Clinical implications of the ethane in exhaled breath in patients with acute paraquat intoxication.

Abstract:

STUDY OBJECTIVES:Pulmonary fibrosis due to lipid peroxidation is a major symptom of paraquat intoxication. Ethane in the expired breath (exEth) reflects lipid peroxidation and may be a measure of the damage effected by oxygen radicals in acute lung injury. The purpose of this study was to evaluate the clinical efficacy of exEth as a measure of exposure to paraquat and as an indicator of lung damage. DESIGN:Exposure levels were evaluated by the amount ingested, semiquantitative measurement of urine paraquat levels, and plasma paraquat concentration. End-tidal breath was collected for measurement of ethane 24 h after paraquat ingestion. Renal function and blood gas analyses were conducted on the same day as the breath collection, and the final clinical outcome was defined as either recovery or death. Associations between exEth and paraquat exposure profiles and clinical outcomes were assessed using linear regression models. PATIENTS:Twenty-one patients poisoned by paraquat were selected for the study during 2001 and 2002. RESULTS:exEth could not be used as a predictor of laboratory parameters such as Pa(O2), Pa(CO2), serum creatinine, and lung injury (as graded by high-resolution CT). A logistical analysis revealed that only the amount of paraquat ingested was a significant predictor of fatality (p = 0.021). The strength of the association between exEth and fatality was unaffected by the addition of potential confounders such as age, sex, and time interval and paraquat concentration. CONCLUSION:exEth cannot be used as either an independent predictor of survival or a specific marker of lung injury in patients with acute paraquat poisoning.

journal_name

Chest

journal_title

Chest

authors

Hong SY,Gil HW,Yang JO,Lee EY,Na JO,Seo KH,Kim YH

doi

10.1378/chest.128.3.1506

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

1506-10

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)52180-6

journal_volume

128

pub_type

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