Supplementing defect in club cell secretory protein attenuates airway inflammation in COPD.

Abstract:

BACKGROUND:Club cell secretory protein (CCSP) is a protective biomarker associated with annual decline in lung function. COPD progression results from an imbalance between injury and repair initially triggered by cigarette smoking. OBJECTIVE:We investigated the effect of CCSP as a therapeutic strategy to restore the balance between injury and repair in COPD simultaneously, validating an ex vivo air-liquid interface (ALI) culture of human bronchial epithelial cells. METHODS:Endobronchial biopsy specimens (EBBs) were obtained from 13 patients with COPD, eight smokers, and eight control subjects. Morphometric analysis of the initial EBBs was performed. ALI cultures derived from the same EBBs were exposed to cigarette smoke extract (CSE) with or without exogenous recombinant human CCSP (rhCCSP) supplementation. CCSP and IL-8 concentrations were assessed at steady state and after CSE exposure. RESULTS:Morphometric analysis of the initial EBBs showed increased cell density but decreased immunostaining of CCSP+ cells in EBBs of patients with COPD (P = .03 vs control subjects). At steady state, lower CCSP (P = .04) and higher IL-8 levels (P < .0001) were found in COPD ALI epithelium. Exogenous rhCCSP supplementation dampened CSE-induced IL-8-release in patients with COPD and returned to levels similar to those of smokers and control subjects (P = .0001). A negative correlation was found between IL-8-release in ALI and CCSP+ cell density in initial biopsy specimens (P = .0073). CONCLUSIONS:In vitro, rhCCSP exogenous supplementation can reverse CSE-induced IL-8 release in biopsy specimens from patients with COPD, indicating a potential use of this strategy in vivo.

journal_name

Chest

journal_title

Chest

authors

Gamez AS,Gras D,Petit A,Knabe L,Molinari N,Vachier I,Chanez P,Bourdin A

doi

10.1378/chest.14-1174

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

1467-1476

issue

6

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)37201-9

journal_volume

147

pub_type

杂志文章

相关文献

CHEST文献大全
  • Subglottic stenosis complicating cardiac surgery in children.

    abstract:OBJECTIVE:To highlight the incidence of subglottic stenosis (SGS) as a complication of surgery for congenital heart disease and the role of single-stage laryngotracheoplasty in treating this complication. DESIGN:Retrospective case series. SETTING:University-based referral center specializing in surgery for congenital...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.111.6.1769

    authors: Pereira KD,Mitchell RB,Younis RT,Lazar RH

    更新日期:1997-06-01 00:00:00

  • Clinical and Imaging Features of COVID-19 in a Neonate.

    abstract::We report the clinical history, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in a neonate whose mother was also a patient. The newborn was the youngest patient with COVID-19 in the world at the time he was diagnosed. This case has brought more attention and understanding to the epid...

    journal_title:Chest

    pub_type:

    doi:10.1016/j.chest.2020.03.018

    authors: Xiong Y,Zhang Q,Zhao L,Shao J,Zhu W

    更新日期:2020-07-01 00:00:00

  • A simplified insertion technique for tracheobronchial silicone stents.

    abstract::In many patients with central airway obstruction due to extrinsic compression or malacia, insertion of tracheobronchial stents can provide effective and permanent relief. Of the various types of prostheses described, the silicone Dumon-Artemis stents (Medicore, Brussels, Belgium) are probably the most efficient. The u...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.2.520

    authors: Noppen M,Dhondt E,Meysman M,Monsieur I,Gepts E,Vincken WG

    更新日期:1994-08-01 00:00:00

  • Intermittent positive pressure inflation during fiberoptic bronchoscopy.

    abstract::We describe a new technique for diagnostic fiberoptic bronchoscopic procedures under general anesthesia. The technique of inflation via nasotracheal catheter, which consists of using intermittent high inflating pressure for ventilation by passing a double catheter through the nose to the glottis and into the trachea, ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.72.4.480

    authors: Heifetz M,De Myttenaere S,Lemer J

    更新日期:1977-10-01 00:00:00

  • Silicosis and tuberculosis.

    abstract::Two subjects had silicosis complicated by tuberculosis. In both patients, there was a relapse of the tuberculosis after chemotherapy was discontinued, in one case after 13 years of therapy with isoniazid and p-aminosalicylic acid. It would appear that the risk of tuberculosis in subjects with silicosis persists for li...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.2.202

    authors: Morgan EJ

    更新日期:1979-02-01 00:00:00

  • Fluid therapy in resuscitated sepsis: less is more.

