Abstract:
BACKGROUND AND OBJECTIVES:Continuous administration of aerosolized beta 2-agonists has been suggested as an effective treatment for severe reversible airways disease. To facilitate continuous therapy and avoid a feed system for small-volume nebulizers (SVNs), a large-volume medication nebulizer (Vortran HEART) was developed. The goal of this study was to determine actual drug delivery of the HEART and conventional SVNs for both adult and pediatric breathing patterns. DESIGN:Output studies were conducted on comparable samples of CIS-US AeroTech II and Hospitak PowerMist SVNs and Vortran HEART large-volume continuous nebulizers. To duplicate clinical aerosol delivery via an aerosol mask, drug particles were inhaled through the mouth of a model of a human face for two test breathing patterns (adult = tidal volume (Vt) of 500 mL, 20 breaths/min, duty cycle of 40%; pediatric = VT of 100 mL, 35 breaths/min, duty cycle of 40%), generated by a ventilator. Radiolabeled particles of saline solution, confirmed to behave identically to albuterol, were collected on absolute filters at the mouth of the face to measure the actual mass of albuterol particles delivered to the airway opening. RESULTS:The AeroTech II and PowerMist SVNs delivered 5.14 and 3.74 mg/h, respectively, for the adult breathing pattern and 2.97 and 2.48 mg/h, respectively, for the pediatric breathing pattern. Drug delivery rates of the HEART were a function of drug concentration and ranged from 0.87 to 3.48 mg/h for the adult breathing pattern. For the pediatric breathing pattern, drug delivery rate was a function of drug concentration and inspired minute ventilation and ranged from 0.41 to 1.83 mg/h. CONCLUSION:Our data demonstrate that drug delivery to the patient, expressed as inhaled mass over time, is similar for continuous nebulization (HEART system) and intermittently filled SVNs. In addition, for all nebulizers, the influence of the pediatric breathing pattern needs to be considered. Continuous nebulization permits the redistribution of health-care personnel and may reduce the costs of therapy.
journal_name
Chestjournal_title
Chestauthors
McPeck M,Tandon R,Hughes K,Smaldone GCdoi
10.1378/chest.111.5.1200subject
Has Abstractpub_date
1997-05-01 00:00:00pages
1200-5issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)46948-Xjournal_volume
111pub_type
杂志文章相关文献
CHEST文献大全abstract::To evaluate whether the response of left ventricular pump function during low-level exercise in the early postinfarction period can anticipate its change during the first year after acute myocardial infarction (MI), global and regional ejection fractions (EF) were investigated using radionuclide angiography in 52 cons...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.2.335
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Increased expression of the human epididymis protein 4 (HE4) was previously described in lung biopsy samples from patients with cystic fibrosis (CF). It remains unknown, however, whether serum HE4 concentrations are elevated in CF. METHODS:Seventy-seven children with CF from six Hungarian CF centers and 57 ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.04.006
更新日期:2016-09-01 00:00:00
abstract:STUDY OBJECTIVE:To examine the relation between left atrial (LA) function and exercise performance. DESIGN AND SETTING:Retrospective study at a referral cardiopulmonary exercise laboratory in a university hospital. PATIENTS:Forty-one patients with recent myocardial infarction. INTERVENTIONS:M-mode echocardiography a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.4.922
更新日期:1997-04-01 00:00:00
abstract::Persistent minor hemoptysis resulted from extensive granulation tissue on the main carina and adjacent bronchi due to frequent spraying of metered-dose inhaler (MDI)-generated aerosol medications directly into a permanent tracheostomy. Salbutamol, containing oleic acid, was considered the most likely cause. After an A...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.1.279
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Two recent studies in resectable non-small cell lung cancer by the Lung Cancer Study Group (LCSG) suggested an advantage to adjuvant therapy with cyclophosphamide, doxorubicin (Adriamycin), and cisplatin (CAP). Neither study had a no-treatment control arm. The purpose of this study was to compare the CAP regi...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1994-12-01 00:00:00
abstract:CONTEXT:Few studies have examined the effect of nicotine replacement therapy (NRT) in COPD patients. STUDY OBJECTIVE:To evaluate the efficacy of nicotine sublingual tablets and two levels of support for smoking cessation in COPD patients. DESIGN:Double-blind, multicenter, placebo-controlled smoking cessation trial. ...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.130.2.334
更新日期:2006-08-01 00:00:00
