Abstract:
:To evaluate the role of inhaled ipratropium bromide in acute asthma, a double-blind study of 384 emergency department patients compared the effect of the combination of ipratropium and albuterol with that of albuterol alone. Patients were randomized to receive nebulizer treatments with either 2.5 mg of albuterol or 2.5 mg of albuterol mixed with 0.5 mg of ipratropium bromide at entry and at 45 min. Spirometry, vital signs, and oxygen saturation were measured before and at 45 and 90 min following the nebulizer treatments. Serum potassium levels were obtained at entry and 90 min. The two groups did not differ significantly in age (mean +/- SD = 33.4 +/- 9.3 and 32.5 +/- 9.7 years for the albuterol and ipratropium group and the albuterol group, respectively), baseline FEV1 (mean +/- SD = 1.22 +/- 0.42 and 1.25 +/- 0.44 L respectively), or prior use of asthma medications. At 45 min, there were significantly more responders (15% increase in FEV1 over baseline) in the group receiving albuterol and ipratropium compared with albuterol and saline solution (85% and 78%, respectively; p = 0.045), but the median change in FEV1 from baseline did not differ (0.530 L for the albuterol and ipratropium group and 0.420 L for the albuterol and saline solution group; p = 0.347). By 90 min, the percentage of responders did not differ (88% and 89%, respectively), and the median change in FEV1 was 0.680 L for the group receiving albuterol and ipratropium and 0.650 L for the group receiving albuterol and saline solution (p = 0.693). There were no significant adverse events experienced by patients in either group. Furthermore, there were no significant differences in the number of patients requiring additional therapy in the emergency department or hospitalization. We conclude that in this population of inner city asthmatics, we were unable to demonstrate significant additive benefit of nebulized ipratropium bromide to nebulized albuterol.
journal_name
Chestjournal_title
Chestauthors
Karpel JP,Schacter EN,Fanta C,Levey D,Spiro P,Aldrich T,Menjoge SS,Witek TJdoi
10.1378/chest.110.3.611subject
Has Abstractpub_date
1996-09-01 00:00:00pages
611-6issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(16)41059-7journal_volume
110pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
CHEST文献大全abstract::Long-term oxygen is the only therapy that has been shown to improve survival in patients with chronic obstructive pulmonary disease. The aim of this study was to assess the predictors of survival in such patients treated with long-term oxygen therapy. We studied 179 patients who were assessed for long-term oxygen ther...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.6.1522
更新日期:1991-12-01 00:00:00
abstract::To determine whether continuous Fick cardiac output measurement is applicable to exercise testing, cardiac output data obtained by the continuous Fick method (Qcf) during exercise were compared with data obtained by the thermodilution method (Qth). Seventeen patients with old myocardial infarction underwent a 1-min or...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.2.419
更新日期:1993-08-01 00:00:00
abstract:AIMS:We assessed early and long-term pulmonary function changes after percutaneous balloon mitral valvotomy (PBMV). METHODS AND RESULTS:Mitral area, lung function, and exercise capacity were evaluated before, immediately after, and 3 months, 6 months, and 12 months after successful PBMV in 24 patients. PBMV resulted i...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.1.40
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The immediate and long-term clinical events associated with the placement and removal of a retrievable filter (ALN filter; ALN Implants Chirurgicaux; Ghisonaccia, France) remain largely unknown. METHODS:This was a prospective cohort study with an 18-month follow-up. All consecutive patients scheduled for pl...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-0631
更新日期:2007-01-01 00:00:00
abstract:SETTING:Seven primary health clinics and a pulmonary disease specialty clinic in Rio de Janeiro City, Brazil. OBJECTIVE:To evaluate a commercial immunochromatographic test kit (ICT Tuberculosis; AMRAD-ICT; Sidney, Australia) employing five recombinant Mycobacterium tuberculosis proteins for the detection of pulmonary ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.1.107
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Solitary pulmonary nodule (SPN) evaluation based on analyses of combined wash-in (WI) and washout (WO) values obtained by helical dynamic CT (HDCT) scanning is useful for malignant SPN characterization, because this method has higher specificity and accuracy than that based on analyses of WI values only. How...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.06-2526
更新日期:2007-05-01 00:00:00