    abstract::Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; sh...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.07-1496

    authors: Durairaj L,Schmidt GA

    更新日期:2008-01-01 00:00:00

  • Sex differences in awake ventilatory drive and abnormal breathing during sleep in eucapnic obesity.

    abstract::We studied hypoxic and hypercapnic ventilatory drives in 22 eucapnic obese subjects (14 female and eight male subjects) referred for weight reduction therapy and 23 normal subjects (eight female and 15 male subjects). In the female subjects, both occlusion pressure, currently used as an indicator of ventilatory drive,...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.5.968

    authors: Kunitomo F,Kimura H,Tatsumi K,Kuriyama T,Watanabe S,Honda Y

    更新日期:1988-05-01 00:00:00

  • The prone position in ARDS patients. A clinical study.

    abstract::The gas exchange and hemodynamics were evaluated before, during, and after a two-hour period of prone position in 13 moderate-severe ARDS patients. Lung computerized tomography was obtained in both the supine and prone positions in two of these patients. Average arterial oxygenation improved after prone positioning (p...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.1.103

    authors: Langer M,Mascheroni D,Marcolin R,Gattinoni L

    更新日期:1988-07-01 00:00:00

  • Left pleural hemorrhagic effusion. A presenting sign of thoracic aortic dissecting aneurysm.

    abstract::Left hemorrhagic pleural effusion was the presenting sign of painless aortic dissecting aneurysm in two elderly hypertensive patients. Computed tomography (CT) of the chest revealed the aneurysmal dilatation of the thoracic aorta and an intimal flap connecting its descending part with the left pleural space. The patie...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.2.636

    authors: Gandelman G,Barzilay N,Krupsky M,Resnitzky P

    更新日期:1994-08-01 00:00:00

  • Maternal Distress During Pregnancy and Recurrence in Early Childhood Predicts Atopic Dermatitis and Asthma in Childhood.

    abstract:BACKGROUND:Early-life stress is becoming an important determinant of immune system programming. Maternal prenatal distress is found to be associated with atopic disease in offspring but the separate effects of postnatal distress are not well-studied. RESEARCH QUESTION:Does the likelihood of asthma and atopic dermatiti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.01.052

    authors: van der Leek AP,Bahreinian S,Chartier M,Dahl ME,Azad MB,Brownell MD,Kozyrskyj AL

    更新日期:2020-07-01 00:00:00

  • Current status of new drugs and multidisciplinary approaches in patients with carcinoma of the esophagus.

    abstract::The incidence of distal esophageal adenocarcinoma and primary proximal gastric carcinoma has increased substantially in the past 15 years, particularly in North America and in some European countries. Patients with curatively resected cancer consistently have a 10 to 20% 5-year survival rate. Radiation therapy alone s...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.113.1_supplement.112s

    authors: Ajani JA

    更新日期:1998-01-01 00:00:00

  • Distinct characteristics of pleuroparenchymal fibroelastosis with usual interstitial pneumonia compared with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) is a rare form of interstitial pneumonia and sometimes coexists with a histologic usual interstitial pneumonia (UIP) pattern. This study aimed to describe the distinct clinical features of PPFE with UIP pattern compared with idiopathic pulmonary fibrosis (IPF). METHOD...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.13-2866

    authors: Oda T,Ogura T,Kitamura H,Hagiwara E,Baba T,Enomoto Y,Iwasawa T,Okudela K,Takemura T,Sakai F,Hasegawa Y

    更新日期:2014-11-01 00:00:00

  • Pulmonary infiltrates in leukemia.

    abstract::We reviewed the inpatient records of 139 adult patients with leukemia to determine the incidence of opportunistic infections in immunocompromised patients and the pattern of roentgenographic involvement of such infections. There were 98 parenchymal infiltrates identified, including 43 episodes of local disease and 55 ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.78.3.468

    authors: Tenholder MF,Hooper RG

    更新日期:1980-09-01 00:00:00

  • Measurement of respiratory acoustic signals. Effect of microphone air cavity width, shape, and venting.

