Abstract:
BACKGROUND:Solitary pulmonary nodule (SPN) evaluation based on analyses of combined wash-in (WI) and washout (WO) values obtained by helical dynamic CT (HDCT) scanning is useful for malignant SPN characterization, because this method has higher specificity and accuracy than that based on analyses of WI values only. However, increased specificity results in reduced sensitivity and the missing of malignant SPNs. Thus, the purpose of this study was to seek the most effective method for SPN characterization during HDCT scanning. METHODS:After obtaining unenhanced CT scans, dynamic CT scanning was performed using a helical technique (images were obtained at 30, 60, 90, and 120 s, and at 5 and 15 min after the initiation of IV contrast administration) in 486 patients with a solid or partly solid SPN. Diagnostic efficacies were compared for three approaches involving considerations of WI values (in Housfield units [HU]) only, both WI and WO HU values, and WI HU values and morphologic characteristics. RESULTS:Considering WI values only (> or = 25 HU), sensitivity, specificity, and accuracy for malignancy were 98% (233 of 237 nodules), 46% (114 of 249 nodules), and 71% (347 of 486 nodules), respectively. Using both a WI value of > or = 25 HU and a WO value of 5 to 36 HU, the corresponding values were 89% (212 of 237 nodules), 79% (197 of 249 nodules), and 84% (409 of 486 nodules), respectively; for a WI value of > or = 25 HU and a malignant morphology, the corresponding values were 92% (219 of 237 nodules), 79% (197 of 249 nodules), and 86% (416 of 486 nodules), respectively (these values were significantly different between the WI-only group and the other two groups; p = 0.001). CONCLUSIONS:The efficacy of SPN evaluation based on analyses of WI values plus morphologic features during HDCT scanning appears to be equivalent to that based on analyses of WI plus WO values, thus obviating the need for WO scans, which saves time and reduces radiation exposure of the patient.
journal_name
Chestjournal_title
Chestauthors
Lee KS,Yi CA,Jeong SY,Jeong YJ,Kim S,Chung MJ,Kim HY,Kim YK,Lee KHdoi
10.1378/chest.06-2526subject
Has Abstractpub_date
2007-05-01 00:00:00pages
1516-25issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)31625-1journal_volume
131pub_type
临床试验,杂志文章相关文献
CHEST文献大全abstract::We describe the management of bronchopleurobiliary fistula in a 56-year-old woman who underwent a (L) mastectomy with postoperative radio- and chemotherapy for advanced breast carcinoma and required insertion of inhabiliary Silastic stents for the relief of severe obstructive jaundice. During restaging of her carcinom...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.4.874
更新日期:1988-10-01 00:00:00
abstract::Each of four examiners performed standardized physical examinations on a group of patients who had just undergone tests of ventilatory function. The intensity of breath sounds heard with deep inspiration was graded on a rating scale of 0 to 4; the grades in six areas of the chest were added to give a total score, with...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.70.3.341
更新日期:1976-09-01 00:00:00
abstract::A 19-year-old man with untreated systemic lupus erythematosus had an acute myocardial infarction. A coronary arteriogram five hours after the onset of symptoms revealed total occlusion of the left anterior descending coronary artery. Reperfusion was achieved by coronary thrombolytic therapy with urokinase. Four weeks ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.88.1.147
更新日期:1985-07-01 00:00:00
abstract::A study to assess the effect of the long-term use of triamcinolone acetonide (TA) on adrenal function was conducted with 143 male and female patients with asthma who were randomly assigned to receive 800, 1200, or 1,600 micrograms of TA daily for six months. Adrenal function was assessed prior to treatment and after t...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.101.5.1250
更新日期:1992-05-01 00:00:00
abstract::The first report of coincident IHSS and ostium secundum ASD is corroborated and successful septal myotomy and myectomy with patch closure of the ASD is described. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.68.2.246
更新日期:1975-08-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the chest radiographic filling pattern associated with partial liquid ventilation (PLV) with the perfluorochemical perflubron (LiquiVent; Alliance Pharmaceutical Corp; San Diego CA) as a function of dose and timing. DESIGN:Post hoc review of chest radiographs by three independent observers...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.119.5.1503
更新日期:2001-05-01 00:00:00
abstract:STUDY OBJECTIVES:Acute exposure to the air in swine confinement units causes bronchial hyperresponsiveness and inflammation of the airways. This study was performed to assess the longitudinal development of bronchial responsiveness in pig farmers and to establish exposure-response relationships. METHODS:A cohort of 17...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.5.1488