abstract:STUDY OBJECTIVES:(1) To define the incidence and natural history of Aspergillus colonization and infection in lung transplant recipients, and (2) to assess the impact of prophylaxis, surveillance, and therapy on the incidence and outcome of the disease. DESIGN:Retrospective review of 133 consecutive single or bilatera...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.119.1.169
更新日期:2001-01-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if a training session using videotaped metered dose inhaler (MDI) performances can result in high interrater and intrarater reliability of five evaluators assessing MDI technique. DESIGN:Five evaluators (three pharmacists, two pulmonary fellows) were trained to evaluate MDI technique durin...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.3.710
更新日期:1994-03-01 00:00:00
abstract::The clinical, roentgenographic and laboratory findings, their relationship to each other and to the subsequent hospital course are reported for 14 victims of gaseous ammonia inhalation. Initial physical examination enabled differentiation of a mildly affected from a moderately affected group, but patients in both grou...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.4.496
更新日期:1980-04-01 00:00:00
abstract:STUDY OBJECTIVES:Prior to the availability of the oral endothelin antagonist bosentan, most patients with pulmonary arterial hypertension (PAH) were treated with continuously infused prostacyclins. Many patients receiving prostacyclins would have received bosentan if it had been available at the time of their diagnosis...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.3.808
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:CPAP effectiveness is limited by suboptimal adherence. Prior studies of adherence have focused on middle-aged men. RESEARCH QUESTION:Does CPAP adherence vary by age and sex? STUDY DESIGN AND METHODS:Telemonitoring data from a CPAP manufacturer database were used to assess adherence in patients initiating C...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.07.017
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Over the last 25 years, a growing number of clinical trials have evaluated novel sepsis therapies. To promote uniformity in inclusion criteria for patient enrollment, the American College of Chest Physicians and Society of Critical Care Medicine first published consensus conference definitions for sepsis in ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.1.242
更新日期:2005-01-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the efficacy of the chest radiograph in identifying patients with miliary tuberculosis. DESIGN:Retrospective case-controlled review by three independent blinded chest radiologists. SETTING:Provincial tuberculosis control center. PATIENTS:Population-based sample, including all proved cases o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.2.339
更新日期:1996-08-01 00:00:00
abstract::Antemortem diagnosis of a perforated MV aneurysm by Doppler echocardiography, as well as two-dimensional echocardiography (2-DE), has not been reported. Herein we present such a case. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.3.753
更新日期:1990-03-01 00:00:00
abstract::It was previously thought that diagnostic or therapeutic ionizing radiation did not have an adverse effect on the function of cardiac pacemakers. Recently, however, some authors have reported damaging effect of the therapeutic radiation on cardiac pulse generators. An analysis of a recently-extracted pacemaker documen...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.84.4.499
更新日期:1983-10-01 00:00:00
abstract:STUDY OBJECTIVE:Factors influencing diastolic filling of the left ventricle may serve as critical determinants of both maximal cardiac output and oxygen uptake. This study was conducted to assess diastolic filling dynamics of the left ventricle during progressive upright cycle exercise in children. METHODS:Twelve boys...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.1.145
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:The natural history of flock worker's lung (FWL) and longitudinal lung function changes in nylon flock-exposed workers have not been well characterized. METHODS:Symptoms, pulmonary function testing, and chest radiographs from five index cases, subsequent case referrals, and screened employees of a flocking ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-0920
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:The relationships among systolic pulmonary artery pressure (SPAP), diastolic pulmonary artery pressure (DPAP), and mean pulmonary artery pressure (MPAP) have been found to be constant in humans breathing air, at rest, while supine. It would be important for those studying the pulmonary circulation if this re...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-1367
更新日期:2008-03-01 00:00:00
