The Future of Lung Transplantation.

Abstract:

:The field of lung transplant has made significant advances over the last several decades. Despite these advances, morbidity and mortality remain high when compared with other solid organ transplants. As the field moves forward, the speed by which progress can be made will in part be determined by our ability to overcome several stumbling blocks, including donor shortage, proper selection of candidates, primary graft dysfunction, and chronic lung allograft dysfunction. The advances and developments surrounding these factors will have a significant impact on shaping the field within the coming years. In this review, we look at the current climate (ripe for expanding the donor pool), new technology (ex vivo lung perfusion and bioengineered lungs), cutting-edge innovation (novel biomarkers and new ways to treat infected donors), and evidence-based medicine to discuss current trends and predict future developments for what we hope is a bright future for the field of lung transplantation.

journal_name

Chest

journal_title

Chest

authors

Young KA,Dilling DF

doi

10.1016/j.chest.2018.08.1036

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

465-473

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(18)32283-9

journal_volume

155

pub_type

杂志文章,评审

相关文献

CHEST文献大全
  • Pulmonary mass and air meniscus sign in a 19-year-old man.

    abstract::Sacrococcygeal teratoma is rarely diagnosed in adults. Pulmonary mass as the presenting clinical form of the malignant variety of this germ-cell tumor is exceptional. We report herein such a case with the noticeable peculiarity of showing the air meniscus sign on chest roentgenographic examination. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.2.562

    authors: Roig J,Aguilar X,Maestre J,Domingo C,Morera J

    更新日期:1991-08-01 00:00:00

  • Epigenetics and prenatal influences on asthma and allergic airways disease.

    abstract::Uterine life is arguably the most critical time in developmental programming, when environmental exposures may have the greatest potential to influence evolving fetal structure and function. There has been substantial progress in understanding the epigenetic mechanisms through which environmental exposures can permane...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.10-1800

    authors: Martino D,Prescott S

    更新日期:2011-03-01 00:00:00

  • Inhaled Tranexamic Acid for Hemoptysis Treatment: A Randomized Controlled Trial.

    abstract:BACKGROUND:Tranexamic acid (TA) is an antifibrinolytic drug currently used systemically to control bleeding. To date, there have been no prospective studies of the effectiveness of inhaled TA for the treatment of hemoptysis. OBJECTIVES:The goal of this study was to prospectively assess the effectiveness of TA inhalati...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.chest.2018.09.026

    authors: Wand O,Guber E,Guber A,Epstein Shochet G,Israeli-Shani L,Shitrit D

    更新日期:2018-12-01 00:00:00

  • Hemolysis in the aortic prosthetic valve.

    abstract::A review of the incidence and severity of hemolysis in the aortic prosthesis is presented. The noncloth-covered Starr-Edwards prosthetic series 1000, 1200, and 1260 had a 2 percent (1/54) incidence of anemia. The cloth-covered Starr-Edwards aortic prosthetic series 2300 was associated with anemia in 61 percent (28/46)...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.1.56

    authors: Santinga JT,Batsakis JT,Flora JD,Kirsh MM

    更新日期:1976-01-01 00:00:00

  • Clinical implications of the ethane in exhaled breath in patients with acute paraquat intoxication.

    abstract:STUDY OBJECTIVES:Pulmonary fibrosis due to lipid peroxidation is a major symptom of paraquat intoxication. Ethane in the expired breath (exEth) reflects lipid peroxidation and may be a measure of the damage effected by oxygen radicals in acute lung injury. The purpose of this study was to evaluate the clinical efficacy...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.3.1506

    authors: Hong SY,Gil HW,Yang JO,Lee EY,Na JO,Seo KH,Kim YH

    更新日期:2005-09-01 00:00:00

  • Frequency of pleural effusions in patients with pulmonary arterial hypertension associated with connective tissue diseases.

    abstract:BACKGROUND:Pleural effusions frequently accumulate in patients with left-sided heart failure. However, our recent study in patients with idiopathic and heritable pulmonary arterial hypertension (PAH) demonstrated that pleural effusions frequently occur in patients with isolated right-sided heart failure (RHF). The obje...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-0227

    authors: Luo YF,Robbins IM,Karatas M,Brixey AG,Rice TW,Light RW

    更新日期:2011-07-01 00:00:00

  • Ostium primum defect in the adult: postoperative follow-up studies.

