Abstract:
BACKGROUND:Small cell lung carcinoma (SCLC) continues to have a poor prognosis, with a 2-year survival of < 20%. Studies have suggested that SCLC may affect the immune system to allow it to evade immunologic responses. We hypothesized that any such effect would be characterized by a decrease in the lymphoid cells associated with the tumor in biopsy specimens and that this might relate to patient outcome. METHODS:Sixty-four SCLC biopsy specimens were immunohistochemically stained with anti-CD45 antibody to identify immune cells associated with the tumor. A mean CD45 count per high-power field for each case was obtained, and the results were correlated with age, sex, stage, performance status (PS), treatment with chemotherapy/radiotherapy, and overall survival. RESULTS:The median CD45 count for all cases was taken as 40 (CD45(40)). Kaplan-Meier plots demonstrated better survival for patients with a CD45(40) > 40 ( P < .009). No relationship between CD45 40 and age, sex, stage, or treatment by chemotherapy or radiotherapy was identified. Although PS was a significant predictor of survival ( P = .014), it did not correlate with CD45 40. In patients with better Eastern Cooperative Oncology Group PS (≤ 2), the CD45(40) demonstrated a highly significant survival advantage for those with CD45(40) > 40 ( P < .0001). CONCLUSIONS:The data indicate that (1) simple immunohistochemical assessment of immune cell infiltrates in routinely processed and stained biopsy specimens of primary tumors can provide prognostic information in SCLC and (2) tumor-associated CD45(+) cells in SCLC biopsy specimens may be a good clinical marker to identify patients with poor prognosis despite good PS.
journal_name
Chestjournal_title
Chestauthors
Wang W,Hodkinson P,McLaren F,Mackean MJ,Williams L,Howie SEM,Wallace WAH,Sethi Tdoi
10.1378/chest.12-0681subject
Has Abstractpub_date
2013-01-01 00:00:00pages
146-151issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(13)60024-0journal_volume
143pub_type
杂志文章相关文献
CHEST文献大全abstract::We have assessed right and left ventricular function by multigated radionuclide ventriculography in 12 consecutive patients with acquired immunodeficiency syndrome (AIDS) grouped according to the CDC classification system for HIV infection. Results were correlated with clinical, electrocardiographic and echocardiograp...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.592
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:IV hydration before and after cardiac catheterization is effective in preventing contrast-associated renal dysfunction for patients with mild-to-moderate renal insufficiency, but necessitates overnight hospital admission. We tested an outpatient oral precatheterization hydration strategy in comparison with o...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.114.6.1570
更新日期:1998-12-01 00:00:00
abstract::Nocturnal noninvasive ventilation (NNV), the provision of ventilatory assistance via a noninvasive interface mainly during sleep, has assumed an important role in the management of chronic hypoventilatory syndromes. This review focuses on recent developments related to the use of NNV to treat various forms of chronic ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.07-1527
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical feasibility of using real-time measurements of work of breathing obtained at the bedside with a portable, commercially available respiratory monitor as an objective and quantifiable guideline for appropriately setting pressure support ventilation (PSV) to partially and totally unload ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.6.1835
更新日期:1994-12-01 00:00:00
abstract::The concentrations of gentamicin, netilmicin, and amikacin were determined after one single intravenous injection in uninfected pleural fluid after thoracotomy and in purulent pleural empyemas. The mean peak concentrations in the pleural fluid after the injection of gentamicin (1.5 mg/kg), netilmicin (2.0 mg/kg), and ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.530
更新日期:1988-03-01 00:00:00
abstract::Intraoperative two-dimensional echocardiography allows visualization of cardiac anatomy and function not possible by other techniques. Although preoperative evaluation by noninvasive methods is usually adequate for diagnosis of cardiac tumors, two-dimensional echocardiography can be beneficial intraoperatively. Intrao...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.1.142
更新日期:1987-01-01 00:00:00
abstract::Severe head injury often results in hypoxemia, but the pathophysiology of this phenomenon is unclear. We studied 24 patients hospitalized after severe head injury to determine whether the abnormality of oxygen transfer as measured by venous admixture (Qs/Qt) was associated with a reduction in functional residual capac...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.84.1.29