    abstract:STUDY OBJECTIVE:We have previously investigated the effects of microphone type and coupler air chamber depth on lung sound characteristics. We now report the results of experiments exploring the effects of air chamber width, shape, and venting on lung sounds. DESIGN:We used a single electret microphone with a variety ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.108.4.1004

    authors: Kraman SS,Wodicka GR,Oh Y,Pasterkamp H

    更新日期:1995-10-01 00:00:00

  • Left ventricular laceration due to stented prosthesis.

    abstract::Complications following open chest massage in patients with porcine xenografts in the mitral location have not been previously described. The authors report a case of cardiac resuscitation following mitral valve replacement with a stented porcine valve. The patient died following brief closed chest, and then, prolonge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.77.2.216

    authors: Wild LM,Lajos TZ,Lee AB Jr,Wright J

    更新日期:1980-02-01 00:00:00

  • Two-year follow-up in patients treated with emphysematous lung sealant for advanced emphysema.

    abstract::Endoscopic lung volume-reduction therapy for emphysema has been associated with therapeutic responses smaller in magnitude and less durable than surgical volume reduction (LVRS). Bronchoscopic emphysematous lung sealant (ELS) therapy has been shown to produce improvements in pulmonary function similar to surgery at 1 ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.13-0446

    authors: Kramer MR,Refaely Y,Maimon N,Rosengarten D,Fruchter O

    更新日期:2013-11-01 00:00:00

  • Smoking-Related Diffuse Cystic Lung Disease.

    abstract::Exposure to cigarette smoke can lead to a variety of parenchymal lung diseases, including diffuse cystic lung diseases (DCLDs). Lymphangioleiomyomatosis (LAM) is the prototypical DCLD and has a characteristic appearance on high-resolution CT (HRCT). We present a series of four patients with DCLD on HRCT who were refer...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2018.02.027

    authors: Gupta N,Colby TV,Meyer CA,McCormack FX,Wikenheiser-Brokamp KA

    更新日期:2018-08-01 00:00:00

  • Effects of theophylline on breathlessness and exercise tolerance in patients with chronic airflow obstruction.

    abstract::Theophylline is commonly prescribed for patients with nonasthmatic chronic airflow obstruction (CAO) even though clinical efficacy is not well established. We studied objective and subjective responses to theophylline in 14 men with CAO. Subjects randomly received week-long treatments of placebo or theophylline at two...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.82.5.538

    authors: Eaton ML,MacDonald FM,Church TR,Niewoehner DE

    更新日期:1982-11-01 00:00:00

  • Venous air embolism. Diagnosis by spontaneous right-sided contrast echocardiography.

    abstract::This report describes the definitive diagnosis of venous air-embolism by documentation of spontaneous echo contrast in the right cardiac chambers following removal of a jugular venous catheter in a patient with hepatic failure. This complication was potentiated by the presence of concurrent hepatic coagulopathy which ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.3.784

    authors: Marcus RH,Weinert L,Neumann A,Borow KM,Lang RM

    更新日期:1991-03-01 00:00:00

  • The Future of Lung Transplantation.

    abstract::The field of lung transplant has made significant advances over the last several decades. Despite these advances, morbidity and mortality remain high when compared with other solid organ transplants. As the field moves forward, the speed by which progress can be made will in part be determined by our ability to overco...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2018.08.1036

    authors: Young KA,Dilling DF

    更新日期:2019-03-01 00:00:00

  • Lung elastic recoil does not correlate with pulmonary hemodynamics in severe emphysema.

    abstract:BACKGROUND:It has been postulated that right ventricular (RV) function may improve after lung volume reduction surgery (LVRS) for severe emphysema due to improvement in lung elastic recoil. Improved lung elastic recoil after LVRS is hypothesized to "tether" open extraalveolar vessels, thereby leading to a decrease in p...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.07-0041

    authors: Falk JA,Martin UJ,Scharf S,Criner GJ

    更新日期:2007-11-01 00:00:00

  • The Neurokinin-1 Receptor Antagonist Orvepitant Is a Novel Antitussive Therapy for Chronic Refractory Cough: Results From a Phase 2 Pilot Study (VOLCANO-1).

    abstract:BACKGROUND:Substance P and the neurokinin-1 (NK-1) receptor are implicated in chronic refractory cough pathophysiology. We assessed the efficacy and safety of orvepitant, a brain-penetrant NK-1 antagonist, in an open-label study in CRC patients with chronic refractory cough. METHODS:Thirteen patients with daytime coug...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.chest.2019.08.001

    authors: Smith J,Allman D,Badri H,Miller R,Morris J,Satia I,Wood A,K Trower M

    更新日期:2020-01-01 00:00:00

  • Asthma treatment preference study: a conjoint analysis of preferred drug treatments.

