Abstract:
:Identifying patients with impaired renal function is crucial in the setting of critical illness. Serum creatinine serves as the gold standard for assessing steady-state renal function, helping to define those with chronic kidney disease (CKD). Although these baseline creatinine values are often not available in the setting of critical illness, CKD, whether defined by serum creatinine or proteinuria, increases the risk of developing acute kidney injury (AKI). Despite delays in elevations following renal insults, serum creatinine remains the standard for assessing acute changes in renal function. Standardized definitions of AKI, using changes in serum creatinine and urine output, have informed the epidemiology of ICU-acquired AKI and have helped define the long-term outcomes in patients who experience AKI. A complex cyclical interplay exists between AKI and CKD, in which CKD predisposes patients to an increased risk of AKI, whereas those with AKI, regardless of baseline renal function, are more likely to suffer from post-AKI CKD. The clarification of the AKI-CKD dynamic remains a work in progress and will be aided by the implementation of novel measures of renal function. Several novel biomarkers of renal function have been proposed to augment serum creatinine in the diagnosis of AKI and CKD. These biomarkers, taken with recent clinical investigations, have laid the groundwork for the impending paradigm shift in risk stratifying and in diagnosing changes in renal function in the ICU.
journal_name
Chestjournal_title
Chestauthors
Koyner JLdoi
10.1378/chest.11-1513subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1584-1594issue
6eissn
0012-3692issn
1931-3543pii
S0012-3692(12)60349-3journal_volume
141pub_type
杂志文章,评审相关文献
CHEST文献大全abstract:STUDY OBJECTIVES:Gastroesophageal reflux disease (GERD) and asthma are common causes for consultation in primary care, but the relationship between the two remains unclear. The aim of our study was to investigate the temporal relationship between first diagnoses of GERD and asthma in general practice. METHODS:We used ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.1.85
更新日期:2005-07-01 00:00:00
abstract::It has been demonstrated that total parenteral nutrition (TPN) results in increased O2 consumption (VO2), CO2 production (VCO2) and minute ventilation (VE). TPN consists of a mixture of glucose and amino acids. The individual role of each of these nutrients in mediating these changes has not been well established. To ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.88.4.512
更新日期:1985-10-01 00:00:00
abstract::To assess the effects of intravenous aminophylline on the sinus node, 12 patients with clinical and Holter monitor-documented sick sinus syndrome were studied (1) during the control state, (2) after pharmacologic autonomic blockade and (3) 5 min after intravenous administration of aminophylline. The effects of aminoph...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.4.887
更新日期:1991-04-01 00:00:00
abstract::Postoperative cardiac tamponade due to localized compression of the atria occurred in a 64-year-old man after aortic valve replacement and repair of an ascending aortic dissection. The clinical findings were subtle and the echocardiographic findings were unusual. Color Doppler flow imaging assisted in making the diagn...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.4.1003
更新日期:1990-04-01 00:00:00
abstract::The effect of clenbuterol, a beta adrenergic drug, and ambroxol, a secretolytic agent, on regional mucociliary clearance and pulmonary radioaerosol distribution was investigated in two groups of 15 patients with COLD in a double-blind cross-over trial with placebo. Clearance rates of inhaled 99mTc-labelled human serum...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.80.6.881
更新日期:1981-12-01 00:00:00
abstract::The self-expandable stainless steel stents (Gianturco, William Cook, Bjaeverskov, Denmark) used extensively in biliary ducts and the vascular system have recently been modified for use in the tracheobronchial tree. Between March 1991 and September 1992, six patients with unresectable tracheobronchial and mediastinal d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.1.86
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Patients with chronic bird fancier's lung (BFL) can be classified into two types. One group of patients develops chronic disease with fluctuating acute episodes, including low-grade fever, mild exertional dyspnea, and cough (fluctuating chronic BFL; formerly termed recurrent and relapsing chronic BFL). The o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.5.1382
更新日期:2000-11-01 00:00:00
abstract:STUDY OBJECTIVE:Low-grade systemic inflammation may cause a chronic catabolic state that may affect trainability in patients with COPD as has been seen previously in healthy elderly. Therefore, the aim of the present study was to study the relationship between baseline circulating levels of inflammatory markers and the...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.5.3183
更新日期:2005-11-01 00:00:00
abstract::An unruptured aneurysm of the left sinus of Valsalva was diagnosed by angiography in a 16-year-old male subject 19 years ago. A recent repeated angiographic study documented no change in the aneurysm over the 19-year interval, and the patient has remained asymptomatic. We are aware of no other long-term follow-up repo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.1.143
更新日期:1986-07-01 00:00:00
abstract::An unusual case of essential thrombocythemia in a young man presenting with progressive angina pectoris is presented. Angiography revealed proximal left anterior descending artery stenosis. Successful percutaneous transluminal angioplasty along with antiplatelet therapy and a calcium channel blocking drug have rendere...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.6.933
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:To evaluate changes in cerebral tissue oxygenation and blood volume during obstructive sleep apnea (OSA). METHODS:We studied eight men with moderate to severe OSA by near-infrared spectroscopy (NIRS) simultaneously with polysomnography during nocturnal sleep (five patients) and daytime naps (three). RESULTS...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.109.4.916
更新日期:1996-04-01 00:00:00
abstract::Eighteen asymptomatic postmenopausal women volunteered to ingest 2 ml of 100-proof vodka per kg of body weight in orange juice on one night and a placebo on another. Overnight sleep monitoring was performed immediately thereafter. Alcohol ingestion caused reduction in total sleep time from 329 to 281 minutes and a dec...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.88.2.181
更新日期:1985-08-01 00:00:00
abstract::Prior to 1978, the conventional treatment of pneumothorax generally consisted of conservative therapies such as rest, needle puncture, or thoracic cavity drainage; however, when conservative therapies were ineffective or relapse occurred therapeutic approach, 34 percent (11/32) of our patients required a thoracotomy. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.4.953