    abstract::Twelve adult patients with ostium primum atrial septal defects (incomplete endocardial cushion defect) who underwent surgical repair of their lesions were evaluated in the late postoperative period. All had closure of the low-lying atrial septal defect, with suturing of the mitral valve cleft in 11 patients. Although ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.67.2.185

    authors: Goodman DJ,Harrison DC,Schroeder JS

    更新日期:1975-02-01 00:00:00

  • Epidemiology and clinicopathology of aortic dissection.

    abstract:STUDY OBJECTIVES:To determine the incidence and mortality as well as to analyze the clinical and pathologic changes of aortic dissection. DESIGN AND SETTING:A population-based longitudinal study over 27 years on a study population of 106,500, including 66 hospitalized and 18 nonhospitalized consecutively observed pati...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.5.1271

    authors: Mészáros I,Mórocz J,Szlávi J,Schmidt J,Tornóci L,Nagy L,Szép L

    更新日期:2000-05-01 00:00:00

  • Improvement in pulmonary function with diuretic therapy in the hypervolemic and polycythemic patient with chronic obstructive pulmonary disease.

    abstract::Central hemodynamics and gas exchange were studied in six patients with chronic obstructive pulmonary disease (mean age, 60 years). Patients were selected for the study if the volume of blood was 1 L larger than the predicted normal value, if there was no history of infection, and if no drug assumed to influence pulmo...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.2.146

    authors: Gertz I,Hedenstierna G,Wester PO

    更新日期:1979-02-01 00:00:00

  • Late outcome from percutaneous tracheostomy using the Portex kit.

    abstract:OBJECTIVE:To assess late outcome following percutaneous tracheostomy using the Portex kit (Hythe, Kent, UK). DESIGN:Prospective observational cohort study. SETTING:Teaching hospital. PATIENTS:Forty-nine consecutive patients who underwent percutaneous tracheostomy in the ICU using the Portex kit and who survived 6 mo...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.4.1070

    authors: Leonard RC,Lewis RH,Singh B,van Heerden PV

    更新日期:1999-04-01 00:00:00

  • Underestimation of nocturnal hypoxemia due to monitoring conditions in patients with COPD.

    abstract:STUDY OBJECTIVES:COPD patients run a risk of developing nocturnal oxygen desaturation. When evaluating patients with nocturnal hypoxemia, an unfamiliar hospital environment and the monitoring equipment may cause sleep disturbances. It was hypothesized that increased sleep disruption will lead to fewer instances of desa...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.119.6.1820

    authors: Brijker F,van den Elshout FJ,Heijdra YF,Folgering HT

    更新日期:2001-06-01 00:00:00

  • Resource-poor settings: response, recovery, and research: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement.

    abstract:BACKGROUND:Planning for mass critical care in resource-poor and constrained settings has been largely ignored, despite large, densely crowded populations who are prone to suffer disproportionately from natural disasters. As a result, disaster response has been suboptimal and in many instances hampered by lack of planni...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.14-0745

    authors: Geiling J,Burkle FM Jr,West TE,Uyeki TM,Amundson D,Dominguez-Cherit G,Gomersall CD,Lim ML,Luyckx V,Sarani B,Christian MD,Devereaux AV,Dichter JR,Kissoon N,Task Force for Mass Critical Care.,Task Force for Mass Critical Care

    更新日期:2014-10-01 00:00:00

  • Ventilating with tracheal gas insufflation and periodic tracheal occlusion during sleep and wakefulness.

    abstract:INTRODUCTION:The current invasive and noninvasive methods for delivering long-term ventilatory support rely on cumbersome patient interfaces that may interfere with upper airway function. To overcome these limitations, a novel system was developed to ventilate conscious, spontaneously breathing dogs through a self-cont...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.122.5.1742

    authors: Tagaito Y,Schneider H,O'Donnell CP,Smith PL,Schwartz AR

    更新日期:2002-11-01 00:00:00

  • Surgical management of unresolved pulmonary embolism. A personal series of 72 patients.

    abstract::Chronic thromboembolic pulmonary hypertension (CT-E PH) is a rare and aberrant outcome of acute pulmonary embolism. Because it has become a potentially curable form of pulmonary hypertension, the frequency of recognized cases has increased. We report a case series of 72 patients with CT-E PH evaluated in our instituti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.1_supplement.52s

    authors: Simonneau G,Azarian R,Brenot F,Dartevelle PG,Musset D,Duroux P

    更新日期:1995-01-01 00:00:00

  • Amiodarone-associated hemoptysis.

