Abstract:
:Exposure to cigarette smoke can lead to a variety of parenchymal lung diseases, including diffuse cystic lung diseases (DCLDs). Lymphangioleiomyomatosis (LAM) is the prototypical DCLD and has a characteristic appearance on high-resolution CT (HRCT). We present a series of four patients with DCLD on HRCT who were referred to our institution with a presumed diagnosis of LAM and who were found instead to have smoking-related injury of the small airways on histopathological analysis. We submit that cigarette smoke-induced small airway injury can present as DCLD on HRCT in a pattern that can mimic LAM. A detailed history of cigarette smoke exposure should be obtained in patients presenting with DCLD, and imaging features should not be used in isolation to establish a firm diagnosis of LAM.
journal_name
Chestjournal_title
Chestauthors
Gupta N,Colby TV,Meyer CA,McCormack FX,Wikenheiser-Brokamp KAdoi
10.1016/j.chest.2018.02.027subject
Has Abstractpub_date
2018-08-01 00:00:00pages
e31-e35issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(18)30395-7journal_volume
154pub_type
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