Spectrum of Aspergillus infection in lung transplant recipients: case series and review of the literature.

Abstract:

STUDY OBJECTIVES:(1) To define the incidence and natural history of Aspergillus colonization and infection in lung transplant recipients, and (2) to assess the impact of prophylaxis, surveillance, and therapy on the incidence and outcome of the disease. DESIGN:Retrospective review of 133 consecutive single or bilateral lung transplantations performed at a single institution, and review of the published literature. RESULTS:Airway colonization, isolated tracheobronchitis, and invasive pneumonia due to Aspergillus species occurred in 29%, 5%, and 8% of our series, and in 26%, 4%, and 5% of the pooled published data (all series, including ours), respectively. Greater than 50% of all diagnoses were made in the first 6 months after transplantation in both our series and the published literature. Incidence of progression from airway colonization to invasive disease was 1 in 38 in our series and 3 of 97 (3%) in the pooled published data. In patients with isolated tracheobronchitis, all 6 patients in our series and 41 of 50 patients (82%) in all published series, including ours, responded to antifungal therapy and/or surgical debridement. Among patients with invasive pneumonia or disseminated disease, however, 5 of 10 patients in our series and 26 of 64 patients (41%) in the pooled series survived their infection. CONCLUSIONS:The role of antifungal therapy in Aspergillus airway colonization in lung transplant recipients is unclear. Data support a strategy of scheduled screening bronchoscopy followed by aggressive treatment for isolated Aspergillus tracheobronchitis in lung transplant recipients.

journal_name

Chest

journal_title

Chest

authors

Mehrad B,Paciocco G,Martinez FJ,Ojo TC,Iannettoni MD,Lynch JP 3rd

doi

10.1378/chest.119.1.169

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

169-75

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)37580-2

journal_volume

119

pub_type

杂志文章,评审

相关文献

CHEST文献大全
  • Aberrant systemic arterial supply to the left lung with congestive heart failure.

    abstract::A six-month-old girl with an aberrant systemic arterial supply from the descending thoracic aorta to the left lower lobe had congestive heart failure. Although the pulmonary parenchyma was normal, there was an absence of normal pulmonary arterial supply to the left lower lobe. Main pulmonary arterial and aortic cinean...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.80.5.636

    authors: Yabek SM,Burstein J,Berman W Jr,Dillon T

    更新日期:1981-11-01 00:00:00

  • Gastroesophageal reflux-induced bronchoconstriction. An intraesophageal acid infusion study using state-of-the-art technology.

    abstract:STUDY OBJECTIVE:To study mechanisms of gastroesophageal reflux-induced bronchoconstriction during intraesophageal infusions. DESIGN:Prospective study blinded to the subject. SETTING:Outpatient pulmonary function laboratory at a 908-bed university hospital. PARTICIPANTS:Forty-seven adult subjects divided into four gr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.3.731

    authors: Schan CA,Harding SM,Haile JM,Bradley LA,Richter JE

    更新日期:1994-09-01 00:00:00

  • Experimental orthotopic heart and bilateral lung transplantation completed without cardiopulmonary bypass.

    abstract:INTRODUCTION:Most experimental studies of orthotopic heart and lung graft failure are complicated by an inability to eliminate the rejection-specific inflammatory mediator from the cardiopulmonary bypass. METHODS:The following model was developed in our laboratory to investigate the feasibility of performing an orthot...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.5.1360

    authors: Otaki M,Inoue T,Matsumoto T,Kitayama H,Oku H

    更新日期:1999-11-01 00:00:00

  • Evaluation of a practice guideline for noninvasive positive-pressure ventilation for acute respiratory failure.

    abstract:OBJECTIVES:Clinical practice guidelines have been devised to change practitioner performance and to improve the process and outcomes of care. The objective of this study was to determine whether adherence to a practice guideline on noninvasive positive-pressure ventilation (NPPV) for the treatment of patients with acut...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.123.6.2062

    authors: Sinuff T,Cook DJ,Randall J,Allen CJ

    更新日期:2003-06-01 00:00:00

  • A 62-Year-Old Woman With Diffuse Myalgias, Fatigue, and Shortness of Breath.

    abstract:CASE PRESENTATION:A 62-year-old woman with a history of partially treated Graves disease and hypertension presented with approximately 3 weeks of worsening fatigue, lower extremity myalgias, and shortness of breath. Her medical history included a thyroid radiofrequency ablation several years earlier. Following the abla...

