Hypercapnic ventilatory response in patients with and without obstructive sleep apnea: do age, gender, obesity, and daytime PaCO(2) matter?


STUDY OBJECTIVE:To evaluate the relationship between obstructive sleep apnea (OSA) and ventilatory responsiveness to carbon dioxide in both men and women. DESIGN:An analysis of 219 patients referred to an university-based sleep center between 1989 to 1994 was conducted (104 with OSA and 115 without OSA; 43 women and 176 men). These patients had spirometry and a daytime hypercapnic ventilatory response (HCVR) test that was corrected to the patient's ability to attain maximal ventilation. Comparisons between OSA and no-OSA groups, as well as between men and women, were made using multivariate modeling techniques. RESULTS:There was no significant difference in the slope of correlated HCVR (cHCVR) between those with and without OSA (1.57 +/- 0.57 vs 1.63 +/- 0.66; p = 0.48). In men, an inverse correlation between daytime PCO(2) and cHCVR was observed in both crude and multivariate analyses (crude beta-coefficient = - 0.04 +/- 0.02, p = 0.02; adjusted beta-coefficient = 0.07 +/- 0.02, p < 0.01). Although age and cHCVR did not share a significant relationship in the crude analysis (crude beta-coefficient = - 0.01 +/- 0.01, p = 0.10), with adjustments for confounding variables, a significant inverse relationship between age and cHCVR was observed (beta-coefficient = - 0.02 +/- 0.01, p = 0.04). On the other hand, in women, only body mass index (BMI) was positively correlated with cHCVR (crude beta-coefficient = 0.03 +/- 0.01, p = 0.01; adjusted beta-coefficient = 0.04 +/- 0.01, p < 0.01). CONCLUSION:OSA disorder is not associated with a blunted ventilatory chemoresponsiveness to carbon dioxide. Elevated PaCO(2) and older age are significant correlates for a low cHCVR in men. For women only, BMI was associated with cHCVR. These findings suggest that men and women may have different ventilatory control mechanisms.






Sin DD,Jones RL,Man GC




Has Abstract


2000-02-01 00:00:00
















  • Potential future therapies for the management of cough: ACCP evidence-based clinical practice guidelines.

    abstract:BACKGROUND:When the etiology of a patient's chronic cough is established, specific antitussive therapy that is aimed at a particular cause of cough is highly effective. Nevertheless, in certain situations, therapy with cough suppressants, which previously were classified as nonspecific antitussive therapy, and which ai...


    pub_type: 杂志文章,评审


    authors: Dicpinigaitis PV

    更新日期:2006-01-01 00:00:00

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    abstract:BACKGROUND:The US Centers for Disease Control and Prevention has implemented a new, multitiered definition for ventilator-associated events (VAEs) to replace their former definition of ventilator-associated pneumonia (VAP). We hypothesized that the new definition could be implemented in an automated, efficient, and rel...


    pub_type: 杂志文章


    authors: Stevens JP,Silva G,Gillis J,Novack V,Talmor D,Klompas M,Howell MD

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    abstract::Present-day technology has greatly facilitated the monitoring of respiratory gas exchange in the clinical exercise laboratory. Despite the growing use of these techniques to assess the severity and progression of disease or therapeutic response in patients with heart failure, the long-term reproducibility of oxygen up...


    pub_type: 杂志文章


    authors: Janicki JS,Gupta S,Ferris ST,McElroy PA

    更新日期:1990-01-01 00:00:00

  • Intermittent positive pressure inflation during fiberoptic bronchoscopy.

    abstract::We describe a new technique for diagnostic fiberoptic bronchoscopic procedures under general anesthesia. The technique of inflation via nasotracheal catheter, which consists of using intermittent high inflating pressure for ventilation by passing a double catheter through the nose to the glottis and into the trachea, ...


    pub_type: 杂志文章


    authors: Heifetz M,De Myttenaere S,Lemer J

    更新日期:1977-10-01 00:00:00

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    authors: McDuffie HH,Cockcroft DW,Talebi Z,Klaassen DJ,Dosman JA

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    pub_type: 杂志文章,多中心研究


    authors: Velthuis S,Buscarini E,van Gent MWF,Gazzaniga P,Manfredi G,Danesino C,Schonewille WJ,Westermann CJJ,Snijder RJ,Mager JJ,Post MC

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    pub_type: 杂志文章,随机对照试验


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    authors: Roberts A,Kagan A,Rhoads GG,Pierce JA,Bruce RM

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  • Spectrum of Aspergillus infection in lung transplant recipients: case series and review of the literature.

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    authors: Levin PD,Simor AE,Moses AE,Sprung CL

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    authors: Nakagawa M,Hamaoka K

    更新日期:1993-12-01 00:00:00

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    pub_type: 杂志文章,评审


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    authors: Kraut A,Lilis R

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    authors: Leuchte HH,El Nounou M,Tuerpe JC,Hartmann B,Baumgartner RA,Vogeser M,Muehling O,Behr J

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    authors: Loke J,Farmer W,Matthay RA,Putman CE,Smith GJ

    更新日期:1980-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Toivonen LK,Pohjola-Sintonen S

    更新日期:1987-06-01 00:00:00

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    pub_type: 杂志文章


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