Abstract:
:Central hemodynamics and gas exchange were studied in six patients with chronic obstructive pulmonary disease (mean age, 60 years). Patients were selected for the study if the volume of blood was 1 L larger than the predicted normal value, if there was no history of infection, and if no drug assumed to influence pulmonary circulation had been given during the last four weeks. Measurements were first performed in the hypervolemic state. This was followed by a venesection of 0.5 L, and the measurements were repeated 15 minutes later (immediate effects of dehydration). After two weeks to two months of intensive diuretic therapy, new measurements were performed (long-term effects of dehydration). With hypervolemia, there was pulmonary hypertension, increased pulmonary vascular resistance, and normal cardiac output. The arterial oxygen tension (PaO2) was markedly reduced. The arterial carbon dioxide tension (PaCO2) was increased in two patients, and dead-space ventilation (VD/VT) increased in all. The sole immediate effect of venesection was a small increase in heart rate and a reduction in PaCO2. The long-term effects were a maintained low blood volume (on the average, 0.7 L less than before bloodletting) and lowered hematocrit reading (8 percent less than before bloodletting), a reduced and in some patients normalized pulmonary arterial pressure, a reduced pulmonary vascular resistance, and an unchanged cardiac output. The PaO2 improved, while PaCO2 did not change; neither did VD/VT. The changes correlated partly with the diminution in blood volume and partly with the reduction in hematocrit reading.
journal_name
Chestjournal_title
Chestauthors
Gertz I,Hedenstierna G,Wester POdoi
10.1378/chest.75.2.146subject
Has Abstractpub_date
1979-02-01 00:00:00pages
146-51issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)30517-1journal_volume
75pub_type
杂志文章相关文献
CHEST文献大全abstract::Eighteen asymptomatic postmenopausal women volunteered to ingest 2 ml of 100-proof vodka per kg of body weight in orange juice on one night and a placebo on another. Overnight sleep monitoring was performed immediately thereafter. Alcohol ingestion caused reduction in total sleep time from 329 to 281 minutes and a dec...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.88.2.181
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:Morbid obesity produces a variety of ECG alterations, including leftward shifts of the P-wave, QRS, and T-wave axes; disproportionately high frequencies of low QRS voltage; left ventricular hypertrophy and left atrial abnormality; and a high frequency of T-wave flattening in the inferior and lateral leads. T...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.2.507
更新日期:2001-02-01 00:00:00
abstract::Identifying patients with impaired renal function is crucial in the setting of critical illness. Serum creatinine serves as the gold standard for assessing steady-state renal function, helping to define those with chronic kidney disease (CKD). Although these baseline creatinine values are often not available in the se...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.11-1513
更新日期:2012-06-01 00:00:00
abstract::Impedance measurement of the respiratory system by forced oscillations is a sensitive and accurate method to detect mechanical parameters, especially in normal subjects. The effects of inhalation of 0.2 mg of fenoterol and 0.02 mg of ipratropium bromide on the impedance of the respiratory system was studied in 20 heal...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.5.1137
更新日期:1990-05-01 00:00:00
abstract::We describe the first reported case (to our knowledge) of pulmonary granulomatosis caused by aspirated green tea. In this case, we found granulomatous alveolitis with lymph follicles, T lymphocytosis with predominantly CD8+ cells in the bronchoalveolar lavage fluids, positive serum precipitin and proliferative respons...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.1.308
更新日期:1994-07-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the impact on survival and clinical correlates of pulmonary hypertension (PH) occurring in patients with idiopathic pulmonary fibrosis (IPF). DESIGN:Retrospective study. SETTING:Tertiary care, referral medical center. PATIENTS:Among 487 consecutive patients with IPF, we identified 136 p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.4.2393
更新日期:2005-10-01 00:00:00
abstract::Medical malpractice with its associated costs, including insurance premiums, impact on practice, consequences for career and insurability, and emotional toll, is a reality of practicing medicine in the United States. Understanding the types of claims that may be asserted, the issues to consider when securing insurance...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.08-0186
更新日期:2008-11-01 00:00:00
abstract::A survey of American College of Chest Physicians (ACCP) members was conducted to determine their degree of involvement in the diagnosis and prevention of occupational and environmental respiratory disease (OERD). Although the response rate was relatively low, the results are likely to be representative. Calculations b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.4.1156
更新日期:1995-04-01 00:00:00
abstract::Flexible bronchoscopy (FB) is uniquely suited for the study of large airway lesions in the ventilated premature infant. However, no standardized clinical scoring system of distal tracheal injury exists and the adverse consequences of FB in ventilated premature infants are not well described. Using a prototype Olympus ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.5.1219
更新日期:1990-11-01 00:00:00
abstract::Antemortem diagnosis of a perforated MV aneurysm by Doppler echocardiography, as well as two-dimensional echocardiography (2-DE), has not been reported. Herein we present such a case. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.3.753
更新日期:1990-03-01 00:00:00
abstract::Tobacco smoking increases the risk of sudden cardiac death, possibly by altering the substrate for propagation or sustainment of ventricular tachyarrhythmias. To test this hypothesis, 15 long-term smokers without known coronary artery disease abstained from tobacco smoking for 12 h, after which they underwent SAECG be...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.1.121
更新日期:1991-01-01 00:00:00
abstract::To determine if respiratory maneuvers may enhance the response to inhaled bronchodilator drugs, we evaluated the bronchodilator responses when isoproterenol was: inhaled as a bolus high (80 percent VC) compared to low (20 percent VC) lung volumes, and inhaled as a single 800 microgram dose compared to four 200 microgr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.76.5.501
更新日期:1979-11-01 00:00:00
abstract::We report the occurrence of an unusual variant of congenital adenomatoid malformation (CAM) of the lung in a 16-year-old male. Abundant cartilage in the walls of malformed bronchioles, an extremely rare finding in CAM, distinguishes this lesion from the usual forms. We present the roentgenographic, computed tomographi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.3.514