    journal_title:Chest

    pub_type:

    doi:10.1016/j.chest.2019.09.041

    authors: Park BD,Lyn-Kew K,Granchelli A,Mehta A

    更新日期:2020-03-01 00:00:00

  • Prevention and Treatment of Smoking and Tobacco Use During Pregnancy in Selected Indigenous Communities in High-Income Countries of the United States, Canada, Australia, and New Zealand: An Evidence-Based Review.

    abstract::Tobacco smoking during pregnancy is the most important modifiable risk factor for adverse pregnancy outcomes and long-term health complications for mother and baby. Tobacco use during pregnancy has decreased in high-income countries but not in Indigenous women in Australia, New Zealand, the United States, and Canada. ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2017.06.033

    authors: Gould GS,Lim LL,Mattes J

    更新日期:2017-10-01 00:00:00

  • Snoring, nocturnal hypoxemia, and the effect of oxygen inhalation.

    abstract::Men who snore heavily have an increased incidence of hypertension, angina, stroke, and neuropsychologic dysfunction, which may be due to nocturnal oxygen desaturation. Nocturnal oxygen therapy might be beneficial to such individuals by improving oxygenation and relieving tissue hypoxia. Twenty-eight asymptomatic heavy...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.3.411

    authors: Block AJ,Hellard DW,Cicale MJ

    更新日期:1987-09-01 00:00:00

  • Frequency of subspecialty physician care for elderly patients with community-acquired pneumonia.

    abstract:STUDY OBJECTIVES:Specialty societies have developed practice guidelines for the treatment of community-acquired pneumonia (CAP). To aid in adapting specialty recommendations for a pneumonia practice guideline at Intermountain Health Care, we investigated which physicians care for pneumonia patients in Utah. We wanted t...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.2.393

    authors: Dean NC,Silver MP,Bateman KA

    更新日期:2000-02-01 00:00:00

  • Pulse transit time improves detection of sleep respiratory events and microarousals in children.

    abstract:OBJECTIVES:To evaluate the additional information provided by pulse transit time (PTT), a noninvasive tool, when using during polysomnography for the diagnosis of sleep breathing disorders in a pediatric population. MAIN FINDINGS:Respiratory and microarousals events were scored twice. The first scoring was performed u...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.3.722

    authors: Pépin JL,Delavie N,Pin I,Deschaux C,Argod J,Bost M,Levy P

    更新日期:2005-03-01 00:00:00

  • Clinical and Imaging Features of COVID-19 in a Neonate.

    abstract::We report the clinical history, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in a neonate whose mother was also a patient. The newborn was the youngest patient with COVID-19 in the world at the time he was diagnosed. This case has brought more attention and understanding to the epid...

    journal_title:Chest

    pub_type:

    doi:10.1016/j.chest.2020.03.018

    authors: Xiong Y,Zhang Q,Zhao L,Shao J,Zhu W

    更新日期:2020-07-01 00:00:00

  • Prolonged myocardial ischemia after intravenous dipyridamole thallium imaging.

    abstract::Intravenous dipyridamole thallium imaging is reported to be a safe test with minimal side effects. It has been proposed by some that the test simply dilates the coronary vessels without actually producing myocardial ischemia. In this report, we describe a patient who, following intravenous dipyridamole thallium imagin...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.6.1102

    authors: Lewen MK,Labovitz AJ,Kern MJ,Chaitman BR

    更新日期:1987-12-01 00:00:00

  • The endocrinometabolic effects of beclomethasone dipropionate in asthmatic patients.

    abstract::The endocrinometabolic effects of the aerosol administration of beclomethasone dipropionate (100 microng four times daily) were evaluated in 20 asthmatic patients (11 corticodependent and nine noncorticodependent) during one month. In the noncorticodependent group, aerosol administration of beclomethasone had no stati...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.6.698

    authors: Yernault JC,Leclercq R,Schandevyl W,Virasoro E,De Coster A,Copinschi G

    更新日期:1977-06-01 00:00:00

  • Methodologic standards for diagnostic test research in pulmonary medicine.

    abstract:STUDY OBJECTIVES:To determine conformance with methodologic standards in the evaluation of diagnostic tests. DATA SOURCES:MEDLINE database search (1992 to 1997) of nine prominent general medicine and six subspecialty journals for articles that report discriminative properties of diagnostic tests in pulmonary medicine....

