COPD: exacerbation.


:A renewed interest in the clinical and pathogenic aspects of COPD exacerbation is timely in view of national and global COPD initiatives. The three big problems regarding COPD continue to be the following: prevention of the disease; slowing progression of the disease once diagnosis has been established; and prevention and more effective treatment of the so-called exacerbation. The following assessment will raise more questions than answers and will review some of the past and current concepts and contexts.






Voelkel NF,Tuder R




Has Abstract


2000-05-01 00:00:00




5 Suppl 2












  • Gastroesophageal reflux disease and asthma: a longitudinal study in UK general practice.

    abstract:STUDY OBJECTIVES:Gastroesophageal reflux disease (GERD) and asthma are common causes for consultation in primary care, but the relationship between the two remains unclear. The aim of our study was to investigate the temporal relationship between first diagnoses of GERD and asthma in general practice. METHODS:We used ...


    pub_type: 杂志文章


    authors: Ruigómez A,Rodríguez LA,Wallander MA,Johansson S,Thomas M,Price D

    更新日期:2005-07-01 00:00:00

  • Predictors of symptoms are different from predictors of severe exacerbations from asthma in children.

    abstract:BACKGROUND:Asthma therapy is typically prescribed and titrated based on patient or parent self-report of symptoms. No longitudinal studies have assessed the relationship between symptoms and severe asthma exacerbations in children. The goal of our study was (1) to assess the association of asthma symptoms with severe a...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wu AC,Tantisira K,Li L,Schuemann B,Weiss ST,Fuhlbrigge AL,Childhood Asthma Management Program Research Group.

    更新日期:2011-07-01 00:00:00

  • Improved accuracy of the exercise electrocardiogram in detection of coronary artery and three-vessel coronary disease.

    abstract::The study objective was to assess the widespread applicability of ST/HR slope for the modified Bruce exercise test using a computerized electrocardiogram (ECG); compare the usefulness of the ST/HR slope with standard ECG criteria in detection of coronary artery disease (CAD) and identification of three-vessel or left ...


    pub_type: 杂志文章


    authors: Sato I,Keta K,Aihara N,Ohe T,Shimomura K,Hasegawa Y

    更新日期:1988-10-01 00:00:00

  • Dieulafoy's disease of the bronchus in association with a paravertebral neurilemoma.

    abstract::Dieulafoy's disease is a vascular anomaly characterized by the presence of a dysplastic artery that is related to an epithelial ulcer. While it is most frequently a GI condition, occurrence in the bronchus has been reported previously in six cases. We present the case of a 51-year-old man with severe hemoptysis and ep...


    pub_type: 杂志文章


    authors: Stoopen E,Baquera-Heredia J,Cortes D,Green L

    更新日期:2001-01-01 00:00:00

  • A 78-Year-Old Man With Repeated Dyspnea and Neutrophilia in Peripheral Blood and BAL.

    abstract:CASE PRESENTATION:A 78-year-old man with asthma and COPD presented with shortness of breath, cough, and severe malaise for 4 days. Upon arrival, the patient was conscious and body temperature was 37.5°C. Arterial oxygen saturation (Spo2) was 80% on room air. Laboratory data demonstrated a WBC count of 17,400/μL (89.5% ...


    pub_type: 杂志文章


    authors: Nakamatsu E,Morita T,Morishima A,Tagawa H,Furukawa M,Matsushita M,Yamane H

    更新日期:2020-01-01 00:00:00

  • Chronic persistent cough: an uncommon presenting complaint of thyroiditis.

    abstract::We report two patients with non-conventional thyroiditis whose chief complaint was chronic persistent cough. Cough was attributed to thyroiditis only after extensive diagnostic evaluations failed to uncover another cause and only after cough and thyroiditis disappeared simultaneously with suppressive therapy for the l...


    pub_type: 杂志文章


    authors: Irwin RS,Pratter MR,Hamolsky MW

    更新日期:1982-03-01 00:00:00

  • Airway pressure release ventilation in severe acute respiratory failure.

    abstract::Airway pressure release ventilation (APRV), a new ventilatory support technique, was compared with conventional intermittent positive-pressure ventilation plus PEEP (CPPV) in 18 patients with severe acute respiratory failure. Patients were initially stabilized on CPPV and then switched to APRV. The APRV provided effec...