    abstract::The manifestations of amiodarone pulmonary toxicity (APT) are generally nonspecific, and a diagnosis requires appropriate clinical history, laboratory testing consistent with toxicity, and exclusion of other disease entities. To our knowledge, hemoptysis associated with APT has not been described before; the following...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.1.305

    authors: Vizioli LD,Cho S

    更新日期:1994-01-01 00:00:00

  • Myocardial thickening in children with acute myocarditis.

    abstract::Two-dimensional echocardiography showed myocardial thickening in 3 of 16 acute myocarditis patients in childhood. In all 3 cases, this myocardial thickening was transient and diminished within 3 weeks. This myocardial thickening was most marked at a few days after the onset; the interventricular septal thickness for e...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.6.1676

    authors: Nakagawa M,Hamaoka K

    更新日期:1993-12-01 00:00:00

  • A comprehensive, national survey of spirometry in Spain: current bottlenecks and future directions in primary and secondary care.

    abstract:BACKGROUND:We aimed to evaluate the availability and practice of spirometry, training of technicians, and spirometer features and maintenance in Spain in both primary care (PC) and secondary care (SC) centers. METHODS:We used a nationwide, cross-sectional, 36-item telephone survey of health-care centers in Spain to ta...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-2690

    authors: López-Campos JL,Soriano JB,Calle M,Encuesta de Espirometría en España (3E) Project.

    更新日期:2013-08-01 00:00:00

  • Catamenial pneumothorax: a prospective study.

    abstract:OBJECTIVES:To evaluate the incidence of catamenial pneumothorax (CP) among women who have been referred for the surgical treatment of spontaneous pneumothorax (SP) and to study its pathogenic mechanisms. DESIGN:A prospective study of women of reproductive age who have been referred to our center for the surgical treat...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.124.3.1004

    authors: Alifano M,Roth T,Broët SC,Schussler O,Magdeleinat P,Regnard JF

    更新日期:2003-09-01 00:00:00

  • Effects of the Combination of Atomoxetine and Oxybutynin on OSA Endotypic Traits.

    abstract:BACKGROUND:We recently showed that administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep greatly reduced OSA severity, likely by increasing upper airway dilator muscle activity during sleep. In patients with OSA who performed the ato-oxy tria...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.01.012

    authors: Taranto-Montemurro L,Messineo L,Azarbarzin A,Vena D,Hess LB,Calianese NA,White DP,Wellman A,Sands SA

    更新日期:2020-06-01 00:00:00

  • Follow-up and surveillance of the lung cancer patient following curative intent therapy: ACCP evidence-based clinical practice guideline (2nd edition).

    abstract:BACKGROUND:To develop an evidence-based approach to follow-up of patients after curative intent therapy for lung cancer. METHODS:Guidelines on lung cancer diagnosis and management published between 2002 and December 2005 were identified by a systematic review of the literature, and supplemental material appropriate to...

    journal_title:Chest

    pub_type: 杂志文章,实务指引

    doi:10.1378/chest.07-1390

    authors: Rubins J,Unger M,Colice GL,American College of Chest Physicians.

    更新日期:2007-09-01 00:00:00

  • Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in iran.

    abstract:BACKGROUND:The study documented the emergence of new forms of resistant bacilli (totally drug-resistant [TDR] or super extensively drug-resistant [XDR] tuberculosis [TB] strains) among patients with multidrug-resistant TB (MDR-TB). METHODS:Susceptibility testing against first- and second-line drugs was performed on is...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-2427

    authors: Velayati AA,Masjedi MR,Farnia P,Tabarsi P,Ghanavi J,ZiaZarifi AH,Hoffner SE

    更新日期:2009-08-01 00:00:00

  • Periodic breathing with no heart beat.

    abstract::A protocol was originally designed to study breathing control during and following cardiac arrest in humans, taking advantage of the period of pulseless ventricular fibrillation (PVF) produced while testing a newly implanted cardioverter-defibrillator device. A patient aged in his 60s with New York Heart Association c...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-2950

    authors: Bartsch S,Haouzi P

    更新日期:2013-10-01 00:00:00

  • Beliefs among pulmonologists and thoracic surgeons in the therapeutic approach to non-small cell lung cancer.