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Ultrasound enables the visualization of pleural-based lesions with a poor correlation to specific pathology. At this time, there are no data about the diagnostic value of contrast-enhanced sonography (CES) in pleural lesions. METHODS:From August 2004 to January 2005, 25 consecutive patients with clinical sy...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.6.3894
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated that high-flow nasal cannula (HFNC) prevents intubation in acute hypoxic respiratory failure when compared with conventional oxygen therapy (COT). However, the data examining routine HFNC use in the immediate postoperative period are less clear. RESEARCH QUESTION:Is routine HFNC us...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.06.038
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Patients admitted to the medical ICU (MICU) are often subjected to multiple radiologic studies. We hypothesized that some endure radiation dose exposure (cumulative effective dose [CED]) in excess of annual US federal occupational health standard limits (CED ≥ 50 mSv) and 5-year cumulative limit (CED ≥ 100 m...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.01.019
更新日期:2018-05-01 00:00:00
abstract:STUDY OBJECTIVE:We assessed whether transpleural methods for diagnosing peripheral lung cancer, such as needle aspiration or tumor excision, affect relapse and prognosis, because these techniques have potential to spread malignant cells from the tumor. DESIGN:A retrospective study. SETTING:National referral hospital....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.5.1595
更新日期:2001-11-01 00:00:00
abstract::We report two patients with non-conventional thyroiditis whose chief complaint was chronic persistent cough. Cough was attributed to thyroiditis only after extensive diagnostic evaluations failed to uncover another cause and only after cough and thyroiditis disappeared simultaneously with suppressive therapy for the l...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.81.3.386
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Over the last 25 years, a growing number of clinical trials have evaluated novel sepsis therapies. To promote uniformity in inclusion criteria for patient enrollment, the American College of Chest Physicians and Society of Critical Care Medicine first published consensus conference definitions for sepsis in ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.1.242
更新日期:2005-01-01 00:00:00
abstract::Pulmonary hypertension and related pulmonary vascular diseases cause significant morbidities and high mortality and present many unique challenges toward improving outcomes in neonates, infants, and children. Differences between pediatric and adult disease are reflected in controversies regarding etiologies, classific...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2016.01.007
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:It has been postulated that differences in provocative concentration of methacholine causing a 20% fall in FEV1 (PC20) values between the dosimeter method and tidal breathing method might be due to differences in the dose of agonist delivered to the mouth. The aim of the present study was to determine the in...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.08-0093
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare the pressure required to abolish apneas as predicted from a previously derived algorithm (Ppred) with the true effective pressure (Peff) determined during a continuous positive airway pressure (CPAP) titration study. SETTING:Sleep clinic of a university hospital. METHO...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.4.1061
更新日期:2000-04-01 00:00:00
abstract::We describe the Ca2+ movements in smooth muscle cells at rest and during activation and relaxation as deduced from transplasmalemmal Ca2+ fluxes and contractile respnses. The general picture which emerges is: the resting cell has a [Ca2+]cyt below 10(-7) M and large gradients are poised across both the cell membrane a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.1_supplement.157
更新日期:1980-07-01 00:00:00
abstract::The results of computed chest tomograms (CT) and chest roentgenograms (CR) were compared in 32 patients who presented with hemoptysis. The CT demonstrated roentgenographic abnormalities more often than CR (p less than 0.01), providing new diagnostic information in 15 patients (46.9 percent), and clarifying CR abnormal...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.1.80
更新日期:1987-01-01 00:00:00
abstract::A radioaerosol procedure using 99mcTc-DTPA (diethylene triamine penta acetate) was used to evaluate the permeability of the pulmonary epithelium in smokers and nonsmokers. The average clearance of this indicator from the lungs of smokers without significant airway obstruction exceeded that found in normal subjects by ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.1.6
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The presence and progression of interstitial lung abnormalities (ILAs) is known to be associated with a decline of lung function and increased risk of mortality. RESEARCH QUESTION:We aimed to elucidate the clinical course according to ILAs in patients with COPD. STUDY DESIGN AND METHODS:A retrospective stu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.08.017
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Failure to reliably diagnose ARDS may be a major driver of negative clinical trials and underrecognition and treatment in clinical practice. We sought to examine the interobserver reliability of the Berlin ARDS definition and examine strategies for improving the reliability of ARDS diagnosis. METHODS:Two hu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2017.11.037
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Unlike studies on leg exercise, reports on the regulation of dynamic hyperinflation during arm exercise are scanty. We ascertained the following in patients with COPD: (1) whether and to what extent upper-limb exercise results in dynamic hyperinflation, and (2) the mechanism whereby an arm-training program (...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1225
更新日期:2005-09-01 00:00:00
abstract:STUDY OBJECTIVES:To determine and compare the values of positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG) and CT for predicting clinical outcome of patients with aggressive lymphoma undergoing salvage cytoreductive chemotherapy followed by high-dose chemotherapy and autologous stem-cell transplantat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.2.608
更新日期:2003-08-01 00:00:00
abstract:STUDY OBJECTIVE:To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care. DESIGN:Retrospective chart review. SETTING:Two ICUs from a tertiary-care teaching hospital. PATIENTS:Twenty-seven adult ICU patients with microbiologically documented melioidosis. INTER...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.5.3674
更新日期:2005-11-01 00:00:00