abstract::Acute bacterial endocarditis developed in a 65-year-old man two years after surgical resection of a false aneurysm of the left ventricle. The patient had cerebral embolic manifestations, and coagulase-positive Staphylococcus aureus was cultured from each of six blood samples. A pericardial friction rub and a changing ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.2.227
更新日期:1977-02-01 00:00:00
abstract::Various malformations of the aortic arch and great vessels have been reported in the literature, which reflects the complexity of their embryologic development. Most of them are of incidental finding and remain asymptomatic but can be responsible for respiratory or digestive symptoms and be associated with congenital ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-2244
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The ratio of FVC to slow inspiratory vital capacity (SVC) has been reported to reflect small airways obstruction, but its validity as such is still unclear. The aim of this study was to assess the applicability of the FVC/SVC ratio as a marker of small airways function in patients with bronchiolitis oblitera...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-2763
更新日期:2007-10-01 00:00:00
abstract:STUDY OBJECTIVES:The physicians who initially evaluate patients with non-small cell lung cancer (NSCLC) strongly impact the course of therapy. Their beliefs in treatment and prognosis may contribute to practices of variable quality and appropriateness. We sought to better describe beliefs among pulmonologists and thora...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.1.129
更新日期:2000-07-01 00:00:00
abstract:INTRODUCTION:CT scan-guided fine-needle aspiration (FNA) of lung nodules is a well-established diagnostic technique. In our institution, both FNA and tissue core biopsy (using a 20-gauge needle) under CT scan guidance are routinely performed during the same procedure, and a preliminary diagnosis (an immediate assessmen...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.3.739
更新日期:2004-09-01 00:00:00
abstract:STUDY OBJECTIVES:To describe four patients having total anomalous pulmonary venous connection with an intrapulmonary vertical vein, rendering difficulty in diagnosis and surgery. SETTING:a tertiary referral center. PATIENTS AND METHODS:By reviewing medical records, 4 of 25 patients with right atrial isomerism and tot...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.5.1363
更新日期:1996-11-01 00:00:00
abstract::Because T-piece breathing may impair oxygenation, the best airway pressure from which to extubate ventilated patients is controversial. We compared the effects of extubation after 1 h of either CPAP 5 and T-piece/ZEEP. Once weaned from mechanical ventilation and breathing spontaneously, 106 patients were randomized to...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.100.6.1655
更新日期:1991-12-01 00:00:00
abstract::In patients at risk for sepsis after cardiac surgery, the efficacy of intravenous immunoglobulin (Ig) treatment was compared with a historical control population, equivalent in patient characteristics and disease severity. Using APACHE II scores, especially in the high-risk group (IgG), we could discriminate between l...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.105.1.76
更新日期:1994-01-01 00:00:00
abstract::Uterine life is arguably the most critical time in developmental programming, when environmental exposures may have the greatest potential to influence evolving fetal structure and function. There has been substantial progress in understanding the epigenetic mechanisms through which environmental exposures can permane...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.10-1800
更新日期:2011-03-01 00:00:00
abstract::Lung volume reduction surgery (LVRS) is being evaluated in the treatment of emphysema. The proposed mechanisms of improvement are increased elastic recoil of the lung and improved mechanical efficiency of the muscles of respiration. We report a unique patient with emphysema who developed a giant bulla 3 years subseque...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.6.1809
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:In COPD, a decreased inspiratory capacity to total lung capacity ratio (IC/TLC) is associated with dynamic hyperinflation and poor exercise capacity. The association with upper-extremity force measured by handgrip strength (HGS) and 6-min walk distance (6MWD) has not been previously described. We hypothesize...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-2878
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Although the physiologic range of pulmonary artery systolic pressure (PASP) has been reported, data on how it is manifested in athletes are limited. The aim of the present study was to explore the full spectrum of PASP and the long-term training impact in a large population of highly trained athletes. METHO...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-1260
更新日期:2011-04-01 00:00:00