更新日期:1983-07-01 00:00:00
abstract::The assessment of the structure and function of the subvalvular apparatus (SVA) in patients with rheumatic mitral stenosis (MS) is complex, yet is of major importance prior to therapeutic decision making. Currently available methods of assessment are neither sufficiently accurate nor feasible. We review anatomic and f...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.124.5.1929
更新日期:2003-11-01 00:00:00
abstract:STUDY OBJECTIVES:Clinical prediction models for the diagnosis of obstructive sleep apnea (OSA) have lacked the accuracy necessary to confidently replace polysomnography (PSG). Artificial neural networks are computer programs that can be trained to predict outcomes based on experience. This study was conducted to test t...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.2.409
更新日期:1999-08-01 00:00:00
abstract::We report a case of Behçet's disease with pulmonary and splenic involvement. The radiologic presentation was quite different from the modes defined in the literature. A large, anteriorly located, well circumscribed ovoid mass was the x-ray film image of a large area of infarction with hemorrhage. The involved pulmonar...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.104.5.1635
更新日期:1993-11-01 00:00:00
abstract::Elimination half-life and apparent volume of distribution of theophylline were determined in ten healthy volunteers who used smokeless tobacco (snuff or chewing tobacco) regularly but did not smoke cigarettes. Serum concentrations of the acute phase reactant alpha 1-acid glycoprotein (AAG) were also measured. The elim...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.6.1253
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Patients presenting with acute pulmonary embolism associated with hemodynamic compromise exhibit right ventricular enlargement and dysfunction on transthoracic echocardiogram. However, the degree of echocardiographic abnormalities among hemodynamically stable patients without preexisting cardiopul...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.3.665
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To study the incidence of phrenic neuropathy following coronary artery bypass grafting and determine long-term outcome. DESIGN:Prospective observational. SETTING:Surgical ICU in a university hospital, out-patient follow-up. PATIENTS:Ninety-two consecutive patients undergoing open heart surgery. INTERVENTI...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.3.850
更新日期:1993-03-01 00:00:00
abstract::The definition of a standard therapy for resectable esophageal cancer remains a clinical controversy. In the past decade, a variety of strategies have been developed in an attempt to improve local control and decrease the all too common problem of distant metastases. Preoperative treatment with radiotherapy or chemoth...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.116.suppl_3.466s
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Approximately 40% of patients in medical ICUs require mechanical ventilation (MV). Approximately 20% to 25% of these patients will encounter difficulties in discontinuing MV. Multiple studies have suggested that MV has an unloading effect on the respiratory muscles that leads to diaphragmatic atrophy and dys...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-1638
更新日期:2012-12-01 00:00:00
abstract:STUDY OBJECTIVES:Although percutaneous transluminal coronary angioplasty (PTCA) is known to have beneficial effects on exercise capacity, its effects on the cardiovascular response during the onset of exercise have not been clarified. The present study was undertaken to determine the effects of PTCA on the kinetics of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.2.329
更新日期:2000-08-01 00:00:00
abstract::The literature contains many reports of the echocardiographic findings in left atrial myxoma and clot; however, descriptions of left ventricular thrombus or tumor are rare. We discuss here the echocardiographic findings in a patient with a large apical left ventricular thrombus which was confirmed both angiographicall...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.3.417
更新日期:1977-03-01 00:00:00
abstract::Systolic time interval studies were performed to evaluate left ventricular performance in 28 patients with untreated systemic hypertension but without clinical heart failure. The pre-ejection period (PEP) was significantly prolonged (p smaller than 0.001) and left ventricular ejectime time (LVET) was shortened (p smal...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.68.1.51
更新日期:1975-07-01 00:00:00
