Multimodality therapy for stage IIIA (N2) lung cancer. An overview.

Abstract:

:Disappointing results of surgery and postoperative adjuvant chemotherapy or chemoradiotherapy in stage IIIA (N2) lung cancer have led to a number of phase II trials of induction (neoadjuvant) chemotherapy given prior to surgery. Preliminary results of 2 such studies indicate that mitomycin, vinca alkaloid, and platinum (MVP) given before surgical excision induces an overall response rate of 70% (9 complete responses and 71 partial responses in 112 patients). Of 80 patients who ultimately underwent surgery, complete resection was achieved in 62 (55%). Survival data reflect a median survival of 19.5 months for the entire cohort of 112 patients and 27 months for those who had complete resection. The 5-year-survival rate is expected to reach 15%. Randomized trials are now under way to establish whether this aggressive approach to therapy represents the most appropriate form of treatment for patients with stage IIIA (N2) lung cancer.

journal_name

Chest

journal_title

Chest

authors

Ginsberg RJ

doi

10.1378/chest.103.4_supplement.356s

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

356S-359S

issue

4 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)37099-9

journal_volume

103

pub_type

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