abstract::Treatment failure (TF) is defined as a clinical condition with inadequate response to antimicrobial therapy. Clinical response should be evaluated within the first 72 h of treatment, whereas infiltrate images may take up to 6 weeks to resolve. Early failure is considered when ventilatory support and/or septic shock ap...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.06-1995
更新日期:2007-10-01 00:00:00
abstract::All aspects of medical education were affected by the Novel Coronavirus Infectious Disease-19 (COVID-19) pandemic. Several challenges were experienced by trainees and programs alike due to the economic repercussions of the pandemic, how social distancing affected the delivery of medical education, testing and intervie...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2020.12.026
更新日期:2020-12-29 00:00:00
abstract::In this investigation, we examined changes in exfoliated tracheobronchial cells in sputum in 46 individuals (mean age = 49.2 years; mean packyears = 48.7) who discontinued smoking and 37 individuals (mean age = 54.9 years; mean packyears = 65.2) who continued to smoke over a 12-month period after participation in the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.3.607
更新日期:1992-03-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the utility of urinary uric acid excretion as a marker of nocturnal hypoxia in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after the institution of nasal continuous positive airway pressure (CPAP). DESIGN:Prospective, open. SETTING:Sleep Disorders Laboratory, V...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.6.1604
更新日期:1998-06-01 00:00:00
abstract::Atrioventricular nodal alternating Wenckebach periods were defined as episodes of 2:1 atrioventricular block in which there was a gradual increase in transmission intervals of conducted beats ending in two or three consecutively blocked atrial impulses. This is one of the mechanisms whereby 2:1 atrioventricular block ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.73.1.69
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Failure to reliably diagnose ARDS may be a major driver of negative clinical trials and underrecognition and treatment in clinical practice. We sought to examine the interobserver reliability of the Berlin ARDS definition and examine strategies for improving the reliability of ARDS diagnosis. METHODS:Two hu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2017.11.037
更新日期:2018-02-01 00:00:00
abstract::Spontaneous pneumomediastinum is an uncommon benign condition that is occasionally associated with air within the spinal canal. We describe a further case in a 14-year-old girl and suggest a classification system based on a detailed review of the previous literature. Forty-eight patients with spontaneous pneumomediast...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.09-0514
更新日期:2010-05-01 00:00:00
abstract::The adverse effects of prolonged immobility are due primarily to gravitational effects on blood flow and ventilation, impairment of the normal mucociliary escalator and possibly an increase in extravascular lung water. However, CLRT theoretically should reverse these abnormalities. The sequence of events that culminat...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1378/chest.99.5.1263
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:COPD and hypertension both increase the risk of congestive heart failure (CHF). Current clinical trials do not inform the selection of combination antihypertensive therapy among patients with COPD. We performed a comparative effectiveness study to investigate whether choice of dual agent antihypertensive the...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-1770
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are recommended as initial maintenance treatments for COPD, with their combination (LABA-LAMA) advocated as the disease progresses. Randomized trials comparing the effectiveness of this combination with the alternative combination...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.03.005
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Ultrafiltration (UF) can improve the exercise performance of patients with moderate congestive heart failure (CHF). Our aim was to define the starting levels of performance below which UF is beneficial. PATIENTS AND METHOD:We studied 26 patients in 2 to 3 NYHA class, whose clinical condition was stable, left...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.1.94
更新日期:1995-07-01 00:00:00
abstract::This study compared the nutritional status of patients with emphysema and chronic bronchitis and examined the relationship between lung dysfunction and nutritional depletion in patients with emphysema. There was no evidence of nutritional depletion in patients with chronic bronchitis (n = 4). In contrast, patients wit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.1.17
