Roxithromycin reduces the degree of bronchial hyperresponsiveness in children with asthma.

Abstract:

:We evaluated the effects of a new semisynthetic macrolide antibiotic, roxithromycin, on the bronchial hyperresponsiveness to histamine in children with asthma. Twelve hospitalized asthmatic children, aged 11 to 15 years (mean age, 12.9 years), were enrolled in this study. They were treated with 150 mg of roxithromycin once a day orally for 8 weeks without any side effects. The PC20 value 4 or 8 weeks after the administration of roxithromycin increased significantly over the initial values (p < 0.05, p < 0.01, respectively). No significant change was observed in serum theophylline concentrations during this study. Serum cortisol level in the morning did not change after the administration of roxithromycin for 4 weeks. These results suggest that administration of roxithromycin may act favorably in the treatment of childhood asthma.

journal_name

Chest

journal_title

Chest

authors

Shimizu T,Kato M,Mochizuki H,Tokuyama K,Morikawa A,Kuroume T

doi

10.1378/chest.106.2.458

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

458-61

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)44224-2

journal_volume

106

pub_type

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