Abstract:
:To evaluate whether epithelial damage of airways in asthma could be related to diminished levels of the low molecular weight bronchial leukocyte proteinase inhibitor (BLPI) in airways, we determined BLPI in bronchial washings of 13 asthma patients and 13 healthy subjects, using a sensitive enzyme-linked immunoassay. The patients had asthma due to western red cedar and had bronchial washings done 24 to 48 hours after a mild to moderate asthmatic reaction induced by inhalation challenge. We did not find significant differences in BLPI concentrations in lavage fluid of asthma patients and healthy control subjects. The ratios of BLPI to albumin levels in bronchial washings appeared to be lower among asthmatic patients, but this difference was mainly due to an increase in albumin levels in lavage fluid in asthma. In addition, there were no significant differences in BLPI levels in washings obtained from main and segmental bronchi in both control subjects and asthma patients.
journal_name
Chestjournal_title
Chestauthors
Ochnio JJ,Abboud RT,Lam S,Johal SS,Smith CE,Johnson DAdoi
10.1378/chest.93.5.1008subject
Has Abstractpub_date
1988-05-01 00:00:00pages
1008-12issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(16)31019-4journal_volume
93pub_type
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