更新日期:1983-01-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the chest radiographic filling pattern associated with partial liquid ventilation (PLV) with the perfluorochemical perflubron (LiquiVent; Alliance Pharmaceutical Corp; San Diego CA) as a function of dose and timing. DESIGN:Post hoc review of chest radiographs by three independent observers...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.119.5.1503
更新日期:2001-05-01 00:00:00
abstract:STUDY OBJECTIVE:To validate a noninvasive first-pass radionuclide ventriculographic (FPRV) measurement of maximum cardiac output (Qv) during exercise. DESIGN:Comparison of Qv to that measured by the Fick principle (Qf) at peak exercise. SETTING:Academic cardiopulmonary exercise laboratory. PATIENTS:Seventy-eight con...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.2.457
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To assess the incidence of pseudomonal infection, colonization, and inflammation in the allograft of lung transplant recipients with cystic fibrosis (CF) as compared with recipients with other end-stage lung disease. DESIGN:Retrospective review. SETTING:University medical center transplant service. PATIENT...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.5.1235
更新日期:1998-05-01 00:00:00
abstract:STUDY OBJECTIVES:To compare the outcome of Legionnaires disease (LD) in patients with and without HIV infection. DESIGN:Retrospective review of clinical charts. SETTING:Six hundred-bed university hospital. PATIENTS:We studied the clinical findings of 64 patients without HIV and 15 patients with HIV. Patients with a ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.2.543
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Spontaneous pneumothorax (SPTX) is an uncommon phenomenon in the general population and is most commonly associated with prior bulbous emphysema, cystic parenchymal lung disease, and tuberculous lung disease. A rare cause of SPTX is malignant disease, either in the form of primary lung or pleural cancers, or...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.09-2292
更新日期:2010-09-01 00:00:00
abstract::To assess the left ventricular function during sustained stable ventricular tachycardia (VT), ten patients, aged 58 to 74, underwent simultaneous echo-Doppler and hemodynamic studies during sinus rhythm and induced sustained stable monomorphic VT. The VT cycle length was 447 +/- 92 ms (mean +/- SD). During VT, cardiac...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.2.275
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Inhaled magnesium (Mg) seemed to have a mild protective (nonbronchodilator) effect against histamine and methacholine. Inhaled sodium metabisulfite (MBS) causes bronchoconstriction in asthma through indirect mechanisms that involve sensory nerve stimulation, and it is extensively used to study airway hyperre...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.111.4.858
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:We investigated whether artificial neural networks (ANNs) could diagnose pathology of lymph nodes by feeding B-mode images from convex-type echobronchoscopy to ANNs. METHODS:Subjects comprised 91 patients who had undergone endobronchial ultrasonography transbronchial needle aspiration at our hospital betwee...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-1497
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine if a small pneumothorax would influence the pleurodesis resulting from talc instillation. METHODS:Sixty rabbits received an intrapleural injection of 400 mg/kg talc slurry. One half also received 10 mL of air intrapleurally after the talc. Ten rabbits in each group ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.4.1143
更新日期:1998-10-01 00:00:00
abstract::The efficacy of continuous positive airway pressure (CPAP) administered with a face mask was compared to oxygen supplementation in 40 patients with acute cardiogenic pulmonary edema. Baseline arterial blood gas values and pH, heart rate, respiratory rate, and blood pressure were recorded after patients breathed 28 per...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.3.481
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Fibrotic interstitial lung diseases (ILDs) are highly morbid chronic disorders that frequently occur in working age individuals. The goal of this study was to determine workplace productivity loss, its determinants, and its estimated costs in patients with fibrotic ILD. METHODS:Patients with idiopathic pulm...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.04.016
更新日期:2019-11-01 00:00:00
abstract:INTRODUCTION:The specific causes and mechanism(s) for asthma occurring among occupants of non-residential buildings with poor indoor air quality are not known, but allergic and nonallergic processes are possible explanations METHODS:Repeated indoor air quality measurements were made while employees were working in a b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1720
更新日期:2005-09-01 00:00:00