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.3.877

    authors: Heffner JE,Feinstein D,Barbieri C

    更新日期:1998-09-01 00:00:00

  • Improved surgical approach to cardiac tumors with intraoperative two-dimensional echocardiography.

    abstract::Intraoperative two-dimensional echocardiography allows visualization of cardiac anatomy and function not possible by other techniques. Although preoperative evaluation by noninvasive methods is usually adequate for diagnosis of cardiac tumors, two-dimensional echocardiography can be beneficial intraoperatively. Intrao...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.1.142

    authors: Mora F,Mindich BP,Guarino T,Goldman ME

    更新日期:1987-01-01 00:00:00

  • Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation.

    abstract::In airway diseases such as asthma and COPD, specific structural changes may be observed, very likely secondary to an underlying inflammatory process. Although it is still controversial, airway remodeling may contribute to the development of these diseases and to their clinical expression and outcome. Airway remodeling...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.129.4.1068

    authors: Bergeron C,Boulet LP

    更新日期:2006-04-01 00:00:00

  • Differences in end-of-life care in the ICU across patients cared for by medicine, surgery, neurology, and neurosurgery physicians.

    abstract:BACKGROUND:Some of the challenges in the delivery of high-quality end-of-life care in the ICU include the variability in the characteristics of patients with certain illnesses and the practice of critical care by different specialties. METHODS:We examined whether ICU attending specialty was associated with quality of ...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.13-1351

    authors: Kross EK,Engelberg RA,Downey L,Cuschieri J,Hallman MR,Longstreth WT Jr,Tirschwell DL,Curtis JR

    更新日期:2014-02-01 00:00:00

  • Myocardial contractile reserve as prognostic determinant in patients with idiopathic dilated cardiomyopathy without overt heart failure.

    abstract::To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hem...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.111.2.344

    authors: Nagaoka H,Isobe N,Kubota S,Iizuka T,Imai S,Suzuki T,Nagai R

    更新日期:1997-02-01 00:00:00

  • Ventilatory effects of doxapram in conscious human subjects.

    abstract::The ventilatory effects of a bolus intravenous dose of doxapram (0.37 to 0.47 mg/kg) were studied in ten healthy normal subjects. An immediate significant (p less than 0.001) increase in minute ventilation (VE) was due, in equal part, to significant increases in tidal volume (VT) and frequency (f). The inspiratory (TI...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.85.5.600

    authors: Burki NK

    更新日期:1984-05-01 00:00:00

  • Release of lipopolysaccharide toxicity-modulating proteins in patients undergoing cardiopulmonary bypass using noncoated and heparin-coated extracorporeal circuits. A clinical pilot study.

    abstract:STUDY OBJECTIVE:Cardiopulmonary bypass (CPB) induces a generalized inflammatory response, including activation of leukocytes, contributing to postoperative morbidity. The inflammatory pathways leading to this systemic inflammatory response syndrome are considered identical to those involved in septic shock. Therefore, ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.111.3.577

    authors: Bouma M,Maessen J,Weerwind P,Dentener M,Fransen E,de Jong D,Buurman W

    更新日期:1997-03-01 00:00:00

  • Advantages of endurance treadmill walking compared with cycling to assess bronchodilator therapy.

    abstract:BACKGROUND:Walking is a familiar daily activity that is generally limited by breathlessness, whereas cycling is an uncommon physical effort typically limited by leg discomfort. The hypothesis was that patients with COPD would exhibit greater improvements in exercise endurance and relief of breathlessness with bronchodi...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.09-2470

    authors: Zhang X,Waterman LA,Ward J,Baird JC,Mahler DA

    更新日期:2010-06-01 00:00:00

  • Pain location, distribution, and intensity after cardiac surgery.

    abstract:STUDY OBJECTIVES:To study the location, distribution, and intensity of pain in a sample of adult cardiac surgery patients during their postoperative hospital stay. DESIGN:In a prospective study, pain location, distribution (number of pain areas per patient), and intensity (0 to 10 numerical rating scale) were document...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.2.391

    authors: Mueller XM,Tinguely F,Tevaearai HT,Revelly JP,Chioléro R,von Segesser LK

    更新日期:2000-08-01 00:00:00

  • Integration of clinical and hemodynamic parameters in the prediction of long-term survival in patients with pulmonary arterial hypertension.

