Smoking-Related Diffuse Cystic Lung Disease.

Abstract:

:Exposure to cigarette smoke can lead to a variety of parenchymal lung diseases, including diffuse cystic lung diseases (DCLDs). Lymphangioleiomyomatosis (LAM) is the prototypical DCLD and has a characteristic appearance on high-resolution CT (HRCT). We present a series of four patients with DCLD on HRCT who were referred to our institution with a presumed diagnosis of LAM and who were found instead to have smoking-related injury of the small airways on histopathological analysis. We submit that cigarette smoke-induced small airway injury can present as DCLD on HRCT in a pattern that can mimic LAM. A detailed history of cigarette smoke exposure should be obtained in patients presenting with DCLD, and imaging features should not be used in isolation to establish a firm diagnosis of LAM.

journal_name

Chest

journal_title

Chest

authors

Gupta N,Colby TV,Meyer CA,McCormack FX,Wikenheiser-Brokamp KA

doi

10.1016/j.chest.2018.02.027

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

e31-e35

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(18)30395-7

journal_volume

154

pub_type

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