Abstract:
BACKGROUND:The ratio of FVC to slow inspiratory vital capacity (SVC) has been reported to reflect small airways obstruction, but its validity as such is still unclear. The aim of this study was to assess the applicability of the FVC/SVC ratio as a marker of small airways function in patients with bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTX), which is a disorder in which predominantly small airways obstruction causes progressive airflow limitation. METHODS:The FVC/SVC ratio was analyzed both cross-sectionally and longitudinally in 39 patients (26 men) with BOS after bilateral LTX (median age, 47 years; interquartile range [IQR], 35 to 54 years), and 36 bilateral lung transplant recipients without BOS (14 men; median age, 46 years; IQR, 41 to 53 years). RESULTS:The FVC/SVC ratio decreased significantly during follow-up in patients with BOS stages 1 and 2, by 2.2% and 4.4%, respectively, from baseline (p < 0.001). This decrease was not significantly associated with the decrease in FEV(1). The FVC/SVC ratio increased, though not significantly, in the group in which BOS did not develop by 1.1%, which is a significant difference from the average fall of 4.4% in the group in which BOS developed. CONCLUSIONS:Significant, yet small decreases in FVC/SVC ratio occur in patients in whom BOS develops, independent from changes in FEV(1). At a group level, FVC/SVC ratio is able to detect small airways changes. These results merit prospective studies to determine the sensitivity of FVC/SVC ratio to quantifying small airways dysfunction at an individual level and in other airway diseases.
journal_name
Chestjournal_title
Chestauthors
Cohen J,Postma DS,Vink-Klooster K,van der Bij W,Verschuuren E,Ten Hacken NH,Koëter GH,Douma WRdoi
10.1378/chest.06-2763subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1198-203issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(15)36713-1journal_volume
132pub_type
杂志文章相关文献
CHEST文献大全abstract::An unusual case of essential thrombocythemia in a young man presenting with progressive angina pectoris is presented. Angiography revealed proximal left anterior descending artery stenosis. Successful percutaneous transluminal angioplasty along with antiplatelet therapy and a calcium channel blocking drug have rendere...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.6.933
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:There is no consensus at the present time about the effect of welding on lung function decline. This study compared lung function decline between blue-collar workers exposed and not exposed to welding fumes in a French longitudinal cohort of 21,238 subjects aged 37 to 52 years at inclusion. METHODS:Medical ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-0647
更新日期:2012-07-01 00:00:00
abstract::Random assessments of SaO2 were performed via pulse oximetry in 274 hospitalized non-ICU patients prescribed supplemental O2 in a large tertiary care university hospital. In 507 assessments performed in patients inspiring the prescribed O2, 426 were receiving excessive amounts of O2 to maintain a SaO2 > or = 92 percen...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1672
更新日期:1992-12-01 00:00:00
abstract::We studied the possibility of predicting PaO2 during exercise of a given oxygen uptake (VO2) from resting pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD). The three-minute incremental treadmill exercise was performed with serial measurements of PaO2 via intra-arterial cath...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.3.328
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Thirty to 50% of all COPD patients experience tissue wasting that may be caused by hypermetabolism, but the cause of the perturbed metabolic state is unclear. We hypothesized that the elevated O2 cost of ventilation (O2 COV) may be a contributing factor. All of the data are presented as means ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.3.708
更新日期:1999-03-01 00:00:00
abstract::Flecainide and propafenone are effective in suppressing both ventricular and supraventricular tachyarrhythmias, but their efficacy is often limited by dose-related side effects. This study was performed to evaluate noninvasively the effects of intravenous flecainide and propafenone on left ventricular systolic functio...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.103.4.1068
更新日期:1993-04-01 00:00:00
abstract::Residual volume (RV) was obtained by subtracting vital capacity from total lung capacity determined by the single breath helium dilution (TLCsb) to measure CO diffusing capacity in 2,680 subjects (8 to 64 years old) of a general population sample. There were 712 normal subjects (243 male and 469 female subjects) selec...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.4.1209
更新日期:1992-10-01 00:00:00
abstract::Cardiac tamponade, a potentially lethal complication following cardiac surgery, may present either early or late postoperatively and may be difficult to diagnose due to atypical clinical, hemodynamic, or echocardiographic findings. To determine the frequency and clinical features of postoperative cardiac tamponade, we...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.1.71
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Cilia line the surface of the respiratory tract and beat in a coordinated wave to protect the lungs against infection. Bardet Biedl Syndrome (BBS) is a rare condition attributed to cilia dysfunction. Murine models of BBS suggest a respiratory phenotype; however, no reports have studied the translation of the...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-2913
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Skeletal muscle dysfunction occurring as a result of ICU admission associates with higher mortality. Although preadmission higher BMI correlates with better outcomes, the impact of baseline muscle and fat mass has not been defined. We therefore investigated the association of skeletal muscle and fat mass at ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.10.023
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Adjunctive strategies are an important part of the management of ARDS. However, their application in clinical practice remains inconsistent. RESEARCH QUESTION:We wished to determine the frequency and patterns of use of adjunctive strategies in patients with moderate to severe ARDS (Pao2/Fio2 [P/F ratio] < 1...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.01.041
更新日期:2020-06-01 00:00:00
abstract::Several reports have implicated pregnancy as a cause of deterioration in patients with pulmonary arteriovenous fistulas. We report a 27-year-old woman with multiple pulmonary arteriovenous fistulas who required coil spring embolotherapy in her 24th week of pregnancy due to a spontaneous hemothorax and hypoxemia. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.6.1522
更新日期:1990-12-01 00:00:00