    abstract:OBJECTIVE:Assessment of patient preferences for attributes of asthma treatments. METHODS:Two hundred ninety-eight patients (age range, 18 to 60 years) from 15 centers in Sweden completed a questionnaire concerning their asthma, and ranked 18 alternative treatments using conjoint analysis. Patients were receiving treat...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.125.3.916

    authors: Johansson G,Ställberg B,Tornling G,Andersson S,Karlsson GS,Fält K,Berggren F

    更新日期:2004-03-01 00:00:00

  • Successful resection of alpha-fetoprotein-producing lung cancer.

    abstract::We present a case of successfully resected alpha-fetoprotein (AFP)-producing primary lung cancer. AFP in the serum decreased from 289 ng/ml to an undetectable level after a curative operation. The resected tumor was stained positively by the immunohistochemical study for AFP. The histologic appearance of the tumor was...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.4.879

    authors: Saka H,Sakai S,Kondo N,Ito M,Shimokata K

    更新日期:1988-10-01 00:00:00

  • Löffler's syndrome secondary to crack cocaine.

    abstract::Eosinophilic pulmonary infiltration is an uncommon presentation from cocaine abuse. We present a patient with migratory pulmonary infiltrates and eosinophilia consistent with Löffler's syndrome. Our review uncovered two other similar patients. The importance of early recognition is stressed in our report. Either absti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.5.1599

    authors: Nadeem S,Nasir N,Israel RH

    更新日期:1994-05-01 00:00:00

  • Effects of expiratory flow resistance on inspiratory work of breathing.

    abstract::To minimize work of breathing, airway pressure should not fluctuate during spontaneous breathing with continuous positive airway pressure (CPAP). However, flow resistance in the inspiratory limb of the breathing circuit and an inadequate continuous gas flow rate result in airway pressure fluctuation and increased work...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.4.795

    authors: Banner MJ,Downs JB,Kirby RR,Smith RA,Boysen PG,Lampotang S

    更新日期:1988-04-01 00:00:00

  • Prolongation of ventricular depolarization. ECG manifestation of mexiletine toxicity.

    abstract::Mexiletine is a type 1B antiarrhythmic drug similar to lidocaine. Prolongation of ventricular depolarization has not been previously reported with the usual oral dosage of mexiletine. We describe a patient with renal failure and heart failure on low-dose oral therapy who developed mexiletine toxicity, which was manife...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.4.925

    authors: Nora MO,Chandrasekaran K,Hammill SC,Reeder GS

    更新日期:1989-04-01 00:00:00

  • Trends in the prevalence of obstructive and restrictive lung function among adults in the United States: findings from the National Health and Nutrition Examination surveys from 1988-1994 to 2007-2010.

    abstract:BACKGROUND:National spirometric surveillance data in the United States were last collected during 1988-1994. The objective of this study was to provide current estimates for obstructive and restrictive impairment of lung function and to examine changes since 1988-1994. METHODS:We used data from 14,360 participants age...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-1135

    authors: Ford ES,Mannino DM,Wheaton AG,Giles WH,Presley-Cantrell L,Croft JB

    更新日期:2013-05-01 00:00:00

  • Mediastinal lymph node enlargement as a result of mitral valve stenosis.

    abstract::Two patients are described with severe MVS, pulmonary venous hypertension and enlarged mediastinal, pulmonary and hilar lymph nodes. These enlargements were diagnosed on a preoperative chest CT. After MV replacement these enlarged lymph nodes nearly all resolved. The lymphadenopathy should be considered to be secondar...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.4.1269

    authors: Drent M,Gelissen JP,Ascoop CA,Wagenaar SS,van den Bosch JM

    更新日期:1992-10-01 00:00:00

  • Left subclavian steal, interrupted aortic arch, complete transposition of the great vessels and single left ventricle.

    abstract::Congenital subclavian steal consists of atresia of the proximal end of the subclavian artery, while the blood supply to the distal portion of the subclavian artery originates from the circle of Willis. It should be suspected in complicated malformations of the heart associated with marked hypoplasia or interruption of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.67.3.352

    authors: Garcia O,Wilkins R,Cunha D,Jesse MJ

    更新日期:1975-03-01 00:00:00