    pub_type: 杂志文章


    authors: Cane RD,Peruzzi WT,Shapiro BA

    更新日期:1991-08-01 00:00:00

  • Depression of cardiac output is a mechanism of shunt reduction in the therapy of acute respiratory failure.

    abstract::The relationship between changes in cardiac output and intrapulmonary shunt associated with mechanical ventilation was evaluated in 20 patients with the adult respiratory distress syndrome (ARDS). The distribution of ventilation-perfusion (VA/Q) ratios and the level of intrapulmonary shunt was determined by the multip...


    pub_type: 杂志文章


    authors: Dantzker DR,Lynch JP,Weg JG

    更新日期:1980-05-01 00:00:00

  • A combined modality approach to recurrent cardiac sarcoma resulting in a prolonged remission: a case report.

    abstract::We report a case of cardiac fibrosarcoma that was treated with cardiac tumor resection, chemotherapy, cardiac explantation, tumor repeat resection, and autotransplantation followed by external beam irradiation. The patient was able to achieve clinical remission and remained disease free > 2 years after the initial dia...


    pub_type: 杂志文章


    authors: Mery GM,Reardon MJ,Haas J,Lazar J,Hindenburg A

    更新日期:2003-05-01 00:00:00

  • A simplified insertion technique for tracheobronchial silicone stents.

    abstract::In many patients with central airway obstruction due to extrinsic compression or malacia, insertion of tracheobronchial stents can provide effective and permanent relief. Of the various types of prostheses described, the silicone Dumon-Artemis stents (Medicore, Brussels, Belgium) are probably the most efficient. The u...


    pub_type: 杂志文章


    authors: Noppen M,Dhondt E,Meysman M,Monsieur I,Gepts E,Vincken WG

    更新日期:1994-08-01 00:00:00

  • Number of lymph nodes harvested from a mediastinal lymphadenectomy: results of the randomized, prospective American College of Surgeons Oncology Group Z0030 trial.

    abstract:BACKGROUND:Lymph node status is a major determinant of stage and survival in patients with lung cancer; however, little information is available about the expected yield of a mediastinal lymphadenectomy. METHODS:The American College of Surgeons Oncology Group Z0030 prospective, randomized trial of mediastinal lymph no...


    pub_type: 杂志文章,随机对照试验


    authors: Darling GE,Allen MS,Decker PA,Ballman K,Malthaner RA,Inculet RI,Jones DR,McKenna RJ,Landreneau RJ,Putnam JB Jr

    更新日期:2011-05-01 00:00:00

  • Atrial function during cardiac arrest caused by ventricular fibrillation.

    abstract:OBJECTIVES:To report observations on preserved regular atrial electrical and mechanical systole during ventricular fibrillation (VF) and to quantitate blood flow generated by atrial contractions in this setting. METHODS:In 10 rats, right atrial pressure pulses were continuously recorded before and for an interval of 8...


    pub_type: 杂志文章


    authors: Pernat A,Weil MH,Sun S,Tang W,Yamaguchi H,Bisera J

    更新日期:2000-04-01 00:00:00

  • High altitude pulmonary edema and exercise at 4,400 meters on Mount McKinley. Effect of expiratory positive airway pressure.

    abstract::Breathing against positive expiratory pressure has been used to improve gas exchange in many forms of pulmonary edema, and forced expiration against resistance during exercise has been advocated for climbing at high altitude as a method to optimize performance. To evaluate the effect of expiratory positive airway pres...


    pub_type: 杂志文章


    authors: Schoene RB,Roach RC,Hackett PH,Harrison G,Mills WJ Jr

    更新日期:1985-03-01 00:00:00

  • COPD-OSA Overlap Syndrome: Evolving Evidence Regarding Epidemiology, Clinical Consequences, and Management.

    abstract::COPD and OSA are both highly prevalent, which implies that both disorders occurring together (overlap syndrome) is likely to be common based on chance association alone. However, different clinical COPD phenotypes influence the likelihood of coexisting OSA in that the increased lung volumes and low BMI associated with...


    pub_type: 杂志文章,评审


    authors: McNicholas WT

    更新日期:2017-12-01 00:00:00

  • Unruptured congenital aneurysm of the left sinus of Valsalva presenting as acute right ventricular failure.

    abstract::A patient with unruptured congenital aneurysm of the left coronary sinus of Valsalva presented with acute right-sided heart failure due to right ventricular outflow tract obstruction. The mechanism for such an acute presentation may have been a sudden increase in the size of the aneurysm. The surgical importance of th...