abstract::The efficacy of a new tissue-culture technique for the diagnosis of malignant pleural effusions was contrasted with conventional cytologic methods. The new technique is based on the ability of the tissue-culture medium to transform mesothelial cells into fibroblasts while not sustaining lymphoreticular cells. Against ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.5.626
更新日期:1976-05-01 00:00:00
abstract::A 66-year-old man with a history of COPD and Aspergillus fumigatus infection developed massive hemoptysis. Pulmonary artery angiography revealed an aneurysm which was successfully treated with coil embolization. This is the first known report of a pulmonary artery aneurysm causing massive hemoptysis in a patient with ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.4.1130
更新日期:1998-04-01 00:00:00
abstract::Respiratory rate is a sensitive clinical parameter in a multitude of pulmonary diseases, especially in the critical care setting. In order to validate the routine recording of the respiratory rate in the intensive care unit, we compared the values obtained from the nursing records with the breathing frequency continuo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.5.632
更新日期:1986-11-01 00:00:00
abstract::Acute hypoxemia produces opposite effects on the pulmonary and systemic vascular resistance. To assess the influence of acute hypoxemia on cardiac murmurs, 36 patients with a single valvular or congenital heart lesion were studied. As expected from these hemodynamic effects, right-sided regurgitant type murmurs increa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.81.2.159
更新日期:1982-02-01 00:00:00
abstract::We compared, in a controlled clinical trial, the effect of specific inspiratory muscle training combined with general exercise reconditioning, for six months, with that of general exercise reconditioning alone on inspiratory muscle strength, endurance, and exercise performance in patients with COPD. Thirty-six patient...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.102.5.1351
更新日期:1992-11-01 00:00:00
abstract:STUDY OBJECTIVES:Sputum induction (SI) is a noninvasive tool for sampling inflamed airways. The purpose of this study was to determine the optimal duration of collection in patients with cystic fibrosis (CF). The hypothesis was that the duration of SI collection would quantitatively and qualitatively alter the content ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.3.792
更新日期:2003-03-01 00:00:00
abstract::Nd-YAG laser resection of a completely obstructing right mainstem tumor in a 36-year-old man was complicated by right lung hyperinflation and left lung collapse and accompanying ventilatory failure. This was attributed to obstruction of the right mainstem bronchus during exhalation, but not inhalation, in a patent but...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.6.1302
更新日期:1988-06-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if screening by specialists could reduce unnecessary test ordering and reduce costs related to diagnostic workup in patients undergoing evaluation for tuberculosis. DESIGN:Prospective evaluation of expert opinion in consecutive patients suspected of having tuberculosis. SETTING:A large mu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.3.681
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To assess whether severe gastroesophageal reflux (GER) is associated with abnormalities in lung function including measures of lung volume and gas diffusion. METHODS:Data from 147 patients with obesity (body mass index [BMI] range, 31.7 to 70 kg/m(2)) who presented for obesity surgery was analyzed retrospect...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.6.1932
更新日期:2003-06-01 00:00:00
abstract::Lung volume reduction surgery (LVRS) is being evaluated in the treatment of emphysema. The proposed mechanisms of improvement are increased elastic recoil of the lung and improved mechanical efficiency of the muscles of respiration. We report a unique patient with emphysema who developed a giant bulla 3 years subseque...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.6.1809
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To study the incidence and severity of organ dysfunction associated with sepsis. DESIGN:Comprehensive review of prospectively collected data from intensive care patients hospitalized between 1997 and 2001. SETTING:Thirty-five ICUs in nonuniversity and university hospitals located in the Paris area. PATIENT...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.127.3.942
更新日期:2005-03-01 00:00:00
abstract::In 283 patients referred for testing in an outpatient pulmonary function laboratory, we studied the single-breath diffusing capacity of the lungs for carbon monoxide (Dco) using the Ogilvie (Og), Jones-Meade (JM), Epidemiological Standardization Project (ESP), and three-phase iterative methods (3PIT, similar to the th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.2.594
更新日期:1994-02-01 00:00:00
abstract::Tracheal extubation after laryngotracheal reconstruction in children may be complicated by postoperative tracheal edema and pulmonary dysfunction. The replacement of a tracheal tube in this situation may exacerbate the existing injury to the tracheal mucosa, complicating subsequent attempts at tracheal extubation. We ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.1.260
更新日期:1999-07-01 00:00:00
abstract::Arrhythmias that may accompany myocardial reperfusion have generated significant clinical interest. First, there were concerns, based on animal studies, that high-grade ventricular tachyarrhythmias would pose a serious threat following thrombolytic therapy to treat an evolving myocardial infarction. Second, lower-grad...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.99.4.135s
更新日期:1991-04-01 00:00:00
abstract::Symptom-limited supine bicycle exercise with radionuclide angiography was performed on 11 patients with severe mitral regurgitation (who were not receiving vasodilators), to assess changes in left ventricular volume, regurgitant fraction, forward flow and regurgitant flow during exercise. All patients were in normal s...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.5.1086
更新日期:1989-11-01 00:00:00
abstract:STUDY OBJECTIVE:To compare drug output from a vented nebulizer (Pari LC Jet Plus) with a traditional unvented nebulizer (Hudson 1730 T Up-Draft 11) using aerosolized tobramycin, which is frequently used in the treatment of cystic fibrosis. DESIGN:Six nebulizers of each type were filled with a 4 mL tobramycin (80 mg) s...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.4.951
更新日期:1998-04-01 00:00:00
abstract::A novel technique has been developed for the isolation and lavaging of a central airway segment in humans. The procedure uses a double-balloon airway-sampling catheter that is placed into the airways with fiberoptic bronchoscopic guidance. A protocol using this technique was attempted in 32 subjects (18 normal subject...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.1.105
更新日期:1987-07-01 00:00:00
abstract::This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that i...
journal_title:Chest
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1378/chest.126.3_suppl.429S
更新日期:2004-09-01 00:00:00