Abstract:
:In this pilot study, murine monoclonal anti-TNF antibody (2 mg/kg) was administered to ten patients within 24 h of septic shock which persisted after initial resuscitation with intravenous fluids and adrenergic agents. This treatment resulted in a reduction in heart rate (from 122 +/- 10 to 113 +/- 10 beats per minute at 4 h, p less than 0.01) associated with an increase in LVSWI (from 26.5 +/- 5.6 to 31.5 +/- 10.5 g.m2 at 2 h, p less than 0.05), indicating in the absence of change in cardiac filling pressures, an improvement in ventricular function. Arterial oxygenation improved concurrently in six patients. These changes, however, appeared transient. The improvement in cardiac function following anti-TNF antibody administration in patients is in keeping with recent experimental studies indicating the role of TNF in the myocardial depression characterizing septic shock.
journal_name
Chestjournal_title
Chestauthors
Vincent JL,Bakker J,Marécaux G,Schandene L,Kahn RJ,Dupont Edoi
10.1378/chest.101.3.810subject
Has Abstractpub_date
1992-03-01 00:00:00pages
810-5issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(16)31960-2journal_volume
101pub_type
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