Abstract:
:Symptom-limited supine bicycle exercise with radionuclide angiography was performed on 11 patients with severe mitral regurgitation (who were not receiving vasodilators), to assess changes in left ventricular volume, regurgitant fraction, forward flow and regurgitant flow during exercise. All patients were in normal sinus rhythm with a normal resting ejection fraction (greater than 0.50). During exercise, the end-diastolic volume index, end-systolic volume index, ejection fraction, and regurgitant fraction of the left ventricle did not change significantly. The forward cardiac index increased by 86 percent (p less than 0.01) with exercise. This increase was explained by an 87 percent increase in the heart rate (p less than 0.01); there was no significant change in the forward stroke volume index. Although the regurgitant stroke volume index declined by 12 percent with exercise (p = 0.07), the regurgitant flow increased markedly by 64 percent (p less than 0.01) to a mean of 8.2 L/min/m2. These data indicate that in patients with severe mitral regurgitation, the increase in the exercise forward flow is totally dependent on the heart rate response. There is a marked increase in regurgitant flow during exercise, which presumably contributes to dyspnea.
journal_name
Chestjournal_title
Chestauthors
Lavie CJ,Lam JB,Gibbons RJdoi
10.1378/chest.96.5.1086subject
Has Abstractpub_date
1989-11-01 00:00:00pages
1086-91issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(16)35134-0journal_volume
96pub_type
杂志文章相关文献
CHEST文献大全abstract::A case of acute pneumonia due to Pasteurella multocida ssp multocida occurred in a young man with AIDS and chronic sinusitis. The pneumonia was diagnosed by bronchoscopy and responded to treatment with aztreonam. Epidemiologic investigation revealed the case was temporally related to nontraumatic exposure to cat secre...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.1.7
更新日期:1993-01-01 00:00:00
abstract::The clinical, roentgenographic and laboratory findings, their relationship to each other and to the subsequent hospital course are reported for 14 victims of gaseous ammonia inhalation. Initial physical examination enabled differentiation of a mildly affected from a moderately affected group, but patients in both grou...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.4.496
更新日期:1980-04-01 00:00:00
abstract::The efficacy of bronchoscopy for the diagnosis of tuberculosis in patients infected with human immunodeficiency virus (HIV) has not been systematically evaluated. We therefore compared the diagnostic yield of bronchoscopy in 67 HIV-infected and 45 non-HIV-infected patients with culture-proven pulmonary tuberculosis. I...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.4.1040
更新日期:1992-10-01 00:00:00
abstract:STUDY OBJECTIVE:Cardiopulmonary bypass (CPB) induces a generalized inflammatory response, including activation of leukocytes, contributing to postoperative morbidity. The inflammatory pathways leading to this systemic inflammatory response syndrome are considered identical to those involved in septic shock. Therefore, ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.111.3.577
更新日期:1997-03-01 00:00:00
abstract::Twenty-eight patients developed severe, progressive acute respiratory insufficiency despite aggressive application of conventional respiratory therapy. Application of increased PEEP (18 torr or greater) resulted in a significant decrease in QA/QT. Selection of the optimal levle of PEEP for each patient required seria...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.2.156
更新日期:1975-02-01 00:00:00
abstract:INTRODUCTION:CD14 is a cell surface glycoprotein expressed mainly on mature monocytes and macrophages. Soluble CD14 (sCD14) is present in normal plasma and is found increased in serum of patients with septicemia, polytrauma, and sarcoidosis. In active sarcoidosis, increased levels of sCD14 in BAL supernatant have been ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.6.1614
更新日期:1995-12-01 00:00:00
abstract:STUDY OBJECTIVE:We undertook the present study to investigate the perception of dyspnea (with respect to changes in end-inspiratory and end-expiratory lung volumes), during four different levels of high-intensity constant work rate exercise (CWRE) in patients with severe COPD. DESIGN:Crossover descriptive study with c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.2.651
更新日期:2005-08-01 00:00:00
