Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation.

abstract：:Spontaneous pneumothorax is a known complication of Pneumocystis carinii pneumonia (PCP) in patients with acquired immunodeficiency syndrome. From a series of 61 patients with PCP, we identified two cases, not associated with aerosolized pentamidine, that presented with spontaneous pneumothorax and cystic changes seen...

journal_title：Chest

authors： Smith RL,Berkowitz KA,Aranda CP

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The "Dutch hypothesis" suggests that asthma and COPD have common genetic determinants. The serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) gene previously has been associated with COPD. We sought to determine whether SERPINE2 is associated with asthma ...

journal_title：Chest

authors： Himes BE,Klanderman B,Ziniti J,Senter-Sylvia J,Soto-Quiros ME,Avila L,Celedón JC,Lange C,Mariani TJ,Lasky-Su J,Hersh CP,Raby BA,Silverman EK,Weiss ST,DeMeo DL

更新日期：2011-09-01 00:00:00

abstract：:Arterial blood samples from 75 patients were analyzed for PO2, PCO2, and pH at 0, 15, and 30 min. After the baseline analysis, 60 samples were kept in ice while 59 samples were left at room temperature. There was a statistically significant increase in the PO2 at 15 min and again at 30 min in both groups. There was a ...

journal_title：Chest

authors： Liss HP,Payne CP Jr

更新日期：1993-04-01 00:00:00

abstract：:Parenteral tetracycline, one of the most commonly used agents for producing pleurodesis, is no longer available because of stricter regulations governing the manufacturing process. The objective of this project was to determine whether minocycline, a tetracycline derivative, is an effective sclerosant in an experiment...

journal_title：Chest

authors： Light RW,Wang NS,Sassoon CS,Gruer SE,Vargas FS

更新日期：1994-08-01 00:00:00

abstract：:A 51-year-old man suffered third-degree caustic burns of the esophagus and proximal two-thirds of the stomach. A tracheoesophageal fistula developed, and surgery was performed to exclude the esophagus from gastrointestinal reflux and to divert the oral secretions. An uneventful postoperative course was interrupted on ...

journal_title：Chest

authors： Singh AK,Kothawla LK,Karlson KE

更新日期：1976-10-01 00:00:00

abstract：:Mechanical ventilation was able to induce a decrease in cardiac output and regional blood flow, especially hepatic flow. Thus, hepatic elimination of drugs with a high hepatic-extraction ratio, which was linked to alteration in hepatic blood flow, could be reduced during mechanical ventilation. The aim of this work wa...

journal_title：Chest

authors： Richard C,Berdeaux A,Delion F,Riou B,Rimailho A,Giudicelli JF,Auzépy P

更新日期：1986-12-01 00:00:00

abstract：:Tobacco smoking during pregnancy is the most important modifiable risk factor for adverse pregnancy outcomes and long-term health complications for mother and baby. Tobacco use during pregnancy has decreased in high-income countries but not in Indigenous women in Australia, New Zealand, the United States, and Canada. ...

journal_title：Chest

authors： Gould GS,Lim LL,Mattes J

更新日期：2017-10-01 00:00:00

abstract：:A series of 24 adult male patients undergoing thoracotomy were found to have a reduction in their cough pressures in the immediate postoperative period to 29 percent of their preoperative values. Cough pressures still averaged only 50 percent of control values one week following surgery, with slow return toward normal...

journal_title：Chest

authors： Byrd RB,Burns JR

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:The synthetic peptide solnatide is a novel pharmacologic agent that reduces extravascular lung water, blunts reactive oxygen species production, and improves lung function due to its ability to directly activate the epithelial sodium channel. The goal of this study was to investigate the effect of solnatide ...

journal_title：Chest

authors： Zhou Q,Wang D,Liu Y,Yang X,Lucas R,Fischer B

更新日期：2017-03-01 00:00:00

abstract：:Disputes regarding life-prolonging treatments are stressful for all parties involved. These disagreements are appropriately almost always resolved with intensive communication and negotiation. Those rare cases that are not require a resolution process that ensures fairness and due process. We describe three recent cas...