更新日期:2000-05-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the usefulness of a specific inspiratory muscle training in Duchenne muscular dystrophy (DMD). PATIENTS AND METHODS:Fifteen patients with DMD started 6 months of training the inspiratory muscles and 15 patients served as a control group. Pulmonary and inspiratory muscle func...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.105.2.475
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:We hypothesized that intermittent hypoxia might influence serum substance P levels, and that this effect might in turn contribute in excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea syndrome (OSAS). PATIENTS AND METHODS:Fifty-five patients with newly diagnosed OSAS and 15 age-match...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-2348
更新日期:2007-05-01 00:00:00
abstract::The need for fiberoptic bronchoscopy in the patient with hemoptysis and a normal or nonlocalizing chest roentgenogram remains a subject of debate. Currently, diagnostic fiberoptic bronchoscopy is recommended as the investigative procedure of choice. To develop predictors that identify the patient in whom fiberoptic br...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.1.70
更新日期:1988-01-01 00:00:00
abstract::In most studies, many statistical tests are performed. They can be run to compare the groups at baseline, look at relationships among the various measures, and, for intervention trials, examine more than one end point. As the number of tests increases, so does the probability of finding at least one of them to be stat...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.11-0523
更新日期:2011-07-01 00:00:00
abstract:UNLABELLED:Protected specimen brush (PSB) is considered to be one of the standard methods for the diagnosis of ventilator-associated pneumonia, but to our knowledge, intraindividual variability in results has not been reported previously. PURPOSE:To compare the results of two PSB performed in the same subsegment on pa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.1.104
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To describe trends of reported alpha 1-antitrypsin deficiency mortality in the United States from 1979-1991. METHODS:We analyzed death certificate reports in the multiple-cause mortality files compiled by the National Center for Health Statistics. RESULTS:Of the 26,866,600 deaths that occurred during the 13...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.1.78
更新日期:1996-07-01 00:00:00
abstract:STUDY OBJECTIVE:Estimating lung volume using inspiratory capacity (IC) maneuvers is a useful way of tracking dynamic hyperinflation. An understanding of the repeatability of the IC in a clinical setting is important when evaluating an individual's response to a therapeutic intervention that might influence lung volume....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.3.708
更新日期:2002-03-01 00:00:00
abstract::We report 4 cases of Churg-Strauss syndrome (CSS) that occurred in patients being treated with corticosteroids for a diagnosis of asthma. One patient had asthma, eosinophilia, and eosinophilic lymphadenopathy that regressed with higher doses of corticosteroids. The second patient had both eosinophilic tissue infiltrat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.2.320
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND AND STUDY OBJECTIVE:Phrenic nerve injury may occur after cardiac surgery; however, its cause has not been extensively investigated with electrophysiology. The purpose of this study was to determine by electrophysiologic means the importance of various possible risk factors in the development of phrenic nerve...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.1.8
更新日期:1998-01-01 00:00:00
abstract::A patient with rheumatic heart disease, mitral stenosis, and mitral insufficiency is described. The thrombosed giant left atrium paralyzed the left vocal cord and completely obstructed the bronchi to the middle and lower lobes of the right lung. The giant left atrium mimicked a mediastinal tumor on the chest x-ray fil...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.3.406
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:Little information exists about the expected time to death after terminal withdrawal of mechanical ventilation. We sought to determine the independent predictors of time to death after withdrawal of mechanical ventilation. METHODS:We conducted a secondary analysis from a cluster randomized trial of an end-o...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.10-0289