abstract:CASE PRESENTATION:A 76-year-old nonsmoking woman visiting from Honduras for the last 6 months with no known medical history originally presented to the ED complaining of abdominal pain. While in the ED, an incidental right middle lobe collapse was found on CT abdomen scan. Review of systems was positive for a chronic p...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2018.10.030
更新日期:2019-05-01 00:00:00
abstract::The purpose of this study was to determine the frequency and severity of arterial oxygen desaturation during and after endotracheal suctioning in a group of ventilator-dependent patients with acute respiratory failure (the majority of whom had underlying obstructive lung disease) and to evaluate the efficacy of severa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.4.621
更新日期:1983-04-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the utility of urinary uric acid excretion as a marker of nocturnal hypoxia in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after the institution of nasal continuous positive airway pressure (CPAP). DESIGN:Prospective, open. SETTING:Sleep Disorders Laboratory, V...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.6.1604
更新日期:1998-06-01 00:00:00
abstract::Hyperlipemia in an acyanotic patient with diabetic ketoacidosis, alcoholism, and pancreatitis produced a falsely elevated concentration of methemoglobin (19 percent) and a lower-than-expected oxygen saturation measured with an automated spectrophotometer (IL-282 CO-Oximeter). In addition, there was a "normal" hemoglob...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.1.84
更新日期:1984-07-01 00:00:00
abstract::Neurosarcoidosis occurs in approximately 5% of patients with systemic sarcoidosis. A review of medical literature shows that intracranial mass-like lesions secondary to sarcoidosis are quite rare. CT and MRI scanning would suggest that this manifestation of neurosarcoidosis may be more common than previously realized....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.2.518
更新日期:1997-02-01 00:00:00
abstract::Pulmonary function studies were conducted one to two days prior to, two weeks after, and an average of 116 days after coronary artery revascularization surgery. Preoperation it was found that 11 of 19 patients had mild to moderate obstruction, 8 of 17 had diffusing capacity less than 80 percent of predicted, and 9 of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.73.3.316
更新日期:1978-03-01 00:00:00
abstract::Lymphoid interstitial pneumonia (LIP) is regarded as both a disease and a nonneoplastic, inflammatory pulmonary reaction to various external stimuli or systemic diseases. It is an uncommon condition with incidence and prevalence rates that are largely unknown. Liebow and Carrington originally classified LIP as an idio...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.122.6.2150
更新日期:2002-12-01 00:00:00
abstract::Stage IIIA non-small cell lung cancer represents a relatively heterogeneous group of patients with metastatic disease to the ipsilateral mediastinal (N2) lymph nodes and also includes T3N1 patients. Presentations of disease range from apparently resectable tumors with occult microscopic nodal metastases to unresectabl...
journal_title:Chest
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1378/chest.123.1_suppl.202s
更新日期:2003-01-01 00:00:00
abstract:STUDY OBJECTIVE:s: To analyze the perception of sexual content (PSC) of tobacco advertisements and its potential impact on the process of smoking in adolescents. DESIGN, PARTICIPANTS, AND SETTING:A questionnaire was administered to 1,186 adolescents at the National Institute of Respiratory Diseases in Mexico City to d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.6.2016
更新日期:2002-06-01 00:00:00
abstract::We retrospectively studied the acute toxicity of corticosteroid therapy in 23 episodes of PCP occurring in the setting of AIDS and determined the incidence of HIV-related complications following these and 16 other contemporaneous episodes of AIDS-related PCP treated with antimicrobials alone. The mean duration of cort...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.1.38
更新日期:1990-07-01 00:00:00
abstract::To evaluate the role of inhaled ipratropium bromide in acute asthma, a double-blind study of 384 emergency department patients compared the effect of the combination of ipratropium and albuterol with that of albuterol alone. Patients were randomized to receive nebulizer treatments with either 2.5 mg of albuterol or 2....