journal_title：Chest

authors： Bosslet GT,Baker M,Pope TM

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:To review statistics on smoking prevalence and to analyze whether the implementation of national tobacco control legislation had an association with the prevalence of smoking, and thereby, with the occurrence of smoking-related lung diseases. DESIGN:Smoking prevalence rates (from 1960 to 2000), lung cancer ...

journal_title：Chest

authors： Heloma A,Nurminen M,Reijula K,Rantanen J

更新日期：2004-12-01 00:00:00

abstract：:Pulmonary function studies were conducted one to two days prior to, two weeks after, and an average of 116 days after coronary artery revascularization surgery. Preoperation it was found that 11 of 19 patients had mild to moderate obstruction, 8 of 17 had diffusing capacity less than 80 percent of predicted, and 9 of ...

journal_title：Chest

authors： Braun SR,Birnbaum ML,Chopra PS

更新日期：1978-03-01 00:00:00

abstract：:In rabbits, an experimental model of fat embolism was produced that simulates the course of events in the clinical situation. Small doses of fat-cell suspension (0.075 ml/kg of body weight), prepared by collagenase treatment of homologous adipose tissue, were injected intravenously. Concomitantly, hypovolemia was prod...

journal_title：Chest

authors： Cotev S,Rosenmann E,Eyal Z,Weinberg H,Shafrir E,Davidson JT

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:There is a growing understanding of the prevalence and impact of psychological disorders on COPD. However, the role of these disorders in early readmission is unclear. METHODS:We analyzed data from 5% fee-for-service Medicare beneficiaries diagnosed with COPD (International Classification of Diseases, Ninth...

journal_title：Chest

authors： Singh G,Zhang W,Kuo YF,Sharma G

更新日期：2016-04-01 00:00:00

abstract：:Imaging and Doppler echocardiography permits assessment of right ventricular size and systolic function and of pulmonary arterial pressures, and it may facilitate detection of thromboemboli within the heart or pulmonary artery. In patients with acute pulmonary embolism of sufficient severity to appreciably increase ri...

journal_title：Chest

authors： Come PC

更新日期：1992-04-01 00:00:00

abstract：STUDY OBJECTIVES:To define characteristics of surgically curable, early cancers of the lung, we retrospectively studied relationships between thin-section CT (TS-CT) scans, pathologic features, and outcome data in 287 patients with resected small-diameter (< 20 mm) peripheral lung carcinoma. Cases included 260 adenocar...

journal_title：Chest

authors： Shimizu K,Yamada K,Saito H,Noda K,Nakayama H,Kameda Y,Nakata K

更新日期：2005-03-01 00:00:00

abstract：:Several reports have implicated pregnancy as a cause of deterioration in patients with pulmonary arteriovenous fistulas. We report a 27-year-old woman with multiple pulmonary arteriovenous fistulas who required coil spring embolotherapy in her 24th week of pregnancy due to a spontaneous hemothorax and hypoxemia. ...

journal_title：Chest

authors： Gammon RB,Miksa AK,Keller FS

更新日期：1990-12-01 00:00:00

abstract：STUDY OBJECTIVES:Levofloxacin is a fluoroquinolone antimicrobial agent for which pharmacodynamic relationships between the maximum serum antibiotic concentration (Cmax)/minimum inhibitory concentration (MIC) ratio and/or the area under the serum concentration-time curve during a 24-h dosing period (AUC(0-24))/MIC ratio...

journal_title：Chest

authors： Cazzola M,Matera MG,Donnarumma G,Tufano MA,Sanduzzi A,Marchetti F,Blasi F

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Club cell secretory protein (CCSP) is a protective biomarker associated with annual decline in lung function. COPD progression results from an imbalance between injury and repair initially triggered by cigarette smoking. OBJECTIVE:We investigated the effect of CCSP as a therapeutic strategy to restore the b...

journal_title：Chest

authors： Gamez AS,Gras D,Petit A,Knabe L,Molinari N,Vachier I,Chanez P,Bourdin A

更新日期：2015-06-01 00:00:00

abstract：STUDY OBJECTIVES:Precise epidemiologic data regarding nontuberculous mycobacterial (NTM) lung infection in many Asian countries have been relatively unavailable. In order to determine the clinical significance of NTM isolated from respiratory specimens, we reviewed medical records from all patients from whom NTM isolat...