    pub_type: 杂志文章


    authors: D'Silva SA,Dalvi BV,Lokhandwala YY,Kale PA,Tendolkar AG

    更新日期:1992-02-01 00:00:00

  • Antibiotic levels in empyemic pleural fluid.

    abstract:OBJECTIVE:To determine the degree to which bioactive penicillin, metronidazole, ceftriaxone, clindamycin, vancomycin, and gentamicin penetrate into empyemic pleural fluid using our new rabbit model of empyema. METHODS:An empyema was created via the intrapleural injection of 10(8)()Pasteurella multocida bacteria into t...


    pub_type: 杂志文章


    authors: Teixeira LR,Sasse SA,Villarino MA,Nguyen T,Mulligan ME,Light RW

    更新日期:2000-06-01 00:00:00

  • Amiodarone-associated hemoptysis.

    abstract::The manifestations of amiodarone pulmonary toxicity (APT) are generally nonspecific, and a diagnosis requires appropriate clinical history, laboratory testing consistent with toxicity, and exclusion of other disease entities. To our knowledge, hemoptysis associated with APT has not been described before; the following...


    pub_type: 杂志文章


    authors: Vizioli LD,Cho S

    更新日期:1994-01-01 00:00:00

  • Echocardiographic diagnosis of intraventricular clot.

    abstract::The literature contains many reports of the echocardiographic findings in left atrial myxoma and clot; however, descriptions of left ventricular thrombus or tumor are rare. We discuss here the echocardiographic findings in a patient with a large apical left ventricular thrombus which was confirmed both angiographicall...


    pub_type: 杂志文章


    authors: DeJoseph RL,Shiroff RA,Levenson LW,Martin CE,Zelis RF

    更新日期:1977-03-01 00:00:00

  • Pathologic and radiologic differences between idiopathic and collagen vascular disease-related usual interstitial pneumonia.

    abstract:BACKGROUND:Patients with usual interstitial pneumonia (UIP) associated with collagen vascular disease (CVD) have been reported to have a better prognosis than those with idiopathic pulmonary fibrosis with a UIP pattern (IPF/UIP) seen on histology. The aim of this study was to evaluate the pathologic and radiologic diff...


    pub_type: 杂志文章


    authors: Song JW,Do KH,Kim MY,Jang SJ,Colby TV,Kim DS

    更新日期:2009-07-01 00:00:00

  • The prevalence of exercise-induced bronchospasm among US Army recruits and its effects on physical performance.

    abstract:STUDY OBJECTIVES:To measure the prevalence of exercise-induced bronchospasm (EIB) and to determine its effect on the physical performance response to training in otherwise healthy young adults. DESIGN:Observational, retrospective study. SETTING:Fort Jackson, SC, May to July 1998. PARTICIPANTS:One hundred thirty-seve...


    pub_type: 杂志文章


    authors: Sonna LA,Angel KC,Sharp MA,Knapik JJ,Patton JF,Lilly CM

    更新日期:2001-06-01 00:00:00

  • Tracheomalacia and bronchomalacia in children: incidence and patient characteristics.

    abstract:OBJECTIVE:Congenital airway malacia is one of the few causes of irreversible airways obstruction in children, but the incidence in the general population is unknown. Severe airway malacia or malacia associated with specific syndromes is usually recognized and diagnosed early in infancy, but information about clinical f...


    pub_type: 杂志文章


    authors: Boogaard R,Huijsmans SH,Pijnenburg MW,Tiddens HA,de Jongste JC,Merkus PJ

    更新日期:2005-11-01 00:00:00

  • Analysis of sequential aliquots of hypertonic saline solution-induced sputum from clinically stable patients with cystic fibrosis.

    abstract:STUDY OBJECTIVES:Sputum induction (SI) is a noninvasive tool for sampling inflamed airways. The purpose of this study was to determine the optimal duration of collection in patients with cystic fibrosis (CF). The hypothesis was that the duration of SI collection would quantitatively and qualitatively alter the content ...


    pub_type: 杂志文章


    authors: Aitken ML,Greene KE,Tonelli MR,Burns JL,Emerson JC,Goss CH,Gibson RL

    更新日期:2003-03-01 00:00:00

  • Pulmonary involvement in the eosinophilia-myalgia syndrome.