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.110.3.611
更新日期:1996-09-01 00:00:00
abstract::We studied six patients with type A botulism to determine the degree of initial respiratory compromise and to quantitate the time course and extent of recovery of the ventilatory and upper airway muscles and exercise performance. The VM weakness was identified in all patients early after botulism. Upper airway muscle ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.3.620
更新日期:1990-09-01 00:00:00
abstract::99mTechnetium macroaggregated albumin has successfully been used to define severe postoperative pulmonary vasoconstriction in a four-month-old boy with D-transposition of the great vessels who had undergone a Blalock-Hanlon surgical atrial septectomy. Radionuclide imaging documented clinically suspected pulmonary vaso...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.76.3.274
更新日期:1979-09-01 00:00:00
abstract::Normal subjects were exposed to an aerosol of Escherichia coli endotoxin. Carbon monoxide diffusion (Dco), spirometry, blood neutrophils, white blood cells, and platelets were determined at various times thereafter. A significant decrease in Dco and an increase in blood neutrophils was found, with a maximum effect 4 t...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.4.1095
更新日期:1992-10-01 00:00:00
abstract::Point-of-care ultrasonography is a key skill for the critical care clinician and is gaining widespread acceptance by clinicians in all areas of medicine. In addition to mastery of image acquisition, image interpretation, and clinical application, intensivists need to be adept with billing for their scanning activity. ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2019.06.006
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:DVT is common among critically ill patients. A rapid and accurate diagnosis is essential for patient care. We assessed the accuracy and timeliness of intensivist-performed compression ultrasonography studies (IP-CUS) for proximal lower extremity DVT (PLEDVT) by comparing results with the formal vascular stud...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.10-1479
更新日期:2011-03-01 00:00:00
abstract::Numerous clinical trials of chemotherapy for tuberculosis conducted throughout the world over the past 4 decades have established 2 basic principles of treatment: effective treatment requires the initial concomitant administration of at least 2 drugs to which the patient's organisms are susceptible; and cure of tuber...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.87.2.117s
更新日期:1985-02-01 00:00:00
abstract::Prosthetic valve endocarditis is a formidable complication following cardiac valve replacement. Surgical intervention has resulted in a significant reduction in mortality when certain complications prevail. We report two such cases of prosthetic valve endocarditis in which the use of transesophageal echocardiography p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1886
更新日期:1992-12-01 00:00:00
abstract:STUDY OBJECTIVE:The chronically critically ill (CCI) are a subgroup of critically ill patients who have survived an acute critical illness but remain profoundly debilitated and ventilator dependent. We have previously shown that CCI patients have a very high prevalence of bone hyperresorption. The objective of this pre...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.3.761
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Ultrasound enables the visualization of pleural-based lesions with a poor correlation to specific pathology. At this time, there are no data about the diagnostic value of contrast-enhanced sonography (CES) in pleural lesions. METHODS:From August 2004 to January 2005, 25 consecutive patients with clinical sy...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.6.3894
更新日期:2005-12-01 00:00:00
abstract::Three patients had angiographic appearance of chronic primary coronary artery dissection with features that differed from other patients with this entity studied at autopsy; they were men, greater than or equal to 40 years of age, had angina pectoris and severe coronary artery disease. The right coronary artery, which...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.87.2.227
更新日期:1985-02-01 00:00:00
abstract:STUDY OBJECTIVES:Obstructive sleep apnea (OSA) is characterized by recurrent apnea during sleep that may compromise oxidative balance. Oxidative stress is increased in the blood and in the airways of OSA patients. DESIGN:The aim of this study was to investigate whether oxidative stress is determined by nocturnal apnea...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.4.1386
更新日期:2003-10-01 00:00:00
abstract::A 25-year-old man was treated with gastric lavage and activated charcoal for alcohol and drug overdose; immediately following the initial treatment he developed tension pneumothorax successfully managed with a chest tube. The patient presented four weeks later with a charcoal-containing empyema, an unreported conditio...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.87.3.404
更新日期:1985-03-01 00:00:00