    abstract:STUDY OBJECTIVES:The physicians who initially evaluate patients with non-small cell lung cancer (NSCLC) strongly impact the course of therapy. Their beliefs in treatment and prognosis may contribute to practices of variable quality and appropriateness. We sought to better describe beliefs among pulmonologists and thora...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.1.129

    authors: Schroen AT,Detterbeck FC,Crawford R,Rivera MP,Socinski MA

    更新日期:2000-07-01 00:00:00

  • Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study.

    abstract:STUDY OBJECTIVES:To evaluate the safety and efficacy of sitaxsentan, an endothelin-A receptor antagonist, in a 12-week, open-label trial of patients with pulmonary arterial hypertension (PAH). PATIENTS:Six children and 14 adults with New York Heart Association (NYHA) functional class II, III, or IV primary pulmonary h...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1378/chest.121.6.1860

    authors: Barst RJ,Rich S,Widlitz A,Horn EM,McLaughlin V,McFarlin J

    更新日期:2002-06-01 00:00:00

  • Purulent pericarditis with tamponade in a postpartum patient due to group F streptococcus.

    abstract::Bacterial pericarditis with cardiac tamponade is a life-threatening disorder that has been associated with a variety of organisms. There is usually an associated underlying condition or a seeding of the pericardium from an infection elsewhere. We report the development of cardiac tamponade and a subsequent pericardial...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.6.1746

    authors: Snyder RW,Braun TI

    更新日期:1999-06-01 00:00:00

  • Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience.

    abstract:BACKGROUND:Pulmonary hypertension (PH) is a common complication of sarcoidosis that is associated with increased mortality. The pathogenesis of PH in sarcoidosis is uncertain, and the role of pulmonary arterial hypertension (PAH)-specific therapies remains to be determined. METHODS:We conducted a retrospective study o...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.08-1881

    authors: Barnett CF,Bonura EJ,Nathan SD,Ahmad S,Shlobin OA,Osei K,Zaiman AL,Hassoun PM,Moller DR,Barnett SD,Girgis RE

    更新日期:2009-06-01 00:00:00

  • Cost-effective preoperative evaluation and testing.

    abstract::Cost-effective preoperative evaluation can be approached from a variety of methods, educational strategies, and use of data to modify clinical practice. This article focuses on the proposed organizational and clinical changes in the process of preoperative evaluations, the cost-effective outcomes, and the relative mer...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.115.suppl_2.96s

    authors: Fischer SP

    更新日期:1999-05-01 00:00:00

  • Establishment of the cardio-ankle vascular index in patients with obstructive sleep apnea.

    abstract:BACKGROUND:An arterial stiffness parameter, the cardio-ankle vascular index (CAVI), has been developed. CAVI is adjusted for BP and can be used to measure arterial stiffness with little influence of BP. The purpose of this study was to evaluate the reproducibility, validity, and clinical usefulness of CAVI among patien...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.09-0178

    authors: Kumagai T,Kasai T,Kato M,Naito R,Maeno KI,Kasagi S,Kawana F,Ishiwata S,Narui K

    更新日期:2009-09-01 00:00:00

  • Expression of the atypical chemokine receptor D6 in human alveolar macrophages in COPD.

    abstract:BACKGROUND:D6 is an atypical chemokine receptor involved in chemokine degradation and resolution of acute inflammatory responses in mice. Emerging evidence suggests that D6 might behave differently in human chronic inflammatory conditions. We, therefore, investigated the involvement of D6 in the immune responses in COP...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-3220

    authors: Bazzan E,Saetta M,Turato G,Borroni EM,Cancellieri C,Baraldo S,Savino B,Calabrese F,Ballarin A,Balestro E,Mantovani A,Cosio MG,Bonecchi R,Locati M

    更新日期:2013-01-01 00:00:00

  • The subvalvular apparatus in rheumatic mitral stenosis: methods of assessment and therapeutic implications.

    abstract::The assessment of the structure and function of the subvalvular apparatus (SVA) in patients with rheumatic mitral stenosis (MS) is complex, yet is of major importance prior to therapeutic decision making. Currently available methods of assessment are neither sufficiently accurate nor feasible. We review anatomic and f...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.124.5.1929

    authors: Turgeman Y,Atar S,Rosenfeld T

    更新日期:2003-11-01 00:00:00