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The measure of sputum eosinophil counts is a useful tool in the investigation of occupational asthma (OA), but processing sputum is time consuming. Measuring the fractional concentration of exhaled nitric oxide (FENO) may be an alternative in clinical practice. The aim of this study was to assess the respect...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.09-2081
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:In daily clinical work, we often face delayed or recurrent pneumothorax after radiofrequency (RF) ablation for lung tumors, but a large study on this theme has not been done. Thus, we examined the rate of delayed or recurrent pneumothorax after RF ablation for lung tumors and the risk factors associated with...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-1499
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Small cell lung carcinoma (SCLC) continues to have a poor prognosis, with a 2-year survival of < 20%. Studies have suggested that SCLC may affect the immune system to allow it to evade immunologic responses. We hypothesized that any such effect would be characterized by a decrease in the lymphoid cells assoc...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-0681
更新日期:2013-01-01 00:00:00
abstract::A post-right pneumonectomy syndrome is described which manifests symptoms of exertional dyspnea and inspiratory stridor on rapid inspiration. These symptoms were associated with marked rightward and posterior deviation of the trachea, over-distention of the left lung with its herniation into the right side of the ches...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.1.78
更新日期:1979-01-01 00:00:00
abstract::The alterations in metabolic (oxygen consumption [VO2] and carbon dioxide production [VCO2]) and hemodynamic (heart rate and blood pressure) parameters caused by various common intensive care activities were examined in a group of 23 mechanically-ventilated critically-ill patients. The observed variations in metabolic...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.6.815
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:The impact of new-onset postoperative atrial fibrillation (NAF) on in-hospital mortality (IHM) following cardiac surgery is unknown. METHODS:All patients without preoperative atrial fibrillation undergoing isolated coronary artery bypass graft surgery (CABG) and concomitant CABG and valve surgery were ident...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-0735
更新日期:2007-03-01 00:00:00
abstract::Pulmonary hypertension (PH) due to chronic lung disease is associated with a poor prognosis, regardless of the underlying respiratory condition. Updated PH guidelines recommend optimal treatment of the underlying lung disease, including long-term oxygen therapy, in patients with chronic hypoxemia despite the lack of r...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2017.06.008
更新日期:2018-01-01 00:00:00
abstract::To determine whether sectional development in pulmonary and critical care medicine influences medical house officers' (HO) interests and knowledge about respiratory medicine, we reviewed HO performance on the American Board of Internal Medicine (ABIM) certifying examination during 4 years before and 5 years after reor...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.2.533
更新日期:1996-08-01 00:00:00
abstract::A unique association of giant lymph node hyperplasia (Castleman's disease) and cardiac tamponade is presented. Although pleural effusions have been previously described with Castleman's disease, the authors believe this to be the first report of pericardial effusion and tamponade with this entity. The development of e...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.2.637
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Continuous administration of aerosolized beta 2-agonists has been suggested as an effective treatment for severe reversible airways disease. To facilitate continuous therapy and avoid a feed system for small-volume nebulizers (SVNs), a large-volume medication nebulizer (Vortran HEART) was deve...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.5.1200
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:To compare the rapid shallow breathing index (RSBI) under different ventilatory support settings prior to extubation trials. DESIGN:Prospective study. SETTING:Cardiac surgery unit at a university hospital. PATIENTS:A total of 33 coronary artery bypass grafting patients ready for extubation. INTERVENTIONS...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.121.2.475
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Chlorofluorocarbons (CFCs) used as propellants in metered-dose inhalers deplete stratospheric ozone, which results in serious public health concerns. Albuterol has been reformulated in the non-ozone-depleting propellant, hydrofluoroalkane-134a (HFA albuterol). OBJECTIVES:The primary objective was to compare...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.115.4.945
更新日期:1999-04-01 00:00:00