Cardiac arrhythmias during the combined use of beta-adrenergic agonist drugs and theophylline.

Abstract:

:We studied 15 nonsmoking, clinically stable asthmatic subjects aged 27 to 39 years to evaluate the potential cardiotoxic effects of combined use of a beta-adrenergic agonist drug and theophylline in the treatment of asthma. Subjects underwent a one-week washout period followed by two one-week periods of study receiving either oral terbutaline or sustained-release theophylline during week 1 and both drugs during week 2. Thirty-six-hour Holter monitoring was performed at the end of each period of study. No significant increase in the total number of ventricular premature beats was noted, although the average heart rate increased significantly between each period of study. Although not statistically significant, the number of individuals with multiform or complete and repetitive ventricular premature beats increased from one at baseline to three during each period of study, including one subject with ventricular tachycardia on combined therapy. These data suggest that combined therapy with theophylline and a beta-adrenergic agonist in young, otherwise healthy asthmatic subjects does not lead to an increase in the total number of ectopic beats but may increase the degree of complexity of ventricular premature beats.

journal_name

Chest

journal_title

Chest

authors

Coleman JJ,Vollmer WM,Barker AF,Schultz GE,Buist AS

doi

10.1378/chest.90.1.45

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

45-51

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)42702-3

journal_volume

90

pub_type

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