    abstract:BACKGROUND:Current management guidelines for pulmonary arterial hypertension (PAH) recommend a treatment choice based primarily on World Health Organization (WHO) functional class. This study was designed to assess how the incorporation of readily obtained clinical and test-based information may significantly improve t...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-1293

    authors: Kane GC,Maradit-Kremers H,Slusser JP,Scott CG,Frantz RP,McGoon MD

    更新日期:2011-06-01 00:00:00

  • Randomized, controlled trials of interventions to improve communication in intensive care: a systematic review.

    abstract:BACKGROUND:Communication between families and providers in the ICU affects patient and family outcomes and use of health-care resources. Recent research studies have tested interventions designed to improve communication quality and outcomes between providers and families of patients in the ICU. We conducted a systemat...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.10-0595

    authors: Scheunemann LP,McDevitt M,Carson SS,Hanson LC

    更新日期:2011-03-01 00:00:00

  • Passive smoking in children. Racial differences in systemic exposure to cotinine by hair and urine analysis.

    abstract::Passive smoking has been shown to adversely affect the health of infants and children. Black children and adults appear to be more susceptible to a variety of tobacco smoke health hazards for unknown reason. The objectives of this study were as follows: (1) to correlate the number of cigarettes reported to have been s...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.109.2.446

    authors: Knight JM,Eliopoulos C,Klein J,Greenwald M,Koren G

    更新日期:1996-02-01 00:00:00

  • Pulmonary reaction to upper mantle radiation therapy for Hodgkin's disease.

    abstract::To study the effects of upper mantle radiation therapy on pulmonary function, forced expiratory volume in one second (FEV1), vital capacity (VC), inspiratory capacity (IC), diffusing capacity for CO (DLCO) and diffusion per unit of alveolar volume (DL/VA were determined in 28 patients with Hodgkin's disease, stages 1-...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.6.688

    authors: do Pico GA,Wiley AL Jr,Rao P,Dickie HA

    更新日期:1979-06-01 00:00:00

  • Lymphoid interstitial pneumonia: a narrative review.

    abstract::Lymphoid interstitial pneumonia (LIP) is regarded as both a disease and a nonneoplastic, inflammatory pulmonary reaction to various external stimuli or systemic diseases. It is an uncommon condition with incidence and prevalence rates that are largely unknown. Liebow and Carrington originally classified LIP as an idio...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.122.6.2150

    authors: Swigris JJ,Berry GJ,Raffin TA,Kuschner WG

    更新日期:2002-12-01 00:00:00

  • Distinguishing left ventricular aneurysm from pseudoaneurysm. A review of the literature.

    abstract::A postmyocardial infarction left ventricular pseudoaneurysm occurs when a rupture of the ventricular free wall is contained by overlying, adherent pericardium. A postinfarction aneurysm, in contrast, is caused by scar formation resulting in thinning of the myocardium. Although the usual treatment for patients with pse...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.111.5.1403

    authors: Brown SL,Gropler RJ,Harris KM

    更新日期:1997-05-01 00:00:00

  • Cost-effectiveness of fluticasone propionate administered via metered-dose inhaler plus babyhaler spacer in the treatment of asthma in preschool-aged children.

    abstract:STUDY OBJECTIVES:To evaluate the cost-effectiveness of inhaled fluticasone propionate (FP) in children aged 12 to 47 months with asthma symptoms. DESIGN:A retrospective economic analysis conducted from the perspective of the Danish health-care system, based on clinical data from a 12-week study. SETTING:Thirty-three ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.120.6.1835

    authors: Bisgaard H,Price MJ,Maden C,Olsen NA

    更新日期:2001-12-01 00:00:00

  • Left ventricular laceration due to stented prosthesis.

    abstract::Complications following open chest massage in patients with porcine xenografts in the mitral location have not been previously described. The authors report a case of cardiac resuscitation following mitral valve replacement with a stented porcine valve. The patient died following brief closed chest, and then, prolonge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.77.2.216

    authors: Wild LM,Lajos TZ,Lee AB Jr,Wright J

    更新日期:1980-02-01 00:00:00

  • Complementary therapies and integrative medicine in lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.

    abstract:BACKGROUND:Physicians are often asked about complementary therapies by patients with cancer, and data show that the interest in and use of these therapies among patients with cancer is common. Therefore, it is important to assess the current evidence base on the benefits and risks of complementary therapies (modalities...

    journal_title:Chest

    pub_type: 杂志文章,实务指引

    doi:10.1378/chest.12-2364

    authors: Deng GE,Rausch SM,Jones LW,Gulati A,Kumar NB,Greenlee H,Pietanza MC,Cassileth BR

    更新日期:2013-05-01 00:00:00