Bad medicine: low-dose dopamine in the ICU.

Abstract:

:Low-dose dopamine administration (ie, doses < 5 microg/kg/min) has been advocated for 30 years as therapy in oliguric patients on the basis of its action on dopaminergic renal receptors. Recently, a large, multicenter, randomized, controlled trial has demonstrated that low-dose dopamine administered to critically ill patients who are at risk of renal failure does not confer clinically significant protection from renal dysfunction. In this review, we present the best evidence and summarize the effects of low-dose dopamine infusion in critically ill patients. We review the history and physiology of low-dose dopamine administration and discuss the reasons why dopamine is not clinically effective in the critically ill. In addition to the lack of renal efficacy, we present evidence that low-dose dopamine administration worsens splanchnic oxygenation, impairs GI function, impairs the endocrine and immunologic systems, and blunts ventilatory drive. We conclude that there is no justification for the use of low-dose dopamine administration in the critically ill.

journal_name

Chest

journal_title

Chest

authors

Holmes CL,Walley KR

doi

10.1378/chest.123.4.1266

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

1266-75

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)32544-7

journal_volume

123

pub_type

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