更新日期:1987-09-01 00:00:00
abstract::This study was undertaken to determine if the production of pulsatile flow by the intra-aortic balloon pump during cardiopulmonary bypass has any beneficial effect on coronary flow, regional myocardial flow, myocardial metabolism, and left ventricular function. Thirty-six conditioned dogs were subjected to one hour of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.1.37
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:To gain more knowledge of changes in main pulmonary artery flow and right ventricular mass and volumes in patients with pulmonary hypertension during epoprostenol therapy. METHODS:Eleven patients (9 women) were evaluated before the start of therapy and every 4 months thereafter. Right and left ventricular v...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.125.2.572
更新日期:2004-02-01 00:00:00
abstract::Airway pressure release ventilation (APRV), a new ventilatory support technique, was compared with conventional intermittent positive-pressure ventilation plus PEEP (CPPV) in 18 patients with severe acute respiratory failure. Patients were initially stabilized on CPPV and then switched to APRV. The APRV provided effec...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.2.460
更新日期:1991-08-01 00:00:00
abstract:STUDY OBJECTIVE:To study mechanisms of gastroesophageal reflux-induced bronchoconstriction during intraesophageal infusions. DESIGN:Prospective study blinded to the subject. SETTING:Outpatient pulmonary function laboratory at a 908-bed university hospital. PARTICIPANTS:Forty-seven adult subjects divided into four gr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.3.731
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:The ratio of FVC to slow inspiratory vital capacity (SVC) has been reported to reflect small airways obstruction, but its validity as such is still unclear. The aim of this study was to assess the applicability of the FVC/SVC ratio as a marker of small airways function in patients with bronchiolitis oblitera...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-2763
更新日期:2007-10-01 00:00:00
abstract::Hyperbaric oxygen therapy, the administration of 100% oxygen at pressures > 1 atm, is believed to promote wound healing by increasing angiogenesis and collagen synthesis. To our knowledge, this treatment modality has never been described in patients with tracheal radionecrosis. Here, we report the case of a 55-year-ol...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.03.027
更新日期:2016-12-01 00:00:00
abstract::Invasive thymoma recently has been shown to be sensitive to combination chemotherapy and in some cases to be relatively indolent. Two cases of extensive thymoma which responded to primary treatment with a combination of a platinum compound (carboplatin or cisplatin), doxorubicin (Adriamycin), and cyclophosphamide (or ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.4.1115
更新日期:1996-10-01 00:00:00
abstract:STUDY OBJECTIVE:To obtain information about the diagnosis and management of primary pulmonary hypertension (PPH), especially about the use of epoprostenol (Glaxo-Wellcome; Research Triangle Park, NC) in this patient population. BACKGROUND:Long-term IV epoprostenol therapy was approved recently for use in patients with...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.5.1269
更新日期:1998-11-01 00:00:00
abstract:AIMS:We assessed early and long-term pulmonary function changes after percutaneous balloon mitral valvotomy (PBMV). METHODS AND RESULTS:Mitral area, lung function, and exercise capacity were evaluated before, immediately after, and 3 months, 6 months, and 12 months after successful PBMV in 24 patients. PBMV resulted i...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.1.40
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Early appropriate diagnosis of acute heart failure (AHF) is recommended by international guidelines. This study assessed the value of several lung ultrasound (LUS) strategies for identifying AHF in the ED. METHODS:This prospective study, conducted in four EDs, included patients with diagnostic uncertainty b...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1016/j.chest.2019.07.017
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Bosentan, an oral endothelin (ET)-A/ET-B receptor antagonist, is effective in the treatment of pulmonary arterial hypertension. OBJECTIVE:To investigate the safety and efficacy of bosentan therapy in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). DESIGN:Case series. SETTIN...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.128.4.2599
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVES:Tumor necrosis factor (TNF)-alpha is known to be a proinflammatory cytokine that has a pronounced negative inotropic effect and plays an important role in ischemic-reperfusion injury. METHODS:Twenty isolated rat hearts were randomly divided equally into two groups (heparin and non-heparin) and were perfused...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1805
更新日期:2005-09-01 00:00:00
abstract::This chapter about implementation strategies for practice guidelines is part of the 7th ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that feasib...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.126.3_suppl.688S
更新日期:2004-09-01 00:00:00
abstract::Malignant pleural effusions cause significant morbidity, but there is no gold standard minimally invasive treatment. A new therapeutic approach combines talc pleurodesis and indwelling pleural catheters (IPCs) to enable outpatient management. This case series summarizes the safety and efficacy data of all patients (24...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.14-0394
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The benefits of inhaled corticosteroids in the management of COPD are less apparent than they are in asthma therapy, and the potential for adverse systemic effects of high-dose inhaled corticosteroids has been recognized recently. It is therefore essential to know the maximal obtainable benefits in order to ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.115.1.31
更新日期:1999-01-01 00:00:00
abstract:STUDY OBJECTIVES:The objectives of this study are as follows: (1) to determine the incidence of complications from thoracentesis performed under ultrasound guidance by interventional radiologists in a tertiary referral teaching hospital; (2) to evaluate the incidence of vasovagal events without the use of atropine prio...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.2.418
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:Stenosis and occlusion rates of internal mammary artery (IMA) and saphenous vein (SV) coronary artery bypass grafts (CABGs) are markedly different, which result from respective disparities in vascular remodeling. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate vascu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.125.5.1853
更新日期:2004-05-01 00:00:00