    abstract::We describe the cases of three women with pulmonary involvement in the eosinophilia-myalgia syndrome. The illness was characterized by elevated peripheral blood eosinophil counts, myalgias, fatigue, and dyspnea. Two of three patients had bilateral infiltrates on chest roentgenograms. All three had markedly decreased c...


    pub_type: 杂志文章


    authors: Catton CK,Elmer JC,Whitehouse AC,Clode JB,Hustrulid RI

    更新日期:1991-02-01 00:00:00

  • Comparison of Dynamic Expiratory CT With Bronchoscopy for Diagnosing Airway Malacia: A Pilot Evaluation.

    abstract:OBJECTIVE:To assess the accuracy of dynamic expiratory CT for detecting airway malacia using bronchoscopy as the diagnostic "gold standard." MATERIALS AND METHODS:A computerized hospital information system was used to retrospectively identify all patients with bronchoscopically proven airway malacia referred for CT ai...


    pub_type: 杂志文章


    authors: Lee KS,Sun MRM,Ernst A,Feller-Kopman D,Majid A,Boiselle PM

    更新日期:2007-03-01 00:00:00

  • Bronchoalveolar lavage neutrophilia seen in Pneumocystis pneumonia presenting with pneumothorax.

    abstract::Spontaneous pneumothorax is a known complication of Pneumocystis carinii pneumonia (PCP) in patients with acquired immunodeficiency syndrome. From a series of 61 patients with PCP, we identified two cases, not associated with aerosolized pentamidine, that presented with spontaneous pneumothorax and cystic changes seen...


    pub_type: 杂志文章


    authors: Smith RL,Berkowitz KA,Aranda CP

    更新日期:1991-09-01 00:00:00

  • Airway inflammation and etiology of acute exacerbations of chronic bronchitis.

    abstract:STUDY OBJECTIVES:The etiologic role of bacterial pathogens isolated from sputum culture in 40 to 50% of acute exacerbations of chronic bronchitis (AECB) is controversial. If bacterial pathogens cause these AECB, they should be associated with greater neutrophilic airway inflammation than pathogen-negative exacerbations...


    pub_type: 杂志文章


    authors: Sethi S,Muscarella K,Evans N,Klingman KL,Grant BJ,Murphy TF

    更新日期:2000-12-01 00:00:00

  • Diagnosis of severe tricuspid regurgitation.

    abstract::Fifty-nine patients were studied who had severe tricuspid regurgitation which was confirmed by right ventriculography and during surgery in order to determine the incidence of clinical, radiologic, and hemodynamic clues of severe tricuspid regurgitation. Eighty-eight percent of patients had Carvallo sign alone or in c...


    pub_type: 杂志文章


    authors: Cha SD,Desai RS,Gooch AS,Maranhao V,Goldberg H

    更新日期:1982-12-01 00:00:00

  • Diagnosis and treatment of cystic fibrosis. An update.

    abstract::Cystic fibrosis is the most common fatal inherited disease of Caucasians. At present, cystic fibrosis accounts for most cases of chronic progressive pulmonary disease and for many other clinical features in the first three decades of life. Thus, it is a challenge to both pediatricians and internists, particularly ches...


    pub_type: 杂志文章,评审


    authors: Davis PB,di Sant'Agnese PA

    更新日期:1984-06-01 00:00:00

  • Effect of Age on Phenotype and Outcomes in Pulmonary Arterial Hypertension Trials.

    abstract:BACKGROUND:In recent years, the population of patients with pulmonary arterial hypertension (PAH) has changed dramatically, including more advanced age at diagnosis. We hypothesized that older patients have a distinct clinical profile with different disease characteristics and response to intervention. METHODS:All pre...


    pub_type: 杂志文章


    authors: Rose JA,Cleveland JM,Rao Y,Minai OA,Tonelli AR

    更新日期:2016-05-01 00:00:00

  • Relationship between serum substance P levels and daytime sleepiness in obstructive sleep apnea syndrome.

    abstract:OBJECTIVE:We hypothesized that intermittent hypoxia might influence serum substance P levels, and that this effect might in turn contribute in excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea syndrome (OSAS). PATIENTS AND METHODS:Fifty-five patients with newly diagnosed OSAS and 15 age-match...


    pub_type: 杂志文章


    authors: Ursavas A,Karadag M,Ilcol YO,Burgazlioglu B,Ercan I,Gozu RO

    更新日期:2007-05-01 00:00:00