journal_title：Chest

authors： Koh WJ,Kwon OJ,Jeon K,Kim TS,Lee KS,Park YK,Bai GH

更新日期：2006-02-01 00:00:00

abstract：:We investigated 654 subjects of a small Lombardy (Italy) town between 15 and 64 years of age who were representative of the general population. By clinical examination, the sample included 535 normal subjects (164 normal smokers, 341 normal nonsmokers, 30 normal subjects with acute upper respiratory illness within 30 ...

journal_title：Chest

authors： Cerveri I,Bruschi C,Zoia MC,Zanon P,Maccarini L,Grassi M,Rampulla C

更新日期：1988-01-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the efficacy of albuterol by metered-dose inhaler (MDI) and spacer compared to a nebulizer. DESIGN:A prospective, open-label study. SETTING:Large urban emergency department (ED). PATIENTS:All consecutive adult asthma patients over a 2.5-year period. INTERVENTIONS:ED personnel used a st...

journal_title：Chest

authors： Newman KB,Milne S,Hamilton C,Hall K

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine how common sleep-related desaturation with preserved awake resting pulse oximetric saturation (SpO(2)) was in a large cohort of adult cystic fibrosis (CF) patients with variable degrees of pulmonary disease. We then determined whether nocturnal desaturation could re...

journal_title：Chest

authors： Frangolias DD,Wilcox PG

更新日期：2001-02-01 00:00:00

abstract：STUDY OBJECTIVE:To ascertain the incidence, types, morbidity, and mortality of infectious episodes in isolated lung transplant recipients. DESIGN:Retrospective chart review of patients who have undergone transplants over a six-year period in one institution. PATIENTS:Twenty-three single and 17 double lung transplants...

journal_title：Chest

authors： Maurer JR,Tullis DE,Grossman RF,Vellend H,Winton TL,Patterson GA

更新日期：1992-04-01 00:00:00

abstract：:The inhibitory effect of lidocaine and lidocaine plus methylparaben as a preservative was studied with 25 strains of bacteria. The tested strains were mixed with each topical anesthetic preparation, and quantitative cultures were performed on aspirates at 0, 30, 60, and 120 minutes. Results were compared to counts obt...

journal_title：Chest

authors： Wimberley N,Willey S,Sullivan N,Bartlett JG

更新日期：1979-07-01 00:00:00

abstract：:Numerous clinical trials of chemotherapy for tuberculosis conducted throughout the world over the past 4 decades have established 2 basic principles of treatment: effective treatment requires the initial concomitant administration of at least 2 drugs to which the patient's organisms are susceptible; and cure of tuber...

journal_title：Chest

authors： Snider DE Jr,Cohn DL,Davidson PT,Hershfield ES,Smith MH,Sutton FD Jr

更新日期：1985-02-01 00:00:00

abstract：:OSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction du...

journal_title：Chest

authors： Farré N,Farré R,Gozal D

更新日期：2018-10-01 00:00:00

abstract：:Although metastatic carcinoma from an unknown primary tumor is known to occur, the combination of squamous cell carcinoma histologic findings and a mediastinal location is quite unusual. The evaluation of a case of a patient with a posterior mediastinal mass, eventually shown to be metastatic squamous cell carcinoma o...

journal_title：Chest

authors： Blanco N,Kirgan DM,Little AG

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:We hypothesized that pentoxifylline, administered after phorbol myristate acetate (PMA), would diminish the severity of lung injury. SETTING:Animal research laboratory. DESIGN:Comparative study. SUBJECTS:Mongrel dogs (n = 33). INTERVENTIONS:Baseline measurements were obtained from the isolated blood-perfu...

journal_title：Chest

authors： Creamer KM,McCloud LL,Fisher LE,Ehrhart IC

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Elevated cardiac troponin levels have been shown to be associated with adverse outcomes in patients with acute pulmonary embolism (PE). However, few data address the management implications of undetectable cardiac troponin I (cTnI) using a highly sensitive assay. We hypothesized that undetectable cTnI predic...

journal_title：Chest

authors： Hakemi EU,Alyousef T,Dang G,Hakmei J,Doukky R

更新日期：2015-03-01 00:00:00