Abstract:
:We evaluated the effects of a new semisynthetic macrolide antibiotic, roxithromycin, on the bronchial hyperresponsiveness to histamine in children with asthma. Twelve hospitalized asthmatic children, aged 11 to 15 years (mean age, 12.9 years), were enrolled in this study. They were treated with 150 mg of roxithromycin once a day orally for 8 weeks without any side effects. The PC20 value 4 or 8 weeks after the administration of roxithromycin increased significantly over the initial values (p < 0.05, p < 0.01, respectively). No significant change was observed in serum theophylline concentrations during this study. Serum cortisol level in the morning did not change after the administration of roxithromycin for 4 weeks. These results suggest that administration of roxithromycin may act favorably in the treatment of childhood asthma.
journal_name
Chestjournal_title
Chestauthors
Shimizu T,Kato M,Mochizuki H,Tokuyama K,Morikawa A,Kuroume Tdoi
10.1378/chest.106.2.458subject
Has Abstractpub_date
1994-08-01 00:00:00pages
458-61issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)44224-2journal_volume
106pub_type
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