometr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2016.06.047

    authors: Dilektasli AG,Porszasz J,Casaburi R,Stringer WW,Bhatt SP,Pak Y,Rossiter HB,Washko G,Castaldi PJ,Estepar RSJ,Hansen JE,COPDGene investigators.

    更新日期:2016-11-01 00:00:00

  • Alpha 1-antitrypsin deficiency deaths in the United States from 1979-1991. An analysis using multiple-cause mortality data.

    abstract:OBJECTIVE:To describe trends of reported alpha 1-antitrypsin deficiency mortality in the United States from 1979-1991. METHODS:We analyzed death certificate reports in the multiple-cause mortality files compiled by the National Center for Health Statistics. RESULTS:Of the 26,866,600 deaths that occurred during the 13...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.1.78

    authors: Browne RJ,Mannino DM,Khoury MJ

    更新日期:1996-07-01 00:00:00

  • Mediastinal abscess due to passage of a broncholith.

    abstract::We report a case of a 32-year-old woman who, after passage of broncholiths, developed a mediastinal abscess that required surgical drainage for treatment. Previously reported infectious complications resulting from broncholiths include obstructive pneumonitis and recurrent aspiration pneumonitis secondary to bronchoes...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.121.1.296

    authors: Studer SM,Heitmiller RF,Terry PB

    更新日期:2002-01-01 00:00:00

  • Combined operations for lung volume reduction surgery and lung cancer.

    abstract::Fifty-three lung masses were found in 51 (16%) of 325 patients who underwent lung volume reduction surgery. This included 11 non-small cell lung cancers and 42 benign lung masses. Eleven patients (mean age, 69.4 years) underwent a combined lung volume reduction surgery and resection of clinical stage I lung cancers (l...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.4.885

    authors: McKenna RJ Jr,Fischel RJ,Brenner M,Gelb AF

    更新日期:1996-10-01 00:00:00