abstract::From March 1, 1979 thru September 30, 1984 we performed 56 cardiac transplants (Tx). The first 32 patients received conventional immunosuppression therapy consisting of azathioprine/prednisone (I/P), while the subsequent 24 patients received cyclosporine/prednisone (C/P). Twenty-one of 32 I/P patients ages 39 +/- 3 ye...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.1.29
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Balloon pulmonary angioplasty (BPA) in chronic thromboembolic pulmonary hypertension (CTEPH) improves hemodynamics and exercise capacity. However, its effect on respiratory function is unclear. Our objective was to investigate the effect of BPA on respiratory function. METHODS:We enrolled patients with inop...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.10.002
更新日期:2017-03-01 00:00:00
abstract::A 33-year-old man with a two-year history of asthma and sinusitis presented with wheezing, pleuritis, bilateral pleural effusions, and patchy basilar infiltrates on chest roentgenogram. Laboratory studies revealed peripheral blood eosinophilia, and pulmonary function studies showed an obstructive pattern which was bro...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.6.1357
更新日期:1989-06-01 00:00:00
abstract::Single-breath carbon monoxide diffusing capacity (Dsb) was measured before and during immersion of one hand in ice water (cold pressor test) in the following three groups of subjects: (1) normal subjects; (2) patients with isolated Raynaud's disease; and (3) patients with Raynaud's phenomenon and progressive systemic ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.84.3.264
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:There is controversy about whether therapy with inhaled corticosteroids (ICSs) modifies the natural history of COPD, characterized by an accelerated decline in FEV(1). METHODS:The Inhaled Steroids Effect Evaluation in COPD (ISEEC) study is a pooled study of patient-level data from seven long-term randomized...
journal_title:Chest
pub_type: 杂志文章,meta分析
doi:10.1378/chest.06-1696
更新日期:2007-03-01 00:00:00
abstract::A five-year clinical follow-up and the results of myocardial biopsies are described in a patient with primary restrictive cardiomyopathy. Histologic examination of a right ventricular endomyocardial biopsy taken early in the course of the illness was not contributory. Histologic examination of a left ventricular endom...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.84.2.236
更新日期:1983-08-01 00:00:00
abstract:STUDY OBJECTIVES:We designed and performed a survey to assess the roles and knowledge level of physicians, by specialty, in the management of non-small cell lung cancer (NSCLC). The primary objective was to evaluate the potential variability of physician perceptions of prognosis, recommended treatments, and the impact ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.2.593
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Increased expression of the human epididymis protein 4 (HE4) was previously described in lung biopsy samples from patients with cystic fibrosis (CF). It remains unknown, however, whether serum HE4 concentrations are elevated in CF. METHODS:Seventy-seven children with CF from six Hungarian CF centers and 57 ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.04.006
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Male sex is an independent predictor of worse survival in pulmonary arterial hypertension (PAH). This finding might be explained by more severe pulmonary vascular disease, worse right ventricular (RV) function, or different response to therapy. The aim of this study was to investigate the underlying cause of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-1291
更新日期:2014-06-01 00:00:00
abstract::Fifteen patients (range of ages, 18 to 35 years) who survived an acute episole of the adult respiratory distress syndrome caused by mechanical or thermal injuries, sepsis, and shock were studied during 1 to 30 months after recovery. The patients had had no previous pulmonary diseases, and only two had been smokers. Al...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.74.3.247
更新日期:1978-09-01 00:00:00
abstract:STUDY OBJECTIVES:The aim was to evaluate demographic, clinical, and laboratory variables in febrile patients, with or without a microbiologically confirmed infection, for prediction of death, in comparison to the systemic inflammatory response syndrome (SIRS) and its criteria, such as abnormal temperature, tachycardia,...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.6.1533
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:The reported experience is sparse for patients with prior pneumonectomy who are undergoing surgery for ischemic or valvular heart disease. Such surgery poses special technical challenges. To expand the experience with this challenging clinical intervention, we reviewed the reported patients with prior pneumo...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.06-2545
更新日期:2007-07-01 00:00:00